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The map label for this gene is lepB [H]

Identifier: 85860052

GI number: 85860052

Start: 2263293

End: 2263904

Strand: Direct

Name: lepB [H]

Synonym: SYN_01527

Alternate gene names: 85860052

Gene position: 2263293-2263904 (Clockwise)

Preceding gene: 85860051

Following gene: 85860055

Centisome position: 71.19

GC content: 48.69

Gene sequence:

>612_bases
ATGACCAAAAGAAAATCAAAGCTTCAGGAATATATCGAGGCCATCGTCATCGCCCTGATTGTCGCGTTCTTCATCCGGAC
CTTTGTGATTCAGGCTTACAAGATACCATCCGGATCGATGAAGCCGACCCTTCTGATAGGAGATCACATCCTCGTCAACA
AATTCATCTACGGAATCAAAGTGCCGCACTTCCGCAACACTTTGATCTCCATCAAGGAACCGAAAAAAGGGGATATCGTG
GTCTTTATCTATCCGGAGGACAGGACCAAGGATTTCATTAAACGGGTAATTGCCACCAGCGGCGATACCGTGGAAATCCG
CAATAAGAAGATTTACCTCAATGGCCGACTCTATGAGGAAAGTCACGGTGTTTATACCGACCAGTTTGTCATCCCCGGCT
CTATTCAGCCCCGGGACAATTTCGGACCTGTCACCGTCCCTCCTTCATCCATCTTTGTCATGGGGGACAACAGAGACCAG
AGCTATGACAGCCGTTTCTGGGGATTTGTCGATCTCAAGGACGTCCTGGGCAAAGCCTTCATCATTTACTGGTCATGGGA
TCGCGAAGATCACGGTGTGCGCTGGAACCGCTTTGGAAATATCCTCCATTAA

Upstream 100 bases:

>100_bases
ATGGTCATCATGACCCTGATGTCTATTTACTCATAGAATGTAACCGGCCCATTTACGGACTGTAATAACCGCCAAGTCAA
ACAACAAGAAGGATTGTTTT

Downstream 100 bases:

>100_bases
AAGTCAATCCCGCAAGAGCCCGCGAAAGCTTTCAGGCGGTTTTACAGGAGAGCGGCCGCAACCGTGGCCAGAGACAGCAT
GATCAGCACGGCGACAGTGG

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 203; Mature: 202

Protein sequence:

>203_residues
MTKRKSKLQEYIEAIVIALIVAFFIRTFVIQAYKIPSGSMKPTLLIGDHILVNKFIYGIKVPHFRNTLISIKEPKKGDIV
VFIYPEDRTKDFIKRVIATSGDTVEIRNKKIYLNGRLYEESHGVYTDQFVIPGSIQPRDNFGPVTVPPSSIFVMGDNRDQ
SYDSRFWGFVDLKDVLGKAFIIYWSWDREDHGVRWNRFGNILH

Sequences:

>Translated_203_residues
MTKRKSKLQEYIEAIVIALIVAFFIRTFVIQAYKIPSGSMKPTLLIGDHILVNKFIYGIKVPHFRNTLISIKEPKKGDIV
VFIYPEDRTKDFIKRVIATSGDTVEIRNKKIYLNGRLYEESHGVYTDQFVIPGSIQPRDNFGPVTVPPSSIFVMGDNRDQ
SYDSRFWGFVDLKDVLGKAFIIYWSWDREDHGVRWNRFGNILH
>Mature_202_residues
TKRKSKLQEYIEAIVIALIVAFFIRTFVIQAYKIPSGSMKPTLLIGDHILVNKFIYGIKVPHFRNTLISIKEPKKGDIVV
FIYPEDRTKDFIKRVIATSGDTVEIRNKKIYLNGRLYEESHGVYTDQFVIPGSIQPRDNFGPVTVPPSSIFVMGDNRDQS
YDSRFWGFVDLKDVLGKAFIIYWSWDREDHGVRWNRFGNILH

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=254, Percent_Identity=32.2834645669291, Blast_Score=102, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 23561; Mature: 23429

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: PS00501 SPASE_I_1 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKRKSKLQEYIEAIVIALIVAFFIRTFVIQAYKIPSGSMKPTLLIGDHILVNKFIYGIK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEEECCHHHHHHHHHEEE
VPHFRNTLISIKEPKKGDIVVFIYPEDRTKDFIKRVIATSGDTVEIRNKKIYLNGRLYEE
CCCCCCCEEEECCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCEEEECCEEEEC
SHGVYTDQFVIPGSIQPRDNFGPVTVPPSSIFVMGDNRDQSYDSRFWGFVDLKDVLGKAF
CCCEEECCEEECCCCCCCCCCCCEEECCCEEEEEECCCCCCCCCCEECEEEHHHHCCCEE
IIYWSWDREDHGVRWNRFGNILH
EEEEEECCCCCCEEHHHCCCCCC
>Mature Secondary Structure 
TKRKSKLQEYIEAIVIALIVAFFIRTFVIQAYKIPSGSMKPTLLIGDHILVNKFIYGIK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEEECCHHHHHHHHHEEE
VPHFRNTLISIKEPKKGDIVVFIYPEDRTKDFIKRVIATSGDTVEIRNKKIYLNGRLYEE
CCCCCCCEEEECCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCEEEECCEEEEC
SHGVYTDQFVIPGSIQPRDNFGPVTVPPSSIFVMGDNRDQSYDSRFWGFVDLKDVLGKAF
CCCEEECCEEECCCCCCCCCCCCEEECCCEEEEEECCCCCCCCCCEECEEEHHHHCCCEE
IIYWSWDREDHGVRWNRFGNILH
EEEEEECCCCCCEEHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]