Click here to switch to the map view.

The map label for this gene is ubiB [C]

Identifier: 85375808

GI number: 85375808

Start: 3002555

End: 3004141

Strand: Reverse

Name: ubiB [C]

Synonym: ELI_14905

Alternate gene names: 85375808

Gene position: 3004141-3002555 (Counterclockwise)

Preceding gene: 85375809

Following gene: 85375805

Centisome position: 98.42

GC content: 57.84

Gene sequence:

>1587_bases
ATGAAGCATGATCTGGAAAACAGTGTCGGTGAACTGACGCGGCTAGCAGAACTCGGTCAGATTTTCGCCCGGCACGGTCT
GAAAAATCTCGGAAGCTTGCTTGGCTTTATGCCGGTTTCGGAGAATGAGCCAGATACCGAGGACTTGCGTCCTGCATCGG
TGGTGGCGCTGTTGCGCGATGTCGGCCCTGTCGGAATAAAGCTTGGCCAGCTCCTGGCGACCAGAAGCGATCTGTTTACA
CAACCCTGGATTTCCGCGTTCGGCACTCTCCACGACCAGGTGGAACCGCTGCCGTTCGATAAGATCGAACCGGTGATTGT
ATCGGCTTGGGGCAGCGACTGGGAACGTGAATTCGCCGCTTTCGAGAGAAACCCGATCGCCTCAGCCTCTATCGCGCAGA
CTTATGTCGCAACCCTGCTGGACGGAAGCGAGACTATCGTGAAAATCCGCCGACCCGGCATGGCGTCCAGGATCGAGGCG
GACATGAGGCTGTTGACACGGCTCGCGGGCCTCGCCGAGCGTCGGTCAAGCGACATTGCTCGCTATCGACCCGTGGAATT
CCTTCAGACATTCGCCAAGAATTTAGCGCGGGAGATGGACCTGGCGGCAGAAGCACGTGCCTGTGAAAGGATTGGCGGTT
ATCTGGAGATGCTTGGGGTGAAGACGCCCGCGATCCACTGGGAACTCACAGGCTTGACGATCAATGTGCAGGAAGCCCTG
GGCGGAAAGCCCGCGTCGCGGCACCCGGCAACTGATCCGGCAGGGAATGCCCAGTTCGCGAAGCGCTATGCCGATGCAGT
GCTACGGATGATCCTTCTCAATGGAGAGTTTCATGGCGACCCGCATCCCGGCAACGTCTTCTGGATGGAAGGGAACCAGG
TAGGCTTCATCGATTTCGGCTCGGTCGGCTTTCTCAGCGGCGCGCGGCGTCAGGAAATCGTCCGACTGATTTTCGCTATC
GCGAACGGACAGATAGACAAGGTGGCCGATCTGCTGCTCGACTGGGCAGGCAATCCACTCGTGGATCGCGCGCAATTGGT
GATGGACCTGGATGAGCTGATCGCGGAATTTAGCGGCACAGCTCTTGCCGGGATAGAATTCGCGGCAATTTTCGATCGGG
TTTTCGGATTGTTGCGCGATTATCGCCTCGTATTGCCGCCCGACCTCGCTATTTTGCTGCGCACCCTGCTGACCGCAGAG
GGCTTCGTTCGCTCTTTGGCGCCGGACTACAATATCGCCGAAGAAACGAAGCCGATCGTGATGCAATTGTTTGCCGAGCG
ATTTTCGATCGGAGCCGCGCGGGATCATTTGGCCAAGGTCCGCAGTGGCCTGCTTGATTTCTCGGCATCGCTGCCCGAGC
TAATCGATAACGTTGCCTCGGTCGCTCGATCAGGTACGATTCAGGTATCCATCGACCCAGCCAGTCTGAACCATCTGACG
CGGGAAGAGGACCGCAGCACCCCCGTCAAGGGTCCGGTGGTGGCAGCGTTGATCATCTCTGCCGCATTGCTGGCCGACCA
ATCGTTGTTACTGGCAGGAATTGTTCTGGCTTTCGCGGGAATAGCACTCATTCCTAGATGGAACTGA

Upstream 100 bases:

>100_bases
TCTGGAAGGGAATGTCTGCGCCTCAAATCGACCTCCTGCGTACGATGCTTCGAAAAGTTGCGGAGAATCAGAAGCAGGCT
GACACTTGCGAAGAAAGCCG

Downstream 100 bases:

>100_bases
TAAGACCACACACAATGAACGCTTAGACCACGGCCGCCCGGCACCGATATTGGCTACATCAAGGGAGAAGAGTGGAAATG
ACCGAACAGAAACCTGCCGA

Product: ubiquinone biosynthesis protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MKHDLENSVGELTRLAELGQIFARHGLKNLGSLLGFMPVSENEPDTEDLRPASVVALLRDVGPVGIKLGQLLATRSDLFT
QPWISAFGTLHDQVEPLPFDKIEPVIVSAWGSDWEREFAAFERNPIASASIAQTYVATLLDGSETIVKIRRPGMASRIEA
DMRLLTRLAGLAERRSSDIARYRPVEFLQTFAKNLAREMDLAAEARACERIGGYLEMLGVKTPAIHWELTGLTINVQEAL
GGKPASRHPATDPAGNAQFAKRYADAVLRMILLNGEFHGDPHPGNVFWMEGNQVGFIDFGSVGFLSGARRQEIVRLIFAI
ANGQIDKVADLLLDWAGNPLVDRAQLVMDLDELIAEFSGTALAGIEFAAIFDRVFGLLRDYRLVLPPDLAILLRTLLTAE
GFVRSLAPDYNIAEETKPIVMQLFAERFSIGAARDHLAKVRSGLLDFSASLPELIDNVASVARSGTIQVSIDPASLNHLT
REEDRSTPVKGPVVAALIISAALLADQSLLLAGIVLAFAGIALIPRWN

Sequences:

>Translated_528_residues
MKHDLENSVGELTRLAELGQIFARHGLKNLGSLLGFMPVSENEPDTEDLRPASVVALLRDVGPVGIKLGQLLATRSDLFT
QPWISAFGTLHDQVEPLPFDKIEPVIVSAWGSDWEREFAAFERNPIASASIAQTYVATLLDGSETIVKIRRPGMASRIEA
DMRLLTRLAGLAERRSSDIARYRPVEFLQTFAKNLAREMDLAAEARACERIGGYLEMLGVKTPAIHWELTGLTINVQEAL
GGKPASRHPATDPAGNAQFAKRYADAVLRMILLNGEFHGDPHPGNVFWMEGNQVGFIDFGSVGFLSGARRQEIVRLIFAI
ANGQIDKVADLLLDWAGNPLVDRAQLVMDLDELIAEFSGTALAGIEFAAIFDRVFGLLRDYRLVLPPDLAILLRTLLTAE
GFVRSLAPDYNIAEETKPIVMQLFAERFSIGAARDHLAKVRSGLLDFSASLPELIDNVASVARSGTIQVSIDPASLNHLT
REEDRSTPVKGPVVAALIISAALLADQSLLLAGIVLAFAGIALIPRWN
>Mature_528_residues
MKHDLENSVGELTRLAELGQIFARHGLKNLGSLLGFMPVSENEPDTEDLRPASVVALLRDVGPVGIKLGQLLATRSDLFT
QPWISAFGTLHDQVEPLPFDKIEPVIVSAWGSDWEREFAAFERNPIASASIAQTYVATLLDGSETIVKIRRPGMASRIEA
DMRLLTRLAGLAERRSSDIARYRPVEFLQTFAKNLAREMDLAAEARACERIGGYLEMLGVKTPAIHWELTGLTINVQEAL
GGKPASRHPATDPAGNAQFAKRYADAVLRMILLNGEFHGDPHPGNVFWMEGNQVGFIDFGSVGFLSGARRQEIVRLIFAI
ANGQIDKVADLLLDWAGNPLVDRAQLVMDLDELIAEFSGTALAGIEFAAIFDRVFGLLRDYRLVLPPDLAILLRTLLTAE
GFVRSLAPDYNIAEETKPIVMQLFAERFSIGAARDHLAKVRSGLLDFSASLPELIDNVASVARSGTIQVSIDPASLNHLT
REEDRSTPVKGPVVAALIISAALLADQSLLLAGIVLAFAGIALIPRWN

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=225, Percent_Identity=28.4444444444444, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI41393593, Length=266, Percent_Identity=26.6917293233083, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI27363457, Length=281, Percent_Identity=25.2669039145907, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI217035081, Length=173, Percent_Identity=28.9017341040462, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI34147522, Length=258, Percent_Identity=25.1937984496124, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI2367309, Length=474, Percent_Identity=28.2700421940928, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI32565180, Length=397, Percent_Identity=21.9143576826196, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17559152, Length=233, Percent_Identity=24.0343347639485, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6325148, Length=427, Percent_Identity=22.4824355971897, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6321319, Length=241, Percent_Identity=22.4066390041494, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24662575, Length=273, Percent_Identity=25.6410256410256, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI22024280, Length=227, Percent_Identity=26.431718061674, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI18859849, Length=276, Percent_Identity=25.7246376811594, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 57564; Mature: 57564

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHDLENSVGELTRLAELGQIFARHGLKNLGSLLGFMPVSENEPDTEDLRPASVVALLRD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHHH
VGPVGIKLGQLLATRSDLFTQPWISAFGTLHDQVEPLPFDKIEPVIVSAWGSDWEREFAA
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHH
FERNPIASASIAQTYVATLLDGSETIVKIRRPGMASRIEADMRLLTRLAGLAERRSSDIA
HHCCCCCHHHHHHHHHHHHHCCCHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
RYRPVEFLQTFAKNLAREMDLAAEARACERIGGYLEMLGVKTPAIHWELTGLTINVQEAL
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEHHHHH
GGKPASRHPATDPAGNAQFAKRYADAVLRMILLNGEFHGDPHPGNVFWMEGNQVGFIDFG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEEEEEECC
SVGFLSGARRQEIVRLIFAIANGQIDKVADLLLDWAGNPLVDRAQLVMDLDELIAEFSGT
CHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
ALAGIEFAAIFDRVFGLLRDYRLVLPPDLAILLRTLLTAEGFVRSLAPDYNIAEETKPIV
HHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
MQLFAERFSIGAARDHLAKVRSGLLDFSASLPELIDNVASVARSGTIQVSIDPASLNHLT
HHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEEEECHHHHHHHH
REEDRSTPVKGPVVAALIISAALLADQSLLLAGIVLAFAGIALIPRWN
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKHDLENSVGELTRLAELGQIFARHGLKNLGSLLGFMPVSENEPDTEDLRPASVVALLRD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHHH
VGPVGIKLGQLLATRSDLFTQPWISAFGTLHDQVEPLPFDKIEPVIVSAWGSDWEREFAA
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHH
FERNPIASASIAQTYVATLLDGSETIVKIRRPGMASRIEADMRLLTRLAGLAERRSSDIA
HHCCCCCHHHHHHHHHHHHHCCCHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
RYRPVEFLQTFAKNLAREMDLAAEARACERIGGYLEMLGVKTPAIHWELTGLTINVQEAL
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEHHHHH
GGKPASRHPATDPAGNAQFAKRYADAVLRMILLNGEFHGDPHPGNVFWMEGNQVGFIDFG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEEEEEECC
SVGFLSGARRQEIVRLIFAIANGQIDKVADLLLDWAGNPLVDRAQLVMDLDELIAEFSGT
CHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
ALAGIEFAAIFDRVFGLLRDYRLVLPPDLAILLRTLLTAEGFVRSLAPDYNIAEETKPIV
HHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
MQLFAERFSIGAARDHLAKVRSGLLDFSASLPELIDNVASVARSGTIQVSIDPASLNHLT
HHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEEEECHHHHHHHH
REEDRSTPVKGPVVAALIISAALLADQSLLLAGIVLAFAGIALIPRWN
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA