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The map label for this gene is ygcA [C]

Identifier: 85858975

GI number: 85858975

Start: 1156677

End: 1157966

Strand: Direct

Name: ygcA [C]

Synonym: SYN_01023

Alternate gene names: 85858975

Gene position: 1156677-1157966 (Clockwise)

Preceding gene: 85858973

Following gene: 85858976

Centisome position: 36.38

GC content: 54.34

Gene sequence:

>1290_bases
TTGCCATCCCGGATGACTGTCGATAGTAACGGAGAAAAGATGAACAAAAAGAATGCATGGAAGTTGCCGCGAATTGGTCA
AAAAGTTGAAATAACAATAGAAAGTGTGGCATTCGGCGGTTCAGGGATCGGCCGTTTTGCCGGATTGGTGATCTTCGTTC
CTTTCACGGTTGATGGGGATAGAGTTGAGATTGAAATTACCGAGGTGCGACAGTCCTATGCCAAGGGACGGATGTGCCGG
ATATTAAAGCCTTCGCCGTTCCGGACCGTGCCGGAATGTTCCCTGTACGAACGCTGCGGCGGGTGCCAGTATCAGCATAT
CGCGTACACCCACCAGCTGGAGATCAAAAAAAATCAGGTTATTGATGCCTTTGAACGGATCGGAAAGCATCCTGCACCTC
CTGTCAGGGATGTCATCGCCTCCCCGATGCCTTATGCCTATCGGGGGAAAGCGGAATTCCACATCAGTTTTAAATCGGGG
CGGCTCCCTGTAATCGGTTACAAGGAGGCTGCCGACAGCCGGATCGTTCCGGTGTCGCGATGTGCAATAGTGGACGAGTC
CGTCAACCGGTCCCTGACGGCTCTCCGGGGGAAGCTGAACGCCATTTCTGCCGCGGGTCGAAGAGGCGGAAAAAAGGAGG
AACGGGTTATCCTCTGGTCCGATACCGGGAAAGCCGCTGTTGACCCCGGCGTTTCCGGGGGCCGGGGCGGGCTTGTGATG
CGTCCGGTAAAGGAAAAAATGCTGCGCGCTCCTTTTCAGGGGTTTTTCCAGGCCAACAGTGCTCTCGTCGGTTCCATGGT
CGATTCGGTGATCCGGGCCTGCGCGCTTACCGGGAAAGAAACCGTTCTGGATGCATACTGCGGTTCCGGTCTTTTTTCCC
TCTTTCTGGCTTCTTCTGCACGGCAGCTGTTTGGGGTGGATGCGGACGGGGAGGCTGTCCACTGTGCTGCTGAGAATCTT
TCGAAGGAGGGGATATCGAACGCGGAATTTTTTGCCGGTGATGTAGGTGAAATTTTACGGCACACTTTTCTGAAAACGCA
GCAGTCCGTGGATATCGTGGTTCTGGATCCCCCGAGGATCGGTTGCAGTTCCGACGTACTGGAGGCTCTCAAGAGCCTTG
GCCCTGCCCGGATCATTTATATTTCCTGCAATCCGGCCACCCAGGCCCGGGATGTCCGCCGTTTGCGGGATAGCGGATAT
ATTTTGAGAGATCTGCAGCCCATCGATATGTTTCCCCAGACGAAGCACATCGAAATCGTCGGTCTGCTGGAAAGGGAAAA
CAGGATATAA

Upstream 100 bases:

>100_bases
AAAGGGGAAAATATGGGAGGGCTTTCAAATTACCGGCGGATCTGCCTCCTCAACTATTTTGAGGTAATCATATTTGTTCG
CTGTGAGGATTTCGGGTTGA

Downstream 100 bases:

>100_bases
GACCAGTCTCATATCAAAGCGCGCCATGCGTCGGTTTCGTTATCGGCTTCCCGACGGCGCCGGTCTGCGCCTGGATGACA
GCAGTACCGCCGCAGGCCCG

Product: SAM-dependent methyltransferase related to tRNA (uracil-5-)-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MPSRMTVDSNGEKMNKKNAWKLPRIGQKVEITIESVAFGGSGIGRFAGLVIFVPFTVDGDRVEIEITEVRQSYAKGRMCR
ILKPSPFRTVPECSLYERCGGCQYQHIAYTHQLEIKKNQVIDAFERIGKHPAPPVRDVIASPMPYAYRGKAEFHISFKSG
RLPVIGYKEAADSRIVPVSRCAIVDESVNRSLTALRGKLNAISAAGRRGGKKEERVILWSDTGKAAVDPGVSGGRGGLVM
RPVKEKMLRAPFQGFFQANSALVGSMVDSVIRACALTGKETVLDAYCGSGLFSLFLASSARQLFGVDADGEAVHCAAENL
SKEGISNAEFFAGDVGEILRHTFLKTQQSVDIVVLDPPRIGCSSDVLEALKSLGPARIIYISCNPATQARDVRRLRDSGY
ILRDLQPIDMFPQTKHIEIVGLLERENRI

Sequences:

>Translated_429_residues
MPSRMTVDSNGEKMNKKNAWKLPRIGQKVEITIESVAFGGSGIGRFAGLVIFVPFTVDGDRVEIEITEVRQSYAKGRMCR
ILKPSPFRTVPECSLYERCGGCQYQHIAYTHQLEIKKNQVIDAFERIGKHPAPPVRDVIASPMPYAYRGKAEFHISFKSG
RLPVIGYKEAADSRIVPVSRCAIVDESVNRSLTALRGKLNAISAAGRRGGKKEERVILWSDTGKAAVDPGVSGGRGGLVM
RPVKEKMLRAPFQGFFQANSALVGSMVDSVIRACALTGKETVLDAYCGSGLFSLFLASSARQLFGVDADGEAVHCAAENL
SKEGISNAEFFAGDVGEILRHTFLKTQQSVDIVVLDPPRIGCSSDVLEALKSLGPARIIYISCNPATQARDVRRLRDSGY
ILRDLQPIDMFPQTKHIEIVGLLERENRI
>Mature_428_residues
PSRMTVDSNGEKMNKKNAWKLPRIGQKVEITIESVAFGGSGIGRFAGLVIFVPFTVDGDRVEIEITEVRQSYAKGRMCRI
LKPSPFRTVPECSLYERCGGCQYQHIAYTHQLEIKKNQVIDAFERIGKHPAPPVRDVIASPMPYAYRGKAEFHISFKSGR
LPVIGYKEAADSRIVPVSRCAIVDESVNRSLTALRGKLNAISAAGRRGGKKEERVILWSDTGKAAVDPGVSGGRGGLVMR
PVKEKMLRAPFQGFFQANSALVGSMVDSVIRACALTGKETVLDAYCGSGLFSLFLASSARQLFGVDADGEAVHCAAENLS
KEGISNAEFFAGDVGEILRHTFLKTQQSVDIVVLDPPRIGCSSDVLEALKSLGPARIIYISCNPATQARDVRRLRDSGYI
LRDLQPIDMFPQTKHIEIVGLLERENRI

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=198, Percent_Identity=29.7979797979798, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI51173878, Length=198, Percent_Identity=29.7979797979798, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI269784678, Length=185, Percent_Identity=27.027027027027, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI269784680, Length=185, Percent_Identity=27.027027027027, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI269784676, Length=185, Percent_Identity=27.027027027027, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI20149688, Length=185, Percent_Identity=27.027027027027, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1789148, Length=433, Percent_Identity=28.8683602771363, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1787083, Length=175, Percent_Identity=32, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790403, Length=338, Percent_Identity=26.9230769230769, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24666579, Length=189, Percent_Identity=30.1587301587302, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 47002; Mature: 46871

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS50926 TRAM ; PS01230 TRMA_1 ; PS01231 TRMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSRMTVDSNGEKMNKKNAWKLPRIGQKVEITIESVAFGGSGIGRFAGLVIFVPFTVDGD
CCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCHHHHCCEEEEEEEEECCC
RVEIEITEVRQSYAKGRMCRILKPSPFRTVPECSLYERCGGCQYQHIAYTHQLEIKKNQV
EEEEEHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHCCCCEEEEEEEEEEEECHHHH
IDAFERIGKHPAPPVRDVIASPMPYAYRGKAEFHISFKSGRLPVIGYKEAADSRIVPVSR
HHHHHHHCCCCCCCHHHHHCCCCCCEECCCEEEEEEECCCCEEEEEEHHCCCCCCCCHHH
CAIVDESVNRSLTALRGKLNAISAAGRRGGKKEERVILWSDTGKAAVDPGVSGGRGGLVM
HEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEECCCCCCCCCCEEE
RPVKEKMLRAPFQGFFQANSALVGSMVDSVIRACALTGKETVLDAYCGSGLFSLFLASSA
CHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHH
RQLFGVDADGEAVHCAAENLSKEGISNAEFFAGDVGEILRHTFLKTQQSVDIVVLDPPRI
HHHCCCCCCCCEEEEEHHHHHHCCCCCCHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCC
GCSSDVLEALKSLGPARIIYISCNPATQARDVRRLRDSGYILRDLQPIDMFPQTKHIEIV
CCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCEEEE
GLLERENRI
EEECCCCCC
>Mature Secondary Structure 
PSRMTVDSNGEKMNKKNAWKLPRIGQKVEITIESVAFGGSGIGRFAGLVIFVPFTVDGD
CCCEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCHHHHCCEEEEEEEEECCC
RVEIEITEVRQSYAKGRMCRILKPSPFRTVPECSLYERCGGCQYQHIAYTHQLEIKKNQV
EEEEEHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHCCCCEEEEEEEEEEEECHHHH
IDAFERIGKHPAPPVRDVIASPMPYAYRGKAEFHISFKSGRLPVIGYKEAADSRIVPVSR
HHHHHHHCCCCCCCHHHHHCCCCCCEECCCEEEEEEECCCCEEEEEEHHCCCCCCCCHHH
CAIVDESVNRSLTALRGKLNAISAAGRRGGKKEERVILWSDTGKAAVDPGVSGGRGGLVM
HEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEECCCCCCCCCCEEE
RPVKEKMLRAPFQGFFQANSALVGSMVDSVIRACALTGKETVLDAYCGSGLFSLFLASSA
CHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHH
RQLFGVDADGEAVHCAAENLSKEGISNAEFFAGDVGEILRHTFLKTQQSVDIVVLDPPRI
HHHCCCCCCCCEEEEEHHHHHHCCCCCCHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCC
GCSSDVLEALKSLGPARIIYISCNPATQARDVRRLRDSGYILRDLQPIDMFPQTKHIEIV
CCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCEEEE
GLLERENRI
EEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292 [H]