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The map label for this gene is cyaB [H]

Identifier: 85858947

GI number: 85858947

Start: 1130054

End: 1131058

Strand: Direct

Name: cyaB [H]

Synonym: SYN_01363

Alternate gene names: 85858947

Gene position: 1130054-1131058 (Clockwise)

Preceding gene: 85858946

Following gene: 85858948

Centisome position: 35.54

GC content: 46.17

Gene sequence:

>1005_bases
GTGAAAATGAACTATCTGATGGTTGTGGATGATGAGGAGGGTGTCAGGCGATCTCTGCGCAAGGTGCTTGCAAAGGATGG
TTATGAGGTGATCACGGCAGAAACCGGAGAAGAGGCCCTGAAAATCGTGGCAGACAGGAAGCATGATCTTGAAACGGTCA
TTTCTGATTTCAAGATGCCGGGCATGGACGGATTGCAGACCCTTGTCGAAATCGGCAGGATGAATTCGGAAATTACCCGG
ATTATGCTGACCGGTTACGCGACCATGGAAAGTGCCATTGCTGCCGTCAATGCAGGGATCGACGGTTTTTTGACAAAGCC
TTTTGAGAATATTGAAATCCGGGCCAAGGTTCGTGAATACAACATAAAGAAACGGTTGAAATCCTTTGTTTCTGTGCAGA
TATTGAATGAACTTCAGAAGGGAAATCGTACGATCGCGCCACGAAGACAGAAGGTCAGCGTCCTCTTCAGTGATATTCGA
GGGTTTTCTGAAATTGCGGAGAAAATGTCAGCGCAGGAACTTGCAGACATGATGAACGACAATTATTTCGAACCCTTGGA
CAACATCGTTTATGAATGCGACGGGACTCTGGATAAGCATATCGGCGACAGCATCATGGGGGTTTTTGGATCGCCGCTTT
CCCATGATGATGATTCGTACCGTGCGGTGTCATGCGCTATCCGCATGAAAGAGACCATGAAAGCCGTGAATGAAAATCTG
CCTGGAAATCGATATTTCAACATCGGCATCGGGATCAGCACCGGCGAGGCCATGGCGGGCATCTTCGGTTCTTCTCACAA
AAAGGAATACACGGTTTTCGGTCCGACTGTCAACCTGGCTTCAAGGTTGGAGAAATTGGCTCAAGAGAATCAGATTTTGA
TCTGTGAAGAAACCTATCAGCAGGTGCGAGATCTCGTTTCTGCTGAACCTGTTTATTCATCAACTGAAATCAAAGGGATA
GAACGAAAAATAAATATATACAGTGTCATTGATCATATAAAATAG

Upstream 100 bases:

>100_bases
TTTCTCATGAAATCATCAAAAAACACGAGGGCTCCATTCGGGTCGAGAGCGAGAAAGGGAAGGGGACCATATTTAATATC
GAAATACCGCGAAACAGGGA

Downstream 100 bases:

>100_bases
AAATTTGTCTTGACAGCCGACAGGTTTCTGAGCTAAGTAGACCCTTCAATTTCATTTAATGCTGACGCGGGGTGGAGCAG
TCCGGTAGCTCGTTGGGCTC

Product: adenylate and guanylate cyclase catalytic domain-containing protein

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 2; Adenylyl cyclase 2; AC2 [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MKMNYLMVVDDEEGVRRSLRKVLAKDGYEVITAETGEEALKIVADRKHDLETVISDFKMPGMDGLQTLVEIGRMNSEITR
IMLTGYATMESAIAAVNAGIDGFLTKPFENIEIRAKVREYNIKKRLKSFVSVQILNELQKGNRTIAPRRQKVSVLFSDIR
GFSEIAEKMSAQELADMMNDNYFEPLDNIVYECDGTLDKHIGDSIMGVFGSPLSHDDDSYRAVSCAIRMKETMKAVNENL
PGNRYFNIGIGISTGEAMAGIFGSSHKKEYTVFGPTVNLASRLEKLAQENQILICEETYQQVRDLVSAEPVYSSTEIKGI
ERKINIYSVIDHIK

Sequences:

>Translated_334_residues
MKMNYLMVVDDEEGVRRSLRKVLAKDGYEVITAETGEEALKIVADRKHDLETVISDFKMPGMDGLQTLVEIGRMNSEITR
IMLTGYATMESAIAAVNAGIDGFLTKPFENIEIRAKVREYNIKKRLKSFVSVQILNELQKGNRTIAPRRQKVSVLFSDIR
GFSEIAEKMSAQELADMMNDNYFEPLDNIVYECDGTLDKHIGDSIMGVFGSPLSHDDDSYRAVSCAIRMKETMKAVNENL
PGNRYFNIGIGISTGEAMAGIFGSSHKKEYTVFGPTVNLASRLEKLAQENQILICEETYQQVRDLVSAEPVYSSTEIKGI
ERKINIYSVIDHIK
>Mature_334_residues
MKMNYLMVVDDEEGVRRSLRKVLAKDGYEVITAETGEEALKIVADRKHDLETVISDFKMPGMDGLQTLVEIGRMNSEITR
IMLTGYATMESAIAAVNAGIDGFLTKPFENIEIRAKVREYNIKKRLKSFVSVQILNELQKGNRTIAPRRQKVSVLFSDIR
GFSEIAEKMSAQELADMMNDNYFEPLDNIVYECDGTLDKHIGDSIMGVFGSPLSHDDDSYRAVSCAIRMKETMKAVNENL
PGNRYFNIGIGISTGEAMAGIFGSSHKKEYTVFGPTVNLASRLEKLAQENQILICEETYQQVRDLVSAEPVYSSTEIKGI
ERKINIYSVIDHIK

Specific function: Member Of The Two-Component Regulatory System Atos/Atoc Involved In The Transcriptional Regulation Of The Ato Genes For Acetoacetate Metabolism. Also An Inhibitor Of Polyamine Biosynthesis. [C]

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Homo sapiens, GI4557257, Length=182, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4504215, Length=198, Percent_Identity=28.7878787878788, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI4557255, Length=246, Percent_Identity=27.6422764227642, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI10947061, Length=163, Percent_Identity=29.4478527607362, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI10181096, Length=163, Percent_Identity=29.4478527607362, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI148536830, Length=193, Percent_Identity=24.8704663212435, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1788550, Length=131, Percent_Identity=32.0610687022901, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788905, Length=108, Percent_Identity=39.8148148148148, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790299, Length=109, Percent_Identity=33.9449541284404, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786911, Length=116, Percent_Identity=37.0689655172414, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790437, Length=109, Percent_Identity=35.7798165137615, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790863, Length=118, Percent_Identity=29.6610169491525, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI212659371, Length=205, Percent_Identity=28.780487804878, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI193206632, Length=192, Percent_Identity=28.6458333333333, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17534657, Length=202, Percent_Identity=27.7227722772277, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17561802, Length=170, Percent_Identity=28.2352941176471, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71995895, Length=204, Percent_Identity=26.9607843137255, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71983004, Length=197, Percent_Identity=26.3959390862944, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17561804, Length=202, Percent_Identity=24.2574257425743, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17534655, Length=218, Percent_Identity=26.1467889908257, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71995899, Length=203, Percent_Identity=28.0788177339901, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71995893, Length=204, Percent_Identity=26.9607843137255, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71989805, Length=192, Percent_Identity=25.5208333333333, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17551720, Length=178, Percent_Identity=28.0898876404494, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71989822, Length=192, Percent_Identity=25.5208333333333, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193207841, Length=224, Percent_Identity=24.1071428571429, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17561800, Length=170, Percent_Identity=27.6470588235294, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17534659, Length=197, Percent_Identity=30.4568527918782, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI28574512, Length=164, Percent_Identity=32.3170731707317, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI161076872, Length=164, Percent_Identity=32.3170731707317, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24663843, Length=155, Percent_Identity=33.5483870967742, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24663839, Length=155, Percent_Identity=33.5483870967742, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI62484477, Length=179, Percent_Identity=30.7262569832402, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI62484298, Length=179, Percent_Identity=30.7262569832402, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI116008008, Length=179, Percent_Identity=30.7262569832402, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI161078020, Length=222, Percent_Identity=29.2792792792793, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24585694, Length=151, Percent_Identity=28.476821192053, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI85725044, Length=201, Percent_Identity=28.3582089552239, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI221330470, Length=192, Percent_Identity=27.6041666666667, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI221330468, Length=192, Percent_Identity=27.6041666666667, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI281366320, Length=151, Percent_Identity=29.8013245033113, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161084260, Length=153, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24651577, Length=182, Percent_Identity=30.2197802197802, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281366555, Length=198, Percent_Identity=29.7979797979798, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00072 Response_reg [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 37506; Mature: 37506

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMNYLMVVDDEEGVRRSLRKVLAKDGYEVITAETGEEALKIVADRKHDLETVISDFKMP
CCCEEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHCCCC
GMDGLQTLVEIGRMNSEITRIMLTGYATMESAIAAVNAGIDGFLTKPFENIEIRAKVREY
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHH
NIKKRLKSFVSVQILNELQKGNRTIAPRRQKVSVLFSDIRGFSEIAEKMSAQELADMMND
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
NYFEPLDNIVYECDGTLDKHIGDSIMGVFGSPLSHDDDSYRAVSCAIRMKETMKAVNENL
CCCCHHHHHHHHCCCCHHHHHCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
PGNRYFNIGIGISTGEAMAGIFGSSHKKEYTVFGPTVNLASRLEKLAQENQILICEETYQ
CCCEEEEEEEECCCCHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHCCCEEEEHHHHH
QVRDLVSAEPVYSSTEIKGIERKINIYSVIDHIK
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKMNYLMVVDDEEGVRRSLRKVLAKDGYEVITAETGEEALKIVADRKHDLETVISDFKMP
CCCEEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHCCCC
GMDGLQTLVEIGRMNSEITRIMLTGYATMESAIAAVNAGIDGFLTKPFENIEIRAKVREY
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHH
NIKKRLKSFVSVQILNELQKGNRTIAPRRQKVSVLFSDIRGFSEIAEKMSAQELADMMND
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
NYFEPLDNIVYECDGTLDKHIGDSIMGVFGSPLSHDDDSYRAVSCAIRMKETMKAVNENL
CCCCHHHHHHHHCCCCHHHHHCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
PGNRYFNIGIGISTGEAMAGIFGSSHKKEYTVFGPTVNLASRLEKLAQENQILICEETYQ
CCCEEEEEEEECCCCHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHCCCEEEEHHHHH
QVRDLVSAEPVYSSTEIKGIERKINIYSVIDHIK
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]