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The map label for this gene is gpmA

Identifier: 85375544

GI number: 85375544

Start: 2737542

End: 2738228

Strand: Reverse

Name: gpmA

Synonym: ELI_13585

Alternate gene names: 85375544

Gene position: 2738228-2737542 (Counterclockwise)

Preceding gene: 85375545

Following gene: 85375543

Centisome position: 89.71

GC content: 62.3

Gene sequence:

>687_bases
ATGCCTACTCTCATCCTCGTTCGCCACGGCCAGAGCCAGTGGAACCTCGAAAACCGTTTCACCGGCTGGTGGGATGTCGA
CCTGACCGAGAAGGGCGTCGAGGAAGCCAAGGCGGCAGGCACGCTTTTGAAGGAGAAGGGCGTGCTGCCCACGGTCGCTT
TCACCAGCTTCCAGACCCGCGCGATCAAAACGTTGCATCTGGCGCTGGAAGAAGCGGACCGGCTGTGGATCCCGGAAACC
AAGGACTGGCGGCTCAACGAGCGGCATTATGGCGGGCTGACCGGGCTCGACAAGCAGGAAATGCGCGACAAGCACGGTGA
CGAGCAGGTGCATATCTGGCGCCGCAGCTTCGACGTGCCGCCGCCCGACATGGAGCCCGGACATCAATACGATCCCGGCG
CCGATCCGCGCTATGACGGGATCGACGTGCCGACCACGGAAAGCCTCAAGCTCACCATCGAGCGGGTGCTGCCTTATTGG
GAAAGCGAGATCCTGCCGGTGCTGGCGAGCGGTGAAACGGTGATCATTTCCGCCCATGGCAACAGCTTGCGCGCGCTGGT
GAAGCACCTGTCCGGCATCTCGGATGAGGATATCACCGGGCTCGAGATTCCCACCGGCCAGCCGATCATCTACCAATTCG
ACGACCGGATGCAGCCGGGCGAGCGCTATTACCTGAAGGACAGCTGA

Upstream 100 bases:

>100_bases
CCAGCGAATCGGACGAAAGTGGGCTTTCCAAGCACAAAGACGCGGGCTAACGCGTCTTGCTCTTGTTCACGGGGCCAAGG
CCCGGGATAGCGGAGCAAAA

Downstream 100 bases:

>100_bases
GGCATGGGCGGAGCTAAAGTCGCTATCATCATGGGCAGCCAGTCCGACTGGCCGACGATGCAATGCGCCGCCGAGGTGCT
CGACGAGCTGGAAGTGGCTT

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MPTLILVRHGQSQWNLENRFTGWWDVDLTEKGVEEAKAAGTLLKEKGVLPTVAFTSFQTRAIKTLHLALEEADRLWIPET
KDWRLNERHYGGLTGLDKQEMRDKHGDEQVHIWRRSFDVPPPDMEPGHQYDPGADPRYDGIDVPTTESLKLTIERVLPYW
ESEILPVLASGETVIISAHGNSLRALVKHLSGISDEDITGLEIPTGQPIIYQFDDRMQPGERYYLKDS

Sequences:

>Translated_228_residues
MPTLILVRHGQSQWNLENRFTGWWDVDLTEKGVEEAKAAGTLLKEKGVLPTVAFTSFQTRAIKTLHLALEEADRLWIPET
KDWRLNERHYGGLTGLDKQEMRDKHGDEQVHIWRRSFDVPPPDMEPGHQYDPGADPRYDGIDVPTTESLKLTIERVLPYW
ESEILPVLASGETVIISAHGNSLRALVKHLSGISDEDITGLEIPTGQPIIYQFDDRMQPGERYYLKDS
>Mature_227_residues
PTLILVRHGQSQWNLENRFTGWWDVDLTEKGVEEAKAAGTLLKEKGVLPTVAFTSFQTRAIKTLHLALEEADRLWIPETK
DWRLNERHYGGLTGLDKQEMRDKHGDEQVHIWRRSFDVPPPDMEPGHQYDPGADPRYDGIDVPTTESLKLTIERVLPYWE
SEILPVLASGETVIISAHGNSLRALVKHLSGISDEDITGLEIPTGQPIIYQFDDRMQPGERYYLKDS

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI50593010, Length=221, Percent_Identity=51.5837104072398, Blast_Score=244, Evalue=4e-65,
Organism=Homo sapiens, GI4505753, Length=221, Percent_Identity=53.393665158371, Blast_Score=231, Evalue=4e-61,
Organism=Homo sapiens, GI71274132, Length=221, Percent_Identity=50.2262443438914, Blast_Score=216, Evalue=1e-56,
Organism=Homo sapiens, GI4502445, Length=232, Percent_Identity=47.4137931034483, Blast_Score=215, Evalue=2e-56,
Organism=Homo sapiens, GI40353764, Length=232, Percent_Identity=47.4137931034483, Blast_Score=215, Evalue=2e-56,
Organism=Homo sapiens, GI310129614, Length=160, Percent_Identity=54.375, Blast_Score=160, Evalue=9e-40,
Organism=Escherichia coli, GI1786970, Length=228, Percent_Identity=58.3333333333333, Blast_Score=273, Evalue=8e-75,
Organism=Saccharomyces cerevisiae, GI6322697, Length=229, Percent_Identity=55.8951965065502, Blast_Score=259, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6320183, Length=267, Percent_Identity=30.3370786516854, Blast_Score=125, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6324516, Length=274, Percent_Identity=31.021897810219, Blast_Score=124, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24646216, Length=222, Percent_Identity=52.7027027027027, Blast_Score=238, Evalue=2e-63,
Organism=Drosophila melanogaster, GI85725270, Length=222, Percent_Identity=52.7027027027027, Blast_Score=213, Evalue=6e-56,
Organism=Drosophila melanogaster, GI85725272, Length=222, Percent_Identity=52.7027027027027, Blast_Score=213, Evalue=6e-56,
Organism=Drosophila melanogaster, GI24650981, Length=222, Percent_Identity=52.7027027027027, Blast_Score=213, Evalue=6e-56,
Organism=Drosophila melanogaster, GI28571815, Length=217, Percent_Identity=39.63133640553, Blast_Score=165, Evalue=2e-41,
Organism=Drosophila melanogaster, GI28571817, Length=217, Percent_Identity=39.63133640553, Blast_Score=165, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24648979, Length=217, Percent_Identity=39.63133640553, Blast_Score=164, Evalue=3e-41,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA_ERYLH (Q2N682)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_459606.1
- HSSP:   P07738
- ProteinModelPortal:   Q2N682
- SMR:   Q2N682
- STRING:   Q2N682
- GeneID:   3870417
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_13585
- NMPDR:   fig|314225.3.peg.301
- eggNOG:   COG0588
- HOGENOM:   HBG658938
- OMA:   TGWKDPD
- PhylomeDB:   Q2N682
- ProtClustDB:   PRK14115
- BioCyc:   ELIT314225:ELI_13585-MONOMER
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 26013; Mature: 25881

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 9-9 ACT_SITE 179-179

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTLILVRHGQSQWNLENRFTGWWDVDLTEKGVEEAKAAGTLLKEKGVLPTVAFTSFQTR
CCEEEEEECCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEECCHHHH
AIKTLHLALEEADRLWIPETKDWRLNERHYGGLTGLDKQEMRDKHGDEQVHIWRRSFDVP
HHHHHHHHHHHHCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCC
PPDMEPGHQYDPGADPRYDGIDVPTTESLKLTIERVLPYWESEILPVLASGETVIISAHG
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEHHHHCCCCCCCCEEEEECCCEEEEEECC
NSLRALVKHLSGISDEDITGLEIPTGQPIIYQFDDRMQPGERYYLKDS
CHHHHHHHHHCCCCCCCCCEEECCCCCEEEEEECCCCCCCCEEEECCC
>Mature Secondary Structure 
PTLILVRHGQSQWNLENRFTGWWDVDLTEKGVEEAKAAGTLLKEKGVLPTVAFTSFQTR
CEEEEEECCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEECCHHHH
AIKTLHLALEEADRLWIPETKDWRLNERHYGGLTGLDKQEMRDKHGDEQVHIWRRSFDVP
HHHHHHHHHHHHCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEEECCCCC
PPDMEPGHQYDPGADPRYDGIDVPTTESLKLTIERVLPYWESEILPVLASGETVIISAHG
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEHHHHCCCCCCCCEEEEECCCEEEEEECC
NSLRALVKHLSGISDEDITGLEIPTGQPIIYQFDDRMQPGERYYLKDS
CHHHHHHHHHCCCCCCCCCEEECCCCCEEEEEECCCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA