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The map label for this gene is hpt [H]

Identifier: 85858559

GI number: 85858559

Start: 718465

End: 718986

Strand: Direct

Name: hpt [H]

Synonym: SYN_02450

Alternate gene names: 85858559

Gene position: 718465-718986 (Clockwise)

Preceding gene: 85858558

Following gene: 85858560

Centisome position: 22.6

GC content: 49.23

Gene sequence:

>522_bases
ATGGAAAGCATGAACAAAAGTATCTTCATTCCCAGGGAGACTATTGAGAAACGGGTCAAAGAACTGGGAGAGCAGATATC
CCGGGATTATGCCGAAAGCGAACTCATCATTGTCGGGGTTCTCAAAGGGGCTTTTATTTTCATGGCCGATCTGATTCGGG
CTCTGAGCATTCCCTGTCGCGTCGATTTTGCCAGGCTCGCCAGCTATGGCTCCGGAGCGGCGAGTTCCGGAAAGGTGATC
ATGACGAAGGATATTGAAACCTCCATCAGGGGAAGGGATATCCTCATCGTCGAGGATATCGTGGATACGGGACTGACCCT
GAAATTTCTGGTGGACTGGTTTCGGGAGCGTAATCCTCGTTCACTGAAGGTCTGTGCGTTCCTCGATAAGCAGGGACGAA
GAAAGGTTCCGTTTGAAGCCGACTACGTCGGATTCAGTGTGGATGATGCCTTCGTGATCGGCTATGGTCTTGATTTTGAT
GAAAAAGGCCGTTTTCTTCCCGATGTATATATTGTTGAATGA

Upstream 100 bases:

>100_bases
TGTTCCTGAGATTAATCTCGTCATGGCTGACTGGGGATCCTGCTGGAAGGGATTACTTCTCTGGTTTACAGATCCGATTC
TTTGAGGGTTTTAAAACGTT

Downstream 100 bases:

>100_bases
CTTCCTCGGACTGGTTCGTGATTCCCTGTTGGAGAAACTATGATTATTTCGTGCATTAAGTGTTTTACAAAGTACCGGTT
TGATGATTCCCTGATGGAGG

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MESMNKSIFIPRETIEKRVKELGEQISRDYAESELIIVGVLKGAFIFMADLIRALSIPCRVDFARLASYGSGAASSGKVI
MTKDIETSIRGRDILIVEDIVDTGLTLKFLVDWFRERNPRSLKVCAFLDKQGRRKVPFEADYVGFSVDDAFVIGYGLDFD
EKGRFLPDVYIVE

Sequences:

>Translated_173_residues
MESMNKSIFIPRETIEKRVKELGEQISRDYAESELIIVGVLKGAFIFMADLIRALSIPCRVDFARLASYGSGAASSGKVI
MTKDIETSIRGRDILIVEDIVDTGLTLKFLVDWFRERNPRSLKVCAFLDKQGRRKVPFEADYVGFSVDDAFVIGYGLDFD
EKGRFLPDVYIVE
>Mature_173_residues
MESMNKSIFIPRETIEKRVKELGEQISRDYAESELIIVGVLKGAFIFMADLIRALSIPCRVDFARLASYGSGAASSGKVI
MTKDIETSIRGRDILIVEDIVDTGLTLKFLVDWFRERNPRSLKVCAFLDKQGRRKVPFEADYVGFSVDDAFVIGYGLDFD
EKGRFLPDVYIVE

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=175, Percent_Identity=36.5714285714286, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI9910262, Length=175, Percent_Identity=33.1428571428571, Blast_Score=104, Evalue=4e-23,
Organism=Escherichia coli, GI87081689, Length=162, Percent_Identity=43.8271604938272, Blast_Score=152, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17510817, Length=172, Percent_Identity=29.6511627906977, Blast_Score=86, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19558; Mature: 19558

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESMNKSIFIPRETIEKRVKELGEQISRDYAESELIIVGVLKGAFIFMADLIRALSIPCR
CCCCCCCEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHCCCCC
VDFARLASYGSGAASSGKVIMTKDIETSIRGRDILIVEDIVDTGLTLKFLVDWFRERNPR
CCHHHHHCCCCCCCCCCCEEEEECCCCCCCCCEEEEEHHHHCCCCHHHHHHHHHHCCCCC
SLKVCAFLDKQGRRKVPFEADYVGFSVDDAFVIGYGLDFDEKGRFLPDVYIVE
EEEEEEEECCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MESMNKSIFIPRETIEKRVKELGEQISRDYAESELIIVGVLKGAFIFMADLIRALSIPCR
CCCCCCCEECCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHCCCCC
VDFARLASYGSGAASSGKVIMTKDIETSIRGRDILIVEDIVDTGLTLKFLVDWFRERNPR
CCHHHHHCCCCCCCCCCCEEEEECCCCCCCCCEEEEEHHHHCCCCHHHHHHHHHHCCCCC
SLKVCAFLDKQGRRKVPFEADYVGFSVDDAFVIGYGLDFDEKGRFLPDVYIVE
EEEEEEEECCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]