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The map label for this gene is nadC [H]

Identifier: 85375361

GI number: 85375361

Start: 2563929

End: 2564792

Strand: Direct

Name: nadC [H]

Synonym: ELI_12670

Alternate gene names: 85375361

Gene position: 2563929-2564792 (Clockwise)

Preceding gene: 85375359

Following gene: 85375362

Centisome position: 84.0

GC content: 67.01

Gene sequence:

>864_bases
ATGAGCACATTCGACTTGCCCGGCTTCGACCTCGACCGTTTCGTGCGCGACACGCTGGCGGAGGACCTGGGCGAAGGCCT
GCCTGGCGGCGGGCGCGACGTGACCAGCGAGAGCGTGATCCCCGCCGAAGCGCGCTTCGCCGGCGTGATGGACAGCCGCA
ACCCGATAGTGGTTGCGGGTCTCCCCGTCGCCGCAGCTTTCTTCCGCGCGCTCGATCCGGCGATGGCGATCGACATTCTG
GTCGAGGAAGGCGCCGCAGTCGAACCCGGCGCGGACCTGATGCGGCTGGAGGGCAATGCCCGCGCCATGCTGACGGCGGA
GCGCAGTGCGCTCAACACTGTCCAGCACCTCTCGGGCATCGCCACCATGGTGCGCGAGTATGTCGATGCGATGGACAATC
CCGATTGCACGCTGCTCGACACGCGCAAGACCATTCCCGGCCTGCGGCATCTGGAGAAATACGCCACCCGCATGGGCGGG
GCATCGAACCACCGCATGGGGCTGTGGGATGCGGCGATGATCAAGGACAACCACGTGCTCGTGGCCGGAAACGTCGGCGA
GGCGGTGCGCCGCGCGGTCGCGGCAGGGGTCGAGGAGATCATCTGCGAAGTCGACCGGCTCGACCAGATCGAACCTGCGC
TCCGGGCAGGCGCGACACGGCTGTTGCTCGACAATATGGGGCCCGACACTTTGCGTGAAGCCGTGAGCATCGTGGCAGGC
CGCGTACCGACCGAAGCCAGCGGCGGGATCACTCTCGACACGATCAAGGCCAAGGCCGCGACGGGTGTCGATTACGTTTC
CGTCGGCCGCCTGACCCAGAGCGCGCCCGCCGCCGATATCGGACTGGATTTCACACCGCTGTGA

Upstream 100 bases:

>100_bases
GCCTCGCAGTCGGAGTGGCGTTCGCTGTATCAATGGATCGCGCAAGGCCCCGTTCCGCTGCGCTTGAGAATGCAGGCAAA
ATCGCGCAGGACGTGCCGCC

Downstream 100 bases:

>100_bases
GATTTGCCCTTCTTCATCATCGCGAGCGACGCAGTCGCGTGGCGATCCATGGAGCCGCCGCCGCTTTGCTCGCTTTGAGC
CATGGATTGCCGCGGCGCTT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MSTFDLPGFDLDRFVRDTLAEDLGEGLPGGGRDVTSESVIPAEARFAGVMDSRNPIVVAGLPVAAAFFRALDPAMAIDIL
VEEGAAVEPGADLMRLEGNARAMLTAERSALNTVQHLSGIATMVREYVDAMDNPDCTLLDTRKTIPGLRHLEKYATRMGG
ASNHRMGLWDAAMIKDNHVLVAGNVGEAVRRAVAAGVEEIICEVDRLDQIEPALRAGATRLLLDNMGPDTLREAVSIVAG
RVPTEASGGITLDTIKAKAATGVDYVSVGRLTQSAPAADIGLDFTPL

Sequences:

>Translated_287_residues
MSTFDLPGFDLDRFVRDTLAEDLGEGLPGGGRDVTSESVIPAEARFAGVMDSRNPIVVAGLPVAAAFFRALDPAMAIDIL
VEEGAAVEPGADLMRLEGNARAMLTAERSALNTVQHLSGIATMVREYVDAMDNPDCTLLDTRKTIPGLRHLEKYATRMGG
ASNHRMGLWDAAMIKDNHVLVAGNVGEAVRRAVAAGVEEIICEVDRLDQIEPALRAGATRLLLDNMGPDTLREAVSIVAG
RVPTEASGGITLDTIKAKAATGVDYVSVGRLTQSAPAADIGLDFTPL
>Mature_286_residues
STFDLPGFDLDRFVRDTLAEDLGEGLPGGGRDVTSESVIPAEARFAGVMDSRNPIVVAGLPVAAAFFRALDPAMAIDILV
EEGAAVEPGADLMRLEGNARAMLTAERSALNTVQHLSGIATMVREYVDAMDNPDCTLLDTRKTIPGLRHLEKYATRMGGA
SNHRMGLWDAAMIKDNHVLVAGNVGEAVRRAVAAGVEEIICEVDRLDQIEPALRAGATRLLLDNMGPDTLREAVSIVAGR
VPTEASGGITLDTIKAKAATGVDYVSVGRLTQSAPAADIGLDFTPL

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=286, Percent_Identity=35.6643356643357, Blast_Score=136, Evalue=2e-32,
Organism=Escherichia coli, GI1786299, Length=284, Percent_Identity=38.7323943661972, Blast_Score=171, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6321162, Length=242, Percent_Identity=31.404958677686, Blast_Score=117, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30319; Mature: 30188

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTFDLPGFDLDRFVRDTLAEDLGEGLPGGGRDVTSESVIPAEARFAGVMDSRNPIVVAG
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEC
LPVAAAFFRALDPAMAIDILVEEGAAVEPGADLMRLEGNARAMLTAERSALNTVQHLSGI
HHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCHHEEECCCCEEEEEHHHHHHHHHHHHHHH
ATMVREYVDAMDNPDCTLLDTRKTIPGLRHLEKYATRMGGASNHRMGLWDAAMIKDNHVL
HHHHHHHHHHCCCCCCEEEECHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHEECCCCEE
VAGNVGEAVRRAVAAGVEEIICEVDRLDQIEPALRAGATRLLLDNMGPDTLREAVSIVAG
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHC
RVPTEASGGITLDTIKAKAATGVDYVSVGRLTQSAPAADIGLDFTPL
CCCCCCCCCEEEEEEHHHHHCCCCHHHHCCHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
STFDLPGFDLDRFVRDTLAEDLGEGLPGGGRDVTSESVIPAEARFAGVMDSRNPIVVAG
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEC
LPVAAAFFRALDPAMAIDILVEEGAAVEPGADLMRLEGNARAMLTAERSALNTVQHLSGI
HHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCHHEEECCCCEEEEEHHHHHHHHHHHHHHH
ATMVREYVDAMDNPDCTLLDTRKTIPGLRHLEKYATRMGGASNHRMGLWDAAMIKDNHVL
HHHHHHHHHHCCCCCCEEEECHHHCCHHHHHHHHHHHHCCCCCCCCCCHHHHEECCCCEE
VAGNVGEAVRRAVAAGVEEIICEVDRLDQIEPALRAGATRLLLDNMGPDTLREAVSIVAG
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHC
RVPTEASGGITLDTIKAKAATGVDYVSVGRLTQSAPAADIGLDFTPL
CCCCCCCCCEEEEEEHHHHHCCCCHHHHCCHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]