Click here to switch to the map view.

The map label for this gene is kdsA [H]

Identifier: 85859053

GI number: 85859053

Start: 1227158

End: 1228036

Strand: Direct

Name: kdsA [H]

Synonym: SYN_00950

Alternate gene names: 85859053

Gene position: 1227158-1228036 (Clockwise)

Preceding gene: 85859052

Following gene: 85859054

Centisome position: 38.6

GC content: 53.81

Gene sequence:

>879_bases
GTGTGCGGTGGTCCGCTGTATGTTTTTAAGAGGAAAGATGTTATGAAACCTGTTCATGTCGGCGGTCTGGTTGTCGGGGG
AGGGAGCCCCCTCGTGCTTATTGCCGGACCCTGCGTTATCGAGGATGAGGAACGGACACGGGACATTGCCCTTTATCTGA
AAAAACTCACGGATGAAATGGATATCCCTTTTATTTTCAAGGCCTCCTATGACAAAGCCAACCGGACATCGGGGAAAGCC
TATCGCGGTCCAGGCCTCGAGCGAGGGATTGAAATTCTGAAAGCCATCAAGGGCGATCTGGGTATTCCCATCCTTTCCGA
TGTCCATAGTCGCGAGGAAATCGAGAAGGCGGCTGAAATCCTGGATGTGGTTCAGATTCCGGCTTTTCTTTGTCGTCAGA
CCGACCTTGTAAGGGAAGTCGCCCGTCTTGCCAGAGCCGTCAATATCAAAAAGGGCCAGTTTCTGGCTCCGTGGGATGTC
CGGAATATCATCGAAAAAGTCCTCTCCGAAGGAAATGAGCGGATTCTGGTTACCGAACGGGGGACAAGTTTCGGTTACAA
CAACCTGGTCGTGGATTTCCGTTCCCTGCCCCTGCTGAGAAGGGAAGGTTATCCCGTGATTTTTGACGCAACGCACAGCG
TTCAGCTTCCCGGCGGCCAGGGGACTGCCTCGGGGGGGCAGAGAGAAATGGTGCCCTGTCTGATGCGAGCCGCCGCAGCG
GTTGGTATTGACGGTCTTTTTCTTGAGGTGCACCCGGATCCGGAGAAGGCCCTGTGTGACGGTCCGAATTCTCTTTATCT
CGATGCCCTTCCTGAGCTCCTGAGCACGGTGAAATCCATCGACCGGCTGGTAAAAAACAGGGCGGACGGCATTTTTTAA

Upstream 100 bases:

>100_bases
GGAAGATTCCCAGGTTAAAGATCAAAATTCTGGAGAAGAAACATCAGGAATCCTGAAGCGATGAAGCCCTGTTCGGTTAA
CGCCGGGGCATCTGAAAAAA

Downstream 100 bases:

>100_bases
CGATATCGGCTTATGCCGGCAGCTTCGCTCAAATGAGGGTGGTGAATGTGATCAAGGATGAAGCGGTAAAAAGCAGGATC
AGGAAGATCCGTCTTCTGAT

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MCGGPLYVFKRKDVMKPVHVGGLVVGGGSPLVLIAGPCVIEDEERTRDIALYLKKLTDEMDIPFIFKASYDKANRTSGKA
YRGPGLERGIEILKAIKGDLGIPILSDVHSREEIEKAAEILDVVQIPAFLCRQTDLVREVARLARAVNIKKGQFLAPWDV
RNIIEKVLSEGNERILVTERGTSFGYNNLVVDFRSLPLLRREGYPVIFDATHSVQLPGGQGTASGGQREMVPCLMRAAAA
VGIDGLFLEVHPDPEKALCDGPNSLYLDALPELLSTVKSIDRLVKNRADGIF

Sequences:

>Translated_292_residues
MCGGPLYVFKRKDVMKPVHVGGLVVGGGSPLVLIAGPCVIEDEERTRDIALYLKKLTDEMDIPFIFKASYDKANRTSGKA
YRGPGLERGIEILKAIKGDLGIPILSDVHSREEIEKAAEILDVVQIPAFLCRQTDLVREVARLARAVNIKKGQFLAPWDV
RNIIEKVLSEGNERILVTERGTSFGYNNLVVDFRSLPLLRREGYPVIFDATHSVQLPGGQGTASGGQREMVPCLMRAAAA
VGIDGLFLEVHPDPEKALCDGPNSLYLDALPELLSTVKSIDRLVKNRADGIF
>Mature_292_residues
MCGGPLYVFKRKDVMKPVHVGGLVVGGGSPLVLIAGPCVIEDEERTRDIALYLKKLTDEMDIPFIFKASYDKANRTSGKA
YRGPGLERGIEILKAIKGDLGIPILSDVHSREEIEKAAEILDVVQIPAFLCRQTDLVREVARLARAVNIKKGQFLAPWDV
RNIIEKVLSEGNERILVTERGTSFGYNNLVVDFRSLPLLRREGYPVIFDATHSVQLPGGQGTASGGQREMVPCLMRAAAA
VGIDGLFLEVHPDPEKALCDGPNSLYLDALPELLSTVKSIDRLVKNRADGIF

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=272, Percent_Identity=44.4852941176471, Blast_Score=245, Evalue=2e-66,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 31991; Mature: 31991

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGGPLYVFKRKDVMKPVHVGGLVVGGGSPLVLIAGPCVIEDEERTRDIALYLKKLTDEM
CCCCCEEEEECCCCCCCEEECEEEEECCCCEEEEECCEEECCCHHHHHHHHHHHHHHHCC
DIPFIFKASYDKANRTSGKAYRGPGLERGIEILKAIKGDLGIPILSDVHSREEIEKAAEI
CCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LDVVQIPAFLCRQTDLVREVARLARAVNIKKGQFLAPWDVRNIIEKVLSEGNERILVTER
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHCCCCEEEEEEC
GTSFGYNNLVVDFRSLPLLRREGYPVIFDATHSVQLPGGQGTASGGQREMVPCLMRAAAA
CCCCCCCCEEEEHHHCCHHHHCCCCEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHH
VGIDGLFLEVHPDPEKALCDGPNSLYLDALPELLSTVKSIDRLVKNRADGIF
HCCCEEEEEECCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MCGGPLYVFKRKDVMKPVHVGGLVVGGGSPLVLIAGPCVIEDEERTRDIALYLKKLTDEM
CCCCCEEEEECCCCCCCEEECEEEEECCCCEEEEECCEEECCCHHHHHHHHHHHHHHHCC
DIPFIFKASYDKANRTSGKAYRGPGLERGIEILKAIKGDLGIPILSDVHSREEIEKAAEI
CCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
LDVVQIPAFLCRQTDLVREVARLARAVNIKKGQFLAPWDVRNIIEKVLSEGNERILVTER
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHCCCCEEEEEEC
GTSFGYNNLVVDFRSLPLLRREGYPVIFDATHSVQLPGGQGTASGGQREMVPCLMRAAAA
CCCCCCCCEEEEHHHCCHHHHCCCCEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHH
VGIDGLFLEVHPDPEKALCDGPNSLYLDALPELLSTVKSIDRLVKNRADGIF
HCCCEEEEEECCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA