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The map label for this gene is prs [H]

Identifier: 85859730

GI number: 85859730

Start: 1959585

End: 1960526

Strand: Direct

Name: prs [H]

Synonym: SYN_02767

Alternate gene names: 85859730

Gene position: 1959585-1960526 (Clockwise)

Preceding gene: 85859729

Following gene: 85859731

Centisome position: 61.64

GC content: 52.12

Gene sequence:

>942_bases
ATGTTAGAGAGAATTAAGGTTTTTACAGGTAACGCAACGCCCGATCTGGCTCGTAAGATTTGTGACAATCTGGCGATTCC
GCTGGGTAAAGCCAATGTCACCACATTCAGCGATGGCGAAACCAGGGTTGAAATCAATGAAAATGTTCGGGGTATGGATA
TTTTCATTATTCAGTCCACATGCACTCCCGTAAATGTGACATTGATGGAACTGCTGATCATGATTGACGCCCTGAAAAGA
GCGTCGGCAGGCCGCATCACGGCGGTCATTCCCTATTACGGATATGCCCGGCAGGACAGAAAAGTCGCCCCCCGCGCGCC
CATATCGGCAAAACTGGTGGCGGATCTTCTTACCACAGCGGGAGCGAACCGGATTCTATCCCTCGATCTCCATGCCGGCC
AGATTCAGGGATTTTTCAATATTCCCGTCGACAATCTCTTTGCCACACCCGTTCTTCTCAATTACCTGAAGACTCATTAC
CAGGACAATCTGGTCATCGTTTCCCCCGATGCCGGCGGCGTTGAGCGCGCCCGTGCTTTCGCCCGCCGTCTGGACGCCAC
GATCGCCATTATCGACAAACGACGGGAAGGTCCCAATGAGGCCCAGGTCATGAATATCGTCGGCTCGGTAGAGGGAAAAA
ACGTCGTTGTTCTTGACGATATGATCGACACCGCAGGAACTGTCGTGCAGGCGGCAAAAGCTCTTCGCAATGCCGGAGCG
ACCGCCATATCCGTATGCTGTACCCATCCCGTCCTTTCCGGACCGGCTATGGACAGAATAGAGTCTTCTGAAATCAAGGA
AGTCATCGTGACAGACACCATTCCCCTGCACGAAAGGGCGCAGCAGTGCAGCCGGATCAGTGTTCTCTCCGTTGCGGGAC
TGCTCAGTGAAGCAGTCCGGAGAATCTATTATAACGATTCTGTAAGTTCACTTTTTATATAG

Upstream 100 bases:

>100_bases
CGTCAAGCGGTAAGACACAAGATTTTGGTTCTTGCATGCGGAGGTTCGAATCCTCCCGCCCCAGCCAACAACAGTGACAC
GCGCAGTGGGAAGGACATAA

Downstream 100 bases:

>100_bases
GAGGAGTAGATGGAAGCGCGTGAGTTAAAGGCCAACGTACGCAAGGAATCCGGTAAGGAACAAGCCAGGCGTATGCGACG
TGAAGGATTAATCCCTGCAG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MLERIKVFTGNATPDLARKICDNLAIPLGKANVTTFSDGETRVEINENVRGMDIFIIQSTCTPVNVTLMELLIMIDALKR
ASAGRITAVIPYYGYARQDRKVAPRAPISAKLVADLLTTAGANRILSLDLHAGQIQGFFNIPVDNLFATPVLLNYLKTHY
QDNLVIVSPDAGGVERARAFARRLDATIAIIDKRREGPNEAQVMNIVGSVEGKNVVVLDDMIDTAGTVVQAAKALRNAGA
TAISVCCTHPVLSGPAMDRIESSEIKEVIVTDTIPLHERAQQCSRISVLSVAGLLSEAVRRIYYNDSVSSLFI

Sequences:

>Translated_313_residues
MLERIKVFTGNATPDLARKICDNLAIPLGKANVTTFSDGETRVEINENVRGMDIFIIQSTCTPVNVTLMELLIMIDALKR
ASAGRITAVIPYYGYARQDRKVAPRAPISAKLVADLLTTAGANRILSLDLHAGQIQGFFNIPVDNLFATPVLLNYLKTHY
QDNLVIVSPDAGGVERARAFARRLDATIAIIDKRREGPNEAQVMNIVGSVEGKNVVVLDDMIDTAGTVVQAAKALRNAGA
TAISVCCTHPVLSGPAMDRIESSEIKEVIVTDTIPLHERAQQCSRISVLSVAGLLSEAVRRIYYNDSVSSLFI
>Mature_313_residues
MLERIKVFTGNATPDLARKICDNLAIPLGKANVTTFSDGETRVEINENVRGMDIFIIQSTCTPVNVTLMELLIMIDALKR
ASAGRITAVIPYYGYARQDRKVAPRAPISAKLVADLLTTAGANRILSLDLHAGQIQGFFNIPVDNLFATPVLLNYLKTHY
QDNLVIVSPDAGGVERARAFARRLDATIAIIDKRREGPNEAQVMNIVGSVEGKNVVVLDDMIDTAGTVVQAAKALRNAGA
TAISVCCTHPVLSGPAMDRIESSEIKEVIVTDTIPLHERAQQCSRISVLSVAGLLSEAVRRIYYNDSVSSLFI

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=313, Percent_Identity=49.2012779552716, Blast_Score=313, Evalue=1e-85,
Organism=Homo sapiens, GI4506129, Length=313, Percent_Identity=47.9233226837061, Blast_Score=309, Evalue=2e-84,
Organism=Homo sapiens, GI28557709, Length=313, Percent_Identity=48.2428115015974, Blast_Score=306, Evalue=1e-83,
Organism=Homo sapiens, GI84875539, Length=316, Percent_Identity=47.4683544303797, Blast_Score=304, Evalue=7e-83,
Organism=Homo sapiens, GI4506133, Length=342, Percent_Identity=39.1812865497076, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI194018537, Length=342, Percent_Identity=39.4736842105263, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI310128524, Length=147, Percent_Identity=32.6530612244898, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI310115209, Length=147, Percent_Identity=32.6530612244898, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI310118259, Length=147, Percent_Identity=32.6530612244898, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI310119946, Length=147, Percent_Identity=32.6530612244898, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1787458, Length=310, Percent_Identity=55.1612903225806, Blast_Score=348, Evalue=3e-97,
Organism=Caenorhabditis elegans, GI17554702, Length=314, Percent_Identity=50, Blast_Score=320, Evalue=8e-88,
Organism=Caenorhabditis elegans, GI25149168, Length=314, Percent_Identity=50, Blast_Score=320, Evalue=8e-88,
Organism=Caenorhabditis elegans, GI71989924, Length=314, Percent_Identity=50, Blast_Score=318, Evalue=3e-87,
Organism=Caenorhabditis elegans, GI17554704, Length=309, Percent_Identity=50.1618122977346, Blast_Score=316, Evalue=1e-86,
Organism=Caenorhabditis elegans, GI17570245, Length=335, Percent_Identity=37.910447761194, Blast_Score=220, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6319403, Length=316, Percent_Identity=45.253164556962, Blast_Score=270, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6320946, Length=311, Percent_Identity=44.0514469453376, Blast_Score=264, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6321776, Length=311, Percent_Identity=44.3729903536978, Blast_Score=261, Evalue=9e-71,
Organism=Saccharomyces cerevisiae, GI6322667, Length=198, Percent_Identity=39.8989898989899, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324511, Length=110, Percent_Identity=48.1818181818182, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21355239, Length=313, Percent_Identity=50.4792332268371, Blast_Score=307, Evalue=5e-84,
Organism=Drosophila melanogaster, GI45551540, Length=336, Percent_Identity=47.0238095238095, Blast_Score=295, Evalue=4e-80,
Organism=Drosophila melanogaster, GI24651458, Length=353, Percent_Identity=36.2606232294618, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24651456, Length=353, Percent_Identity=36.2606232294618, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI281362873, Length=353, Percent_Identity=36.2606232294618, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24651454, Length=353, Percent_Identity=36.2606232294618, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24651462, Length=372, Percent_Identity=34.1397849462366, Blast_Score=197, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24651464, Length=372, Percent_Identity=34.1397849462366, Blast_Score=197, Evalue=6e-51,
Organism=Drosophila melanogaster, GI45552010, Length=372, Percent_Identity=34.1397849462366, Blast_Score=197, Evalue=7e-51,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33931; Mature: 33931

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERIKVFTGNATPDLARKICDNLAIPLGKANVTTFSDGETRVEINENVRGMDIFIIQST
CCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEECCCCCCEEEEEEECC
CTPVNVTLMELLIMIDALKRASAGRITAVIPYYGYARQDRKVAPRAPISAKLVADLLTTA
CCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
GANRILSLDLHAGQIQGFFNIPVDNLFATPVLLNYLKTHYQDNLVIVSPDAGGVERARAF
CCCEEEEEEECCCEECEEEECCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHH
ARRLDATIAIIDKRREGPNEAQVMNIVGSVEGKNVVVLDDMIDTAGTVVQAAKALRNAGA
HHHHCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCC
TAISVCCTHPVLSGPAMDRIESSEIKEVIVTDTIPLHERAQQCSRISVLSVAGLLSEAVR
CEEEHHHCCCCCCCCHHHHCCHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RIYYNDSVSSLFI
HHHCCCCHHHHCC
>Mature Secondary Structure
MLERIKVFTGNATPDLARKICDNLAIPLGKANVTTFSDGETRVEINENVRGMDIFIIQST
CCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCEEEECCCCEEEEECCCCCCEEEEEEECC
CTPVNVTLMELLIMIDALKRASAGRITAVIPYYGYARQDRKVAPRAPISAKLVADLLTTA
CCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
GANRILSLDLHAGQIQGFFNIPVDNLFATPVLLNYLKTHYQDNLVIVSPDAGGVERARAF
CCCEEEEEEECCCEECEEEECCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHH
ARRLDATIAIIDKRREGPNEAQVMNIVGSVEGKNVVVLDDMIDTAGTVVQAAKALRNAGA
HHHHCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCC
TAISVCCTHPVLSGPAMDRIESSEIKEVIVTDTIPLHERAQQCSRISVLSVAGLLSEAVR
CEEEHHHCCCCCCCCHHHHCCHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RIYYNDSVSSLFI
HHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA