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The map label for this gene is gcp

Identifier: 85859077

GI number: 85859077

Start: 1253011

End: 1254027

Strand: Direct

Name: gcp

Synonym: SYN_00423

Alternate gene names: 85859077

Gene position: 1253011-1254027 (Clockwise)

Preceding gene: 85859075

Following gene: 85859078

Centisome position: 39.41

GC content: 53.59

Gene sequence:

>1017_bases
ATGATTGTTTTAGGGATTGAGTCGTCATGTGACGAAACGGCGGCGGCGGTCGTTCGGGACGGCCGTGTTCTGTTGTCCAA
TGTGATCGCCTCGCAGATTGGCGAACACAGCAAATATGGCGGCGTGGTGCCCGAAATCGCGTCGCGCAAGCATATTGAAG
CGGTCATTCCGGTTATTCTGCAGGCGCTTCATGATGCCGGGATGGAGTTATCGGATATCGAAGGGATCGCAGTAACCAGA
GGACCGGGGCTTGTCGGTTCTCTGCTGGTTGGACTTTCCGTTGCGAAAGCCCTGGCTTTTTCCCGGAAGCTTCCCCTCGT
GGGAATTCATCACCTGGAAGGGCACATAGCGGCCATCTTCCTCAGTGAGAAGGTGCCCGAGTTTCCCTTCATTGCGCTTG
TAGTGTCCGGGGGGCATACCAACATATACTTCGTCCGGGGGTTCGGGTTATTTACTCTTCTGGGTCAGACAAGAGATGAT
GCGGCAGGAGAAGCCTTTGACAAGGCAGCGAAACTGCTGAATATCGGCTATCCCGGAGGAGTGGTGATCGATCGTCTGGC
GAAGGAGGGCGACCGGAATCTGCTGAATTTCCCAAGGGCGATGAAGGAAAGCCTTGATTTCAGTTTCAGCGGACTTAAGA
CGTCTCTTCTTGTTCATGTAAAAAAACATGGGAGCCCTTCTGCCAGGGAAGATCTTGCTCATCTGGTTGCCGCCTATCAG
GAAGCCATTGTCGATGTCCTGGTGGAGAAAACCCTGAAAGCCGCCAAAATGAATTCCGTTCCCCAGGTTGTCGTCTGTGG
CGGAGTGGCCTCGAACAGTCGTCTCAGGGAACATTTTATGGAGAGAAGCCGGGAAGAAAACATCGATCTGTTTATTCCTC
CTCCCGTGCTGTGCACTGACAATGCCGCGATGATCGCCGTGGTGGGCGAAAACCTTCTGAACAAAGGGAAAAGCGAAGAA
CTCAGTATAAATGCCGTATCGCGATGGCCTCTCGATGTGGCGGGATCGTTCCGGTAG

Upstream 100 bases:

>100_bases
TTTCTCTTTCGGCAAATAGAGTCAGCGAAAAGTTTATTTACAAACCTGTGTATTTTCTATATAACCCTCTCCAGCTTTTG
TAAAAGGAAATATTCGGAAA

Downstream 100 bases:

>100_bases
AAAATGATTTTTGAAAACCGGATCAAAAAATTCTATCAGCAGTTCATCAGTCTCAAGGGTGACCCGGAATCGCTGGCGTG
GGGCATGGCGATGGGGGTCT

Product: o-sialoglycoprotein endopeptidase

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MIVLGIESSCDETAAAVVRDGRVLLSNVIASQIGEHSKYGGVVPEIASRKHIEAVIPVILQALHDAGMELSDIEGIAVTR
GPGLVGSLLVGLSVAKALAFSRKLPLVGIHHLEGHIAAIFLSEKVPEFPFIALVVSGGHTNIYFVRGFGLFTLLGQTRDD
AAGEAFDKAAKLLNIGYPGGVVIDRLAKEGDRNLLNFPRAMKESLDFSFSGLKTSLLVHVKKHGSPSAREDLAHLVAAYQ
EAIVDVLVEKTLKAAKMNSVPQVVVCGGVASNSRLREHFMERSREENIDLFIPPPVLCTDNAAMIAVVGENLLNKGKSEE
LSINAVSRWPLDVAGSFR

Sequences:

>Translated_338_residues
MIVLGIESSCDETAAAVVRDGRVLLSNVIASQIGEHSKYGGVVPEIASRKHIEAVIPVILQALHDAGMELSDIEGIAVTR
GPGLVGSLLVGLSVAKALAFSRKLPLVGIHHLEGHIAAIFLSEKVPEFPFIALVVSGGHTNIYFVRGFGLFTLLGQTRDD
AAGEAFDKAAKLLNIGYPGGVVIDRLAKEGDRNLLNFPRAMKESLDFSFSGLKTSLLVHVKKHGSPSAREDLAHLVAAYQ
EAIVDVLVEKTLKAAKMNSVPQVVVCGGVASNSRLREHFMERSREENIDLFIPPPVLCTDNAAMIAVVGENLLNKGKSEE
LSINAVSRWPLDVAGSFR
>Mature_338_residues
MIVLGIESSCDETAAAVVRDGRVLLSNVIASQIGEHSKYGGVVPEIASRKHIEAVIPVILQALHDAGMELSDIEGIAVTR
GPGLVGSLLVGLSVAKALAFSRKLPLVGIHHLEGHIAAIFLSEKVPEFPFIALVVSGGHTNIYFVRGFGLFTLLGQTRDD
AAGEAFDKAAKLLNIGYPGGVVIDRLAKEGDRNLLNFPRAMKESLDFSFSGLKTSLLVHVKKHGSPSAREDLAHLVAAYQ
EAIVDVLVEKTLKAAKMNSVPQVVVCGGVASNSRLREHFMERSREENIDLFIPPPVLCTDNAAMIAVVGENLLNKGKSEE
LSINAVSRWPLDVAGSFR

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=338, Percent_Identity=38.4615384615385, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI8923380, Length=334, Percent_Identity=31.1377245508982, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1789445, Length=334, Percent_Identity=44.9101796407186, Blast_Score=298, Evalue=4e-82,
Organism=Caenorhabditis elegans, GI17557464, Length=324, Percent_Identity=31.1728395061728, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71995670, Length=345, Percent_Identity=31.0144927536232, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320099, Length=363, Percent_Identity=31.9559228650138, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6322891, Length=294, Percent_Identity=30.2721088435374, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI20129063, Length=369, Percent_Identity=30.6233062330623, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI21357207, Length=333, Percent_Identity=30.6306306306306, Blast_Score=132, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_SYNAS (Q2LSP8)

Other databases:

- EMBL:   CP000252
- RefSeq:   YP_461279.1
- ProteinModelPortal:   Q2LSP8
- SMR:   Q2LSP8
- STRING:   Q2LSP8
- MEROPS:   M22.001
- GeneID:   3883586
- GenomeReviews:   CP000252_GR
- KEGG:   sat:SYN_00423
- NMPDR:   fig|56780.10.peg.1216
- eggNOG:   COG0533
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- PhylomeDB:   Q2LSP8
- BioCyc:   SACI56780:SYN_00423-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 36166; Mature: 36166

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVLGIESSCDETAAAVVRDGRVLLSNVIASQIGEHSKYGGVVPEIASRKHIEAVIPVIL
CEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
QALHDAGMELSDIEGIAVTRGPGLVGSLLVGLSVAKALAFSRKLPLVGIHHLEGHIAAIF
HHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEE
LSEKVPEFPFIALVVSGGHTNIYFVRGFGLFTLLGQTRDDAAGEAFDKAAKLLNIGYPGG
ECCCCCCCCEEEEEEECCCCEEEEEECCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCH
VVIDRLAKEGDRNLLNFPRAMKESLDFSFSGLKTSLLVHVKKHGSPSAREDLAHLVAAYQ
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHEEEEEEEECCCCCCHHHHHHHHHHHHH
EAIVDVLVEKTLKAAKMNSVPQVVVCGGVASNSRLREHFMERSREENIDLFIPPPVLCTD
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEECCCEEECC
NAAMIAVVGENLLNKGKSEELSINAVSRWPLDVAGSFR
CCEEEEEECHHHHCCCCCCEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MIVLGIESSCDETAAAVVRDGRVLLSNVIASQIGEHSKYGGVVPEIASRKHIEAVIPVIL
CEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
QALHDAGMELSDIEGIAVTRGPGLVGSLLVGLSVAKALAFSRKLPLVGIHHLEGHIAAIF
HHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEE
LSEKVPEFPFIALVVSGGHTNIYFVRGFGLFTLLGQTRDDAAGEAFDKAAKLLNIGYPGG
ECCCCCCCCEEEEEEECCCCEEEEEECCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCH
VVIDRLAKEGDRNLLNFPRAMKESLDFSFSGLKTSLLVHVKKHGSPSAREDLAHLVAAYQ
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHEEEEEEEECCCCCCHHHHHHHHHHHHH
EAIVDVLVEKTLKAAKMNSVPQVVVCGGVASNSRLREHFMERSREENIDLFIPPPVLCTD
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEECCCEEECC
NAAMIAVVGENLLNKGKSEELSINAVSRWPLDVAGSFR
CCEEEEEECHHHHCCCCCCEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA