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The map label for this gene is rtcA [H]

Identifier: 85860418

GI number: 85860418

Start: 2585093

End: 2586160

Strand: Direct

Name: rtcA [H]

Synonym: SYN_00093

Alternate gene names: 85860418

Gene position: 2585093-2586160 (Clockwise)

Preceding gene: 85860417

Following gene: 85860419

Centisome position: 81.31

GC content: 64.23

Gene sequence:

>1068_bases
ATGATCGAGATTGACGGCAGCCAAAAATCTGGATCGGGAACCATCGTGCGGGACGCCGTTTCCCTGTCCGCCCTGGCCGG
GCGGGATCTGCATCTGACGAACATCCGGGCGAAACGGCGTCCGAAGCCGGGTCTGAGAGCCCAGCATCTCCGGGGCATCG
AGGCCATCGCGGAACTCTGCCGCGGCCGGCTGGAAGGCGCGGCAATCAGCTCCGGAGAGATCCGGTTCTTCCCCGGACAG
ACAATCCGCGGCGGCCGGTATGACTGGGACATCGGCACGGCCGGCTCCACCACGATGCTCGTCCTTTGCGTTCTCCCCCT
GGCTCTGTTTGCCGACGGGCCTTCCCTTTTCCGGATTACAGGCGGGCTCTTTCAGGACTTCGCCCCTTCCGTTTACTCCC
TGCAAACCGTCCTCCTCCCCCTTTTGAGGCGGATGGGCGCACAGATCGATCTTCGCATTATGCGCCCCGGCTATGTCCCC
CAGGGGCAGGGCCAGATCACCGTCGACGTGACGCCGTTGAAGCGCCCGCTGAAGCCGCTGATCCTGACAGCCCAGGGAAA
TCTGCTGGAAATCCGGGGAATCGCCCTGTCCTCCCTGTTGAAAGAGAGACAGGTCTCCGAACGGATGGCGGAGGAATGCC
GGAAAACCCTGCAGGCCGAGGGGCATGACGCCCGGATCGATCTCCTTTACGATACGGCGGGAAACCCCGTCTATGAAAAA
TCGGCGGTCCAGGCGGGAGCTGCCCTCGCCCTCTGGGCGAAAACCGACACGGAATGTCTGCTGGGTGCGGACCGCGCGGG
CGCGCCGCGCCGCAGTTCGGAAACCATCGGCAGGCAGGTGGCCCGGATGATGACGGAAACCCTGCAGACCGGCGCGACTC
TGGATGTTCACGCAGCGGACCAGATCATCCCCTTCGCGGCCCTGGCCGAAGGAGAGAGCTCCTTCGTGATTCCGCGGATG
ACCGATCACATCGATTCCCGGCTCTGGCTGGTGGAAACCTTTCTCGGGGCGGAAACGGAGCTCCGGGACCGCACCCTGCG
CATCCGCGGGATCGGCTACCGGAGATAA

Upstream 100 bases:

>100_bases
ATCCGGCAGCGGCGTGGATTTCAGTGTGAGGTGTAAGGTGTGAGGCGTAAGGCGAGTCTCCATTCGGCAACGGCGCGGAC
TTCGTAAAAGGCGGGGAAAG

Downstream 100 bases:

>100_bases
ACGTTAAAGCTTCAACGTTAAATGCTCACTTGTCCGCACAAAAGTCCGGACAGCGAACATCGAACCTGGAACATTATAAG
GAGTCCCGTCTTGCCCGCTG

Product: RNA 3'-terminal phosphate cyclase

Products: NA

Alternate protein names: RNA cyclase; RNA-3'-phosphate cyclase [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MIEIDGSQKSGSGTIVRDAVSLSALAGRDLHLTNIRAKRRPKPGLRAQHLRGIEAIAELCRGRLEGAAISSGEIRFFPGQ
TIRGGRYDWDIGTAGSTTMLVLCVLPLALFADGPSLFRITGGLFQDFAPSVYSLQTVLLPLLRRMGAQIDLRIMRPGYVP
QGQGQITVDVTPLKRPLKPLILTAQGNLLEIRGIALSSLLKERQVSERMAEECRKTLQAEGHDARIDLLYDTAGNPVYEK
SAVQAGAALALWAKTDTECLLGADRAGAPRRSSETIGRQVARMMTETLQTGATLDVHAADQIIPFAALAEGESSFVIPRM
TDHIDSRLWLVETFLGAETELRDRTLRIRGIGYRR

Sequences:

>Translated_355_residues
MIEIDGSQKSGSGTIVRDAVSLSALAGRDLHLTNIRAKRRPKPGLRAQHLRGIEAIAELCRGRLEGAAISSGEIRFFPGQ
TIRGGRYDWDIGTAGSTTMLVLCVLPLALFADGPSLFRITGGLFQDFAPSVYSLQTVLLPLLRRMGAQIDLRIMRPGYVP
QGQGQITVDVTPLKRPLKPLILTAQGNLLEIRGIALSSLLKERQVSERMAEECRKTLQAEGHDARIDLLYDTAGNPVYEK
SAVQAGAALALWAKTDTECLLGADRAGAPRRSSETIGRQVARMMTETLQTGATLDVHAADQIIPFAALAEGESSFVIPRM
TDHIDSRLWLVETFLGAETELRDRTLRIRGIGYRR
>Mature_355_residues
MIEIDGSQKSGSGTIVRDAVSLSALAGRDLHLTNIRAKRRPKPGLRAQHLRGIEAIAELCRGRLEGAAISSGEIRFFPGQ
TIRGGRYDWDIGTAGSTTMLVLCVLPLALFADGPSLFRITGGLFQDFAPSVYSLQTVLLPLLRRMGAQIDLRIMRPGYVP
QGQGQITVDVTPLKRPLKPLILTAQGNLLEIRGIALSSLLKERQVSERMAEECRKTLQAEGHDARIDLLYDTAGNPVYEK
SAVQAGAALALWAKTDTECLLGADRAGAPRRSSETIGRQVARMMTETLQTGATLDVHAADQIIPFAALAEGESSFVIPRM
TDHIDSRLWLVETFLGAETELRDRTLRIRGIGYRR

Specific function: Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps:(A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA- N3'PP5'A;

COG id: COG0430

COG function: function code A; RNA 3'-terminal phosphate cyclase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI4506589, Length=339, Percent_Identity=33.9233038348083, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI195927044, Length=352, Percent_Identity=32.6704545454545, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI157426877, Length=293, Percent_Identity=27.6450511945392, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI48994937, Length=337, Percent_Identity=33.8278931750742, Blast_Score=155, Evalue=4e-39,
Organism=Drosophila melanogaster, GI18543269, Length=343, Percent_Identity=30.6122448979592, Blast_Score=162, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013791
- InterPro:   IPR000228
- InterPro:   IPR020719
- InterPro:   IPR013796
- InterPro:   IPR020723
- InterPro:   IPR017770
- InterPro:   IPR013792 [H]

Pfam domain/function: PF01137 RTC; PF05189 RTC_insert [H]

EC number: =6.5.1.4 [H]

Molecular weight: Translated: 38765; Mature: 38765

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEIDGSQKSGSGTIVRDAVSLSALAGRDLHLTNIRAKRRPKPGLRAQHLRGIEAIAELC
CEEECCCCCCCCCCEEEHHHHHHHHCCCCEEEECCHHHCCCCCCCHHHHHHHHHHHHHHH
RGRLEGAAISSGEIRFFPGQTIRGGRYDWDIGTAGSTTMLVLCVLPLALFADGPSLFRIT
HCCCCCCEECCCCEEEECCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEH
GGLFQDFAPSVYSLQTVLLPLLRRMGAQIDLRIMRPGYVPQGQGQITVDVTPLKRPLKPL
HHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCEE
ILTAQGNLLEIRGIALSSLLKERQVSERMAEECRKTLQAEGHDARIDLLYDTAGNPVYEK
EEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHH
SAVQAGAALALWAKTDTECLLGADRAGAPRRSSETIGRQVARMMTETLQTGATLDVHAAD
HHHHCCCEEEEEECCCCHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECHH
QIIPFAALAEGESSFVIPRMTDHIDSRLWLVETFLGAETELRDRTLRIRGIGYRR
HHHHHHHHCCCCCCEECCCHHHHHCCHHHHHHHHHCCCCHHCCCEEEEECCCCCC
>Mature Secondary Structure
MIEIDGSQKSGSGTIVRDAVSLSALAGRDLHLTNIRAKRRPKPGLRAQHLRGIEAIAELC
CEEECCCCCCCCCCEEEHHHHHHHHCCCCEEEECCHHHCCCCCCCHHHHHHHHHHHHHHH
RGRLEGAAISSGEIRFFPGQTIRGGRYDWDIGTAGSTTMLVLCVLPLALFADGPSLFRIT
HCCCCCCEECCCCEEEECCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEH
GGLFQDFAPSVYSLQTVLLPLLRRMGAQIDLRIMRPGYVPQGQGQITVDVTPLKRPLKPL
HHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCEE
ILTAQGNLLEIRGIALSSLLKERQVSERMAEECRKTLQAEGHDARIDLLYDTAGNPVYEK
EEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHH
SAVQAGAALALWAKTDTECLLGADRAGAPRRSSETIGRQVARMMTETLQTGATLDVHAAD
HHHHCCCEEEEEECCCCHHEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECHH
QIIPFAALAEGESSFVIPRMTDHIDSRLWLVETFLGAETELRDRTLRIRGIGYRR
HHHHHHHHCCCCCCEECCCHHHHHCCHHHHHHHHHCCCCHHCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]