Click here to switch to the map view.

The map label for this gene is ilvC [H]

Identifier: 85860820

GI number: 85860820

Start: 2985399

End: 2986445

Strand: Direct

Name: ilvC [H]

Synonym: SYN_01709

Alternate gene names: 85860820

Gene position: 2985399-2986445 (Clockwise)

Preceding gene: 85860819

Following gene: 85860821

Centisome position: 93.9

GC content: 56.16

Gene sequence:

>1047_bases
ATGGCAAAAATTGATTTCGGCGGTGTAGTGGAAGATGTCATCACTCTGGAAGAATTTACCCTGGAAAAGGCCAGGGAGGT
ATTGAAGAACGAAGTGATCGCCGTGGTCGGTTACGGAATTCAGGGGCGAGGCCAGTCCTTGAACATGCGCGACAACGGAA
TAAAGGTCATTGTCGGTGAAGGCCCATACTCATGGAACCAGGCCGTAGAAGACGGCTTTGTCCCCGGCGAGACGCTCTTT
TCTCCGGAAGAGGCGGCAAAACGGGCCACCATCATCCAGTATCTGCTTTCCGACGCAGGGCAGAAGGAGATGTGGCCGGT
GATGAAAAACTGCCTTCAGCCGGGCAACGCTCTGTATTTCTCCCATGGATTTTCTATTGTTTACAAGGAACAGACCGGCG
TGATTCCGCCGGCGGATATCGATGTCATTCTGGTGGCCCCAAAAGGATCCGGACGCACCGTGCGGACGAATTTCCTGGAC
GGCAGCGGCATCAATTCCAGTTATGCGGTATTTCAGGATGCAACGGGCAAGGCCCTGGAACGTACCCTGGCGGTAGGCAT
CGCCATTGGTTCCGGTTATCTTTTTCCCACCACCTTTGAAAAGGAGGTTTACAGCGATCTCACCGGCGAACGGGGTGTCC
TTATGGGCTGCCTGGCTGGAGTGATGGAGGCTCAGTACAACGTACTCCGCAGGAACGGCCACAGCCCCAGCGAGGCCTTC
AACGAAACCGTGGAGGAGCTGACCCAGAGCCTCATCCGCCTGGTAGCGGAAAACGGCATGGACTGGATGTATTCCAATTG
CAGCGCCACCGCCCAGCGAGGCGCCCTGGACTGGAAGGATCGCTTCCGTGACGCGGTCGCCCCCGTGTTTGACGCCCTTT
ACGAAAGCGTGGTTACCGGCAAGGAAACCCAGATCGTGCTCGATGCCGGCAAAGATCCCAATTATCGGGAAAAGTTGCAG
AAAGAGCTGGAAGTCATGCACAACAGCGAAATGTGGCGCGCCGGAGCCGCTGTGCGTGATCTGCGACCGGAACGACGCAA
AAAATAG

Upstream 100 bases:

>100_bases
ATCATCCGGGAAGCAGCTCCGGATTCTGAGCAAAACGGCAGATCTGTACTTCAAAGCAACAAGATGAAAATCTCGGTTTT
AATATAGAAGGAGGCTCATT

Downstream 100 bases:

>100_bases
CATCGCCCCCTTCTGCAGGGCAGAATGGTGATGAACAAGGGTACGGATTAAATTTGATTTTTTTGACGGTACCAGGGGGA
TAAACCGGTTGCAACCAGCG

Product: ketol-acid reductoisomerase / 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MAKIDFGGVVEDVITLEEFTLEKAREVLKNEVIAVVGYGIQGRGQSLNMRDNGIKVIVGEGPYSWNQAVEDGFVPGETLF
SPEEAAKRATIIQYLLSDAGQKEMWPVMKNCLQPGNALYFSHGFSIVYKEQTGVIPPADIDVILVAPKGSGRTVRTNFLD
GSGINSSYAVFQDATGKALERTLAVGIAIGSGYLFPTTFEKEVYSDLTGERGVLMGCLAGVMEAQYNVLRRNGHSPSEAF
NETVEELTQSLIRLVAENGMDWMYSNCSATAQRGALDWKDRFRDAVAPVFDALYESVVTGKETQIVLDAGKDPNYREKLQ
KELEVMHNSEMWRAGAAVRDLRPERRKK

Sequences:

>Translated_348_residues
MAKIDFGGVVEDVITLEEFTLEKAREVLKNEVIAVVGYGIQGRGQSLNMRDNGIKVIVGEGPYSWNQAVEDGFVPGETLF
SPEEAAKRATIIQYLLSDAGQKEMWPVMKNCLQPGNALYFSHGFSIVYKEQTGVIPPADIDVILVAPKGSGRTVRTNFLD
GSGINSSYAVFQDATGKALERTLAVGIAIGSGYLFPTTFEKEVYSDLTGERGVLMGCLAGVMEAQYNVLRRNGHSPSEAF
NETVEELTQSLIRLVAENGMDWMYSNCSATAQRGALDWKDRFRDAVAPVFDALYESVVTGKETQIVLDAGKDPNYREKLQ
KELEVMHNSEMWRAGAAVRDLRPERRKK
>Mature_347_residues
AKIDFGGVVEDVITLEEFTLEKAREVLKNEVIAVVGYGIQGRGQSLNMRDNGIKVIVGEGPYSWNQAVEDGFVPGETLFS
PEEAAKRATIIQYLLSDAGQKEMWPVMKNCLQPGNALYFSHGFSIVYKEQTGVIPPADIDVILVAPKGSGRTVRTNFLDG
SGINSSYAVFQDATGKALERTLAVGIAIGSGYLFPTTFEKEVYSDLTGERGVLMGCLAGVMEAQYNVLRRNGHSPSEAFN
ETVEELTQSLIRLVAENGMDWMYSNCSATAQRGALDWKDRFRDAVAPVFDALYESVVTGKETQIVLDAGKDPNYREKLQK
ELEVMHNSEMWRAGAAVRDLRPERRKK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=289, Percent_Identity=28.3737024221453, Blast_Score=101, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6323387, Length=346, Percent_Identity=57.2254335260116, Blast_Score=386, Evalue=1e-108,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 38409; Mature: 38278

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIDFGGVVEDVITLEEFTLEKAREVLKNEVIAVVGYGIQGRGQSLNMRDNGIKVIVGE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCCEEEEECC
GPYSWNQAVEDGFVPGETLFSPEEAAKRATIIQYLLSDAGQKEMWPVMKNCLQPGNALYF
CCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEE
SHGFSIVYKEQTGVIPPADIDVILVAPKGSGRTVRTNFLDGSGINSSYAVFQDATGKALE
ECCEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCEEEEECCCHHHHH
RTLAVGIAIGSGYLFPTTFEKEVYSDLTGERGVLMGCLAGVMEAQYNVLRRNGHSPSEAF
HHHHHEEEECCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
NETVEELTQSLIRLVAENGMDWMYSNCSATAQRGALDWKDRFRDAVAPVFDALYESVVTG
HHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
KETQIVLDAGKDPNYREKLQKELEVMHNSEMWRAGAAVRDLRPERRKK
CCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHCCHHHHCCHHHCCC
>Mature Secondary Structure 
AKIDFGGVVEDVITLEEFTLEKAREVLKNEVIAVVGYGIQGRGQSLNMRDNGIKVIVGE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCCEEEEECC
GPYSWNQAVEDGFVPGETLFSPEEAAKRATIIQYLLSDAGQKEMWPVMKNCLQPGNALYF
CCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEE
SHGFSIVYKEQTGVIPPADIDVILVAPKGSGRTVRTNFLDGSGINSSYAVFQDATGKALE
ECCEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCEEEEECCCHHHHH
RTLAVGIAIGSGYLFPTTFEKEVYSDLTGERGVLMGCLAGVMEAQYNVLRRNGHSPSEAF
HHHHHEEEECCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
NETVEELTQSLIRLVAENGMDWMYSNCSATAQRGALDWKDRFRDAVAPVFDALYESVVTG
HHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
KETQIVLDAGKDPNYREKLQKELEVMHNSEMWRAGAAVRDLRPERRKK
CCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHCCHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]