Click here to switch to the map view.

The map label for this gene is gyrA [H]

Identifier: 85857849

GI number: 85857849

Start: 5347

End: 7848

Strand: Direct

Name: gyrA [H]

Synonym: SYN_02048

Alternate gene names: 85857849

Gene position: 5347-7848 (Clockwise)

Preceding gene: 85857848

Following gene: 85857850

Centisome position: 0.17

GC content: 53.68

Gene sequence:

>2502_bases
ATGGATGCATTGTCAATTCCAAGAAACATTCTTGTAAATATAGAAGATGAAATGAAAAAGTCCTACATGGACTATGCTAT
GAGCGTTATTATCGGCCGGGCTATTCCCGATGTGCGCGATGGCCTGAAGCCGGTTCACCGCCGTGTTCTTTTTGCCATGA
GCGAGATGGGGAACCGCTGGAACAAGCCCTACAAGAAATCCGCCCGCATCGTCGGGGATATTATCGGTAAATACCATCCC
CACGGGGATGCGGCTGCCTACGACACCATTGTCCGTCTAGCGCAGGATTTTTCCATGCGCTATCCCCTTATTGATGGTCA
GGGCAATTTCGGTTCCATTGACGACGATCCTCCGGCGGCCATGAGGTACACGGAAGTTCGCATGGCCCGGATCACGGAGG
AGATTCTGGCGGATCTGGAGAAGGATACCGTCGATTTCGTGCCGAATTACGACGAGTCCCTGATGGAACCGTCCATTCTT
CCTTCGCGTATTCCAACACTTCTGCTGAACGGCACGGCAGGTATTGCCGTCGGTGTGGCGACGAACATACCACCTCACAA
TGTTACGGAAGTCCTGAGTGGAACCATTGCACTGATTCGGAATCCGGAAATGACTCTGGAAGAAATCATGCAGTTCATTC
CCGGACCGGATTTTCCAACGGCTGGTTTTATTAATGGCCGCGAGGGGATTATCTCCGCTTATCGGACGGGACGCGGCATC
ATCCGTTTGCGGGCCAAAGTCGTCATCGAGAAAAATGAGCGGAACGACAGGGAGAGCATCGTAGTAACCGAAATTCCCTA
CCAGGTCAACAAGGCGGCTCTGATCGAAAAGATCTCCGAGCTGGTCAAGGAAAAGAAAATTACCGGAATTTCCGATCTCC
GCGATGAATCCGATCGCGAGGGAATCCGGATCGTCATCGATCTGAAGCGCGACGAAAACTCCAATGTAATCCTGAATCAG
TTGTACAAGCACACACAGATGGAGTCGACCTTCGGGATCATTATGCTGGCCATCGAAAACGGTCAGCCTCATGTCTTCAA
TCTTATTGAAATCCTGAAGAGTTTTATCGAATTTCGCAAAGTCGTCATCGTCCGGCGCACGACTTTCGAGGTCAACAAGG
CGCGGGAACGGGCCCATATCCTGGAAGGCCTCATCATTGCCCTCGACAACATCGATGAAGTGGTCGCCGTCATCAAGGCT
TCCAAGAGCCCTCAGGAGGCGGCTTCCGCTTTGTGCAGCCGTTTTTCTCTGACAGACATTCAGGCCCGGGCGATTCTGGA
TATGAGACTGCAACGGCTGACCGGGCTGGAACAGAGTAAGATAAAGGAAGAATTTGATGCACTGTTGAAGGAGATCGAAC
GGCTGCAGGGCATTCTGGACGATCCCCGGAAAGTGCTTGAAGTGATCATTTCCGAGATGGAGGAGATCATCGATCGCTAC
GGCGATGAACGGCGCACGGAAATCGTGGCCAGTTCGGAAGACATCGACATAGAGGATATGATCGCCGAGGAAGAAATGGT
GGTTACCTACTCGCAGGGAGGGTACATCAAACGCAATCCCTCCAGTCTTTACAGGACGCAGCGCCGGGGCGGACGCGGCA
AGGTCGGGATGATGACCAAGGAAGAGGACGTGGTGGAACGTCTCTTTATTGCTTCCACCCATGACTATGTCCTGATTTTT
ACCAATGCCGGCCGGCTTTACTGGCTGAAGGTGTACCAGATCCCGCAGGCGGGGAGGATGGCCAAAGGCAAGCCCATCGT
CAATCTGATCAATATCGGACCGGATGAACGGGTGGCGGCGGTTCTTCCCGTCCGGTCTTTCGAAGAGGGACAGGCGGTGA
TTATGGCCACCAGGGCGGGCATCGTCAAGAAGACCGATTTAACCGCTTATTCCAATCCCCGATCGGGAGGGATCATCGCC
TTGAGTATCGACGAAGGCGATGAACTGGTCGATGTGAAACTGACGGGCGGCGATCAGGATGTTTTTCTCGCCACGCGTAA
AGGGAAGGCGATCCGTTTCAAGGAGGATGACATCCGCACCATGGGCAGGACGGCCCGGGGTGTACGCGGCATCTCCATGG
ATTCGGATGACGCCGTCATCGGCATGGATATTCCGAGAGAAGGCAATGCGATCGTTACCGTTTCCGAAAAAGGTTGCGGC
AAGCGGACGGCGGTATCGGAATATCGTCTCCAGAAACGCGGTGGCAAGGGAATGATCAACCTGCGCATCGTGCCCAAGGG
AGGACTGGTCGCCGACATCCTGCAGGTTACCGGTGAGGAAGACCTGCTTCTCATGAGCAACAGCGGAAAGATCATCCGGA
TGAAGGTTGAGGATGTCCCTCTGATTCATCGGGTGACCCAGGGCGTCAAGCTGATCGAACTTGATGCTGAAGAGCAGTTG
GTGGGAATGACCAGTGCGGAGCGGGAGGTCCGTGAAGAAGAGGATAATATTCCGGAAGACGATCCGCAGACGGATACGTC
CCTGTCCGGAGAGGATGAATAA

Upstream 100 bases:

>100_bases
CCACATTGATGGGGGATCAGGTTGAACCCCGTAGAGAATTCATTTACCAGAACGCTCTTTACGTGTCCAACCTGGATGTC
TAGAAGGAAGGAATAAAAGA

Downstream 100 bases:

>100_bases
CCGTGAACGAGTTCTGGCGTCTTCTGGATCATACGGCGGATCTCGGCATTGAGGTGGAAGGCCCTTCTCTGGAAGAGCTT
TTTGCCCATGCGGGGGAGGC

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 833; Mature: 833

Protein sequence:

>833_residues
MDALSIPRNILVNIEDEMKKSYMDYAMSVIIGRAIPDVRDGLKPVHRRVLFAMSEMGNRWNKPYKKSARIVGDIIGKYHP
HGDAAAYDTIVRLAQDFSMRYPLIDGQGNFGSIDDDPPAAMRYTEVRMARITEEILADLEKDTVDFVPNYDESLMEPSIL
PSRIPTLLLNGTAGIAVGVATNIPPHNVTEVLSGTIALIRNPEMTLEEIMQFIPGPDFPTAGFINGREGIISAYRTGRGI
IRLRAKVVIEKNERNDRESIVVTEIPYQVNKAALIEKISELVKEKKITGISDLRDESDREGIRIVIDLKRDENSNVILNQ
LYKHTQMESTFGIIMLAIENGQPHVFNLIEILKSFIEFRKVVIVRRTTFEVNKARERAHILEGLIIALDNIDEVVAVIKA
SKSPQEAASALCSRFSLTDIQARAILDMRLQRLTGLEQSKIKEEFDALLKEIERLQGILDDPRKVLEVIISEMEEIIDRY
GDERRTEIVASSEDIDIEDMIAEEEMVVTYSQGGYIKRNPSSLYRTQRRGGRGKVGMMTKEEDVVERLFIASTHDYVLIF
TNAGRLYWLKVYQIPQAGRMAKGKPIVNLINIGPDERVAAVLPVRSFEEGQAVIMATRAGIVKKTDLTAYSNPRSGGIIA
LSIDEGDELVDVKLTGGDQDVFLATRKGKAIRFKEDDIRTMGRTARGVRGISMDSDDAVIGMDIPREGNAIVTVSEKGCG
KRTAVSEYRLQKRGGKGMINLRIVPKGGLVADILQVTGEEDLLLMSNSGKIIRMKVEDVPLIHRVTQGVKLIELDAEEQL
VGMTSAEREVREEEDNIPEDDPQTDTSLSGEDE

Sequences:

>Translated_833_residues
MDALSIPRNILVNIEDEMKKSYMDYAMSVIIGRAIPDVRDGLKPVHRRVLFAMSEMGNRWNKPYKKSARIVGDIIGKYHP
HGDAAAYDTIVRLAQDFSMRYPLIDGQGNFGSIDDDPPAAMRYTEVRMARITEEILADLEKDTVDFVPNYDESLMEPSIL
PSRIPTLLLNGTAGIAVGVATNIPPHNVTEVLSGTIALIRNPEMTLEEIMQFIPGPDFPTAGFINGREGIISAYRTGRGI
IRLRAKVVIEKNERNDRESIVVTEIPYQVNKAALIEKISELVKEKKITGISDLRDESDREGIRIVIDLKRDENSNVILNQ
LYKHTQMESTFGIIMLAIENGQPHVFNLIEILKSFIEFRKVVIVRRTTFEVNKARERAHILEGLIIALDNIDEVVAVIKA
SKSPQEAASALCSRFSLTDIQARAILDMRLQRLTGLEQSKIKEEFDALLKEIERLQGILDDPRKVLEVIISEMEEIIDRY
GDERRTEIVASSEDIDIEDMIAEEEMVVTYSQGGYIKRNPSSLYRTQRRGGRGKVGMMTKEEDVVERLFIASTHDYVLIF
TNAGRLYWLKVYQIPQAGRMAKGKPIVNLINIGPDERVAAVLPVRSFEEGQAVIMATRAGIVKKTDLTAYSNPRSGGIIA
LSIDEGDELVDVKLTGGDQDVFLATRKGKAIRFKEDDIRTMGRTARGVRGISMDSDDAVIGMDIPREGNAIVTVSEKGCG
KRTAVSEYRLQKRGGKGMINLRIVPKGGLVADILQVTGEEDLLLMSNSGKIIRMKVEDVPLIHRVTQGVKLIELDAEEQL
VGMTSAEREVREEEDNIPEDDPQTDTSLSGEDE
>Mature_833_residues
MDALSIPRNILVNIEDEMKKSYMDYAMSVIIGRAIPDVRDGLKPVHRRVLFAMSEMGNRWNKPYKKSARIVGDIIGKYHP
HGDAAAYDTIVRLAQDFSMRYPLIDGQGNFGSIDDDPPAAMRYTEVRMARITEEILADLEKDTVDFVPNYDESLMEPSIL
PSRIPTLLLNGTAGIAVGVATNIPPHNVTEVLSGTIALIRNPEMTLEEIMQFIPGPDFPTAGFINGREGIISAYRTGRGI
IRLRAKVVIEKNERNDRESIVVTEIPYQVNKAALIEKISELVKEKKITGISDLRDESDREGIRIVIDLKRDENSNVILNQ
LYKHTQMESTFGIIMLAIENGQPHVFNLIEILKSFIEFRKVVIVRRTTFEVNKARERAHILEGLIIALDNIDEVVAVIKA
SKSPQEAASALCSRFSLTDIQARAILDMRLQRLTGLEQSKIKEEFDALLKEIERLQGILDDPRKVLEVIISEMEEIIDRY
GDERRTEIVASSEDIDIEDMIAEEEMVVTYSQGGYIKRNPSSLYRTQRRGGRGKVGMMTKEEDVVERLFIASTHDYVLIF
TNAGRLYWLKVYQIPQAGRMAKGKPIVNLINIGPDERVAAVLPVRSFEEGQAVIMATRAGIVKKTDLTAYSNPRSGGIIA
LSIDEGDELVDVKLTGGDQDVFLATRKGKAIRFKEDDIRTMGRTARGVRGISMDSDDAVIGMDIPREGNAIVTVSEKGCG
KRTAVSEYRLQKRGGKGMINLRIVPKGGLVADILQVTGEEDLLLMSNSGKIIRMKVEDVPLIHRVTQGVKLIELDAEEQL
VGMTSAEREVREEEDNIPEDDPQTDTSLSGEDE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=341, Percent_Identity=25.2199413489736, Blast_Score=72, Evalue=3e-12,
Organism=Homo sapiens, GI19913408, Length=339, Percent_Identity=23.0088495575221, Blast_Score=71, Evalue=5e-12,
Organism=Escherichia coli, GI1788562, Length=837, Percent_Identity=51.2544802867383, Blast_Score=887, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=696, Percent_Identity=37.2126436781609, Blast_Score=436, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI212645845, Length=357, Percent_Identity=25.4901960784314, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17535065, Length=174, Percent_Identity=33.9080459770115, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=188, Percent_Identity=31.9148936170213, Blast_Score=76, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=369, Percent_Identity=26.5582655826558, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136538, Length=361, Percent_Identity=26.0387811634349, Blast_Score=73, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 93104; Mature: 93104

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDALSIPRNILVNIEDEMKKSYMDYAMSVIIGRAIPDVRDGLKPVHRRVLFAMSEMGNRW
CCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
NKPYKKSARIVGDIIGKYHPHGDAAAYDTIVRLAQDFSMRYPLIDGQGNFGSIDDDPPAA
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCH
MRYTEVRMARITEEILADLEKDTVDFVPNYDESLMEPSILPSRIPTLLLNGTAGIAVGVA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCHHHCCEEEECCCCCEEEEEE
TNIPPHNVTEVLSGTIALIRNPEMTLEEIMQFIPGPDFPTAGFINGREGIISAYRTGRGI
CCCCCCHHHHHHCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCE
IRLRAKVVIEKNERNDRESIVVTEIPYQVNKAALIEKISELVKEKKITGISDLRDESDRE
EEEEEEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCC
GIRIVIDLKRDENSNVILNQLYKHTQMESTFGIIMLAIENGQPHVFNLIEILKSFIEFRK
CEEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHH
VVIVRRTTFEVNKARERAHILEGLIIALDNIDEVVAVIKASKSPQEAASALCSRFSLTDI
EEEEEECEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCHH
QARAILDMRLQRLTGLEQSKIKEEFDALLKEIERLQGILDDPRKVLEVIISEMEEIIDRY
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
GDERRTEIVASSEDIDIEDMIAEEEMVVTYSQGGYIKRNPSSLYRTQRRGGRGKVGMMTK
CCCHHHEEEECCCCCCHHHHHCCCCEEEEECCCCCEEECHHHHHHHHHCCCCCCCCCCCC
EEDVVERLFIASTHDYVLIFTNAGRLYWLKVYQIPQAGRMAKGKPIVNLINIGPDERVAA
HHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCCCCEEEEECCCCCCEEE
VLPVRSFEEGQAVIMATRAGIVKKTDLTAYSNPRSGGIIALSIDEGDELVDVKLTGGDQD
EECCCCCCCCCEEEEEECCCCEEECCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCE
VFLATRKGKAIRFKEDDIRTMGRTARGVRGISMDSDDAVIGMDIPREGNAIVTVSEKGCG
EEEEECCCCEEEECHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCEEEEEECCCCC
KRTAVSEYRLQKRGGKGMINLRIVPKGGLVADILQVTGEEDLLLMSNSGKIIRMKVEDVP
CCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHCCCCCEEEEECCCCEEEEEECCCC
LIHRVTQGVKLIELDAEEQLVGMTSAEREVREEEDNIPEDDPQTDTSLSGEDE
HHHHHHCCCEEEEECCHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDALSIPRNILVNIEDEMKKSYMDYAMSVIIGRAIPDVRDGLKPVHRRVLFAMSEMGNRW
CCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
NKPYKKSARIVGDIIGKYHPHGDAAAYDTIVRLAQDFSMRYPLIDGQGNFGSIDDDPPAA
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCH
MRYTEVRMARITEEILADLEKDTVDFVPNYDESLMEPSILPSRIPTLLLNGTAGIAVGVA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCHHHCCEEEECCCCCEEEEEE
TNIPPHNVTEVLSGTIALIRNPEMTLEEIMQFIPGPDFPTAGFINGREGIISAYRTGRGI
CCCCCCHHHHHHCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCE
IRLRAKVVIEKNERNDRESIVVTEIPYQVNKAALIEKISELVKEKKITGISDLRDESDRE
EEEEEEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCC
GIRIVIDLKRDENSNVILNQLYKHTQMESTFGIIMLAIENGQPHVFNLIEILKSFIEFRK
CEEEEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHH
VVIVRRTTFEVNKARERAHILEGLIIALDNIDEVVAVIKASKSPQEAASALCSRFSLTDI
EEEEEECEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCHH
QARAILDMRLQRLTGLEQSKIKEEFDALLKEIERLQGILDDPRKVLEVIISEMEEIIDRY
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
GDERRTEIVASSEDIDIEDMIAEEEMVVTYSQGGYIKRNPSSLYRTQRRGGRGKVGMMTK
CCCHHHEEEECCCCCCHHHHHCCCCEEEEECCCCCEEECHHHHHHHHHCCCCCCCCCCCC
EEDVVERLFIASTHDYVLIFTNAGRLYWLKVYQIPQAGRMAKGKPIVNLINIGPDERVAA
HHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCCCCEEEEECCCCCCEEE
VLPVRSFEEGQAVIMATRAGIVKKTDLTAYSNPRSGGIIALSIDEGDELVDVKLTGGDQD
EECCCCCCCCCEEEEEECCCCEEECCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCE
VFLATRKGKAIRFKEDDIRTMGRTARGVRGISMDSDDAVIGMDIPREGNAIVTVSEKGCG
EEEEECCCCEEEECHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCEEEEEECCCCC
KRTAVSEYRLQKRGGKGMINLRIVPKGGLVADILQVTGEEDLLLMSNSGKIIRMKVEDVP
CCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHCCCCCEEEEECCCCEEEEEECCCC
LIHRVTQGVKLIELDAEEQLVGMTSAEREVREEEDNIPEDDPQTDTSLSGEDE
HHHHHHCCCEEEEECCHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609; 8849216 [H]