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The map label for this gene is pdxH

Identifier: 85375514

GI number: 85375514

Start: 2707827

End: 2708465

Strand: Direct

Name: pdxH

Synonym: ELI_13435

Alternate gene names: 85375514

Gene position: 2707827-2708465 (Clockwise)

Preceding gene: 85375511

Following gene: 85375515

Centisome position: 88.71

GC content: 62.91

Gene sequence:

>639_bases
ATGCAATCAGAAGAGTCGATCATGACCGATCTTGCCACCAGCGAAATTCCCGAAACCGATCCCTTCGCGCTGTTTGCCGA
ATGGATGGAGGAAGCGCGCGCAAGCGAACTCAACGATCCCAATGCCATGGCGTTGGCCACGGCGACCCCCGACGGTGCGC
CTTCGGTGCGGATGGTGCTGCTCAAGGACCACGGCCCGCAGGGGTTCACTTTCTACACCAATGCAGAAAGCCGAAAGGGC
GAGGAAATCCGCGCCAACGCGCAGACGGCATTGCTGTTTCACTGGAAGAGCCTGCGCCGCCAGATTCGCGTCGAAGGCCC
TGTGCGCGAAGTCGCGCCCGAAGTGGCGGACGCATATTTTCATTCGCGCGCGCGGGAATCGCAACTGGGCGCCGTTGCCT
CGGACCAGTCGCGCCCGCTGGAAGATCGGCGGGTCTTCGTCGATCGCTTCCGTGCGGCGCAGGAGCGGTTCGATGAAGGC
GAAGTCGAACGTCCGGCGTACTGGACCGGCTTTACGGTCACTCCGCAGCGCATCGAATTCTGGTGCGATCGGCCCAATCG
GCTGCATGACCGCCGCCTTTTCACGCTCAGCGGGGCGGGCGACGCGCTCAGTTGGACGAGCACGTTGCTCTACCCATGA

Upstream 100 bases:

>100_bases
TGGATCAGAGCGCTCATGGTGCGGCCCGTAGCATGAATGCCTCAAGAAAATGTGAGCGATTGCCGTAGTCAGCGCGGCAC
TGTAGGCGGCGCCGCGAGGG

Downstream 100 bases:

>100_bases
GCGACAACCGCGCCACTCTCGCGCGCAGTGCCGCTATCGCTTCGATTTCCGTGGCGATCCTGCTGGTCGTGCTCAAGACC
TGGGCGACTTGGAAGACCGG

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MQSEESIMTDLATSEIPETDPFALFAEWMEEARASELNDPNAMALATATPDGAPSVRMVLLKDHGPQGFTFYTNAESRKG
EEIRANAQTALLFHWKSLRRQIRVEGPVREVAPEVADAYFHSRARESQLGAVASDQSRPLEDRRVFVDRFRAAQERFDEG
EVERPAYWTGFTVTPQRIEFWCDRPNRLHDRRLFTLSGAGDALSWTSTLLYP

Sequences:

>Translated_212_residues
MQSEESIMTDLATSEIPETDPFALFAEWMEEARASELNDPNAMALATATPDGAPSVRMVLLKDHGPQGFTFYTNAESRKG
EEIRANAQTALLFHWKSLRRQIRVEGPVREVAPEVADAYFHSRARESQLGAVASDQSRPLEDRRVFVDRFRAAQERFDEG
EVERPAYWTGFTVTPQRIEFWCDRPNRLHDRRLFTLSGAGDALSWTSTLLYP
>Mature_212_residues
MQSEESIMTDLATSEIPETDPFALFAEWMEEARASELNDPNAMALATATPDGAPSVRMVLLKDHGPQGFTFYTNAESRKG
EEIRANAQTALLFHWKSLRRQIRVEGPVREVAPEVADAYFHSRARESQLGAVASDQSRPLEDRRVFVDRFRAAQERFDEG
EVERPAYWTGFTVTPQRIEFWCDRPNRLHDRRLFTLSGAGDALSWTSTLLYP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=182, Percent_Identity=45.6043956043956, Blast_Score=172, Evalue=2e-43,
Organism=Escherichia coli, GI1787926, Length=175, Percent_Identity=41.7142857142857, Blast_Score=150, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17553712, Length=190, Percent_Identity=41.5789473684211, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6319509, Length=197, Percent_Identity=38.0710659898477, Blast_Score=127, Evalue=1e-30,
Organism=Drosophila melanogaster, GI45551845, Length=187, Percent_Identity=43.3155080213904, Blast_Score=143, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24644901, Length=187, Percent_Identity=43.3155080213904, Blast_Score=143, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_ERYLH (Q2N6B2)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_459576.1
- ProteinModelPortal:   Q2N6B2
- SMR:   Q2N6B2
- STRING:   Q2N6B2
- GeneID:   3871010
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_13435
- NMPDR:   fig|314225.3.peg.333
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   HWSGFRI
- PhylomeDB:   Q2N6B2
- BioCyc:   ELIT314225:ELI_13435-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 24124; Mature: 24124

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 57-57 BINDING 60-60 BINDING 62-62 BINDING 79-79 BINDING 119-119 BINDING 123-123 BINDING 127-127

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSEESIMTDLATSEIPETDPFALFAEWMEEARASELNDPNAMALATATPDGAPSVRMVL
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEE
LKDHGPQGFTFYTNAESRKGEEIRANAQTALLFHWKSLRRQIRVEGPVREVAPEVADAYF
EECCCCCCEEEEECCCCCCCCHHHCCCHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHH
HSRARESQLGAVASDQSRPLEDRRVFVDRFRAAQERFDEGEVERPAYWTGFTVTPQRIEF
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCEECCHHHHHE
WCDRPNRLHDRRLFTLSGAGDALSWTSTLLYP
EECCCCCCCCCEEEEEECCCCCHHHHHHCCCC
>Mature Secondary Structure
MQSEESIMTDLATSEIPETDPFALFAEWMEEARASELNDPNAMALATATPDGAPSVRMVL
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEE
LKDHGPQGFTFYTNAESRKGEEIRANAQTALLFHWKSLRRQIRVEGPVREVAPEVADAYF
EECCCCCCEEEEECCCCCCCCHHHCCCHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHH
HSRARESQLGAVASDQSRPLEDRRVFVDRFRAAQERFDEGEVERPAYWTGFTVTPQRIEF
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCEECCHHHHHE
WCDRPNRLHDRRLFTLSGAGDALSWTSTLLYP
EECCCCCCCCCEEEEEECCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA