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The map label for this gene is ilvD

Identifier: 85860821

GI number: 85860821

Start: 2986593

End: 2988254

Strand: Direct

Name: ilvD

Synonym: SYN_01708

Alternate gene names: 85860821

Gene position: 2986593-2988254 (Clockwise)

Preceding gene: 85860820

Following gene: 85860822

Centisome position: 93.94

GC content: 57.34

Gene sequence:

>1662_bases
ATGCGCAGTGATATCATGAAAAAAGGACTTGAAAAGGCGCCTCATCGATCTCTGTTCAAGGCAATGGGCTATACGGATGA
AGAAATTGCCCGCCCGCTGATCGGTGTTGTCAACGCCGCTAACGAAATCATCCCCGGTCATATCCATCTGGATCGGATCG
TGGAGGATGTCAAGGCGGGCATCCGGATGGCAGGTGGAACGCCGGTGGAGTTTCCCGCCATCGGGATCTGCGACGGCATC
GCCATGGGCCATCTGGGTATGAAATATTCCCTGGCCAGCCGGGAATTGATCGCCGACTCCACAGAAGCCATGGTCATGGC
CCATCCCTTTGACGGCCTGGTTCTTGTTCCTAACTGTGACAAAATCATTCCCGGAATGCTCATGGCCGCCCTGCGCCTCA
ATATTCCATCAATTTTTGTCAGCGGCGGCCCCATGCTGGCCGGACGTCTCGATGGAAAGTCTGTGGATCTCATCAGCGTC
TTCGAAGGAGTCGGCGCCGTGAAGGCGGGCAAGATGACGGAAGAGCAGCTGAAGGCCCTGGAGGACTGCGCCTGTCCCGG
ATGCGGATCCTGTTCCGGAATGTATACGGCCAATTCCATGAACTGCGTGACGGAGGCACTGGGCCTGGGTCTGCCGGGAA
ACGGAACGATTCCTGCGATTCATGCGGCGCGACGGCGCCTTGCTAAAGAGGCGGGAGTCCGAATCATGGATCTGGTCTCC
AAAAACATCCGGCCTCGGGACATCGCCACGCTCGATGCCTTCAAAAATGCCCTCGCTGTGGATATGGCCCTGGGCTGCTC
CACCAATACGGTGCTGCACATCCCGGCGATTGCCCACGAAGCGGGAATTCGACTGGATCTTGACCTTTTCAACGAAATCA
GTGCAAGGACGCCGAATCTCTGTCATCTCAGTCCGGCCGGCCCCCACCATATCGAGGAACTTGATGCCGCCGGCGGGATT
CAGGCGGTCATGAAAGTCATCAGTAAACTGGGGGTGATCCAGGAGTCGGCTTTAACCGTATCCGGCAGGACAGTTGGAGA
AAACCTGGAAAAGGCACGTGTTCTCAATGAGGAGGTGATCCGCCCATTGGACCGTGCCTATCGGCAGGAGGGCGGCATCG
CCATTCTCCGAGGAAATCTTGCTCCCGATGGCGCGGTGGTCAAACAGTCCGGAGTGCTGCCGGAAATGATGATCAATGAA
GGAACGGCTCGCGTCTTCGATTCCGAGGATGAAGCGATTGCCGCAATCCTCGGCGGTAAAATTGTCGCGGGAGATATTGT
GGTCATCCGCTACGAAGGTCCGAAAGGAGGTCCGGGAATGCGGGAAATGCTGAGCCCCACCTCGGCCATCGCGGGCATGG
GTCTGGATACCTCGGTCGCTCTGCTTACGGATGGACGTTTCAGCGGAGGCACCCGCGGCGCCGCCATCGGGCACATTTCT
CCGGAGGCCGCGGAAGGAGGCCCGATTGCCCTGATCCGGGAGGGAGACTGGATCGCCATCAACATCCCGGAAAAAACATT
GACCTTGAAGGTTGACCCGGAAGAACTGGAAAAGAGAAAGCAGGAATGGAAACCCAAAGCATCACAGAACCTGACCGGTT
ATCTGGCCCGTTACGCAAGGCTTGTCACTTCCGCAAGCACGGGCGCCATCTTTAAGGATTAA

Upstream 100 bases:

>100_bases
TTAAATTTGATTTTTTTGACGGTACCAGGGGGATAAACCGGTTGCAACCAGCGGGTTTATCCCTTTTTTTAAGGGAGAAC
ATTCCCGGAAGGAGAGATTC

Downstream 100 bases:

>100_bases
CAGCAGGCATCCATACGATCTCCGGCACCAGTCGTCTTTCCCAGGCTGATCCCGACAGTTTTGACGTCGGCTTCCTGACT
GATCGAACATCAGACGAAGT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 553; Mature: 553

Protein sequence:

>553_residues
MRSDIMKKGLEKAPHRSLFKAMGYTDEEIARPLIGVVNAANEIIPGHIHLDRIVEDVKAGIRMAGGTPVEFPAIGICDGI
AMGHLGMKYSLASRELIADSTEAMVMAHPFDGLVLVPNCDKIIPGMLMAALRLNIPSIFVSGGPMLAGRLDGKSVDLISV
FEGVGAVKAGKMTEEQLKALEDCACPGCGSCSGMYTANSMNCVTEALGLGLPGNGTIPAIHAARRRLAKEAGVRIMDLVS
KNIRPRDIATLDAFKNALAVDMALGCSTNTVLHIPAIAHEAGIRLDLDLFNEISARTPNLCHLSPAGPHHIEELDAAGGI
QAVMKVISKLGVIQESALTVSGRTVGENLEKARVLNEEVIRPLDRAYRQEGGIAILRGNLAPDGAVVKQSGVLPEMMINE
GTARVFDSEDEAIAAILGGKIVAGDIVVIRYEGPKGGPGMREMLSPTSAIAGMGLDTSVALLTDGRFSGGTRGAAIGHIS
PEAAEGGPIALIREGDWIAINIPEKTLTLKVDPEELEKRKQEWKPKASQNLTGYLARYARLVTSASTGAIFKD

Sequences:

>Translated_553_residues
MRSDIMKKGLEKAPHRSLFKAMGYTDEEIARPLIGVVNAANEIIPGHIHLDRIVEDVKAGIRMAGGTPVEFPAIGICDGI
AMGHLGMKYSLASRELIADSTEAMVMAHPFDGLVLVPNCDKIIPGMLMAALRLNIPSIFVSGGPMLAGRLDGKSVDLISV
FEGVGAVKAGKMTEEQLKALEDCACPGCGSCSGMYTANSMNCVTEALGLGLPGNGTIPAIHAARRRLAKEAGVRIMDLVS
KNIRPRDIATLDAFKNALAVDMALGCSTNTVLHIPAIAHEAGIRLDLDLFNEISARTPNLCHLSPAGPHHIEELDAAGGI
QAVMKVISKLGVIQESALTVSGRTVGENLEKARVLNEEVIRPLDRAYRQEGGIAILRGNLAPDGAVVKQSGVLPEMMINE
GTARVFDSEDEAIAAILGGKIVAGDIVVIRYEGPKGGPGMREMLSPTSAIAGMGLDTSVALLTDGRFSGGTRGAAIGHIS
PEAAEGGPIALIREGDWIAINIPEKTLTLKVDPEELEKRKQEWKPKASQNLTGYLARYARLVTSASTGAIFKD
>Mature_553_residues
MRSDIMKKGLEKAPHRSLFKAMGYTDEEIARPLIGVVNAANEIIPGHIHLDRIVEDVKAGIRMAGGTPVEFPAIGICDGI
AMGHLGMKYSLASRELIADSTEAMVMAHPFDGLVLVPNCDKIIPGMLMAALRLNIPSIFVSGGPMLAGRLDGKSVDLISV
FEGVGAVKAGKMTEEQLKALEDCACPGCGSCSGMYTANSMNCVTEALGLGLPGNGTIPAIHAARRRLAKEAGVRIMDLVS
KNIRPRDIATLDAFKNALAVDMALGCSTNTVLHIPAIAHEAGIRLDLDLFNEISARTPNLCHLSPAGPHHIEELDAAGGI
QAVMKVISKLGVIQESALTVSGRTVGENLEKARVLNEEVIRPLDRAYRQEGGIAILRGNLAPDGAVVKQSGVLPEMMINE
GTARVFDSEDEAIAAILGGKIVAGDIVVIRYEGPKGGPGMREMLSPTSAIAGMGLDTSVALLTDGRFSGGTRGAAIGHIS
PEAAEGGPIALIREGDWIAINIPEKTLTLKVDPEELEKRKQEWKPKASQNLTGYLARYARLVTSASTGAIFKD

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=606, Percent_Identity=45.049504950495, Blast_Score=495, Evalue=1e-141,
Organism=Escherichia coli, GI1786464, Length=500, Percent_Identity=34.8, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI2367371, Length=497, Percent_Identity=33.6016096579477, Blast_Score=217, Evalue=2e-57,
Organism=Escherichia coli, GI1788157, Length=527, Percent_Identity=30.9297912713473, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6322476, Length=546, Percent_Identity=41.9413919413919, Blast_Score=410, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_SYNAS (Q2LXP6)

Other databases:

- EMBL:   CP000252
- RefSeq:   YP_463023.1
- ProteinModelPortal:   Q2LXP6
- SMR:   Q2LXP6
- STRING:   Q2LXP6
- GeneID:   3882695
- GenomeReviews:   CP000252_GR
- KEGG:   sat:SYN_01708
- NMPDR:   fig|56780.10.peg.2955
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- PhylomeDB:   Q2LXP6
- BioCyc:   SACI56780:SYN_01708-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 58401; Mature: 58401

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSDIMKKGLEKAPHRSLFKAMGYTDEEIARPLIGVVNAANEIIPGHIHLDRIVEDVKAG
CCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHC
IRMAGGTPVEFPAIGICDGIAMGHLGMKYSLASRELIADSTEAMVMAHPFDGLVLVPNCD
EEECCCCCCCCCCCCHHCCHHHHCCCCEEEHHHHHHHCCCCCEEEEEECCCCEEECCCCH
KIIPGMLMAALRLNIPSIFVSGGPMLAGRLDGKSVDLISVFEGVGAVKAGKMTEEQLKAL
HHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCCCHHHHHHHCCCCCCCCCCCHHHHHHH
EDCACPGCGSCSGMYTANSMNCVTEALGLGLPGNGTIPAIHAARRRLAKEAGVRIMDLVS
HHHCCCCCCCCCCCEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHH
KNIRPRDIATLDAFKNALAVDMALGCSTNTVLHIPAIAHEAGIRLDLDLFNEISARTPNL
CCCCCCHHHHHHHHHHHHHHHHEECCCCCCEEEECHHHHCCCCEEEHHHHHHHHCCCCCE
CHLSPAGPHHIEELDAAGGIQAVMKVISKLGVIQESALTVSGRTVGENLEKARVLNEEVI
EEECCCCCHHHHHHHHCCCHHHHHHHHHHHCCHHHCCEEEECCHHHHHHHHHHHHHHHHH
RPLDRAYRQEGGIAILRGNLAPDGAVVKQSGVLPEMMINEGTARVFDSEDEAIAAILGGK
HHHHHHHHHCCCEEEEECCCCCCCCEEECCCCCHHHHHCCCCCEEECCCCHHHHHHHCCE
IVAGDIVVIRYEGPKGGPGMREMLSPTSAIAGMGLDTSVALLTDGRFSGGTRGAAIGHIS
EEECCEEEEEECCCCCCCCHHHHHCCHHHHHCCCCCCEEEEEECCCCCCCCCCCEEECCC
PEAAEGGPIALIREGDWIAINIPEKTLTLKVDPEELEKRKQEWKPKASQNLTGYLARYAR
CCCCCCCCEEEEECCCEEEEECCCCEEEEEECHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LVTSASTGAIFKD
HHHCCCCCCCCCC
>Mature Secondary Structure
MRSDIMKKGLEKAPHRSLFKAMGYTDEEIARPLIGVVNAANEIIPGHIHLDRIVEDVKAG
CCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHC
IRMAGGTPVEFPAIGICDGIAMGHLGMKYSLASRELIADSTEAMVMAHPFDGLVLVPNCD
EEECCCCCCCCCCCCHHCCHHHHCCCCEEEHHHHHHHCCCCCEEEEEECCCCEEECCCCH
KIIPGMLMAALRLNIPSIFVSGGPMLAGRLDGKSVDLISVFEGVGAVKAGKMTEEQLKAL
HHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCCCHHHHHHHCCCCCCCCCCCHHHHHHH
EDCACPGCGSCSGMYTANSMNCVTEALGLGLPGNGTIPAIHAARRRLAKEAGVRIMDLVS
HHHCCCCCCCCCCCEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHH
KNIRPRDIATLDAFKNALAVDMALGCSTNTVLHIPAIAHEAGIRLDLDLFNEISARTPNL
CCCCCCHHHHHHHHHHHHHHHHEECCCCCCEEEECHHHHCCCCEEEHHHHHHHHCCCCCE
CHLSPAGPHHIEELDAAGGIQAVMKVISKLGVIQESALTVSGRTVGENLEKARVLNEEVI
EEECCCCCHHHHHHHHCCCHHHHHHHHHHHCCHHHCCEEEECCHHHHHHHHHHHHHHHHH
RPLDRAYRQEGGIAILRGNLAPDGAVVKQSGVLPEMMINEGTARVFDSEDEAIAAILGGK
HHHHHHHHHCCCEEEEECCCCCCCCEEECCCCCHHHHHCCCCCEEECCCCHHHHHHHCCE
IVAGDIVVIRYEGPKGGPGMREMLSPTSAIAGMGLDTSVALLTDGRFSGGTRGAAIGHIS
EEECCEEEEEECCCCCCCCHHHHHCCHHHHHCCCCCCEEEEEECCCCCCCCCCCEEECCC
PEAAEGGPIALIREGDWIAINIPEKTLTLKVDPEELEKRKQEWKPKASQNLTGYLARYAR
CCCCCCCCEEEEECCCEEEEECCCCEEEEEECHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LVTSASTGAIFKD
HHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA