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The map label for this gene is ald [H]

Identifier: 85375202

GI number: 85375202

Start: 2395333

End: 2396451

Strand: Direct

Name: ald [H]

Synonym: ELI_11875

Alternate gene names: 85375202

Gene position: 2395333-2396451 (Clockwise)

Preceding gene: 85375199

Following gene: 85375207

Centisome position: 78.47

GC content: 67.65

Gene sequence:

>1119_bases
ATGCGCATCGGTTGCCCTACGGAAATCAAGAACCACGAATATCGCGTCGGCCTGACGCCGGAGAGCGCGCGCGAGCTGGC
CGGGCGCGGCCACGACGTGTGGATCGAAAGCGGCGCCGGGCTCGGCATCGGTGCGACCGACGAGGAATACCGCGCCGCCG
GTGCCACGATCGTCGACGGGCCGGACCCGATCTTCGCCGAATGCGAGATGGTGGTGAAGGTCAAGGAACCGCAAGCGGTC
GAGCGTGCCAAGTTGCGGCCCGACCAGATCCTCTATACCTATCTGCACCTGGCCCCCGACCCGGAACAGACCGAGGACCT
AGTCAAGTCGGGCGTGACTGCGATCGCCTACGAAACCGTCACCGGTCCGCGCGGCTCGCTGCCGCTGCTCAAACCCATGA
GCCAGGTGGCGGGGCGCATGAGCATCCAGGCAGGCGCGTCGGCGCTGGAGAAGGCGCATGGCGGGCGCGGCGTGCTGATC
GGCGGGGTGCCGGGCGTTCTGCCGGGCAAGGTCGTGGTGATCGGCGGCGGCGTGGTCGGCTTCAACGCGGCGCAGATGGC
GGTGGGCCTCGGCGGCGACGTCGAGATCCTCGACCGCGATCCCGAAGTGCTGGAAAAGGTCGGCACCTTCTTCGAAGCCC
GCGCCAGCACGCGCTTTTCCAACAAGACCAACCTCGAAGACGCGGTGTGCCAGGCCGACCTCGTGATCGGCGCGGTGCTG
ATCCCGGGCGCCGCCGCTCCCAAGCTCGTGACCCGAGACCTGCTCAAGCGGATGAAGCCGGGCGCGGTGCTGGTCGACGT
GGCGATCGACCAGGGCGGCTGCTTCGAGACCAGCAAGCCGACGACGCATGACGACCCGACTTACGTGGTCGACGATATCG
TCCATTATTGCGTCGCCAACATGCCCGGCGCGGTCGCGCGCACCAGCACCTATGCGCTCAACAACGTGACGCTGCCGCAC
GCGCTGCAGATGGCCAAGCACGGCTGGAAGGAAGCGATGCGCGCCAATCCGCACCTGGCCGAAGGGCTCAACGTCCACGC
CGGCCATGTGACCTACGAGGCGGTGGCGGAAGAACTGGGCTACGACTATCGCAGCACGGCCGAGGTGCTCGCCGACTAG

Upstream 100 bases:

>100_bases
CAATCGTGTTACAATCACCAGCTTTCGGGCGCATCGCGAATGGTTGCGGCAAACTGGTTACACTTGTAACGAGCGCGGCA
GTTTGAGGAGTCTCCCCACA

Downstream 100 bases:

>100_bases
CGATCAGGCGGCGTTTGCCGCCCGCCACTTGCGATAGCGTTTGGCCCGGCGCGCGGCGCGGTATTGGTCCGCCGCCAGCG
CCAGCGCGGGGGAACCGCCG

Product: alanine dehydrogenase and pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: 40 kDa antigen; TB43 [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MRIGCPTEIKNHEYRVGLTPESARELAGRGHDVWIESGAGLGIGATDEEYRAAGATIVDGPDPIFAECEMVVKVKEPQAV
ERAKLRPDQILYTYLHLAPDPEQTEDLVKSGVTAIAYETVTGPRGSLPLLKPMSQVAGRMSIQAGASALEKAHGGRGVLI
GGVPGVLPGKVVVIGGGVVGFNAAQMAVGLGGDVEILDRDPEVLEKVGTFFEARASTRFSNKTNLEDAVCQADLVIGAVL
IPGAAAPKLVTRDLLKRMKPGAVLVDVAIDQGGCFETSKPTTHDDPTYVVDDIVHYCVANMPGAVARTSTYALNNVTLPH
ALQMAKHGWKEAMRANPHLAEGLNVHAGHVTYEAVAEELGYDYRSTAEVLAD

Sequences:

>Translated_372_residues
MRIGCPTEIKNHEYRVGLTPESARELAGRGHDVWIESGAGLGIGATDEEYRAAGATIVDGPDPIFAECEMVVKVKEPQAV
ERAKLRPDQILYTYLHLAPDPEQTEDLVKSGVTAIAYETVTGPRGSLPLLKPMSQVAGRMSIQAGASALEKAHGGRGVLI
GGVPGVLPGKVVVIGGGVVGFNAAQMAVGLGGDVEILDRDPEVLEKVGTFFEARASTRFSNKTNLEDAVCQADLVIGAVL
IPGAAAPKLVTRDLLKRMKPGAVLVDVAIDQGGCFETSKPTTHDDPTYVVDDIVHYCVANMPGAVARTSTYALNNVTLPH
ALQMAKHGWKEAMRANPHLAEGLNVHAGHVTYEAVAEELGYDYRSTAEVLAD
>Mature_372_residues
MRIGCPTEIKNHEYRVGLTPESARELAGRGHDVWIESGAGLGIGATDEEYRAAGATIVDGPDPIFAECEMVVKVKEPQAV
ERAKLRPDQILYTYLHLAPDPEQTEDLVKSGVTAIAYETVTGPRGSLPLLKPMSQVAGRMSIQAGASALEKAHGGRGVLI
GGVPGVLPGKVVVIGGGVVGFNAAQMAVGLGGDVEILDRDPEVLEKVGTFFEARASTRFSNKTNLEDAVCQADLVIGAVL
IPGAAAPKLVTRDLLKRMKPGAVLVDVAIDQGGCFETSKPTTHDDPTYVVDDIVHYCVANMPGAVARTSTYALNNVTLPH
ALQMAKHGWKEAMRANPHLAEGLNVHAGHVTYEAVAEELGYDYRSTAEVLAD

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=348, Percent_Identity=29.5977011494253, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI122939153, Length=348, Percent_Identity=29.5977011494253, Blast_Score=129, Evalue=5e-30,
Organism=Escherichia coli, GI1787887, Length=358, Percent_Identity=33.2402234636872, Blast_Score=138, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17550456, Length=350, Percent_Identity=28.8571428571429, Blast_Score=122, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 39389; Mature: 39389

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGCPTEIKNHEYRVGLTPESARELAGRGHDVWIESGAGLGIGATDEEYRAAGATIVDG
CCCCCCCCCCCCCEEEECCCHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHCCCEEECC
PDPIFAECEMVVKVKEPQAVERAKLRPDQILYTYLHLAPDPEQTEDLVKSGVTAIAYETV
CCCHHHCCEEEEEECCCCHHHHHHCCHHHEEEEHEEECCCCHHHHHHHHCCCEEEEEEEC
TGPRGSLPLLKPMSQVAGRMSIQAGASALEKAHGGRGVLIGGVPGVLPGKVVVIGGGVVG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCEEC
FNAAQMAVGLGGDVEILDRDPEVLEKVGTFFEARASTRFSNKTNLEDAVCQADLVIGAVL
CCHHHHEECCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHC
IPGAAAPKLVTRDLLKRMKPGAVLVDVAIDQGGCFETSKPTTHDDPTYVVDDIVHYCVAN
CCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
MPGAVARTSTYALNNVTLPHALQMAKHGWKEAMRANPHLAEGLNVHAGHVTYEAVAEELG
CCCCHHHCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCEECCCCHHHHHHHHHC
YDYRSTAEVLAD
CCHHHHHHHHCC
>Mature Secondary Structure
MRIGCPTEIKNHEYRVGLTPESARELAGRGHDVWIESGAGLGIGATDEEYRAAGATIVDG
CCCCCCCCCCCCCEEEECCCHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHCCCEEECC
PDPIFAECEMVVKVKEPQAVERAKLRPDQILYTYLHLAPDPEQTEDLVKSGVTAIAYETV
CCCHHHCCEEEEEECCCCHHHHHHCCHHHEEEEHEEECCCCHHHHHHHHCCCEEEEEEEC
TGPRGSLPLLKPMSQVAGRMSIQAGASALEKAHGGRGVLIGGVPGVLPGKVVVIGGGVVG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCEEC
FNAAQMAVGLGGDVEILDRDPEVLEKVGTFFEARASTRFSNKTNLEDAVCQADLVIGAVL
CCHHHHEECCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHC
IPGAAAPKLVTRDLLKRMKPGAVLVDVAIDQGGCFETSKPTTHDDPTYVVDDIVHYCVAN
CCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
MPGAVARTSTYALNNVTLPHALQMAKHGWKEAMRANPHLAEGLNVHAGHVTYEAVAEELG
CCCCHHHCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCEECCCCHHHHHHHHHC
YDYRSTAEVLAD
CCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1587598; 9634230; 12218036; 7822223 [H]