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The map label for this gene is csd [H]

Identifier: 85375377

GI number: 85375377

Start: 2576118

End: 2577317

Strand: Reverse

Name: csd [H]

Synonym: ELI_12750

Alternate gene names: 85375377

Gene position: 2577317-2576118 (Counterclockwise)

Preceding gene: 85375378

Following gene: 85375376

Centisome position: 84.44

GC content: 63.75

Gene sequence:

>1200_bases
GTGGGCGTACGGTGCGACTTCCCGGGTCTTGTCACCCCCGATGGCAAGCGGTGGCACTATCTCGACACTGCCGCGACCGC
GCAAAAGCCGCAGGCGGTGATCAATGCCATGAGCCGCGCGCTGGGCGAGGATTACGCTACGGTCCACCGCGGGGTCTATG
CGCGCTCGGCCGACATGACCGTCGCCTACGAAGCGGCCCGCAAGCGCACCGCCGAGTTTCTCGGTGCCAAAAGCGAGAAT
GAAATCGTTTTCGTGCGCGGCGCGACCGAGGGGATCAATCTCGTCGCGCACAGCTGGGGCCTTGCGAATCTGAAGGCCGG
CGACCGCATCATGCTGAGCCAGCTCGAACATCACTCCAACATCGTACCGTGGCAGATGGTGGCCGAGCGGGTCGGCGCAG
AAATCGACGTCTGTCCGCTGACCGAAGATGGCCTGATCGATCTGGACTGGCTCGAAGCCAACCTGACCGAGCAGCATGCC
ATCGTCGCGCTGGCGCATGTCTCCAATGTGCTCGGCTCGGTACTGGGCGCGAAGCGCGCGGCCAAGGCAGCGCATGCAGT
CGGGGCAAAGCTGCTCCTCGACGGCTGCCAGTCGGCCCCGCGCATGCGGCTCAACATGGCCGAGCTCGATTGCGACTTCT
TCGTTTTCTCCGGCCACAAAATATACGGCCCGACCGGTATCGGCGTGCTGTGGGCGCGCGAGGAACTGCTCGATGCCATG
CCGCCGTACCAGGGTGGCGGGTCGATGATCGACAAGGTCACATTCGAACAAACCACCTATGCTCCGCCACCGCAGCGCTT
CGAAGCGGGAACGCCGATGATCACCGAAGCGATCGCGCTGCATGCGGCGATCGATTACACCACCCAGTTTGGCATGGAGA
GCCTCTACGCGCACGAGAACGGGCTGGTGCGGCAAGCGCGCGAGGTGTTGAGCCAGATCAACTCGATCCGCCTGTTCGGC
CCCGAATCCTCCGCCGGAATCCTGTCTTTCACCATGGAGGGGGTGCATCCGCACGACCTCGGCACCATATTGGATGAAGA
GAATGTCGCGATTCGGGCCGGGCACCACTGCTGCCAGCCGCTGATGGACTATCTCGGCGTACCCGCGACGGCGCGGGCCA
GCTTCGGCCTTTACAGCGACGAAAGCGACATCGACGCGCTGCTGCGCGGCATTGAACGAACCCAGAGGATCTTCGGATGA

Upstream 100 bases:

>100_bases
GCCAACTTCCGTACGCCCTGAGCCTGTCGAAGGGCAGGCGAAACGCTTGGGCGCGGAGCAAGGCGGTGGCTGGGCTTCGA
CAGGCTCAGCCCGAACGGGC

Downstream 100 bases:

>100_bases
ACAAGCCCAGCGACGAGAAGGACTTTGTCGCCGCCCCCGCGCCGAACGAGGAAGTGCTGCGCGAAGCACCGCCCAAGCCG
CCGCGTGCCAGAGTCGAGGA

Product: selenocysteine lyase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MGVRCDFPGLVTPDGKRWHYLDTAATAQKPQAVINAMSRALGEDYATVHRGVYARSADMTVAYEAARKRTAEFLGAKSEN
EIVFVRGATEGINLVAHSWGLANLKAGDRIMLSQLEHHSNIVPWQMVAERVGAEIDVCPLTEDGLIDLDWLEANLTEQHA
IVALAHVSNVLGSVLGAKRAAKAAHAVGAKLLLDGCQSAPRMRLNMAELDCDFFVFSGHKIYGPTGIGVLWAREELLDAM
PPYQGGGSMIDKVTFEQTTYAPPPQRFEAGTPMITEAIALHAAIDYTTQFGMESLYAHENGLVRQAREVLSQINSIRLFG
PESSAGILSFTMEGVHPHDLGTILDEENVAIRAGHHCCQPLMDYLGVPATARASFGLYSDESDIDALLRGIERTQRIFG

Sequences:

>Translated_399_residues
MGVRCDFPGLVTPDGKRWHYLDTAATAQKPQAVINAMSRALGEDYATVHRGVYARSADMTVAYEAARKRTAEFLGAKSEN
EIVFVRGATEGINLVAHSWGLANLKAGDRIMLSQLEHHSNIVPWQMVAERVGAEIDVCPLTEDGLIDLDWLEANLTEQHA
IVALAHVSNVLGSVLGAKRAAKAAHAVGAKLLLDGCQSAPRMRLNMAELDCDFFVFSGHKIYGPTGIGVLWAREELLDAM
PPYQGGGSMIDKVTFEQTTYAPPPQRFEAGTPMITEAIALHAAIDYTTQFGMESLYAHENGLVRQAREVLSQINSIRLFG
PESSAGILSFTMEGVHPHDLGTILDEENVAIRAGHHCCQPLMDYLGVPATARASFGLYSDESDIDALLRGIERTQRIFG
>Mature_398_residues
GVRCDFPGLVTPDGKRWHYLDTAATAQKPQAVINAMSRALGEDYATVHRGVYARSADMTVAYEAARKRTAEFLGAKSENE
IVFVRGATEGINLVAHSWGLANLKAGDRIMLSQLEHHSNIVPWQMVAERVGAEIDVCPLTEDGLIDLDWLEANLTEQHAI
VALAHVSNVLGSVLGAKRAAKAAHAVGAKLLLDGCQSAPRMRLNMAELDCDFFVFSGHKIYGPTGIGVLWAREELLDAMP
PYQGGGSMIDKVTFEQTTYAPPPQRFEAGTPMITEAIALHAAIDYTTQFGMESLYAHENGLVRQAREVLSQINSIRLFGP
ESSAGILSFTMEGVHPHDLGTILDEENVAIRAGHHCCQPLMDYLGVPATARASFGLYSDESDIDALLRGIERTQRIFG

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=231, Percent_Identity=26.8398268398268, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1787970, Length=399, Percent_Identity=46.3659147869674, Blast_Score=377, Evalue=1e-106,
Organism=Escherichia coli, GI1789175, Length=374, Percent_Identity=41.4438502673797, Blast_Score=300, Evalue=9e-83,
Organism=Escherichia coli, GI48994898, Length=176, Percent_Identity=35.7954545454545, Blast_Score=98, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI25143064, Length=223, Percent_Identity=24.6636771300448, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI193211090, Length=413, Percent_Identity=23.2445520581114, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319831, Length=249, Percent_Identity=26.5060240963855, Blast_Score=90, Evalue=8e-19,
Organism=Drosophila melanogaster, GI20129463, Length=230, Percent_Identity=29.5652173913043, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 43414; Mature: 43283

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVRCDFPGLVTPDGKRWHYLDTAATAQKPQAVINAMSRALGEDYATVHRGVYARSADMT
CCCCCCCCCCCCCCCCEEEEECCHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
VAYEAARKRTAEFLGAKSENEIVFVRGATEGINLVAHSWGLANLKAGDRIMLSQLEHHSN
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCC
IVPWQMVAERVGAEIDVCPLTEDGLIDLDWLEANLTEQHAIVALAHVSNVLGSVLGAKRA
CCCHHHHHHHHCCCEEEECCCCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AKAAHAVGAKLLLDGCQSAPRMRLNMAELDCDFFVFSGHKIYGPTGIGVLWAREELLDAM
HHHHHHHHHHHHHHHHCCCCCEEEEHHHCCCEEEEEECCEEECCCCCCHHHHHHHHHHHC
PPYQGGGSMIDKVTFEQTTYAPPPQRFEAGTPMITEAIALHAAIDYTTQFGMESLYAHEN
CCCCCCCCHHHHEEECCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GLVRQAREVLSQINSIRLFGPESSAGILSFTMEGVHPHDLGTILDEENVAIRAGHHCCQP
CHHHHHHHHHHHHHCEEEECCCCCCCEEEEEECCCCCCHHHHHCCCCCEEEECCHHHHHH
LMDYLGVPATARASFGLYSDESDIDALLRGIERTQRIFG
HHHHHCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GVRCDFPGLVTPDGKRWHYLDTAATAQKPQAVINAMSRALGEDYATVHRGVYARSADMT
CCCCCCCCCCCCCCCEEEEECCHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCC
VAYEAARKRTAEFLGAKSENEIVFVRGATEGINLVAHSWGLANLKAGDRIMLSQLEHHSN
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCC
IVPWQMVAERVGAEIDVCPLTEDGLIDLDWLEANLTEQHAIVALAHVSNVLGSVLGAKRA
CCCHHHHHHHHCCCEEEECCCCCCEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AKAAHAVGAKLLLDGCQSAPRMRLNMAELDCDFFVFSGHKIYGPTGIGVLWAREELLDAM
HHHHHHHHHHHHHHHHCCCCCEEEEHHHCCCEEEEEECCEEECCCCCCHHHHHHHHHHHC
PPYQGGGSMIDKVTFEQTTYAPPPQRFEAGTPMITEAIALHAAIDYTTQFGMESLYAHEN
CCCCCCCCHHHHEEECCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GLVRQAREVLSQINSIRLFGPESSAGILSFTMEGVHPHDLGTILDEENVAIRAGHHCCQP
CHHHHHHHHHHHHHCEEEECCCCCCCEEEEEECCCCCCHHHHHCCCCCEEEECCHHHHHH
LMDYLGVPATARASFGLYSDESDIDALLRGIERTQRIFG
HHHHHCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]