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The map label for this gene is uvrC

Identifier: 85858550

GI number: 85858550

Start: 708313

End: 710169

Strand: Direct

Name: uvrC

Synonym: SYN_01348

Alternate gene names: 85858550

Gene position: 708313-710169 (Clockwise)

Preceding gene: 85858549

Following gene: 85858551

Centisome position: 22.28

GC content: 51.32

Gene sequence:

>1857_bases
ATGAACCGGCAACAACTGGAAGGTCGTATAGACATAGCGCCACGGACGCCCGGTGTTTATCTCATGAAGGATGCCGCCGG
CAAGATCCTCTATGTGGGGAAGGCAAAGAATCTCAAAAGCCGGACTCGCGCTTACTTCAGCGGGACGGATTCCCGCGCCA
TGATCCCCTTTCTTGTTTCCCGAATCCACGATATCGAGTTTATCCTGACGGAGACGGAAAAGGAAGCCCTGATTCTTGAG
AACAATCTGATCAAAGAACACCATCCTCGTTACAATATCTGTTTTCGGGATGACAAGGCCTATTTCAACATCCGTGCGGA
TCTCAACGAACCCTTCCCCAGGTTTCAACTGGTTCGACGCCCCCGCAAAGACGGGGCAAAATACTTCGGACCCTATCCTT
CCAGTGCCTCGGCCCGGGAAACCCTCCAGTTTCTTCAATCCATCTTTCCCCTTCGAACATGCCGCGATGCGGAATTGAAA
TCACGCACGAGGCCCTGTCTTGAATATCAGATCAAGCGGTGTCTTGCTCCCTGTGTTGGTCGAATAAACTCAGAAGACTA
TCTGCAAATGGTCCGGGATGGAGTTTCCTTTCTTGAAGGACGGGGAAATAATCTGCTCCGTGAACTGCGGGAGCGGATGA
AGATGGCGGCTGAACAGATGAATTATGAGGAGGCAGCCTTTTTGAGAGATCGGATCAGGGCGATAGAAGAAACCCTTGAA
AGGCAGCGTATGGTTTCGATGACGTTCAAAGATCAGGATATCTTCGGCTTATACCGGGAAGGACACCTGATTCAGGTCTG
TATTCTTCTGATTCGTCAGGGAAAAATTCTGGGAAGCCGGCTCCTTCCCCTTTTGAAATTTGAAGGCGAGACGGCGGACA
TGCTGTCTTCGCTGCTCATGCAATATTATGATCAATCTGTAGACATTCCTCAGGAAATTCTTATTCCGGCATCGATCGAG
GATCGGCAGGTCATACGGGAATGGCTGGAGGAAAAGCGTGGAAAGGGGCTTTCCATTCTGATTCCCCGAAAAGGGCGAGG
CCTGGAACTTCTCCATATTGCGGAACAGAATGCGGAACATGGCTTCAAAATGGAGCGCAAGTCGCTCGATGATTCTGATG
AGTCCCTGCGGCTGCTCATGGAAAGACTTCATCTCAGACGCTTCCCCAGGAAAATAGAGGCGTTTGACATCTCGAACATC
GGTGGACGGCTGGCTGTCGCCGCCATGGTGACCTTTCAAGATGGCAGACCCTTGAAGTCCGGTTATCGGCGTTTTCGAAT
CCGGACGGTCCATGGAGCAGACGATTATGCCATGATGTATGAGGCTTTGAAGAGGAGGTATCAGGGTAAGGAAAACCTGC
CTGACCTCATTGTCGTGGATGGAGGAAAAGGTCAGCTGGCTGTGGCGTTTTCCCTGTTGAAGGATCTGTCGATTTCGGGA
CAGGATGTGATCGGTCTGGCCAAGGAAAGGGTAAACGGAGTTACCGTGCAGGGGGGAGTCAACAAAAGTGAAGACCGCGT
TTACCTCCCCCATAAAAAGGAAGCCCTGTACCTGAGCCGCTGGCCTGCGGTGCTTTTCCTGCTTCAACGCATTCGGGATG
AGGCGCACCGTTTTGCCGTTTCCTATCATCGAAGTCTGAAGACCCGAAGCGATTTCATGTCTCTTCTGGACGACATACCG
GGTGTGGGAGAAGTTCGTAAAAAGGCCCTTCTCCTGAGTTTCGGAGATCTTGCCCGGATACGAGAGGCAACTGTCGAGGA
GTTGACTCAGGTGGAGGGAATCGGAAAGGATCTGGGAGAAAAAATTCATGCGTTCCTTCACAACGATCAACGATCGGTTG
AACCATCAACAGGATAG

Upstream 100 bases:

>100_bases
GTAAAGATGGACAAAAAGCTGATCCCCTCCTACGGCAGCATGTGGATGTTTGCATCCTGCATCAAAACCTGAAACGATCA
GGAACCCCGTCTGAGCTTTT

Downstream 100 bases:

>100_bases
ATGAATAGATGATATTGCAGATATTCCATGAAGAGAACCTTGCTTGAACGTACGAATCTTCTTCTTTGTATACTGACAAA
AAATGTTTGCTTTCCCCCCT

Product: nuclease subunit of the excinuclease complex

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MNRQQLEGRIDIAPRTPGVYLMKDAAGKILYVGKAKNLKSRTRAYFSGTDSRAMIPFLVSRIHDIEFILTETEKEALILE
NNLIKEHHPRYNICFRDDKAYFNIRADLNEPFPRFQLVRRPRKDGAKYFGPYPSSASARETLQFLQSIFPLRTCRDAELK
SRTRPCLEYQIKRCLAPCVGRINSEDYLQMVRDGVSFLEGRGNNLLRELRERMKMAAEQMNYEEAAFLRDRIRAIEETLE
RQRMVSMTFKDQDIFGLYREGHLIQVCILLIRQGKILGSRLLPLLKFEGETADMLSSLLMQYYDQSVDIPQEILIPASIE
DRQVIREWLEEKRGKGLSILIPRKGRGLELLHIAEQNAEHGFKMERKSLDDSDESLRLLMERLHLRRFPRKIEAFDISNI
GGRLAVAAMVTFQDGRPLKSGYRRFRIRTVHGADDYAMMYEALKRRYQGKENLPDLIVVDGGKGQLAVAFSLLKDLSISG
QDVIGLAKERVNGVTVQGGVNKSEDRVYLPHKKEALYLSRWPAVLFLLQRIRDEAHRFAVSYHRSLKTRSDFMSLLDDIP
GVGEVRKKALLLSFGDLARIREATVEELTQVEGIGKDLGEKIHAFLHNDQRSVEPSTG

Sequences:

>Translated_618_residues
MNRQQLEGRIDIAPRTPGVYLMKDAAGKILYVGKAKNLKSRTRAYFSGTDSRAMIPFLVSRIHDIEFILTETEKEALILE
NNLIKEHHPRYNICFRDDKAYFNIRADLNEPFPRFQLVRRPRKDGAKYFGPYPSSASARETLQFLQSIFPLRTCRDAELK
SRTRPCLEYQIKRCLAPCVGRINSEDYLQMVRDGVSFLEGRGNNLLRELRERMKMAAEQMNYEEAAFLRDRIRAIEETLE
RQRMVSMTFKDQDIFGLYREGHLIQVCILLIRQGKILGSRLLPLLKFEGETADMLSSLLMQYYDQSVDIPQEILIPASIE
DRQVIREWLEEKRGKGLSILIPRKGRGLELLHIAEQNAEHGFKMERKSLDDSDESLRLLMERLHLRRFPRKIEAFDISNI
GGRLAVAAMVTFQDGRPLKSGYRRFRIRTVHGADDYAMMYEALKRRYQGKENLPDLIVVDGGKGQLAVAFSLLKDLSISG
QDVIGLAKERVNGVTVQGGVNKSEDRVYLPHKKEALYLSRWPAVLFLLQRIRDEAHRFAVSYHRSLKTRSDFMSLLDDIP
GVGEVRKKALLLSFGDLARIREATVEELTQVEGIGKDLGEKIHAFLHNDQRSVEPSTG
>Mature_618_residues
MNRQQLEGRIDIAPRTPGVYLMKDAAGKILYVGKAKNLKSRTRAYFSGTDSRAMIPFLVSRIHDIEFILTETEKEALILE
NNLIKEHHPRYNICFRDDKAYFNIRADLNEPFPRFQLVRRPRKDGAKYFGPYPSSASARETLQFLQSIFPLRTCRDAELK
SRTRPCLEYQIKRCLAPCVGRINSEDYLQMVRDGVSFLEGRGNNLLRELRERMKMAAEQMNYEEAAFLRDRIRAIEETLE
RQRMVSMTFKDQDIFGLYREGHLIQVCILLIRQGKILGSRLLPLLKFEGETADMLSSLLMQYYDQSVDIPQEILIPASIE
DRQVIREWLEEKRGKGLSILIPRKGRGLELLHIAEQNAEHGFKMERKSLDDSDESLRLLMERLHLRRFPRKIEAFDISNI
GGRLAVAAMVTFQDGRPLKSGYRRFRIRTVHGADDYAMMYEALKRRYQGKENLPDLIVVDGGKGQLAVAFSLLKDLSISG
QDVIGLAKERVNGVTVQGGVNKSEDRVYLPHKKEALYLSRWPAVLFLLQRIRDEAHRFAVSYHRSLKTRSDFMSLLDDIP
GVGEVRKKALLLSFGDLARIREATVEELTQVEGIGKDLGEKIHAFLHNDQRSVEPSTG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=599, Percent_Identity=36.8948247078464, Blast_Score=368, Evalue=1e-103,
Organism=Escherichia coli, GI1788037, Length=200, Percent_Identity=29.5, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_SYNAS (Q2LR71)

Other databases:

- EMBL:   CP000252
- RefSeq:   YP_460752.1
- ProteinModelPortal:   Q2LR71
- STRING:   Q2LR71
- GeneID:   3884766
- GenomeReviews:   CP000252_GR
- KEGG:   sat:SYN_01348
- NMPDR:   fig|56780.10.peg.698
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q2LR71
- BioCyc:   SACI56780:SYN_01348-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 71120; Mature: 71120

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRQQLEGRIDIAPRTPGVYLMKDAAGKILYVGKAKNLKSRTRAYFSGTDSRAMIPFLVS
CCCHHCCCEEEECCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHH
RIHDIEFILTETEKEALILENNLIKEHHPRYNICFRDDKAYFNIRADLNEPFPRFQLVRR
HHHHHHEEEECCCCCEEEHCCCHHHHCCCCEEEEEECCCEEEEEEECCCCCCHHHHHHHC
PRKDGAKYFGPYPSSASARETLQFLQSIFPLRTCRDAELKSRTRPCLEYQIKRCLAPCVG
CHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHH
RINSEDYLQMVRDGVSFLEGRGNNLLRELRERMKMAAEQMNYEEAAFLRDRIRAIEETLE
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
RQRMVSMTFKDQDIFGLYREGHLIQVCILLIRQGKILGSRLLPLLKFEGETADMLSSLLM
HHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHCCCHHHHHCCHHHHCCCCHHHHHHHHHH
QYYDQSVDIPQEILIPASIEDRQVIREWLEEKRGKGLSILIPRKGRGLELLHIAEQNAEH
HHHCCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCC
GFKMERKSLDDSDESLRLLMERLHLRRFPRKIEAFDISNIGGRLAVAAMVTFQDGRPLKS
CCHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEEEEEEECCCCCHHH
GYRRFRIRTVHGADDYAMMYEALKRRYQGKENLPDLIVVDGGKGQLAVAFSLLKDLSISG
HHHEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCC
QDVIGLAKERVNGVTVQGGVNKSEDRVYLPHKKEALYLSRWPAVLFLLQRIRDEAHRFAV
CHHHHHHHHHCCCEEEECCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SYHRSLKTRSDFMSLLDDIPGVGEVRKKALLLSFGDLARIREATVEELTQVEGIGKDLGE
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIHAFLHNDQRSVEPSTG
HHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNRQQLEGRIDIAPRTPGVYLMKDAAGKILYVGKAKNLKSRTRAYFSGTDSRAMIPFLVS
CCCHHCCCEEEECCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHH
RIHDIEFILTETEKEALILENNLIKEHHPRYNICFRDDKAYFNIRADLNEPFPRFQLVRR
HHHHHHEEEECCCCCEEEHCCCHHHHCCCCEEEEEECCCEEEEEEECCCCCCHHHHHHHC
PRKDGAKYFGPYPSSASARETLQFLQSIFPLRTCRDAELKSRTRPCLEYQIKRCLAPCVG
CHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHH
RINSEDYLQMVRDGVSFLEGRGNNLLRELRERMKMAAEQMNYEEAAFLRDRIRAIEETLE
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
RQRMVSMTFKDQDIFGLYREGHLIQVCILLIRQGKILGSRLLPLLKFEGETADMLSSLLM
HHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHCCCHHHHHCCHHHHCCCCHHHHHHHHHH
QYYDQSVDIPQEILIPASIEDRQVIREWLEEKRGKGLSILIPRKGRGLELLHIAEQNAEH
HHHCCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCC
GFKMERKSLDDSDESLRLLMERLHLRRFPRKIEAFDISNIGGRLAVAAMVTFQDGRPLKS
CCHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEEEEEEEECCCCCHHH
GYRRFRIRTVHGADDYAMMYEALKRRYQGKENLPDLIVVDGGKGQLAVAFSLLKDLSISG
HHHEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCC
QDVIGLAKERVNGVTVQGGVNKSEDRVYLPHKKEALYLSRWPAVLFLLQRIRDEAHRFAV
CHHHHHHHHHCCCEEEECCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SYHRSLKTRSDFMSLLDDIPGVGEVRKKALLLSFGDLARIREATVEELTQVEGIGKDLGE
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIHAFLHNDQRSVEPSTG
HHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA