Click here to switch to the map view.

The map label for this gene is ggt [H]

Identifier: 85375391

GI number: 85375391

Start: 2588279

End: 2590009

Strand: Direct

Name: ggt [H]

Synonym: ELI_12820

Alternate gene names: 85375391

Gene position: 2588279-2590009 (Clockwise)

Preceding gene: 85375390

Following gene: 85375392

Centisome position: 84.79

GC content: 67.76

Gene sequence:

>1731_bases
ATGACAATTCGCCAAATCCTCGCCTCTCTCGCCGCGCTTGCCCTTGTCGGATGCGCCAATGCCTATGCCGAAGAGCCGGT
TGTTGCGCAGCAGGCTGCGCCTGCCTTCGCAGGAACGGTCGCCTCGGCCGATCCGCGCGCCACGGCTGCGGGGGAAGAGA
TGTTGCGCCGCGGCGGCAGCGCGACCGATGCCGCCATTGCCACGATGATCGCGCTGACGGTGGTCGAACCGCAAAGTTCG
GGCATCGGCGGCGGTGGCTTCATCGTGCGCGGGTCGCCCGACGGGACCGTCACCAGTTACGACGGGCGCGAGACGGCCCC
CGCAGGAGCGACACCCGACTGGTTCCTCGGCGAAGACGGTGAGCCCCTGCCGGGCCGCGAAGCGGTACTGTCGGGCCTCA
GCATCGGCGTGCCGGGCAATATCGACGTCGCCCGGCGCGCGCATGACGAGCACGGCAAGCTGCCTTGGGCGACGCTGTTC
GAGCCGGCGATCCGGCTGGCACGCGAGGGCTTCGTCCTCAATCCGCGCCTCAATGCTTCGCTCGACGGCTATGCCGATCG
CGCCGGGCTGACAGAAGGCGGCAGGGCAACTTTTTACGCCGATGACGAGATGCCCAAGGCAGTCGGCGCGCGCATCGTGC
AGGAAGAATTGGCGCAGACGCTCGAAGCCATCGCCGCGAACGGGCCGGAATGGTTCTACGACAGCGAATTCGGCGCAGGC
CTCGCAGAGACCGTTGCCGCCGCCACACCGCGCGAAGGCAAGATGACGACCGAGGACGTCGCGACGTACTCGTCGAAAGA
GCGACCTGCCGTTTGCGGCACCTATCGCCGACACAAGGTCTGCGGCATGGGCCCGCCCTCTTCCGGCGGCATCGCGGTCA
TCCAGATCCTCAAGCAGCTCGAACGTTTCGACCTTGCGGCGATGGGAGCGCAATCGCCCGAAGTCTGGCACCTGTTCGTT
GAGTCGCAGCGCCTCGCCTATGCCGATCGCGAACTCTACACCGGCGACAGCGACTTCGTGGACGTACCAGTCGAAGGGCT
CGTCGCTCCGGCCTATCTTGCCGCGCGCTCGCAATTGATCGATCCCGCAGCGCGCACCGATGAAGTCGAGGCCGGCCAGC
CCCCGCGCGCTCCGCAGGCCCGCGCCACCGGCGAGCACTATCCCGACAGCGGTACGACGCATCTGGTCGCGGTTGGCCCC
GACGGCACCATGGTCAGTTACACCTCCACCATCGAGGGCGCCTTCGGTTCGGGCTACATGTATGGCGGTTTCTACCTCAA
CAACGAGCTGACCGATTTCAGCTTCCGCCCGGAACGCGACGGCGTGCCGGTCGCCAATAGGGTCGAAGGCGGCAAGCGGC
CGCGCAGCTCGATGGCGCCGACGGTCGTCTACGATCCGCAAGGCAAGCCGCTGCTCGCCATCGGGGCCGCCGGCGGCCCG
ACCATCCCGATCCAGACCGCGCGCTCGATCATCGGCGTGATCGACTTCGGGATGGAGCTGGAAGACGCGCTCGCCCTGCC
GATGATCATGGCCTTCGGCGACCGGGTCATCGTGGAGGAAGACACGTGGCTGGCCGGGGCGATCCCGGCGCTCAACGCGC
TCGGCCACGAGCAGGTCGTCACCAGCGGCTTCCTCTTCCGCACCAATGCCGCAATGCGCACGCCGCAAGGCTGGGTCGCG
CGGCACGACCTGCGGCTAGACCCGCTGCTGGCCATGCCGGGGCCAGAGTGA

Upstream 100 bases:

>100_bases
GCCTCGGGCGCTCCATCGCGCGCGGGCTTTCGCGCAAATTGCGCGAACACGGCATGGCTTCGATTGAAGAAGCGGTCGGA
AGCGAATAGCACGCCTTGCC

Downstream 100 bases:

>100_bases
TCCGGCTTGCCGCTACGGCAGCAGCCCCCTAGAAGCGCCGCGATAGTTACAACAGCAACAATTTTCCTTCGGAGCAGGAG
CGCTTGATGGTGCAACTGGG

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 576; Mature: 575

Protein sequence:

>576_residues
MTIRQILASLAALALVGCANAYAEEPVVAQQAAPAFAGTVASADPRATAAGEEMLRRGGSATDAAIATMIALTVVEPQSS
GIGGGGFIVRGSPDGTVTSYDGRETAPAGATPDWFLGEDGEPLPGREAVLSGLSIGVPGNIDVARRAHDEHGKLPWATLF
EPAIRLAREGFVLNPRLNASLDGYADRAGLTEGGRATFYADDEMPKAVGARIVQEELAQTLEAIAANGPEWFYDSEFGAG
LAETVAAATPREGKMTTEDVATYSSKERPAVCGTYRRHKVCGMGPPSSGGIAVIQILKQLERFDLAAMGAQSPEVWHLFV
ESQRLAYADRELYTGDSDFVDVPVEGLVAPAYLAARSQLIDPAARTDEVEAGQPPRAPQARATGEHYPDSGTTHLVAVGP
DGTMVSYTSTIEGAFGSGYMYGGFYLNNELTDFSFRPERDGVPVANRVEGGKRPRSSMAPTVVYDPQGKPLLAIGAAGGP
TIPIQTARSIIGVIDFGMELEDALALPMIMAFGDRVIVEEDTWLAGAIPALNALGHEQVVTSGFLFRTNAAMRTPQGWVA
RHDLRLDPLLAMPGPE

Sequences:

>Translated_576_residues
MTIRQILASLAALALVGCANAYAEEPVVAQQAAPAFAGTVASADPRATAAGEEMLRRGGSATDAAIATMIALTVVEPQSS
GIGGGGFIVRGSPDGTVTSYDGRETAPAGATPDWFLGEDGEPLPGREAVLSGLSIGVPGNIDVARRAHDEHGKLPWATLF
EPAIRLAREGFVLNPRLNASLDGYADRAGLTEGGRATFYADDEMPKAVGARIVQEELAQTLEAIAANGPEWFYDSEFGAG
LAETVAAATPREGKMTTEDVATYSSKERPAVCGTYRRHKVCGMGPPSSGGIAVIQILKQLERFDLAAMGAQSPEVWHLFV
ESQRLAYADRELYTGDSDFVDVPVEGLVAPAYLAARSQLIDPAARTDEVEAGQPPRAPQARATGEHYPDSGTTHLVAVGP
DGTMVSYTSTIEGAFGSGYMYGGFYLNNELTDFSFRPERDGVPVANRVEGGKRPRSSMAPTVVYDPQGKPLLAIGAAGGP
TIPIQTARSIIGVIDFGMELEDALALPMIMAFGDRVIVEEDTWLAGAIPALNALGHEQVVTSGFLFRTNAAMRTPQGWVA
RHDLRLDPLLAMPGPE
>Mature_575_residues
TIRQILASLAALALVGCANAYAEEPVVAQQAAPAFAGTVASADPRATAAGEEMLRRGGSATDAAIATMIALTVVEPQSSG
IGGGGFIVRGSPDGTVTSYDGRETAPAGATPDWFLGEDGEPLPGREAVLSGLSIGVPGNIDVARRAHDEHGKLPWATLFE
PAIRLAREGFVLNPRLNASLDGYADRAGLTEGGRATFYADDEMPKAVGARIVQEELAQTLEAIAANGPEWFYDSEFGAGL
AETVAAATPREGKMTTEDVATYSSKERPAVCGTYRRHKVCGMGPPSSGGIAVIQILKQLERFDLAAMGAQSPEVWHLFVE
SQRLAYADRELYTGDSDFVDVPVEGLVAPAYLAARSQLIDPAARTDEVEAGQPPRAPQARATGEHYPDSGTTHLVAVGPD
GTMVSYTSTIEGAFGSGYMYGGFYLNNELTDFSFRPERDGVPVANRVEGGKRPRSSMAPTVVYDPQGKPLLAIGAAGGPT
IPIQTARSIIGVIDFGMELEDALALPMIMAFGDRVIVEEDTWLAGAIPALNALGHEQVVTSGFLFRTNAAMRTPQGWVAR
HDLRLDPLLAMPGPE

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=545, Percent_Identity=31.9266055045872, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI73915090, Length=545, Percent_Identity=31.9266055045872, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI73915096, Length=545, Percent_Identity=31.9266055045872, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI73915094, Length=545, Percent_Identity=31.9266055045872, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI113429324, Length=534, Percent_Identity=31.6479400749064, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI113429326, Length=536, Percent_Identity=31.1567164179104, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI153266885, Length=553, Percent_Identity=30.1989150090416, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI153266901, Length=554, Percent_Identity=29.7833935018051, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI153266907, Length=551, Percent_Identity=28.4936479128857, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI109148539, Length=501, Percent_Identity=30.7385229540918, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI30581157, Length=190, Percent_Identity=36.8421052631579, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI30581155, Length=190, Percent_Identity=36.8421052631579, Blast_Score=89, Evalue=8e-18,
Organism=Escherichia coli, GI1789856, Length=497, Percent_Identity=38.2293762575453, Blast_Score=291, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI72000294, Length=497, Percent_Identity=31.58953722334, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI212646519, Length=497, Percent_Identity=31.58953722334, Blast_Score=178, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI193208247, Length=491, Percent_Identity=29.1242362525458, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI193208245, Length=491, Percent_Identity=29.1242362525458, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17542894, Length=525, Percent_Identity=28.7619047619048, Blast_Score=152, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17506189, Length=465, Percent_Identity=28.1720430107527, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17564448, Length=430, Percent_Identity=24.4186046511628, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323330, Length=500, Percent_Identity=26.8, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI18859893, Length=478, Percent_Identity=33.2635983263598, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI161077496, Length=474, Percent_Identity=31.6455696202532, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI161077880, Length=523, Percent_Identity=28.4894837476099, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI161077878, Length=523, Percent_Identity=28.4894837476099, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24642670, Length=523, Percent_Identity=28.4894837476099, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24642666, Length=523, Percent_Identity=28.4894837476099, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI45551474, Length=523, Percent_Identity=28.4894837476099, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI18859741, Length=458, Percent_Identity=28.1659388646288, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 60683; Mature: 60552

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRQILASLAALALVGCANAYAEEPVVAQQAAPAFAGTVASADPRATAAGEEMLRRGGS
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHCCCCCCCCCHHHHHHHHHHCCCC
ATDAAIATMIALTVVEPQSSGIGGGGFIVRGSPDGTVTSYDGRETAPAGATPDWFLGEDG
CHHHHHHHHHHHEEECCCCCCCCCCEEEEECCCCCCEEECCCCCCCCCCCCCCCCCCCCC
EPLPGREAVLSGLSIGVPGNIDVARRAHDEHGKLPWATLFEPAIRLAREGFVLNPRLNAS
CCCCCHHHHHCCCEECCCCCCHHHHHCCHHCCCCCHHHHHHHHHHHHHCCEEECCCCCCC
LDGYADRAGLTEGGRATFYADDEMPKAVGARIVQEELAQTLEAIAANGPEWFYDSEFGAG
CCCCHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCC
LAETVAAATPREGKMTTEDVATYSSKERPAVCGTYRRHKVCGMGPPSSGGIAVIQILKQL
HHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHH
ERFDLAAMGAQSPEVWHLFVESQRLAYADRELYTGDSDFVDVPVEGLVAPAYLAARSQLI
HHHHHHHCCCCCCCEEEEEECCCHHHHHCCCEECCCCCEEECCHHHHHHHHHHHHHHHHC
DPAARTDEVEAGQPPRAPQARATGEHYPDSGTTHLVAVGPDGTMVSYTSTIEGAFGSGYM
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCEE
YGGFYLNNELTDFSFRPERDGVPVANRVEGGKRPRSSMAPTVVYDPQGKPLLAIGAAGGP
EEEEEECCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCEEEECCCCCEEEEEECCCCC
TIPIQTARSIIGVIDFGMELEDALALPMIMAFGDRVIVEEDTWLAGAIPALNALGHEQVV
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCHHHH
TSGFLFRTNAAMRTPQGWVARHDLRLDPLLAMPGPE
HCCEEEECCCCCCCCCCCCEECCCCCCCEECCCCCC
>Mature Secondary Structure 
TIRQILASLAALALVGCANAYAEEPVVAQQAAPAFAGTVASADPRATAAGEEMLRRGGS
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHCCCCCCCCCHHHHHHHHHHCCCC
ATDAAIATMIALTVVEPQSSGIGGGGFIVRGSPDGTVTSYDGRETAPAGATPDWFLGEDG
CHHHHHHHHHHHEEECCCCCCCCCCEEEEECCCCCCEEECCCCCCCCCCCCCCCCCCCCC
EPLPGREAVLSGLSIGVPGNIDVARRAHDEHGKLPWATLFEPAIRLAREGFVLNPRLNAS
CCCCCHHHHHCCCEECCCCCCHHHHHCCHHCCCCCHHHHHHHHHHHHHCCEEECCCCCCC
LDGYADRAGLTEGGRATFYADDEMPKAVGARIVQEELAQTLEAIAANGPEWFYDSEFGAG
CCCCHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCC
LAETVAAATPREGKMTTEDVATYSSKERPAVCGTYRRHKVCGMGPPSSGGIAVIQILKQL
HHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHH
ERFDLAAMGAQSPEVWHLFVESQRLAYADRELYTGDSDFVDVPVEGLVAPAYLAARSQLI
HHHHHHHCCCCCCCEEEEEECCCHHHHHCCCEECCCCCEEECCHHHHHHHHHHHHHHHHC
DPAARTDEVEAGQPPRAPQARATGEHYPDSGTTHLVAVGPDGTMVSYTSTIEGAFGSGYM
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCEE
YGGFYLNNELTDFSFRPERDGVPVANRVEGGKRPRSSMAPTVVYDPQGKPLLAIGAAGGP
EEEEEECCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCEEEECCCCCEEEEEECCCCC
TIPIQTARSIIGVIDFGMELEDALALPMIMAFGDRVIVEEDTWLAGAIPALNALGHEQVV
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCHHHH
TSGFLFRTNAAMRTPQGWVARHDLRLDPLLAMPGPE
HCCEEEECCCCCCCCCCCCEECCCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA