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The map label for this gene is hisC [H]

Identifier: 85860396

GI number: 85860396

Start: 2566935

End: 2567945

Strand: Direct

Name: hisC [H]

Synonym: SYN_01164

Alternate gene names: 85860396

Gene position: 2566935-2567945 (Clockwise)

Preceding gene: 85860395

Following gene: 85860398

Centisome position: 80.74

GC content: 55.19

Gene sequence:

>1011_bases
ATGAGCCACATAACAGAAAAAGGCGGGGGAACGTTCCAAGGCATCAAACTCCTCCTTTGCGAAAACCCGTTGCCGCCGAT
TGACCAAGCCATCGCGGCAGCCCGGTCCGAGTTGCCGCGAAGCAATTACTACACGGAACCTTATTCAGCACCTTTGCGCT
CGCTCATCAGCGAACAGCTCGGCATTTCAGAACGACTCATTCACATTAATGCCGGCTCCGAGCTCATCCTCCGACAGCTC
TTTGACCGTTTCGGTCAGCAGGTCCACCTGCTGACTCCGACCTATGTCCTCTTCCCCGAAATCGCGCGGCATTATACAGA
AACACGACTTTCTCCTGAAAAAGATTTCGCATATGACCTGGCCGACGTAGTGATTCCCGAGGGAACCACACTAACCGTTA
TCGTAAATCCAAACAACCCCAATGGGGGCGTTTTCGACATGGCCTCCTTGCCCGAGCTGTTAAGCCGCCACCCGAAGACA
ATGTTCCTTATTGACGAGGCGTTCATCGGCCTGGCCGGAAAATCCGTCACGCACCTGGTTCCGAAGTATCCCAATCTGCT
TGTCACCCGCACCCTCTCCAAGGCGCACAGTCTTGCAGGTTTCCGAGTAGGTTACGGCATATTTCCCGAGGCTGTCGCCG
ATGACTTGAACAACCGTAACGATGCCTATCCGCTTGCCCGCCCCAGCCAGGCGGCAGCCATAGCCACACTCCAAAATGAA
GAACGCATTCAGGAACGGGCTTCCCAGTTGCGCCTCTGGACAGAGGAACTCGCCGTACAATTGCGAACCCTGGGCGTGCG
CACTTTTCCGACTGAAACCTATTTCTTTCTGGCGGACTTCTCACCTCATGACGCATCCAGGATTGCCGATCAGCTTCGCA
GCCGCAACATCCTGATTAAGCCGCTTAACGATCCTGTACTCGGTCCGGGATATATGCGCATTACCACGGCGCTGCCGGAA
GACAACCGCCGGTTCATAGATGCTTTGCGCGAGGTCATGTCCGGTGCCTAA

Upstream 100 bases:

>100_bases
GATGCGGGAGAACTTCTCGATGCCTCTATTCACGAAGATTAAAAAAGGAGTAAATACAACAAAGTAAATAGTCAGCCCAA
TTTGTTTCCAGGAGGCCGTC

Downstream 100 bases:

>100_bases
AATCGTTCCTTTCGAGACTCACCATCGGCGCTATGAAGCGTGGTTTGAAAAGCATGAGGCCGTTTACATCTCCGAGCTGC
TTGCCTTGCGCCCTTTCGTT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSHITEKGGGTFQGIKLLLCENPLPPIDQAIAAARSELPRSNYYTEPYSAPLRSLISEQLGISERLIHINAGSELILRQL
FDRFGQQVHLLTPTYVLFPEIARHYTETRLSPEKDFAYDLADVVIPEGTTLTVIVNPNNPNGGVFDMASLPELLSRHPKT
MFLIDEAFIGLAGKSVTHLVPKYPNLLVTRTLSKAHSLAGFRVGYGIFPEAVADDLNNRNDAYPLARPSQAAAIATLQNE
ERIQERASQLRLWTEELAVQLRTLGVRTFPTETYFFLADFSPHDASRIADQLRSRNILIKPLNDPVLGPGYMRITTALPE
DNRRFIDALREVMSGA

Sequences:

>Translated_336_residues
MSHITEKGGGTFQGIKLLLCENPLPPIDQAIAAARSELPRSNYYTEPYSAPLRSLISEQLGISERLIHINAGSELILRQL
FDRFGQQVHLLTPTYVLFPEIARHYTETRLSPEKDFAYDLADVVIPEGTTLTVIVNPNNPNGGVFDMASLPELLSRHPKT
MFLIDEAFIGLAGKSVTHLVPKYPNLLVTRTLSKAHSLAGFRVGYGIFPEAVADDLNNRNDAYPLARPSQAAAIATLQNE
ERIQERASQLRLWTEELAVQLRTLGVRTFPTETYFFLADFSPHDASRIADQLRSRNILIKPLNDPVLGPGYMRITTALPE
DNRRFIDALREVMSGA
>Mature_335_residues
SHITEKGGGTFQGIKLLLCENPLPPIDQAIAAARSELPRSNYYTEPYSAPLRSLISEQLGISERLIHINAGSELILRQLF
DRFGQQVHLLTPTYVLFPEIARHYTETRLSPEKDFAYDLADVVIPEGTTLTVIVNPNNPNGGVFDMASLPELLSRHPKTM
FLIDEAFIGLAGKSVTHLVPKYPNLLVTRTLSKAHSLAGFRVGYGIFPEAVADDLNNRNDAYPLARPSQAAAIATLQNEE
RIQERASQLRLWTEELAVQLRTLGVRTFPTETYFFLADFSPHDASRIADQLRSRNILIKPLNDPVLGPGYMRITTALPED
NRRFIDALREVMSGA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=270, Percent_Identity=29.2592592592593, Blast_Score=92, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6322075, Length=214, Percent_Identity=25.2336448598131, Blast_Score=73, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 37476; Mature: 37345

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHITEKGGGTFQGIKLLLCENPLPPIDQAIAAARSELPRSNYYTEPYSAPLRSLISEQL
CCCCCCCCCCCHHHEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
GISERLIHINAGSELILRQLFDRFGQQVHLLTPTYVLFPEIARHYTETRLSPEKDFAYDL
CCCCEEEEECCCHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHH
ADVVIPEGTTLTVIVNPNNPNGGVFDMASLPELLSRHPKTMFLIDEAFIGLAGKSVTHLV
HHHEECCCCEEEEEECCCCCCCCEEEHHHHHHHHHCCCCEEEEEHHHHHHCCCCHHHHHC
PKYPNLLVTRTLSKAHSLAGFRVGYGIFPEAVADDLNNRNDAYPLARPSQAAAIATLQNE
CCCCCHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCH
ERIQERASQLRLWTEELAVQLRTLGVRTFPTETYFFLADFSPHDASRIADQLRSRNILIK
HHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCEEEEEEECCCCCHHHHHHHHHCCCEEEE
PLNDPVLGPGYMRITTALPEDNRRFIDALREVMSGA
ECCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SHITEKGGGTFQGIKLLLCENPLPPIDQAIAAARSELPRSNYYTEPYSAPLRSLISEQL
CCCCCCCCCCHHHEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHC
GISERLIHINAGSELILRQLFDRFGQQVHLLTPTYVLFPEIARHYTETRLSPEKDFAYDL
CCCCEEEEECCCHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHH
ADVVIPEGTTLTVIVNPNNPNGGVFDMASLPELLSRHPKTMFLIDEAFIGLAGKSVTHLV
HHHEECCCCEEEEEECCCCCCCCEEEHHHHHHHHHCCCCEEEEEHHHHHHCCCCHHHHHC
PKYPNLLVTRTLSKAHSLAGFRVGYGIFPEAVADDLNNRNDAYPLARPSQAAAIATLQNE
CCCCCHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCH
ERIQERASQLRLWTEELAVQLRTLGVRTFPTETYFFLADFSPHDASRIADQLRSRNILIK
HHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCEEEEEEECCCCCHHHHHHHHHCCCEEEE
PLNDPVLGPGYMRITTALPEDNRRFIDALREVMSGA
ECCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA