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The map label for this gene is serS [H]

Identifier: 85859585

GI number: 85859585

Start: 1816704

End: 1818050

Strand: Direct

Name: serS [H]

Synonym: SYN_00102

Alternate gene names: 85859585

Gene position: 1816704-1818050 (Clockwise)

Preceding gene: 85859584

Following gene: 85859586

Centisome position: 57.14

GC content: 49.15

Gene sequence:

>1347_bases
TTGACTTCAAAATCCCAAGATGATAGAGACATCGTCTCTTGCGGGCACAAAACACTTGAAGGCAATCCGATGCTTGACAT
CAAATTTCTCAGACAGAATGTCGATCTTGTTAAGAAGAAAATCGAGGAGCGGGGCCAGGGTATCGACTTGAGCGCCTTTG
TCAGCATGGATGCAGAACGGCGTGATATTCTTCAGGAAGTCGAGTCCCTTCGTAATGAGCGAAACGCCGTGTCCAGGCAT
ATCGGGGAAAGAAAGAAACGTAAGGAAGACGCGCAGGATCTCATTGATCGGATGGGAACGGTTTCCGGGCGAATCCGGGA
ACTTGAGGAAGGACTTAAGGAAACGGAAGAGAACCTGCATAACCTGCTTCTGACGATCCCCAACATCCCACATGAATCGG
TTGTTTGCGGAGTGAATGCCGAAGACAATCCTGTAGTCCGGGTCTGGGGAGAGAAACCTCTCTTTGATTTTTCTCCGAAA
CCCCATTGGGAGATTGGTGAAGATCTCAGCATTCTCGACTTTGCACGAGGCGCTAAGATTACAGGTGCCCGCTTTACACT
CTATCGCGGGGCAGGCGCCATGCTGGAACGGGCGATTATCAATTTCATGCTGGATCTCCATATCATGGAGCATGGGTACA
CGGAGATTCTGCCGCCCTTTATGGCCAACCGAGACAGCATGACAGGCACGGGTCAGTTGCCGAAGTTCGCAGAAGATCTT
TTCAAAATCGAGAATTTGGAATACTATCTTATCCCCACGGCGGAAGTTCCGGTGACGAACATCCATCGTGAAGAGATTCT
TGAAGAAAAGGCTTTGCCGATTTATTATGTAGCTTACTCACCCTGCTTCCGGGCAGAGGCGGGATCCTATGGGAAAGACA
CCCGGGGGCTGATTCGACAGCATCAGTTCAATAAAGTCGAGATGGTAAAATTTACCTCTCCGGAAACATCTTATGATGAG
CTGGAAAAACTGACGGTCAATGCTGAAGAAGTGCTGAAGCGGCTTAATATACCTTATCGGACCGTAAGTCTTTGTACCGG
CGACTTAGGATTTTCGTCAGCAAAAACCTATGATGTCGAAGCCTGGCTGCCGGGACAGGATACGTACAGAGAAATTTCTT
CATGCAGTAATTTTGAAGACTTTCAGGCTCGAAGAGCTTCCATACGCTTTCGTCGGGAGTCAACCGGTAAGCTGGACTTT
GTCCACACCCTGAACGGCTCCGGTCTAGCAGCTGGAAGAACGCTTGTTGCCGTACTGGAAAATTACCAGCAGGCGGATGG
AAGCATCGTTATTCCTGATGTACTGCGCCCCTACATGAAAGGAATGAAGAAAATTTCCGCGGCATGA

Upstream 100 bases:

>100_bases
CTTTCTTCTCAAAAGCGACGAAATCGTTTCCCTCCTCAATGTCATCCGAAGGAAATTGAGACCTTCATCCCCCTGATCCG
TCTAAGGACGGATAAAATGG

Downstream 100 bases:

>100_bases
AGCGGGAATTTTAATAATTAAAGATTCGGAGGGATGGCCGAGTGGTCTATGGCGGCGGTCTTGAAAACCGTTGACCGAAA
GGTTCGCGGGTTCGAATCCT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MTSKSQDDRDIVSCGHKTLEGNPMLDIKFLRQNVDLVKKKIEERGQGIDLSAFVSMDAERRDILQEVESLRNERNAVSRH
IGERKKRKEDAQDLIDRMGTVSGRIRELEEGLKETEENLHNLLLTIPNIPHESVVCGVNAEDNPVVRVWGEKPLFDFSPK
PHWEIGEDLSILDFARGAKITGARFTLYRGAGAMLERAIINFMLDLHIMEHGYTEILPPFMANRDSMTGTGQLPKFAEDL
FKIENLEYYLIPTAEVPVTNIHREEILEEKALPIYYVAYSPCFRAEAGSYGKDTRGLIRQHQFNKVEMVKFTSPETSYDE
LEKLTVNAEEVLKRLNIPYRTVSLCTGDLGFSSAKTYDVEAWLPGQDTYREISSCSNFEDFQARRASIRFRRESTGKLDF
VHTLNGSGLAAGRTLVAVLENYQQADGSIVIPDVLRPYMKGMKKISAA

Sequences:

>Translated_448_residues
MTSKSQDDRDIVSCGHKTLEGNPMLDIKFLRQNVDLVKKKIEERGQGIDLSAFVSMDAERRDILQEVESLRNERNAVSRH
IGERKKRKEDAQDLIDRMGTVSGRIRELEEGLKETEENLHNLLLTIPNIPHESVVCGVNAEDNPVVRVWGEKPLFDFSPK
PHWEIGEDLSILDFARGAKITGARFTLYRGAGAMLERAIINFMLDLHIMEHGYTEILPPFMANRDSMTGTGQLPKFAEDL
FKIENLEYYLIPTAEVPVTNIHREEILEEKALPIYYVAYSPCFRAEAGSYGKDTRGLIRQHQFNKVEMVKFTSPETSYDE
LEKLTVNAEEVLKRLNIPYRTVSLCTGDLGFSSAKTYDVEAWLPGQDTYREISSCSNFEDFQARRASIRFRRESTGKLDF
VHTLNGSGLAAGRTLVAVLENYQQADGSIVIPDVLRPYMKGMKKISAA
>Mature_447_residues
TSKSQDDRDIVSCGHKTLEGNPMLDIKFLRQNVDLVKKKIEERGQGIDLSAFVSMDAERRDILQEVESLRNERNAVSRHI
GERKKRKEDAQDLIDRMGTVSGRIRELEEGLKETEENLHNLLLTIPNIPHESVVCGVNAEDNPVVRVWGEKPLFDFSPKP
HWEIGEDLSILDFARGAKITGARFTLYRGAGAMLERAIINFMLDLHIMEHGYTEILPPFMANRDSMTGTGQLPKFAEDLF
KIENLEYYLIPTAEVPVTNIHREEILEEKALPIYYVAYSPCFRAEAGSYGKDTRGLIRQHQFNKVEMVKFTSPETSYDEL
EKLTVNAEEVLKRLNIPYRTVSLCTGDLGFSSAKTYDVEAWLPGQDTYREISSCSNFEDFQARRASIRFRRESTGKLDFV
HTLNGSGLAAGRTLVAVLENYQQADGSIVIPDVLRPYMKGMKKISAA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=433, Percent_Identity=33.256351039261, Blast_Score=222, Evalue=6e-58,
Organism=Homo sapiens, GI8923421, Length=444, Percent_Identity=32.2072072072072, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI225579074, Length=446, Percent_Identity=32.0627802690583, Blast_Score=210, Evalue=2e-54,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=50.6976744186047, Blast_Score=426, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17539260, Length=469, Percent_Identity=31.5565031982942, Blast_Score=228, Evalue=7e-60,
Organism=Caenorhabditis elegans, GI17542084, Length=339, Percent_Identity=29.4985250737463, Blast_Score=139, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6320226, Length=441, Percent_Identity=36.734693877551, Blast_Score=268, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6321799, Length=348, Percent_Identity=33.6206896551724, Blast_Score=199, Evalue=9e-52,
Organism=Drosophila melanogaster, GI24581334, Length=464, Percent_Identity=31.6810344827586, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI17737985, Length=391, Percent_Identity=31.4578005115089, Blast_Score=165, Evalue=7e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 50829; Mature: 50698

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSKSQDDRDIVSCGHKTLEGNPMLDIKFLRQNVDLVKKKIEERGQGIDLSAFVSMDAER
CCCCCCCCHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCHHHEECCHHH
RDILQEVESLRNERNAVSRHIGERKKRKEDAQDLIDRMGTVSGRIRELEEGLKETEENLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLLLTIPNIPHESVVCGVNAEDNPVVRVWGEKPLFDFSPKPHWEIGEDLSILDFARGAKI
HHEEECCCCCCCCEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEE
TGARFTLYRGAGAMLERAIINFMLDLHIMEHGYTEILPPFMANRDSMTGTGQLPKFAEDL
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHCCCCCCCCCCCCHHHHHHH
FKIENLEYYLIPTAEVPVTNIHREEILEEKALPIYYVAYSPCFRAEAGSYGKDTRGLIRQ
HHHCCCEEEEEECCCCCCCCCHHHHHHHHCCCCEEEEEECCCHHCCCCCCCCHHHHHHHH
HQFNKVEMVKFTSPETSYDELEKLTVNAEEVLKRLNIPYRTVSLCTGDLGFSSAKTYDVE
HCCCCEEEEEECCCCCCHHHHHHHCCCHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEE
AWLPGQDTYREISSCSNFEDFQARRASIRFRRESTGKLDFVHTLNGSGLAAGRTLVAVLE
EECCCCHHHHHHHCCCCCHHHHHHHHHHEEECCCCCCEEEEEECCCCCCHHHHHHHHHHH
NYQQADGSIVIPDVLRPYMKGMKKISAA
HHHHCCCCEECHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSKSQDDRDIVSCGHKTLEGNPMLDIKFLRQNVDLVKKKIEERGQGIDLSAFVSMDAER
CCCCCCCHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCHHHEECCHHH
RDILQEVESLRNERNAVSRHIGERKKRKEDAQDLIDRMGTVSGRIRELEEGLKETEENLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLLLTIPNIPHESVVCGVNAEDNPVVRVWGEKPLFDFSPKPHWEIGEDLSILDFARGAKI
HHEEECCCCCCCCEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEE
TGARFTLYRGAGAMLERAIINFMLDLHIMEHGYTEILPPFMANRDSMTGTGQLPKFAEDL
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHCCCCCCCCCCCCHHHHHHH
FKIENLEYYLIPTAEVPVTNIHREEILEEKALPIYYVAYSPCFRAEAGSYGKDTRGLIRQ
HHHCCCEEEEEECCCCCCCCCHHHHHHHHCCCCEEEEEECCCHHCCCCCCCCHHHHHHHH
HQFNKVEMVKFTSPETSYDELEKLTVNAEEVLKRLNIPYRTVSLCTGDLGFSSAKTYDVE
HCCCCEEEEEECCCCCCHHHHHHHCCCHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEE
AWLPGQDTYREISSCSNFEDFQARRASIRFRRESTGKLDFVHTLNGSGLAAGRTLVAVLE
EECCCCHHHHHHHCCCCCHHHHHHHHHHEEECCCCCCEEEEEECCCCCCHHHHHHHHHHH
NYQQADGSIVIPDVLRPYMKGMKKISAA
HHHHCCCCEECHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA