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The map label for this gene is rsmA

Identifier: 85859079

GI number: 85859079

Start: 1254476

End: 1255318

Strand: Direct

Name: rsmA

Synonym: SYN_00421

Alternate gene names: 85859079

Gene position: 1254476-1255318 (Clockwise)

Preceding gene: 85859078

Following gene: 85859080

Centisome position: 39.46

GC content: 46.5

Gene sequence:

>843_bases
ATGACATTCGTTCGACAGATTCTCCGTAATCATGATATCAAGCCGGTAAAGAGACTCGGCCAATGTTTTCTTGCAGATTT
CTCCGTCATGAAGAAGATTGTGGAGCTTGCGGAAATCAAGGAGGATGAAACCATCGTGGAGATCGGTTCGGGATTGGGCC
TGATGACCTCCCTGATGGCGGAACGCGCCGCCTGGGTTCATGCCGTGGAAATCGATGGAAAACTGGTTTCCGTTTTGAAA
GAGCGGCTTAAGGAATATCACAATGTCACGGTGATTCATGGAGATATTCTGAAGTATGATTTTCTGACCGCATTGGGTGA
AAATTCTGTTAAAAAGATCAAGATCATAGGAAATATCCCTTACAGTATTTCCTCTCCGATTCTGTTTCATATTCTTGACC
ATCGAAAGCAGATCTCGACGGCCGTGCTGATGATGCAGAAGGAAGTGGCCGACCGCTTGTGTGCCGTTCCTGGGACGAAA
GCTTACGGGATTCCCACCGTGCTCTTTGGTCTCTACGCTAGAATTTCCCGTGAACTGACCGTTGCGCCGGGTTGTTTCTA
TCCGAAGCCGGAGGTAACTTCCACGGTCGTTAAAATGCTGATCCCGGAAGAACCACTGTATTGGGTCGAAAATGACGCGT
TGTTTTTCCGTCTTGTGAAAGCTGCCTTTGCTCAACGTCGAAAAACGCTTTTAAATAATATGAAAAACGCACACTGGAAA
GATTGTGATGCCGGGAGAATAGAAAATTTATTAAGGGATATGGGAGCCGGTGAGAAAATCAGGGCGGAAGAGCTGTCAAT
TCAACAATTTGCGGCACTGTGCAATTCCCTTTCATATTCGTGA

Upstream 100 bases:

>100_bases
CCTCTTCTTCTCGGAGGGTTTCTCCTGGGCCTTGTTTTTACATATCCCGCTTACTTCCTTTCTTATCGACTTTTATCTTT
TATGAGAAAAAAAGAAGCCT

Downstream 100 bases:

>100_bases
AAAAAGAAAGAATATTCTTGACAGTGAAAGGTCTGTCTGGTAGAGAAATTTTCACCGCTTGGATCCGCTGAAGGACTGAG
ACGGAAGGCACAGGAAGAAC

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MTFVRQILRNHDIKPVKRLGQCFLADFSVMKKIVELAEIKEDETIVEIGSGLGLMTSLMAERAAWVHAVEIDGKLVSVLK
ERLKEYHNVTVIHGDILKYDFLTALGENSVKKIKIIGNIPYSISSPILFHILDHRKQISTAVLMMQKEVADRLCAVPGTK
AYGIPTVLFGLYARISRELTVAPGCFYPKPEVTSTVVKMLIPEEPLYWVENDALFFRLVKAAFAQRRKTLLNNMKNAHWK
DCDAGRIENLLRDMGAGEKIRAEELSIQQFAALCNSLSYS

Sequences:

>Translated_280_residues
MTFVRQILRNHDIKPVKRLGQCFLADFSVMKKIVELAEIKEDETIVEIGSGLGLMTSLMAERAAWVHAVEIDGKLVSVLK
ERLKEYHNVTVIHGDILKYDFLTALGENSVKKIKIIGNIPYSISSPILFHILDHRKQISTAVLMMQKEVADRLCAVPGTK
AYGIPTVLFGLYARISRELTVAPGCFYPKPEVTSTVVKMLIPEEPLYWVENDALFFRLVKAAFAQRRKTLLNNMKNAHWK
DCDAGRIENLLRDMGAGEKIRAEELSIQQFAALCNSLSYS
>Mature_279_residues
TFVRQILRNHDIKPVKRLGQCFLADFSVMKKIVELAEIKEDETIVEIGSGLGLMTSLMAERAAWVHAVEIDGKLVSVLKE
RLKEYHNVTVIHGDILKYDFLTALGENSVKKIKIIGNIPYSISSPILFHILDHRKQISTAVLMMQKEVADRLCAVPGTKA
YGIPTVLFGLYARISRELTVAPGCFYPKPEVTSTVVKMLIPEEPLYWVENDALFFRLVKAAFAQRRKTLLNNMKNAHWKD
CDAGRIENLLRDMGAGEKIRAEELSIQQFAALCNSLSYS

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily

Homologues:

Organism=Homo sapiens, GI7657198, Length=289, Percent_Identity=29.757785467128, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI156415992, Length=301, Percent_Identity=27.906976744186, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1786236, Length=263, Percent_Identity=32.6996197718631, Blast_Score=146, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI25146882, Length=282, Percent_Identity=31.9148936170213, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25141369, Length=294, Percent_Identity=24.4897959183673, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324989, Length=228, Percent_Identity=28.9473684210526, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21358017, Length=229, Percent_Identity=34.9344978165939, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI21357273, Length=298, Percent_Identity=27.1812080536913, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RSMA_SYNAS (Q2LSQ6)

Other databases:

- EMBL:   CP000252
- RefSeq:   YP_461281.1
- ProteinModelPortal:   Q2LSQ6
- SMR:   Q2LSQ6
- STRING:   Q2LSQ6
- GeneID:   3883588
- GenomeReviews:   CP000252_GR
- KEGG:   sat:SYN_00421
- NMPDR:   fig|56780.10.peg.1218
- eggNOG:   COG0030
- HOGENOM:   HBG319664
- OMA:   TPIIMKL
- PhylomeDB:   Q2LSQ6
- BioCyc:   SACI56780:SYN_00421-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00607
- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530
- Gene3D:   G3DSA:1.10.8.100
- PANTHER:   PTHR11727
- SMART:   SM00650
- TIGRFAMs:   TIGR00755

Pfam domain/function: PF00398 RrnaAD

EC number: =2.1.1.182

Molecular weight: Translated: 31595; Mature: 31463

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: BINDING 24-24 BINDING 49-49 BINDING 70-70 BINDING 95-95 BINDING 118-118

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFVRQILRNHDIKPVKRLGQCFLADFSVMKKIVELAEIKEDETIVEIGSGLGLMTSLMA
CHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHH
ERAAWVHAVEIDGKLVSVLKERLKEYHNVTVIHGDILKYDFLTALGENSVKKIKIIGNIP
HHHHHHEEEECCHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHCCCCCEEEEEEECCC
YSISSPILFHILDHRKQISTAVLMMQKEVADRLCAVPGTKAYGIPTVLFGLYARISRELT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCE
VAPGCFYPKPEVTSTVVKMLIPEEPLYWVENDALFFRLVKAAFAQRRKTLLNNMKNAHWK
ECCCCCCCCCHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DCDAGRIENLLRDMGAGEKIRAEELSIQQFAALCNSLSYS
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TFVRQILRNHDIKPVKRLGQCFLADFSVMKKIVELAEIKEDETIVEIGSGLGLMTSLMA
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHH
ERAAWVHAVEIDGKLVSVLKERLKEYHNVTVIHGDILKYDFLTALGENSVKKIKIIGNIP
HHHHHHEEEECCHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHCCCCCEEEEEEECCC
YSISSPILFHILDHRKQISTAVLMMQKEVADRLCAVPGTKAYGIPTVLFGLYARISRELT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCE
VAPGCFYPKPEVTSTVVKMLIPEEPLYWVENDALFFRLVKAAFAQRRKTLLNNMKNAHWK
ECCCCCCCCCHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DCDAGRIENLLRDMGAGEKIRAEELSIQQFAALCNSLSYS
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA