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The map label for this gene is fabF [H]

Identifier: 85858047

GI number: 85858047

Start: 208407

End: 209645

Strand: Direct

Name: fabF [H]

Synonym: SYN_02566

Alternate gene names: 85858047

Gene position: 208407-209645 (Clockwise)

Preceding gene: 85858046

Following gene: 85858048

Centisome position: 6.56

GC content: 62.07

Gene sequence:

>1239_bases
GTGAAAGGTCTCGCGAATCCGATGTCAACTTTCCGACGGGTCGTCATAACCGCCCTGGGGGTGATTTCCCCGCTGGGAAA
TTCCGCTGAACAGATCATGACCTCTCTGCGCAGCGGCCGGGTGTCCTTTGCCGCATCGGCCTCTGATCCCCAGGTGATTG
TTGCTCCCGTTCGGGATTTTGAACTGGGGGCTTTTACCGGTTCCTTCAAGGAGCGCCGTTATCTCAACCGGGGTGCCCAG
TTCACTGTCGCCGCGGCGATGGCCGCCGTCGGAAACGCCTCCCTCCGCAGGGAACAAATCACTGGGGCGGGTCTCTTTCT
CGGCGCCGGCCCCAATATGGACATGGGGGGCGAAATTCCGGAAATCCGGCAGGGGGAAATCCAGCACGATACCCTGATGG
CCCTCTGGATTCTCCGCTTCCTGCCGAACACGGCCGCCTCGGTCATTTCCATCCTTGCGGGAATCCGGGGAGATAACCTG
ACCGTCACCTCCGCCTGTTCCTCTTCCCTGCAGGCGATCGGCGAGGCCTTCCACAAAATACGGGACGGGTATCTCGATCT
CGCCTTAGCCGGAGGCGGCGATTCCCGCCTGACGCCGGGAGCGATCCTGGCCTACCGCAAAGCGCGGGCCCTGTATGAAG
GCGGCGGAAATCCCGGGGAAGCCAGTCGCCCCTTCGACAACGGAAGACGGGGATTTGTCCCTGGAGAAGGCGGGGCTGTC
CTGCTTCTGGAAGAACTGGAGCACGCCCGGAGCCGGGGTGCGGCGATTATCGGGGAAGTCCGCGGTTTCGGCGCCTCCCT
GGACGGATACAATGTAACGGCGCCGGAGCCGGAGGGCCGGGGCGGTCAAATGGCCCTGGAGAAGGCGCTGGCGGATGCCG
GTCTTGTTCCGGGAGACGTCGATGTCGTTTCCACCCACGGGACGGGGACCCTTCTCAACGACCGCATGGAGGCCGCCCTG
ATCGAACGGGTTTATGCAGATCAATTGCCCCGGATACTGGCCTTCAAGTCCTGGATCGGACACCTGTCGACGGCCTGCGG
GGCGATGGAAACGGCGCTCAGCATCATCTGCATGCAGAATGATTACCTGCCGGAAATCCGCAATCTCCGGGATGCCTGTT
CTCCCGTAATTCCTTTCGTGCGGGAAGGCGGAAAGCGGTCCACATCCACCTGGGTCATCGAAAACTTCGGCTTCGGCGGG
CAGAATGCGGTCCTGATTGTGAAACGTTATGCCCCCTGA

Upstream 100 bases:

>100_bases
TCTCGCCGGTGACGATCAAATGCTTCCTGACGCTGGGGTTTCCCGATGAAACGCCTGCTCCCCGCAAGAAAAAGAGCGTT
TCCGATATCTATCGGGAACT

Downstream 100 bases:

>100_bases
AAGACGAAAACGAATGCTTCTATCCGATGCAGGCCTGTTTCGCTTCCCCTTCGCGGCCTTGAACATGTCCGTGATCTGGA
ATCGGAATAAAATAAAGATG

Product: 3-oxoacyl-[acyl-carrier-protein] synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MKGLANPMSTFRRVVITALGVISPLGNSAEQIMTSLRSGRVSFAASASDPQVIVAPVRDFELGAFTGSFKERRYLNRGAQ
FTVAAAMAAVGNASLRREQITGAGLFLGAGPNMDMGGEIPEIRQGEIQHDTLMALWILRFLPNTAASVISILAGIRGDNL
TVTSACSSSLQAIGEAFHKIRDGYLDLALAGGGDSRLTPGAILAYRKARALYEGGGNPGEASRPFDNGRRGFVPGEGGAV
LLLEELEHARSRGAAIIGEVRGFGASLDGYNVTAPEPEGRGGQMALEKALADAGLVPGDVDVVSTHGTGTLLNDRMEAAL
IERVYADQLPRILAFKSWIGHLSTACGAMETALSIICMQNDYLPEIRNLRDACSPVIPFVREGGKRSTSTWVIENFGFGG
QNAVLIVKRYAP

Sequences:

>Translated_412_residues
MKGLANPMSTFRRVVITALGVISPLGNSAEQIMTSLRSGRVSFAASASDPQVIVAPVRDFELGAFTGSFKERRYLNRGAQ
FTVAAAMAAVGNASLRREQITGAGLFLGAGPNMDMGGEIPEIRQGEIQHDTLMALWILRFLPNTAASVISILAGIRGDNL
TVTSACSSSLQAIGEAFHKIRDGYLDLALAGGGDSRLTPGAILAYRKARALYEGGGNPGEASRPFDNGRRGFVPGEGGAV
LLLEELEHARSRGAAIIGEVRGFGASLDGYNVTAPEPEGRGGQMALEKALADAGLVPGDVDVVSTHGTGTLLNDRMEAAL
IERVYADQLPRILAFKSWIGHLSTACGAMETALSIICMQNDYLPEIRNLRDACSPVIPFVREGGKRSTSTWVIENFGFGG
QNAVLIVKRYAP
>Mature_412_residues
MKGLANPMSTFRRVVITALGVISPLGNSAEQIMTSLRSGRVSFAASASDPQVIVAPVRDFELGAFTGSFKERRYLNRGAQ
FTVAAAMAAVGNASLRREQITGAGLFLGAGPNMDMGGEIPEIRQGEIQHDTLMALWILRFLPNTAASVISILAGIRGDNL
TVTSACSSSLQAIGEAFHKIRDGYLDLALAGGGDSRLTPGAILAYRKARALYEGGGNPGEASRPFDNGRRGFVPGEGGAV
LLLEELEHARSRGAAIIGEVRGFGASLDGYNVTAPEPEGRGGQMALEKALADAGLVPGDVDVVSTHGTGTLLNDRMEAAL
IERVYADQLPRILAFKSWIGHLSTACGAMETALSIICMQNDYLPEIRNLRDACSPVIPFVREGGKRSTSTWVIENFGFGG
QNAVLIVKRYAP

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=422, Percent_Identity=32.4644549763033, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI223972627, Length=167, Percent_Identity=31.7365269461078, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI41872631, Length=281, Percent_Identity=27.7580071174377, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1787337, Length=418, Percent_Identity=32.5358851674641, Blast_Score=177, Evalue=8e-46,
Organism=Escherichia coli, GI1788663, Length=413, Percent_Identity=28.8135593220339, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71983541, Length=416, Percent_Identity=31.25, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI71983535, Length=263, Percent_Identity=35.7414448669202, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI212642053, Length=366, Percent_Identity=25.4098360655738, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17550940, Length=340, Percent_Identity=25, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=447, Percent_Identity=29.3064876957494, Blast_Score=173, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24644341, Length=426, Percent_Identity=33.3333333333333, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24581345, Length=377, Percent_Identity=26.525198938992, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI221330659, Length=276, Percent_Identity=30.0724637681159, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19920632, Length=276, Percent_Identity=30.0724637681159, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43577; Mature: 43577

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00098 THIOLASE_1 ; PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGLANPMSTFRRVVITALGVISPLGNSAEQIMTSLRSGRVSFAASASDPQVIVAPVRDF
CCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEECCCCCEEEEEECCCC
ELGAFTGSFKERRYLNRGAQFTVAAAMAAVGNASLRREQITGAGLFLGAGPNMDMGGEIP
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHCCCCEEEEECCCCCCCCCCCC
EIRQGEIQHDTLMALWILRFLPNTAASVISILAGIRGDNLTVTSACSSSLQAIGEAFHKI
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHH
RDGYLDLALAGGGDSRLTPGAILAYRKARALYEGGGNPGEASRPFDNGRRGFVPGEGGAV
HCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEE
LLLEELEHARSRGAAIIGEVRGFGASLDGYNVTAPEPEGRGGQMALEKALADAGLVPGDV
EEHHHHHHHHHCCCEEEEHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
DVVSTHGTGTLLNDRMEAALIERVYADQLPRILAFKSWIGHLSTACGAMETALSIICMQN
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
DYLPEIRNLRDACSPVIPFVREGGKRSTSTWVIENFGFGGQNAVLIVKRYAP
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MKGLANPMSTFRRVVITALGVISPLGNSAEQIMTSLRSGRVSFAASASDPQVIVAPVRDF
CCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEECCCCCEEEEEECCCC
ELGAFTGSFKERRYLNRGAQFTVAAAMAAVGNASLRREQITGAGLFLGAGPNMDMGGEIP
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHCCCCEEEEECCCCCCCCCCCC
EIRQGEIQHDTLMALWILRFLPNTAASVISILAGIRGDNLTVTSACSSSLQAIGEAFHKI
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHH
RDGYLDLALAGGGDSRLTPGAILAYRKARALYEGGGNPGEASRPFDNGRRGFVPGEGGAV
HCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEE
LLLEELEHARSRGAAIIGEVRGFGASLDGYNVTAPEPEGRGGQMALEKALADAGLVPGDV
EEHHHHHHHHHCCCEEEEHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
DVVSTHGTGTLLNDRMEAALIERVYADQLPRILAFKSWIGHLSTACGAMETALSIICMQN
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
DYLPEIRNLRDACSPVIPFVREGGKRSTSTWVIENFGFGGQNAVLIVKRYAP
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]