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The map label for this gene is lon

Identifier: 85860155

GI number: 85860155

Start: 2360434

End: 2362806

Strand: Direct

Name: lon

Synonym: SYN_00783

Alternate gene names: 85860155

Gene position: 2360434-2362806 (Clockwise)

Preceding gene: 85860154

Following gene: 85860157

Centisome position: 74.24

GC content: 55.67

Gene sequence:

>2373_bases
GTGGAGGTTCCCATGCCGGAAAGCACGATCAACGAGGATTCCAAAATCTTCAAGTTGCCTGAAATCCTTCCCATCATGCC
TATTTTTCATACCGTGGCCTTCCCGAAGATGATGTTTCCCATGGATATCGTTGGAAATCGTTTCATCCAGTTGGTAGATG
AAGCCATGGCAAAGGACCGGCTGCTGGGACTGGTGCTGACCAGAAAAGCGCCGTCCGCCGAGGGACCGTTATGCCAGTGC
GAGGATCTCCATCGCGTCGGCACCTGCGTATCCATCCTGAAATTGGCCAAACAGGCCGGTGAAAAGGCCCAGCTTGTGGT
CCAGGGTCTTGCCCGCTTCCGGATTGTCGAATTCCTTGAAGAGGAACCTTACATCCAGGCCCGCGTCGAGAAGATCGAGG
CGGACATCCTCATCAAGGATCTTGAAATCGAAGCCCTCATGGCCAATCTTTCCACTCTTTTTGATCGTGTTATCAAGCTG
TCCCCGTTTCTTCCCCAGGAGTTCGCAGCCATGGCCAAATCCATCCAGGAGCCGGGCGATTTGGCCGACATCATTGCTTC
CATCGTCAACGCCTCTGTGGAAGACAAGCAGAAAATCCTCGAGACGCTTGATATCCGGCAGCGCCTGAGAGAAATCACCC
TCATCGTCAACCATCAGCTGGAAATTCTGGAACTGGGCAGTAAAATCCAGTCGCAGGTCCAGGAAGATATCGATAAAAGT
CAGCGGGATTTCTACCTCCGCCAGCAATTGAAGGCAATCCGCGAAGAGCTGGGTGAGTCCGACGAAAACCGGGTCGAAGT
CGCGGAATACCGCAAAAAGATCGAAGAGAAAATGCTGACGGAAGAGGCCAGGAAGGAAGCCTTCCGGGAACTGGACAGGA
TGTCGCGCATGCATCCTGCCTCGGCGGAATATTCCGTGGCGACGACTTATCTGGACTGGATCACGTCGCTTCCGTGGAAT
GAACGGACACAGGACAACCAGGACATCAGGCAGGCCCGTCGAATCCTCGACGAGGACCACTATGGCCTGGATAAGGCCAA
AAAGCGCATCATCGAATATCTCGCTGTCCGCAAACTTAAGCCGGACACGAAAGGGCCGATTCTCTGCTTTGTCGGGCCGC
CGGGAACAGGAAAAACCTCATTGGCCCAATCGATTGCCCGGGCGCTGGGACGGAAATTTTATCGGATTTCTCTGGGCGGG
GTTCACGATGAAGCGGAAATCCGCGGTCACCGCCGGACTTACGTCGGCGCGCTGCCGGGGCGCATCATTCAGGGAATTCG
CCGGGCTGAATCCAGCAACCCCGTTTTCGTACTCGATGAAATCGACAAGGTGGGCAGCGACTTCCGGGGAGATCCCTCCT
CCGCTCTGCTGGAAGTGCTTGATCCGGAGCAGAATTTCGCCTTCATGGATCACTACCTGGGTGTTGCGTTTGACCTTTCC
CATGTGACCTTCATCACCACGGCAAACATCCTGGACACCATCCCGCCCGCCCTCAGGGATCGCCTTGAAGTCATCGAACT
GCCGGGTTACACCCAGGATGAAAAGCTGCGGATCGCGGAACGCTATCTGATTCCCCGGCAGAGGGAGGCCAACGGCCTGA
CTCCGGAGCAGATCAAGTTCACCCGCGGCGCCGCCAGACTGATCATTTCCGGCTATACCCGTGAAGCGGGCGTCCGCAAC
CTGGAACGGGAAATCGCCGCGGTCTGCCGTGGCGTCGCCAGCCAGATTGCCGAAGGTGAAATCTCATCGGCGCTCATCAG
CGCCCGTGATATTCATCGGTACCTGGGACCTGTCCGAATGATTTCGGACGCCAGGGAGCGGATATCCAAACCGGGCATTG
CCATGGGACTGGCCTGGACTCCTACAGGAGGCGACCTGCTGTTTGTTGAAGCGACCGCCATGAAGGGCAGAAAAGGCCTG
ACCCTGACCGGACAACTGGGAGAGGTCATGAAGGAATCGGCCAGCGCCGCGCTCAGTTTCATCCGCTCCAACGCGGTAAA
AATCGGTATCCCGGTCGACTTTTTTGAAGAAACCGACATTCACATACACGTCCCCGCGGGCGCAATCCCCAAGGACGGCC
CTTCCGCCGGGGTGACCATGCTTGCCGCGCTGGCCTCCCTGCTCACAAATCGAACGGTAAAAAACGATCTGGCAATGACG
GGAGAAATTACTCTGCGAGGGCTGGTACTTCCCGTAGGAGGCATCAAGGAGAAAGTGCTGGCTGCTCATCGCGCGGGAAT
CAAAACCATAATTCTTCCCAAATGGAACCGGAAAGATCTGGAGGAAATACCCTCAAAAGTAAGGAAAGAAATGAACTTCG
TCTTCGTCAATGACATGCGTGAAGTTCTGAACATCGCGCTTTCCAGGAAATAA

Upstream 100 bases:

>100_bases
TCTGGAGATTCGCATGACCAAACTTCCTCTGAGCAAAGTCCATAAAATCATGTTCCAGCATCGTTGACAGGAAAAATTCC
CTTAAGGAAACCACATTGCT

Downstream 100 bases:

>100_bases
TGACTACATGCGCAAGGCAATTCGCCGGGAAACCGGCTATATTGCAATTTGAGGGCTTATTCCCTGCCCCGGCACAGGAA
ATCACCTGCATGCAAGCGGA

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La

Number of amino acids: Translated: 790; Mature: 790

Protein sequence:

>790_residues
MEVPMPESTINEDSKIFKLPEILPIMPIFHTVAFPKMMFPMDIVGNRFIQLVDEAMAKDRLLGLVLTRKAPSAEGPLCQC
EDLHRVGTCVSILKLAKQAGEKAQLVVQGLARFRIVEFLEEEPYIQARVEKIEADILIKDLEIEALMANLSTLFDRVIKL
SPFLPQEFAAMAKSIQEPGDLADIIASIVNASVEDKQKILETLDIRQRLREITLIVNHQLEILELGSKIQSQVQEDIDKS
QRDFYLRQQLKAIREELGESDENRVEVAEYRKKIEEKMLTEEARKEAFRELDRMSRMHPASAEYSVATTYLDWITSLPWN
ERTQDNQDIRQARRILDEDHYGLDKAKKRIIEYLAVRKLKPDTKGPILCFVGPPGTGKTSLAQSIARALGRKFYRISLGG
VHDEAEIRGHRRTYVGALPGRIIQGIRRAESSNPVFVLDEIDKVGSDFRGDPSSALLEVLDPEQNFAFMDHYLGVAFDLS
HVTFITTANILDTIPPALRDRLEVIELPGYTQDEKLRIAERYLIPRQREANGLTPEQIKFTRGAARLIISGYTREAGVRN
LEREIAAVCRGVASQIAEGEISSALISARDIHRYLGPVRMISDARERISKPGIAMGLAWTPTGGDLLFVEATAMKGRKGL
TLTGQLGEVMKESASAALSFIRSNAVKIGIPVDFFEETDIHIHVPAGAIPKDGPSAGVTMLAALASLLTNRTVKNDLAMT
GEITLRGLVLPVGGIKEKVLAAHRAGIKTIILPKWNRKDLEEIPSKVRKEMNFVFVNDMREVLNIALSRK

Sequences:

>Translated_790_residues
MEVPMPESTINEDSKIFKLPEILPIMPIFHTVAFPKMMFPMDIVGNRFIQLVDEAMAKDRLLGLVLTRKAPSAEGPLCQC
EDLHRVGTCVSILKLAKQAGEKAQLVVQGLARFRIVEFLEEEPYIQARVEKIEADILIKDLEIEALMANLSTLFDRVIKL
SPFLPQEFAAMAKSIQEPGDLADIIASIVNASVEDKQKILETLDIRQRLREITLIVNHQLEILELGSKIQSQVQEDIDKS
QRDFYLRQQLKAIREELGESDENRVEVAEYRKKIEEKMLTEEARKEAFRELDRMSRMHPASAEYSVATTYLDWITSLPWN
ERTQDNQDIRQARRILDEDHYGLDKAKKRIIEYLAVRKLKPDTKGPILCFVGPPGTGKTSLAQSIARALGRKFYRISLGG
VHDEAEIRGHRRTYVGALPGRIIQGIRRAESSNPVFVLDEIDKVGSDFRGDPSSALLEVLDPEQNFAFMDHYLGVAFDLS
HVTFITTANILDTIPPALRDRLEVIELPGYTQDEKLRIAERYLIPRQREANGLTPEQIKFTRGAARLIISGYTREAGVRN
LEREIAAVCRGVASQIAEGEISSALISARDIHRYLGPVRMISDARERISKPGIAMGLAWTPTGGDLLFVEATAMKGRKGL
TLTGQLGEVMKESASAALSFIRSNAVKIGIPVDFFEETDIHIHVPAGAIPKDGPSAGVTMLAALASLLTNRTVKNDLAMT
GEITLRGLVLPVGGIKEKVLAAHRAGIKTIILPKWNRKDLEEIPSKVRKEMNFVFVNDMREVLNIALSRK
>Mature_790_residues
MEVPMPESTINEDSKIFKLPEILPIMPIFHTVAFPKMMFPMDIVGNRFIQLVDEAMAKDRLLGLVLTRKAPSAEGPLCQC
EDLHRVGTCVSILKLAKQAGEKAQLVVQGLARFRIVEFLEEEPYIQARVEKIEADILIKDLEIEALMANLSTLFDRVIKL
SPFLPQEFAAMAKSIQEPGDLADIIASIVNASVEDKQKILETLDIRQRLREITLIVNHQLEILELGSKIQSQVQEDIDKS
QRDFYLRQQLKAIREELGESDENRVEVAEYRKKIEEKMLTEEARKEAFRELDRMSRMHPASAEYSVATTYLDWITSLPWN
ERTQDNQDIRQARRILDEDHYGLDKAKKRIIEYLAVRKLKPDTKGPILCFVGPPGTGKTSLAQSIARALGRKFYRISLGG
VHDEAEIRGHRRTYVGALPGRIIQGIRRAESSNPVFVLDEIDKVGSDFRGDPSSALLEVLDPEQNFAFMDHYLGVAFDLS
HVTFITTANILDTIPPALRDRLEVIELPGYTQDEKLRIAERYLIPRQREANGLTPEQIKFTRGAARLIISGYTREAGVRN
LEREIAAVCRGVASQIAEGEISSALISARDIHRYLGPVRMISDARERISKPGIAMGLAWTPTGGDLLFVEATAMKGRKGL
TLTGQLGEVMKESASAALSFIRSNAVKIGIPVDFFEETDIHIHVPAGAIPKDGPSAGVTMLAALASLLTNRTVKNDLAMT
GEITLRGLVLPVGGIKEKVLAAHRAGIKTIILPKWNRKDLEEIPSKVRKEMNFVFVNDMREVLNIALSRK

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI31377667, Length=831, Percent_Identity=43.5619735258724, Blast_Score=652, Evalue=0.0,
Organism=Homo sapiens, GI21396489, Length=835, Percent_Identity=37.125748502994, Blast_Score=564, Evalue=1e-160,
Organism=Escherichia coli, GI1786643, Length=766, Percent_Identity=46.3446475195822, Blast_Score=680, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=708, Percent_Identity=39.2655367231638, Blast_Score=502, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17556486, Length=540, Percent_Identity=43.7037037037037, Blast_Score=473, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6319449, Length=695, Percent_Identity=40.431654676259, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI221513036, Length=683, Percent_Identity=42.0204978038067, Blast_Score=553, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24666867, Length=683, Percent_Identity=42.0204978038067, Blast_Score=552, Evalue=1e-157,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON_SYNAS (Q2LVS9)

Other databases:

- EMBL:   CP000252
- RefSeq:   YP_462357.1
- ProteinModelPortal:   Q2LVS9
- STRING:   Q2LVS9
- GeneID:   3883260
- GenomeReviews:   CP000252_GR
- KEGG:   sat:SYN_00783
- NMPDR:   fig|56780.10.peg.2300
- eggNOG:   COG0466
- HOGENOM:   HBG566281
- OMA:   DYRARIE
- PhylomeDB:   Q2LVS9
- ProtClustDB:   CLSK944704
- BioCyc:   SACI56780:SYN_00783-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 88441; Mature: 88441

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 695-695 ACT_SITE 738-738

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVPMPESTINEDSKIFKLPEILPIMPIFHTVAFPKMMFPMDIVGNRFIQLVDEAMAKDR
CCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LLGLVLTRKAPSAEGPLCQCEDLHRVGTCVSILKLAKQAGEKAQLVVQGLARFRIVEFLE
HHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
EEPYIQARVEKIEADILIKDLEIEALMANLSTLFDRVIKLSPFLPQEFAAMAKSIQEPGD
CCCHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCH
LADIIASIVNASVEDKQKILETLDIRQRLREITLIVNHQLEILELGSKIQSQVQEDIDKS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
QRDFYLRQQLKAIREELGESDENRVEVAEYRKKIEEKMLTEEARKEAFRELDRMSRMHPA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SAEYSVATTYLDWITSLPWNERTQDNQDIRQARRILDEDHYGLDKAKKRIIEYLAVRKLK
CCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
PDTKGPILCFVGPPGTGKTSLAQSIARALGRKFYRISLGGVHDEAEIRGHRRTYVGALPG
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCHHHHCCCHHHHHHCCHH
RIIQGIRRAESSNPVFVLDEIDKVGSDFRGDPSSALLEVLDPEQNFAFMDHYLGVAFDLS
HHHHHHHHCCCCCCEEEEECHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
HVTFITTANILDTIPPALRDRLEVIELPGYTQDEKLRIAERYLIPRQREANGLTPEQIKF
HHHHHHHHHHHHHCCHHHHHHHHEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHH
TRGAARLIISGYTREAGVRNLEREIAAVCRGVASQIAEGEISSALISARDIHRYLGPVRM
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
ISDARERISKPGIAMGLAWTPTGGDLLFVEATAMKGRKGLTLTGQLGEVMKESASAALSF
HHHHHHHHCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCEEEHHHHHHHHHHHHHHHHH
IRSNAVKIGIPVDFFEETDIHIHVPAGAIPKDGPSAGVTMLAALASLLTNRTVKNDLAMT
HHCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHEE
GEITLRGLVLPVGGIKEKVLAAHRAGIKTIILPKWNRKDLEEIPSKVRKEMNFVFVNDMR
CCEEEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCEEEHHHHH
EVLNIALSRK
HHHHHHHCCC
>Mature Secondary Structure
MEVPMPESTINEDSKIFKLPEILPIMPIFHTVAFPKMMFPMDIVGNRFIQLVDEAMAKDR
CCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LLGLVLTRKAPSAEGPLCQCEDLHRVGTCVSILKLAKQAGEKAQLVVQGLARFRIVEFLE
HHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
EEPYIQARVEKIEADILIKDLEIEALMANLSTLFDRVIKLSPFLPQEFAAMAKSIQEPGD
CCCHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCH
LADIIASIVNASVEDKQKILETLDIRQRLREITLIVNHQLEILELGSKIQSQVQEDIDKS
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
QRDFYLRQQLKAIREELGESDENRVEVAEYRKKIEEKMLTEEARKEAFRELDRMSRMHPA
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SAEYSVATTYLDWITSLPWNERTQDNQDIRQARRILDEDHYGLDKAKKRIIEYLAVRKLK
CCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
PDTKGPILCFVGPPGTGKTSLAQSIARALGRKFYRISLGGVHDEAEIRGHRRTYVGALPG
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCHHHHCCCHHHHHHCCHH
RIIQGIRRAESSNPVFVLDEIDKVGSDFRGDPSSALLEVLDPEQNFAFMDHYLGVAFDLS
HHHHHHHHCCCCCCEEEEECHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
HVTFITTANILDTIPPALRDRLEVIELPGYTQDEKLRIAERYLIPRQREANGLTPEQIKF
HHHHHHHHHHHHHCCHHHHHHHHEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHH
TRGAARLIISGYTREAGVRNLEREIAAVCRGVASQIAEGEISSALISARDIHRYLGPVRM
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
ISDARERISKPGIAMGLAWTPTGGDLLFVEATAMKGRKGLTLTGQLGEVMKESASAALSF
HHHHHHHHCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCEEEHHHHHHHHHHHHHHHHH
IRSNAVKIGIPVDFFEETDIHIHVPAGAIPKDGPSAGVTMLAALASLLTNRTVKNDLAMT
HHCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHEE
GEITLRGLVLPVGGIKEKVLAAHRAGIKTIILPKWNRKDLEEIPSKVRKEMNFVFVNDMR
CCEEEEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCEEEHHHHH
EVLNIALSRK
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA