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The map label for this gene is atoC [H]

Identifier: 85858813

GI number: 85858813

Start: 1004033

End: 1005454

Strand: Direct

Name: atoC [H]

Synonym: SYN_01466

Alternate gene names: 85858813

Gene position: 1004033-1005454 (Clockwise)

Preceding gene: 85858812

Following gene: 85858814

Centisome position: 31.58

GC content: 47.26

Gene sequence:

>1422_bases
ATGGAAATGAAAGAAGCGCGCATACTGGTCGTGGATGATGACACGTCAATGAGAATGGCACTCTGCGAAACTCTGGAAAG
CTGTGGCTACTGCATTGAAACAGCTTCCAATGGGCTTGAGGCGTTGAAGAAGTTCAGAAAAGGCGCCTTCGAAGCCGTAA
TCACCGATATGCGGATGCCCGGGATGGGTGGTATGGAGGTCTTGAAAACCATCAAAAAGATCTCGCCGGAAAGTCCCGTG
ATTCTGATAACCGCTTATGGAACCGTAAACACTGCTGTCGAAGCCATGAAGGAGGGGGCTTCTGACTTCATCATGAAGCC
CTTTTCCCTGGAAGACATCGAATTCGTCGTCAAAAACGTTATGGCGACATACGAAGAGAAAGAATTCAGGGAAAGCAAAC
CTGTCGAAAAGATGACTTTTACGGATAGAGAGATCATAACGGAAGACGAAAAAATTCTGGGCATTCTCGAATTTCTGAAA
ACGGTGGCACAGAGCAAATCCAGCGTCCTGATTCAGGGCGAAAGTGGAACAGGCAAGGAACTTTTTGCCCGTTATCTCTA
TCTCCACAGCAGCAGGAGGCATATGCCTTTCGTGGCGATCAACTGCGCCGCGATTCCCGACAATCTTCTCGAGAGTGAAA
TGTTCGGGTTTGAAAAAGGGGCTTTTACCGGAGCAATTCAGAGGAAAGTAGGGAAATTCGAACTCGCGAACGGCGGAACG
CTGCTTCTTGATGAAGTGACAGAAATGACTCCACATTTGCAGGCAAAACTTTTACGGGTAATTCAGGAAAAAGAAATCGA
TCGGCTGGGTGGAAAAATGCCATTGCCTGTGGATGTGAGAATTATCGCCACGACAAATGCCGATGTTCGGAAATGTATTG
AAGAGAAGACTTTTCGCGAAGATCTTTATTATCGGCTCAATGTCATTCCCCTTAAAATTCCACCCCTGCGGGAACGAAAA
GGCGATGTTGAGCTTCTGGGTTCTTACTTTTTGAAAAAGTACAGTAATCTTAATGAAAAACCGCTGCCGGTTTTTGCAAA
TGGAACCCTGAAACGGTTGAATGCCTATGACTGGCCCGGCAATGTAAGAGAACTTGAAAACGTGATTGAAAGGGCGGTCC
TTGTCTGCGGCGGGAATGTGGTCTTGCCGGAGCATCTTTATCTGGAAGACCAGGGTTCCGTCAGCCCGGCAGCAGAGGAA
AAAACATCCTGTTCCCTTGAAGAAGTTTCCACAGATATTTCCGGGATTGATCTGTCCCGGGGCATGACGATCTGGGAAAT
GGAAAAGGAACTGATCTTCAGTACTCTGGACAAAGTCAAGGGAAACAAAACCAGAGCATCGGAAATACTGGGGATCAGTG
TCAGAACCATGCGCAACAAACTGCAGGAATATCAGATGAAGGCCTCTCTGACATCGGAATAG

Upstream 100 bases:

>100_bases
GCGGGGTAATCCATGTGGAAAGCGTCGAACAGGAGGGAACTGTTTTTCACGTTCTCCTCCCGTTGATCAGCGAACAAGGC
ACAATGAAGACGAAGGTAGG

Downstream 100 bases:

>100_bases
GTTATCTCCCGATACTGCTTCTTAAGTGGTATGTGCTTTGCTTGAATTCCTTCGGAGGGAGCTGGGATGGACTTTCTGTT
CAGTAAAACAATTGGTATAC

Product: sigma-54 dependent transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MEMKEARILVVDDDTSMRMALCETLESCGYCIETASNGLEALKKFRKGAFEAVITDMRMPGMGGMEVLKTIKKISPESPV
ILITAYGTVNTAVEAMKEGASDFIMKPFSLEDIEFVVKNVMATYEEKEFRESKPVEKMTFTDREIITEDEKILGILEFLK
TVAQSKSSVLIQGESGTGKELFARYLYLHSSRRHMPFVAINCAAIPDNLLESEMFGFEKGAFTGAIQRKVGKFELANGGT
LLLDEVTEMTPHLQAKLLRVIQEKEIDRLGGKMPLPVDVRIIATTNADVRKCIEEKTFREDLYYRLNVIPLKIPPLRERK
GDVELLGSYFLKKYSNLNEKPLPVFANGTLKRLNAYDWPGNVRELENVIERAVLVCGGNVVLPEHLYLEDQGSVSPAAEE
KTSCSLEEVSTDISGIDLSRGMTIWEMEKELIFSTLDKVKGNKTRASEILGISVRTMRNKLQEYQMKASLTSE

Sequences:

>Translated_473_residues
MEMKEARILVVDDDTSMRMALCETLESCGYCIETASNGLEALKKFRKGAFEAVITDMRMPGMGGMEVLKTIKKISPESPV
ILITAYGTVNTAVEAMKEGASDFIMKPFSLEDIEFVVKNVMATYEEKEFRESKPVEKMTFTDREIITEDEKILGILEFLK
TVAQSKSSVLIQGESGTGKELFARYLYLHSSRRHMPFVAINCAAIPDNLLESEMFGFEKGAFTGAIQRKVGKFELANGGT
LLLDEVTEMTPHLQAKLLRVIQEKEIDRLGGKMPLPVDVRIIATTNADVRKCIEEKTFREDLYYRLNVIPLKIPPLRERK
GDVELLGSYFLKKYSNLNEKPLPVFANGTLKRLNAYDWPGNVRELENVIERAVLVCGGNVVLPEHLYLEDQGSVSPAAEE
KTSCSLEEVSTDISGIDLSRGMTIWEMEKELIFSTLDKVKGNKTRASEILGISVRTMRNKLQEYQMKASLTSE
>Mature_473_residues
MEMKEARILVVDDDTSMRMALCETLESCGYCIETASNGLEALKKFRKGAFEAVITDMRMPGMGGMEVLKTIKKISPESPV
ILITAYGTVNTAVEAMKEGASDFIMKPFSLEDIEFVVKNVMATYEEKEFRESKPVEKMTFTDREIITEDEKILGILEFLK
TVAQSKSSVLIQGESGTGKELFARYLYLHSSRRHMPFVAINCAAIPDNLLESEMFGFEKGAFTGAIQRKVGKFELANGGT
LLLDEVTEMTPHLQAKLLRVIQEKEIDRLGGKMPLPVDVRIIATTNADVRKCIEEKTFREDLYYRLNVIPLKIPPLRERK
GDVELLGSYFLKKYSNLNEKPLPVFANGTLKRLNAYDWPGNVRELENVIERAVLVCGGNVVLPEHLYLEDQGSVSPAAEE
KTSCSLEEVSTDISGIDLSRGMTIWEMEKELIFSTLDKVKGNKTRASEILGISVRTMRNKLQEYQMKASLTSE

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=461, Percent_Identity=43.3839479392625, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI1790437, Length=454, Percent_Identity=40.7488986784141, Blast_Score=345, Evalue=5e-96,
Organism=Escherichia coli, GI1790299, Length=478, Percent_Identity=37.0292887029289, Blast_Score=308, Evalue=5e-85,
Organism=Escherichia coli, GI1788905, Length=381, Percent_Identity=41.7322834645669, Blast_Score=301, Evalue=7e-83,
Organism=Escherichia coli, GI87082117, Length=275, Percent_Identity=48, Blast_Score=265, Evalue=7e-72,
Organism=Escherichia coli, GI1789087, Length=291, Percent_Identity=46.0481099656357, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1789233, Length=315, Percent_Identity=44.1269841269841, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI87081872, Length=325, Percent_Identity=40, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI1786524, Length=313, Percent_Identity=39.6166134185303, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI87082152, Length=218, Percent_Identity=49.5412844036697, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1787583, Length=322, Percent_Identity=34.472049689441, Blast_Score=193, Evalue=3e-50,
Organism=Escherichia coli, GI87081858, Length=386, Percent_Identity=29.5336787564767, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1789828, Length=282, Percent_Identity=31.5602836879433, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1788191, Length=117, Percent_Identity=37.6068376068376, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87082012, Length=107, Percent_Identity=30.8411214953271, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786784, Length=115, Percent_Identity=25.2173913043478, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789402, Length=115, Percent_Identity=26.9565217391304, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI145693157, Length=120, Percent_Identity=31.6666666666667, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790552, Length=121, Percent_Identity=24.7933884297521, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786599, Length=117, Percent_Identity=30.7692307692308, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789809, Length=115, Percent_Identity=26.9565217391304, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790860, Length=136, Percent_Identity=25.7352941176471, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 53137; Mature: 53137

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMKEARILVVDDDTSMRMALCETLESCGYCIETASNGLEALKKFRKGAFEAVITDMRMP
CCCCCCEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GMGGMEVLKTIKKISPESPVILITAYGTVNTAVEAMKEGASDFIMKPFSLEDIEFVVKNV
CCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHH
MATYEEKEFRESKPVEKMTFTDREIITEDEKILGILEFLKTVAQSKSSVLIQGESGTGKE
HHHHHHHHHHHCCCCHHHCCCCHHHHCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHH
LFARYLYLHSSRRHMPFVAINCAAIPDNLLESEMFGFEKGAFTGAIQRKVGKFELANGGT
HHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHCCCEEECCCCE
LLLDEVTEMTPHLQAKLLRVIQEKEIDRLGGKMPLPVDVRIIATTNADVRKCIEEKTFRE
EEEHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHH
DLYYRLNVIPLKIPPLRERKGDVELLGSYFLKKYSNLNEKPLPVFANGTLKRLNAYDWPG
HHHEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCHHCCCCCCCCC
NVRELENVIERAVLVCGGNVVLPEHLYLEDQGSVSPAAEEKTSCSLEEVSTDISGIDLSR
CHHHHHHHHHHHHHHCCCCEEECCEEEECCCCCCCCCCHHHHCCCHHHHHCCCCCCCHHC
GMTIWEMEKELIFSTLDKVKGNKTRASEILGISVRTMRNKLQEYQMKASLTSE
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEMKEARILVVDDDTSMRMALCETLESCGYCIETASNGLEALKKFRKGAFEAVITDMRMP
CCCCCCEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GMGGMEVLKTIKKISPESPVILITAYGTVNTAVEAMKEGASDFIMKPFSLEDIEFVVKNV
CCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHH
MATYEEKEFRESKPVEKMTFTDREIITEDEKILGILEFLKTVAQSKSSVLIQGESGTGKE
HHHHHHHHHHHCCCCHHHCCCCHHHHCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHH
LFARYLYLHSSRRHMPFVAINCAAIPDNLLESEMFGFEKGAFTGAIQRKVGKFELANGGT
HHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHCCCEEECCCCE
LLLDEVTEMTPHLQAKLLRVIQEKEIDRLGGKMPLPVDVRIIATTNADVRKCIEEKTFRE
EEEHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHH
DLYYRLNVIPLKIPPLRERKGDVELLGSYFLKKYSNLNEKPLPVFANGTLKRLNAYDWPG
HHHEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCHHCCCCCCCCC
NVRELENVIERAVLVCGGNVVLPEHLYLEDQGSVSPAAEEKTSCSLEEVSTDISGIDLSR
CHHHHHHHHHHHHHHCCCCEEECCEEEECCCCCCCCCCHHHHCCCHHHHHCCCCCCCHHC
GMTIWEMEKELIFSTLDKVKGNKTRASEILGISVRTMRNKLQEYQMKASLTSE
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]