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The map label for this gene is galE [C]

Identifier: 85375481

GI number: 85375481

Start: 2671445

End: 2672533

Strand: Reverse

Name: galE [C]

Synonym: ELI_13270

Alternate gene names: 85375481

Gene position: 2672533-2671445 (Counterclockwise)

Preceding gene: 85375488

Following gene: 85375471

Centisome position: 87.56

GC content: 56.2

Gene sequence:

>1089_bases
TTGTGGCCGACGGTCGATGAAAGGCATCAGCGATTTTTCGAAACTTCGATGCTAGAGAAGCTACTCGATCGATTCAGGGG
CATGATGACAAAACGAATTCTCGTCACTGGCGCAGCAGGTTTCATCGGGGCGGCGCTGTGCGTCCGCCTCGCATCTGAAG
GCCACCGAGTGTTCGGTATCGACAACCTGAACTCCTATTACGATCCGCAACTCAAGCGCGACCGGTTGTCGGAAATCGAG
GCAATTGCCGGGGAGGCCTTTACTTTCAGCCAGTGCGATTTTGCCGACAGAGCTTCTTTCGCAAACTGTCTGGCGGACTT
GGATATCTCGCGAATCGCCCACCTCGGAGCGCAACCCGGTGTCCGCTACTCGCTCGAGAATCCCCACGCCTATATCGAGG
CGAACATCGTTGGGCACCTCAACATGCTGGAGTTTGCCCGAGAGCGGCAGGTCGAACATCTTGTCTACGCCAGTTCCAGC
TCGGTCTATGGCGGCAATGAGAAAGTGCCCTTCTCCGTGGATGATCGCGTCGATCACCCTTTCTCGCTCTACGCCGCGAC
CAAGAAGGCAGACGAGTTGATGAGTGAAACCTACGCTCATCTCTACCGCATCCCCCAAACCGGTCTTCGCTTTTTCACTG
TTTACGGGCCTTGGGGACGGCCCGATATGATGCCGTGGATATTCACCGCGAAGATCCTGCGCGGCGAGCCGATCCCCGTC
TTCAACCATGGGAAGATGCAGCGAGACTTTACCTTTATCGACGATATCGTGTCTGGCATTGTCGCTTGCCTTGGCAGCCC
TCCTGCCGACGACGGAACGCTGAAGCCTGGTGGCAGCACCAAGCCCCATGCAATTTATAACATCGGCAACAATCGACCCG
AACAGCTTTTGGATGTCATCGCCATCATTGAGCGGGCGTGCGGACGCAAGGCGGAGATCGAAATGCTACCGATGCAAAAA
GGCGACGTGCCCCGCACATATGCCGATATCGAGGCGATGGAGCGCGATCACGGCTATTCGCCCACTACGCCAGTCGATGT
CGGTTTTCCGCGGTTTGTCGAGTGGTTCAAATCTTATCACGGGATCTGA

Upstream 100 bases:

>100_bases
ACGCATTCAAAACCATCCCTCGTTAGGTTCGGTCTAATGGAAGTTCGCGAATTGCCTTCGCAGATCGGCGTAAACATAAC
GGTAACGACGTTGCGGCTCA

Downstream 100 bases:

>100_bases
TAGTGCCGCTCAGCGCGCCAGCAGGTCCGCGATGCGCGCTGCGGATTTGCCGTCGCCGAAGGGATTGTGCGCCCGCGCCA
TGGCGGCGTAGGCGGAATCG

Product: nucleotide sugar epimerase

Products: UDP-L-iduronate

Alternate protein names: ORF2 [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MWPTVDERHQRFFETSMLEKLLDRFRGMMTKRILVTGAAGFIGAALCVRLASEGHRVFGIDNLNSYYDPQLKRDRLSEIE
AIAGEAFTFSQCDFADRASFANCLADLDISRIAHLGAQPGVRYSLENPHAYIEANIVGHLNMLEFARERQVEHLVYASSS
SVYGGNEKVPFSVDDRVDHPFSLYAATKKADELMSETYAHLYRIPQTGLRFFTVYGPWGRPDMMPWIFTAKILRGEPIPV
FNHGKMQRDFTFIDDIVSGIVACLGSPPADDGTLKPGGSTKPHAIYNIGNNRPEQLLDVIAIIERACGRKAEIEMLPMQK
GDVPRTYADIEAMERDHGYSPTTPVDVGFPRFVEWFKSYHGI

Sequences:

>Translated_362_residues
MWPTVDERHQRFFETSMLEKLLDRFRGMMTKRILVTGAAGFIGAALCVRLASEGHRVFGIDNLNSYYDPQLKRDRLSEIE
AIAGEAFTFSQCDFADRASFANCLADLDISRIAHLGAQPGVRYSLENPHAYIEANIVGHLNMLEFARERQVEHLVYASSS
SVYGGNEKVPFSVDDRVDHPFSLYAATKKADELMSETYAHLYRIPQTGLRFFTVYGPWGRPDMMPWIFTAKILRGEPIPV
FNHGKMQRDFTFIDDIVSGIVACLGSPPADDGTLKPGGSTKPHAIYNIGNNRPEQLLDVIAIIERACGRKAEIEMLPMQK
GDVPRTYADIEAMERDHGYSPTTPVDVGFPRFVEWFKSYHGI
>Mature_362_residues
MWPTVDERHQRFFETSMLEKLLDRFRGMMTKRILVTGAAGFIGAALCVRLASEGHRVFGIDNLNSYYDPQLKRDRLSEIE
AIAGEAFTFSQCDFADRASFANCLADLDISRIAHLGAQPGVRYSLENPHAYIEANIVGHLNMLEFARERQVEHLVYASSS
SVYGGNEKVPFSVDDRVDHPFSLYAATKKADELMSETYAHLYRIPQTGLRFFTVYGPWGRPDMMPWIFTAKILRGEPIPV
FNHGKMQRDFTFIDDIVSGIVACLGSPPADDGTLKPGGSTKPHAIYNIGNNRPEQLLDVIAIIERACGRKAEIEMLPMQK
GDVPRTYADIEAMERDHGYSPTTPVDVGFPRFVEWFKSYHGI

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=337, Percent_Identity=27.893175074184, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI56237023, Length=352, Percent_Identity=23.5795454545455, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI56118217, Length=352, Percent_Identity=23.5795454545455, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI189083684, Length=352, Percent_Identity=23.5795454545455, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI7657641, Length=343, Percent_Identity=26.8221574344023, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1786974, Length=334, Percent_Identity=27.8443113772455, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788353, Length=354, Percent_Identity=24.2937853107345, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI48994969, Length=356, Percent_Identity=25.2808988764045, Blast_Score=102, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71982035, Length=334, Percent_Identity=23.6526946107784, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71982038, Length=336, Percent_Identity=23.5119047619048, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17539532, Length=347, Percent_Identity=25.9365994236311, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17568069, Length=342, Percent_Identity=23.0994152046784, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI115532424, Length=337, Percent_Identity=25.2225519287834, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319493, Length=352, Percent_Identity=23.2954545454545, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI19923002, Length=338, Percent_Identity=26.9230769230769, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI21356223, Length=339, Percent_Identity=27.4336283185841, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: 5.1.3.12

Molecular weight: Translated: 40778; Mature: 40778

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWPTVDERHQRFFETSMLEKLLDRFRGMMTKRILVTGAAGFIGAALCVRLASEGHRVFGI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHCCCEEEEE
DNLNSYYDPQLKRDRLSEIEAIAGEAFTFSQCDFADRASFANCLADLDISRIAHLGAQPG
CCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHCCHHHHHHCCCCCC
VRYSLENPHAYIEANIVGHLNMLEFARERQVEHLVYASSSSVYGGNEKVPFSVDDRVDHP
CEEECCCCCEEEEEEEHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCC
FSLYAATKKADELMSETYAHLYRIPQTGLRFFTVYGPWGRPDMMPWIFTAKILRGEPIPV
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCE
FNHGKMQRDFTFIDDIVSGIVACLGSPPADDGTLKPGGSTKPHAIYNIGNNRPEQLLDVI
ECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHH
AIIERACGRKAEIEMLPMQKGDVPRTYADIEAMERDHGYSPTTPVDVGFPRFVEWFKSYH
HHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHC
GI
CC
>Mature Secondary Structure
MWPTVDERHQRFFETSMLEKLLDRFRGMMTKRILVTGAAGFIGAALCVRLASEGHRVFGI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHCCCEEEEE
DNLNSYYDPQLKRDRLSEIEAIAGEAFTFSQCDFADRASFANCLADLDISRIAHLGAQPG
CCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHCCHHHHHHCCCCCC
VRYSLENPHAYIEANIVGHLNMLEFARERQVEHLVYASSSSVYGGNEKVPFSVDDRVDHP
CEEECCCCCEEEEEEEHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCC
FSLYAATKKADELMSETYAHLYRIPQTGLRFFTVYGPWGRPDMMPWIFTAKILRGEPIPV
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCE
FNHGKMQRDFTFIDDIVSGIVACLGSPPADDGTLKPGGSTKPHAIYNIGNNRPEQLLDVI
ECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHH
AIIERACGRKAEIEMLPMQKGDVPRTYADIEAMERDHGYSPTTPVDVGFPRFVEWFKSYH
HHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHC
GI
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-glucuronate

Specific reaction: UDP-glucuronate = UDP-L-iduronate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7682279 [H]