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The map label for this gene is phhA

Identifier: 85375237

GI number: 85375237

Start: 2429780

End: 2430673

Strand: Direct

Name: phhA

Synonym: ELI_12050

Alternate gene names: 85375237

Gene position: 2429780-2430673 (Clockwise)

Preceding gene: 85375235

Following gene: 85375243

Centisome position: 79.6

GC content: 61.07

Gene sequence:

>894_bases
ATGCCCGCGGATGTCTTCACCGCGCCGCTCAAGAGGCCCGAGCACGTCGGCGACGATTGGCTCGAGCCGCAGCAGACGCA
CTATACCAGCGAAGACGACGCGATCTGGAACGACTTGTTCGCGCGCCAGATGGACGTCCTGCCTGGTCGCGCGGCCAGCG
CCTTCATGGCGGGGCTGGAAAAACTGGACCTCGGCAAGGGCGGCGTGCCCGATTTCAAACAAATGTCCGAAGAACTGGGT
AAGCTCACCGGCTGGAGCGTGGTGCCGGTACCGATGCTGATCCCCGATCACGTATTCTTCTGGCACCTGGCCAATCGTCG
TTTTCCGGCCGGCAATTTCATCCGCACGCGCGAGACATTCGACTACATCCAGGAACCCGACGTATTCCACGATGTCTTCG
GCCACGTGCCGATGCTGAGCGATCCGACATTTGCCGACTACATGCAGGAATACGGCAAGGCCGGGTGGAAAGCGATGCGC
TACAATCGCCTGAAAGCGCTGGGCTCGCTTTATTGGTACACGGTCGAGTTCGGGCTGATCGAGGAGGGGCCGGACGACAT
CCGGGCCTATGGCGCGGGCATCCTGTCGGGCCCGACCGAGGCGGTGTTCGCGGTCGAGGCCGAAAGCCCCAACCGCATCA
TGCTCAACGTCGACCGTGTGATGCGTACGGACTACGTCATCAGCGATCTGCAGCCGACCTATTTCGTGATCGAAAGTTTC
GAAGATCTCTATCGCCAGACGGTGGAGCGCGATTTCGACCGGCTCTATCGCAATCTGCCGCCCGCTTTCACCTACGCCAA
TTCGGCCATTATCGATGTCGACAATGTCGTTCATCGCGGCACGCAGGAATATCTGCTTCGCGGCGGGCGAGGGTCAGGAG
CGGCGCCAGTCTGA

Upstream 100 bases:

>100_bases
CTCTCCTTCATTGAAAATACAGGCATCCAATGATATGGTTGCAACTGAAACTATGGCCACTCTAGCACAAGCAGAACAGG
ACTTTAGCGTCCTGCCCGAA

Downstream 100 bases:

>100_bases
TATAAAAAACGGCCCCGGGATTGCTCCCAGGGCCGTCTTTGTCGCGAAAAGCGTGCGATTACATTCCGTCGCCGTCGGTC
GCTTCTTCGACCTGAGCTTC

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MPADVFTAPLKRPEHVGDDWLEPQQTHYTSEDDAIWNDLFARQMDVLPGRAASAFMAGLEKLDLGKGGVPDFKQMSEELG
KLTGWSVVPVPMLIPDHVFFWHLANRRFPAGNFIRTRETFDYIQEPDVFHDVFGHVPMLSDPTFADYMQEYGKAGWKAMR
YNRLKALGSLYWYTVEFGLIEEGPDDIRAYGAGILSGPTEAVFAVEAESPNRIMLNVDRVMRTDYVISDLQPTYFVIESF
EDLYRQTVERDFDRLYRNLPPAFTYANSAIIDVDNVVHRGTQEYLLRGGRGSGAAPV

Sequences:

>Translated_297_residues
MPADVFTAPLKRPEHVGDDWLEPQQTHYTSEDDAIWNDLFARQMDVLPGRAASAFMAGLEKLDLGKGGVPDFKQMSEELG
KLTGWSVVPVPMLIPDHVFFWHLANRRFPAGNFIRTRETFDYIQEPDVFHDVFGHVPMLSDPTFADYMQEYGKAGWKAMR
YNRLKALGSLYWYTVEFGLIEEGPDDIRAYGAGILSGPTEAVFAVEAESPNRIMLNVDRVMRTDYVISDLQPTYFVIESF
EDLYRQTVERDFDRLYRNLPPAFTYANSAIIDVDNVVHRGTQEYLLRGGRGSGAAPV
>Mature_296_residues
PADVFTAPLKRPEHVGDDWLEPQQTHYTSEDDAIWNDLFARQMDVLPGRAASAFMAGLEKLDLGKGGVPDFKQMSEELGK
LTGWSVVPVPMLIPDHVFFWHLANRRFPAGNFIRTRETFDYIQEPDVFHDVFGHVPMLSDPTFADYMQEYGKAGWKAMRY
NRLKALGSLYWYTVEFGLIEEGPDDIRAYGAGILSGPTEAVFAVEAESPNRIMLNVDRVMRTDYVISDLQPTYFVIESFE
DLYRQTVERDFDRLYRNLPPAFTYANSAIIDVDNVVHRGTQEYLLRGGRGSGAAPV

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI4557819, Length=222, Percent_Identity=32.8828828828829, Blast_Score=124, Evalue=9e-29,
Organism=Homo sapiens, GI88900503, Length=222, Percent_Identity=31.5315315315315, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI88900505, Length=239, Percent_Identity=30.5439330543933, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI88900501, Length=239, Percent_Identity=30.5439330543933, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI4759248, Length=238, Percent_Identity=29.4117647058824, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI31795563, Length=234, Percent_Identity=30.7692307692308, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17531391, Length=217, Percent_Identity=31.7972350230415, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI115533973, Length=234, Percent_Identity=29.9145299145299, Blast_Score=107, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI115532103, Length=234, Percent_Identity=29.9145299145299, Blast_Score=107, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI71980736, Length=239, Percent_Identity=28.8702928870293, Blast_Score=103, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71980731, Length=149, Percent_Identity=27.5167785234899, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17136776, Length=219, Percent_Identity=33.3333333333333, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI17136774, Length=219, Percent_Identity=33.3333333333333, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24660393, Length=227, Percent_Identity=30.3964757709251, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI62472054, Length=227, Percent_Identity=30.3964757709251, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24654994, Length=227, Percent_Identity=29.9559471365639, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 33775; Mature: 33644

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPADVFTAPLKRPEHVGDDWLEPQQTHYTSEDDAIWNDLFARQMDVLPGRAASAFMAGLE
CCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
KLDLGKGGVPDFKQMSEELGKLTGWSVVPVPMLIPDHVFFWHLANRRFPAGNFIRTRETF
HHCCCCCCCCCHHHHHHHHHHHCCCCEECCCHHCCCHHHHHHHHCCCCCCCCCEEHHHHH
DYIQEPDVFHDVFGHVPMLSDPTFADYMQEYGKAGWKAMRYNRLKALGSLYWYTVEFGLI
HHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCC
EEGPDDIRAYGAGILSGPTEAVFAVEAESPNRIMLNVDRVMRTDYVISDLQPTYFVIESF
CCCHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEHHHHHHHHHHHHCCCCHHHHHHHH
EDLYRQTVERDFDRLYRNLPPAFTYANSAIIDVDNVVHRGTQEYLLRGGRGSGAAPV
HHHHHHHHHHHHHHHHHHCCCHHEECCCEEEEHHHHHHCCCHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
PADVFTAPLKRPEHVGDDWLEPQQTHYTSEDDAIWNDLFARQMDVLPGRAASAFMAGLE
CCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
KLDLGKGGVPDFKQMSEELGKLTGWSVVPVPMLIPDHVFFWHLANRRFPAGNFIRTRETF
HHCCCCCCCCCHHHHHHHHHHHCCCCEECCCHHCCCHHHHHHHHCCCCCCCCCEEHHHHH
DYIQEPDVFHDVFGHVPMLSDPTFADYMQEYGKAGWKAMRYNRLKALGSLYWYTVEFGLI
HHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCC
EEGPDDIRAYGAGILSGPTEAVFAVEAESPNRIMLNVDRVMRTDYVISDLQPTYFVIESF
CCCHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEHHHHHHHHHHHHCCCCHHHHHHHH
EDLYRQTVERDFDRLYRNLPPAFTYANSAIIDVDNVVHRGTQEYLLRGGRGSGAAPV
HHHHHHHHHHHHHHHHHHCCCHHEECCCEEEEHHHHHHCCCHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]