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The map label for this gene is pyrC

Identifier: 85860057

GI number: 85860057

Start: 2268384

End: 2269664

Strand: Direct

Name: pyrC

Synonym: SYN_01533

Alternate gene names: 85860057

Gene position: 2268384-2269664 (Clockwise)

Preceding gene: 85860056

Following gene: 85860058

Centisome position: 71.35

GC content: 55.27

Gene sequence:

>1281_bases
ATGAAAATACTGCTGAAGGGGGGACGCGTAATCGACCCCGCGCAAAATCTCGACGGGCAGATGGATCTCCTGCTGGAAAA
CGGGAAGATTGCCGCCATAGCCGAAGCTGTGGGAAGCGTCCCGGAAGACACCCGGCTTCTCGATCTCAAAGGCATGATTC
TCCTGCCCGGCCTGGTGGACATGCACACTCATCTCCGGGAACCCGGTTACGAATACAAGGAAACCATCCGCTCGGGAAGC
GAAGCGGCCGCGGTCGGGGGGTTCACCTCCATCGCCTGCATGCCGAATACCCTTCCGGTTAATGATAACCGGACTGTCAC
CGAGTATATTCTGAAACGGGCGAAAGAATGCGACACTGTCCATGTCTATCCCGTAGCAGCCGTCTCCCGCAATTCCGAGG
GAAAGATACTCGCGGAATTCGGCGACCTGAAAGAGGCCGGAGCGATTGCCTTTTCCGATGACGGAAAACCCGTCATGAAC
AGCATTCTGATGAGACGTGCCTTGGAGTATGCCTCATCACTGGATCGAATTATCATTTCACACTGCGAGGATCTGAATCT
TTCAGCCGGCGGTCTCATGAACGAAGGAAAAATTTCCACGGAACTGGGACTCCCCGGCATCCCCACCCTTGCGGAGGATG
TGATGGTCGCAAGGGATCTGCTTCTCGCCGAGTTTTCCGGCGCGGCGCTGCATATCGCCCATGTGAGTTCCGCTGGAGCC
GTTCGGATGATCCGGGATGCAAAAAAACGGGGAGTTCGGGTTACGGCGGAAACAACACCTCATTATTTCACTTTGACGGA
CGAGGCCGTGACGAACTTTAACACCAACACCAAGGTCAGTCCCCCCTTAAGGAGCCGCGAGGATCTCCAGGCCGTTCGGG
AAGGACTCCGGGACGGCACTCTCGATGCCATTGTCACGGATCATGCGCCTCATGCCCTTACAGATAAAGAGGTGGAATTT
GAATATGCCGCCAATGGCATCTCCGGTCTCGAAACGGCACTGGCCTTGAGTCTGACGCTGGTCGATGACGGGCTGTTGAC
TCTTTCTGAACTGGTCCGGAAGATGAGTGTCAATCCCGCGAAAATCCTCAATATCCCGAAGGGAACCCTCCGCCCGGGCG
CCGATGCGGACATCACCGTCCTGAATCCCGGAAAAACATGGGTCGTCGATCCTTCAAACTGGCGGTCACAGGGAAAGAAT
ACACCCTTTTTCGGCTGGACATTGAAGGGAAAAGTCATTATGACCCTGGTGCAGGGAAGAATTGTGTATCAGGAGGATTA
G

Upstream 100 bases:

>100_bases
CGGAGATCGCCGACGGCGTTCATTCCGTCATTCTGGAACAAGTCACCAACGGGGTCGCGGTCCGGATGGCCCTTCTTTAT
CTGCTGACAGGAGCCTCTTC

Downstream 100 bases:

>100_bases
GAACCTCTCGACGGGAAAGTCTGGGGTTATCCTGCCTGTCAGCCTGTGACATCCCGGAAATCTCTTATGGACTGAATTCC
AGAAATTCCGTATATCTCCA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MKILLKGGRVIDPAQNLDGQMDLLLENGKIAAIAEAVGSVPEDTRLLDLKGMILLPGLVDMHTHLREPGYEYKETIRSGS
EAAAVGGFTSIACMPNTLPVNDNRTVTEYILKRAKECDTVHVYPVAAVSRNSEGKILAEFGDLKEAGAIAFSDDGKPVMN
SILMRRALEYASSLDRIIISHCEDLNLSAGGLMNEGKISTELGLPGIPTLAEDVMVARDLLLAEFSGAALHIAHVSSAGA
VRMIRDAKKRGVRVTAETTPHYFTLTDEAVTNFNTNTKVSPPLRSREDLQAVREGLRDGTLDAIVTDHAPHALTDKEVEF
EYAANGISGLETALALSLTLVDDGLLTLSELVRKMSVNPAKILNIPKGTLRPGADADITVLNPGKTWVVDPSNWRSQGKN
TPFFGWTLKGKVIMTLVQGRIVYQED

Sequences:

>Translated_426_residues
MKILLKGGRVIDPAQNLDGQMDLLLENGKIAAIAEAVGSVPEDTRLLDLKGMILLPGLVDMHTHLREPGYEYKETIRSGS
EAAAVGGFTSIACMPNTLPVNDNRTVTEYILKRAKECDTVHVYPVAAVSRNSEGKILAEFGDLKEAGAIAFSDDGKPVMN
SILMRRALEYASSLDRIIISHCEDLNLSAGGLMNEGKISTELGLPGIPTLAEDVMVARDLLLAEFSGAALHIAHVSSAGA
VRMIRDAKKRGVRVTAETTPHYFTLTDEAVTNFNTNTKVSPPLRSREDLQAVREGLRDGTLDAIVTDHAPHALTDKEVEF
EYAANGISGLETALALSLTLVDDGLLTLSELVRKMSVNPAKILNIPKGTLRPGADADITVLNPGKTWVVDPSNWRSQGKN
TPFFGWTLKGKVIMTLVQGRIVYQED
>Mature_426_residues
MKILLKGGRVIDPAQNLDGQMDLLLENGKIAAIAEAVGSVPEDTRLLDLKGMILLPGLVDMHTHLREPGYEYKETIRSGS
EAAAVGGFTSIACMPNTLPVNDNRTVTEYILKRAKECDTVHVYPVAAVSRNSEGKILAEFGDLKEAGAIAFSDDGKPVMN
SILMRRALEYASSLDRIIISHCEDLNLSAGGLMNEGKISTELGLPGIPTLAEDVMVARDLLLAEFSGAALHIAHVSSAGA
VRMIRDAKKRGVRVTAETTPHYFTLTDEAVTNFNTNTKVSPPLRSREDLQAVREGLRDGTLDAIVTDHAPHALTDKEVEF
EYAANGISGLETALALSLTLVDDGLLTLSELVRKMSVNPAKILNIPKGTLRPGADADITVLNPGKTWVVDPSNWRSQGKN
TPFFGWTLKGKVIMTLVQGRIVYQED

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI18105007, Length=380, Percent_Identity=28.6842105263158, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4503051, Length=459, Percent_Identity=25.0544662309368, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI62422571, Length=459, Percent_Identity=24.8366013071895, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI190194363, Length=458, Percent_Identity=25.9825327510917, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI19923821, Length=457, Percent_Identity=26.0393873085339, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI4503375, Length=464, Percent_Identity=25.6465517241379, Blast_Score=96, Evalue=6e-20,
Organism=Escherichia coli, GI1786722, Length=439, Percent_Identity=28.7015945330296, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI87082175, Length=448, Percent_Identity=25.2232142857143, Blast_Score=115, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI193204318, Length=396, Percent_Identity=32.8282828282828, Blast_Score=164, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6322218, Length=401, Percent_Identity=28.1795511221945, Blast_Score=119, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24642586, Length=390, Percent_Identity=29.4871794871795, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI18859883, Length=211, Percent_Identity=31.2796208530806, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17137462, Length=448, Percent_Identity=25.4464285714286, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221377917, Length=451, Percent_Identity=25.2771618625277, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRC_SYNAS (Q2LVI3)

Other databases:

- EMBL:   CP000252
- RefSeq:   YP_462259.1
- ProteinModelPortal:   Q2LVI3
- STRING:   Q2LVI3
- GeneID:   3884070
- GenomeReviews:   CP000252_GR
- KEGG:   sat:SYN_01533
- NMPDR:   fig|56780.10.peg.2194
- eggNOG:   COG0044
- HOGENOM:   HBG724623
- OMA:   GVMNEGE
- PhylomeDB:   Q2LVI3
- ProtClustDB:   CLSK2775566
- BioCyc:   SACI56780:SYN_01533-MONOMER
- HAMAP:   MF_00220_B
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059
- TIGRFAMs:   TIGR00857

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.3

Molecular weight: Translated: 46033; Mature: 46033

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILLKGGRVIDPAQNLDGQMDLLLENGKIAAIAEAVGSVPEDTRLLDLKGMILLPGLVD
CEEEEECCEEECHHHCCCCCEEEEEECCCEEEHHHHHCCCCCCCEEEEECCEEECCCHHH
MHTHLREPGYEYKETIRSGSEAAAVGGFTSIACMPNTLPVNDNRTVTEYILKRAKECDTV
HHHHHCCCCHHHHHHHHCCCCCEECCCCEEEEECCCEECCCCCCHHHHHHHHHHHCCCEE
HVYPVAAVSRNSEGKILAEFGDLKEAGAIAFSDDGKPVMNSILMRRALEYASSLDRIIIS
EEEEEEEECCCCCCCEEEECCCCHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
HCEDLNLSAGGLMNEGKISTELGLPGIPTLAEDVMVARDLLLAEFSGAALHIAHVSSAGA
CCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCH
VRMIRDAKKRGVRVTAETTPHYFTLTDEAVTNFNTNTKVSPPLRSREDLQAVREGLRDGT
HHHHHHHHHCCEEEEEECCCCEEEEEHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
LDAIVTDHAPHALTDKEVEFEYAANGISGLETALALSLTLVDDGLLTLSELVRKMSVNPA
EEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHEEEEEEECCCHHHHHHHHHHHCCCHH
KILNIPKGTLRPGADADITVLNPGKTWVVDPSNWRSQGKNTPFFGWTLKGKVIMTLVQGR
HEEECCCCCCCCCCCCCEEEECCCCEEEECCCCHHHCCCCCCEEEEEECCCEEEEEECCE
IVYQED
EEEECC
>Mature Secondary Structure
MKILLKGGRVIDPAQNLDGQMDLLLENGKIAAIAEAVGSVPEDTRLLDLKGMILLPGLVD
CEEEEECCEEECHHHCCCCCEEEEEECCCEEEHHHHHCCCCCCCEEEEECCEEECCCHHH
MHTHLREPGYEYKETIRSGSEAAAVGGFTSIACMPNTLPVNDNRTVTEYILKRAKECDTV
HHHHHCCCCHHHHHHHHCCCCCEECCCCEEEEECCCEECCCCCCHHHHHHHHHHHCCCEE
HVYPVAAVSRNSEGKILAEFGDLKEAGAIAFSDDGKPVMNSILMRRALEYASSLDRIIIS
EEEEEEEECCCCCCCEEEECCCCHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
HCEDLNLSAGGLMNEGKISTELGLPGIPTLAEDVMVARDLLLAEFSGAALHIAHVSSAGA
CCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCH
VRMIRDAKKRGVRVTAETTPHYFTLTDEAVTNFNTNTKVSPPLRSREDLQAVREGLRDGT
HHHHHHHHHCCEEEEEECCCCEEEEEHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
LDAIVTDHAPHALTDKEVEFEYAANGISGLETALALSLTLVDDGLLTLSELVRKMSVNPA
EEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHEEEEEEECCCHHHHHHHHHHHCCCHH
KILNIPKGTLRPGADADITVLNPGKTWVVDPSNWRSQGKNTPFFGWTLKGKVIMTLVQGR
HEEECCCCCCCCCCCCCEEEECCCCEEEECCCCHHHCCCCCCEEEEEECCCEEEEEECCE
IVYQED
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA