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The map label for this gene is ypdF [H]

Identifier: 85375207

GI number: 85375207

Start: 2401124

End: 2402944

Strand: Direct

Name: ypdF [H]

Synonym: ELI_11900

Alternate gene names: 85375207

Gene position: 2401124-2402944 (Clockwise)

Preceding gene: 85375202

Following gene: 85375208

Centisome position: 78.66

GC content: 67.27

Gene sequence:

>1821_bases
ATGCTGATGCAAACCCATGAAGCCCGCCTTGCCGCCCTGCGCGAGGAACTGAAGAAACGCGGGCTCGACGGATTCGTGAT
TCCGATCAGCGACGAGCATATGAGCGAATATGTCGGCGATTATGCCCAGCGGCTCGCCTGGCTGACCGGCTTCGGCGGTT
CGGCCGGGAGCGCGGCGGTTACGCTCGACACGGCGGCGATCTTCGTCGACGGGCGCTACACCGTGCAGGTGCGCGACCAG
GTCGACGAGCGGCTGTTCGCCTACCAGTCGGTCCCCGCCACCAGCCCGGCGAAGTGGCTGGCCGAGAATGCCGGCGAAGG
CGCAAAGGTCGGCTTCGATCCGTGGCTGCATTCACGCGGCTGGGCGAAGGCGGCAGGCAAAGCGCTGGCCGATGTCGGCG
CGGAACTGGTCCCGGTGAGCGGCAATCCCATCGACGCCGTGTGGCAGGACCGGCCCGAGCCCTCCGCCGCCGTGGCGACG
ATCCAGGAAGAAGCACTGGCCGGGCGCGGCCATGCCGACAAGCGCGGCGAAGTGGCGCAGTGGCTGAAAGACAAGAAGCT
CGACGCGGCGGTCATCTCCGCGCTCGATTCGGTCGCCTGGCTGCTCAACATCCGCGGTAAGGACGTGACCCATACGCCGG
TCGCGCTGTCCTATGTGATCGCGCATGAGGACGGCACGGCGGAGCTGTTCATCGCCGAGGAGAAGGTCACGCCCGAGCTC
CGCCAGCATCTCGGCAATGCGGTGACGATCCGTGACCGGATGGACTTCGAACCGGCGCTCAAGAGCCTGTCGGGCAAGCG
CGTGGCGGTCGATCCCGATTACGGCGTCGCGGCGATTTCGCTGGCGCTCGAAGAAGGCGGCGCGACCCCGGTCAGCGAGC
GCGATCCGACGATCCTCGCCAAGGCGGTGAAGAACGGCGTCGAAGCGCAGGGCCACCGCGAGGCGCAGGCGCTCGACGGG
GTGGCGGTGTGCAAATATCTCCACTGGCTGAGCGTCGAAGCGCCCAAGGGCGGGATCGACGAACTGACCGCGGCGGCCAA
GCTGCTCGAATTCCGCCGGCACTACGGCGACCTGCGCGATACCAGCTTCGACACCATTTCGGCCGCATCCGGCCACGCCG
CGCTGCCACACTATAAGGTGGACGAGGACAGCAACATCCCGATCCCGCCGGGCAGCATCTATCTGTGCGATTCGGGCGGG
CAATACCCCTGCGGCACGACCGACATCACCCGCACCGTCTGGATCGGCACGCCCGATGGCCAGGCGCAGCCGACCGCGGA
GATGAAGGATCGCTTCACCCGCGTGCTCAAGGGCCACATCGCCATCGCGCAGGCGATCTTCCCCGAGGGGACCTGCGGCG
GCCAGCTCGATACGCTCGCGCGCCACGCACTATGGCAGGCGGGAACCGACTTCGCCCACGGCACCGGGCACGGCGTCGGC
AGCTTCCTGTCGGTCCACGAGGGTCCGCAGCGGATCGGCAAGGTCAATGGTGCGCAGGCCGGTACGCTGGAGCCGCTCAA
GGCCGGCATGATCCTCTCCAACGAGCCCGGCTATTACAAGGCTGGCGAATTCGGCATCCGGATCGAGAACCTGGTGCTGA
CCGAGGAACGGCACATCGACGGCGCCGACGAAGGCACCTGGTTCGGCTTCGAGAACCTGACCTGGGTGCCGATCGATCGC
ACGCTGATCGAACCGGCCTTGCTGAGCGAGAACGAGCGTTCGTGGCTGAACCGGTACCACGCCGATACCCGCGCCTTGCT
CGCGCCGCGACTCGAAGGCGAGGTGCTCGACTGGCTGATGGAGCAGACCGAGCCGCTCTGA

Upstream 100 bases:

>100_bases
TGATGTCCGAAAGGTCGGCTGGAAAGCCTCACTCGCAAGGCCTATGATAGAGACATGACGCGCACAAGAGCGCACAACCG
ATTACCCGAGGATCGATGAA

Downstream 100 bases:

>100_bases
CACGCCGTTCCCTGCGGTCTTGTGAGTCGATCGATGTTCCACTAATGTTCTCGCCGGCCGAGTCGCCGTCGCGAGTCGGA
ACAGAGGAGGACAGGACATG

Product: aminopeptidase P

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 606; Mature: 606

Protein sequence:

>606_residues
MLMQTHEARLAALREELKKRGLDGFVIPISDEHMSEYVGDYAQRLAWLTGFGGSAGSAAVTLDTAAIFVDGRYTVQVRDQ
VDERLFAYQSVPATSPAKWLAENAGEGAKVGFDPWLHSRGWAKAAGKALADVGAELVPVSGNPIDAVWQDRPEPSAAVAT
IQEEALAGRGHADKRGEVAQWLKDKKLDAAVISALDSVAWLLNIRGKDVTHTPVALSYVIAHEDGTAELFIAEEKVTPEL
RQHLGNAVTIRDRMDFEPALKSLSGKRVAVDPDYGVAAISLALEEGGATPVSERDPTILAKAVKNGVEAQGHREAQALDG
VAVCKYLHWLSVEAPKGGIDELTAAAKLLEFRRHYGDLRDTSFDTISAASGHAALPHYKVDEDSNIPIPPGSIYLCDSGG
QYPCGTTDITRTVWIGTPDGQAQPTAEMKDRFTRVLKGHIAIAQAIFPEGTCGGQLDTLARHALWQAGTDFAHGTGHGVG
SFLSVHEGPQRIGKVNGAQAGTLEPLKAGMILSNEPGYYKAGEFGIRIENLVLTEERHIDGADEGTWFGFENLTWVPIDR
TLIEPALLSENERSWLNRYHADTRALLAPRLEGEVLDWLMEQTEPL

Sequences:

>Translated_606_residues
MLMQTHEARLAALREELKKRGLDGFVIPISDEHMSEYVGDYAQRLAWLTGFGGSAGSAAVTLDTAAIFVDGRYTVQVRDQ
VDERLFAYQSVPATSPAKWLAENAGEGAKVGFDPWLHSRGWAKAAGKALADVGAELVPVSGNPIDAVWQDRPEPSAAVAT
IQEEALAGRGHADKRGEVAQWLKDKKLDAAVISALDSVAWLLNIRGKDVTHTPVALSYVIAHEDGTAELFIAEEKVTPEL
RQHLGNAVTIRDRMDFEPALKSLSGKRVAVDPDYGVAAISLALEEGGATPVSERDPTILAKAVKNGVEAQGHREAQALDG
VAVCKYLHWLSVEAPKGGIDELTAAAKLLEFRRHYGDLRDTSFDTISAASGHAALPHYKVDEDSNIPIPPGSIYLCDSGG
QYPCGTTDITRTVWIGTPDGQAQPTAEMKDRFTRVLKGHIAIAQAIFPEGTCGGQLDTLARHALWQAGTDFAHGTGHGVG
SFLSVHEGPQRIGKVNGAQAGTLEPLKAGMILSNEPGYYKAGEFGIRIENLVLTEERHIDGADEGTWFGFENLTWVPIDR
TLIEPALLSENERSWLNRYHADTRALLAPRLEGEVLDWLMEQTEPL
>Mature_606_residues
MLMQTHEARLAALREELKKRGLDGFVIPISDEHMSEYVGDYAQRLAWLTGFGGSAGSAAVTLDTAAIFVDGRYTVQVRDQ
VDERLFAYQSVPATSPAKWLAENAGEGAKVGFDPWLHSRGWAKAAGKALADVGAELVPVSGNPIDAVWQDRPEPSAAVAT
IQEEALAGRGHADKRGEVAQWLKDKKLDAAVISALDSVAWLLNIRGKDVTHTPVALSYVIAHEDGTAELFIAEEKVTPEL
RQHLGNAVTIRDRMDFEPALKSLSGKRVAVDPDYGVAAISLALEEGGATPVSERDPTILAKAVKNGVEAQGHREAQALDG
VAVCKYLHWLSVEAPKGGIDELTAAAKLLEFRRHYGDLRDTSFDTISAASGHAALPHYKVDEDSNIPIPPGSIYLCDSGG
QYPCGTTDITRTVWIGTPDGQAQPTAEMKDRFTRVLKGHIAIAQAIFPEGTCGGQLDTLARHALWQAGTDFAHGTGHGVG
SFLSVHEGPQRIGKVNGAQAGTLEPLKAGMILSNEPGYYKAGEFGIRIENLVLTEERHIDGADEGTWFGFENLTWVPIDR
TLIEPALLSENERSWLNRYHADTRALLAPRLEGEVLDWLMEQTEPL

Specific function: Hydrolyzes the N-terminal methionine when the next amino acid is alanine, proline or serine. The substrate preference for methionyl aminopeptidase activity is Pro > Ala > Ser. Also able to hydrolyze the Xaa-Pro peptide bond when the first amino acid is al

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24 family [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=623, Percent_Identity=38.5232744783307, Blast_Score=394, Evalue=1e-109,
Organism=Homo sapiens, GI93141226, Length=612, Percent_Identity=36.6013071895425, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI264681565, Length=623, Percent_Identity=37.239165329053, Blast_Score=367, Evalue=1e-101,
Organism=Escherichia coli, GI1788728, Length=201, Percent_Identity=34.3283582089552, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17509539, Length=621, Percent_Identity=36.0708534621578, Blast_Score=333, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI25149105, Length=608, Percent_Identity=30.5921052631579, Blast_Score=263, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6322999, Length=657, Percent_Identity=33.9421613394216, Blast_Score=328, Evalue=1e-90,
Organism=Drosophila melanogaster, GI17137632, Length=604, Percent_Identity=37.0860927152318, Blast_Score=335, Evalue=4e-92,
Organism=Drosophila melanogaster, GI161078230, Length=628, Percent_Identity=31.8471337579618, Blast_Score=278, Evalue=1e-74,
Organism=Drosophila melanogaster, GI21357287, Length=628, Percent_Identity=31.8471337579618, Blast_Score=278, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 65574; Mature: 65574

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMQTHEARLAALREELKKRGLDGFVIPISDEHMSEYVGDYAQRLAWLTGFGGSAGSAAV
CCCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
TLDTAAIFVDGRYTVQVRDQVDERLFAYQSVPATSPAKWLAENAGEGAKVGFDPWLHSRG
EEEEEEEEECCEEEEEEHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCHHHCCCC
WAKAAGKALADVGAELVPVSGNPIDAVWQDRPEPSAAVATIQEEALAGRGHADKRGEVAQ
HHHHHHHHHHHCCCEEEECCCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHH
WLKDKKLDAAVISALDSVAWLLNIRGKDVTHTPVALSYVIAHEDGTAELFIAEEKVTPEL
HHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCHHH
RQHLGNAVTIRDRMDFEPALKSLSGKRVAVDPDYGVAAISLALEEGGATPVSERDPTILA
HHHCCCEEEEECCCCHHHHHHHCCCCEEEECCCCCEEEEEEEECCCCCCCCCCCCHHHHH
KAVKNGVEAQGHREAQALDGVAVCKYLHWLSVEAPKGGIDELTAAAKLLEFRRHYGDLRD
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
TSFDTISAASGHAALPHYKVDEDSNIPIPPGSIYLCDSGGQYPCGTTDITRTVWIGTPDG
CCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEEECCCC
QAQPTAEMKDRFTRVLKGHIAIAQAIFPEGTCGGQLDTLARHALWQAGTDFAHGTGHGVG
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHH
SFLSVHEGPQRIGKVNGAQAGTLEPLKAGMILSNEPGYYKAGEFGIRIENLVLTEERHID
HHHHHHCCHHHHHCCCCCCCCCCCHHHCCEEEECCCCCEECCCCCEEEEEEEEEHHCCCC
GADEGTWFGFENLTWVPIDRTLIEPALLSENERSWLNRYHADTRALLAPRLEGEVLDWLM
CCCCCCEECCCCEEEEECCHHHHCHHHHCCCHHHHHHHHHCCHHHHHCCCCCHHHHHHHH
EQTEPL
HHCCCC
>Mature Secondary Structure
MLMQTHEARLAALREELKKRGLDGFVIPISDEHMSEYVGDYAQRLAWLTGFGGSAGSAAV
CCCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
TLDTAAIFVDGRYTVQVRDQVDERLFAYQSVPATSPAKWLAENAGEGAKVGFDPWLHSRG
EEEEEEEEECCEEEEEEHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCHHHCCCC
WAKAAGKALADVGAELVPVSGNPIDAVWQDRPEPSAAVATIQEEALAGRGHADKRGEVAQ
HHHHHHHHHHHCCCEEEECCCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHH
WLKDKKLDAAVISALDSVAWLLNIRGKDVTHTPVALSYVIAHEDGTAELFIAEEKVTPEL
HHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCHHH
RQHLGNAVTIRDRMDFEPALKSLSGKRVAVDPDYGVAAISLALEEGGATPVSERDPTILA
HHHCCCEEEEECCCCHHHHHHHCCCCEEEECCCCCEEEEEEEECCCCCCCCCCCCHHHHH
KAVKNGVEAQGHREAQALDGVAVCKYLHWLSVEAPKGGIDELTAAAKLLEFRRHYGDLRD
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
TSFDTISAASGHAALPHYKVDEDSNIPIPPGSIYLCDSGGQYPCGTTDITRTVWIGTPDG
CCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEEECCCC
QAQPTAEMKDRFTRVLKGHIAIAQAIFPEGTCGGQLDTLARHALWQAGTDFAHGTGHGVG
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHH
SFLSVHEGPQRIGKVNGAQAGTLEPLKAGMILSNEPGYYKAGEFGIRIENLVLTEERHID
HHHHHHCCHHHHHCCCCCCCCCCCHHHCCEEEECCCCCEECCCCCEEEEEEEEEHHCCCC
GADEGTWFGFENLTWVPIDRTLIEPALLSENERSWLNRYHADTRALLAPRLEGEVLDWLM
CCCCCCEECCCCEEEEECCHHHHCHHHHCCCHHHHHHHHHCCHHHHHCCCCCHHHHHHHH
EQTEPL
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]