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The map label for this gene is 85375195

Identifier: 85375195

GI number: 85375195

Start: 2386170

End: 2386754

Strand: Direct

Name: 85375195

Synonym: ELI_11840

Alternate gene names: NA

Gene position: 2386170-2386754 (Clockwise)

Preceding gene: 85375193

Following gene: 85375196

Centisome position: 78.17

GC content: 66.84

Gene sequence:

>585_bases
ATGGGGCTGCGCTATAGCGGGCGCGTGGCACACTTCCAGACCTGTCTTGAGCGTAGTCGAAAGGACTTACCTGACCTCTG
GCTCCTGTCCGACGAGCGCAACGACGGCGTGCTCGAACACCGCTTGCGCACGCTGCCGCCGGGATCGGGCTTCGTCTATC
GCCATTATCATCTGCCGCCCGCAGAGCGGGTCGCGCGGTTCTTTGCATTAAAGCGTATCGCGGAAGCACGCGGGCATCTC
GTCATCCTCGCCGACAGCGCGTTGACCGCACGCGAATGGGGCGCAGACGGGATCTATGGCGCACCGCGCAGCCTCTATCC
CACGCGCCGCGACCTGGTGACCATCGCTACCGCGCACGACCTTGCGGAAATCGGCCAGGCCAATCGCGCCCGCTCCGACG
CGGTGATGCTTTCGCCAGCCTTCCCCACGCGCTCGCATCCCGGCGCTGCGACGCTCGGCCCGCAGCGGTTCCGACGTCTC
GCGCGTCATGCACAGATGCCGGTCATTGCGCTGGGGGGTATGACGCAAGCCACCGCGCGACGCCTCGATTGGCCGCGCTG
GGCCGCGATCGACGGACTCAGCTAA

Upstream 100 bases:

>100_bases
GACCGCGATCAGCGTGACTTCATCGCGGTCGCGCTGGGCGATTGTGCAGGCCCTGGCGATGCGGGCTTCCGTTTCTTCGA
GCGGGGTAGTGGGATCACTC

Downstream 100 bases:

>100_bases
TTCGCGCCATTCGTCGCGGGAATCTTGACCCGGACTCGCCAAGGATTCATGGTGTGTTCCACGCGAGGAAGGGAACCCGA
TGGCGTCACGAGCAATAAGC

Product: thiamine monophosphate synthase

Products: diphosphate; thiamine monophosphate

Alternate protein names: Regulatory Protein TenI; Mutator MutT Protein

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MGLRYSGRVAHFQTCLERSRKDLPDLWLLSDERNDGVLEHRLRTLPPGSGFVYRHYHLPPAERVARFFALKRIAEARGHL
VILADSALTAREWGADGIYGAPRSLYPTRRDLVTIATAHDLAEIGQANRARSDAVMLSPAFPTRSHPGAATLGPQRFRRL
ARHAQMPVIALGGMTQATARRLDWPRWAAIDGLS

Sequences:

>Translated_194_residues
MGLRYSGRVAHFQTCLERSRKDLPDLWLLSDERNDGVLEHRLRTLPPGSGFVYRHYHLPPAERVARFFALKRIAEARGHL
VILADSALTAREWGADGIYGAPRSLYPTRRDLVTIATAHDLAEIGQANRARSDAVMLSPAFPTRSHPGAATLGPQRFRRL
ARHAQMPVIALGGMTQATARRLDWPRWAAIDGLS
>Mature_193_residues
GLRYSGRVAHFQTCLERSRKDLPDLWLLSDERNDGVLEHRLRTLPPGSGFVYRHYHLPPAERVARFFALKRIAEARGHLV
ILADSALTAREWGADGIYGAPRSLYPTRRDLVTIATAHDLAEIGQANRARSDAVMLSPAFPTRSHPGAATLGPQRFRRLA
RHAQMPVIALGGMTQATARRLDWPRWAAIDGLS

Specific function: Unknown

COG id: COG0352

COG function: function code H; Thiamine monophosphate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.5.1.3

Molecular weight: Translated: 21650; Mature: 21519

Theoretical pI: Translated: 11.35; Mature: 11.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLRYSGRVAHFQTCLERSRKDLPDLWLLSDERNDGVLEHRLRTLPPGSGFVYRHYHLPP
CCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEEEEECCCH
AERVARFFALKRIAEARGHLVILADSALTAREWGADGIYGAPRSLYPTRRDLVTIATAHD
HHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHCCCCCCCCCCCCCCCCCHHEEEEHHHHH
LAEIGQANRARSDAVMLSPAFPTRSHPGAATLGPQRFRRLARHAQMPVIALGGMTQATAR
HHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHH
RLDWPRWAAIDGLS
HCCCCCCCCCCCCC
>Mature Secondary Structure 
GLRYSGRVAHFQTCLERSRKDLPDLWLLSDERNDGVLEHRLRTLPPGSGFVYRHYHLPP
CCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEEEEECCCH
AERVARFFALKRIAEARGHLVILADSALTAREWGADGIYGAPRSLYPTRRDLVTIATAHD
HHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHCCCCCCCCCCCCCCCCCHHEEEEHHHHH
LAEIGQANRARSDAVMLSPAFPTRSHPGAATLGPQRFRRLARHAQMPVIALGGMTQATAR
HHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHH
RLDWPRWAAIDGLS
HCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate; 4-Methyl-5-(2-phosphono-oxyethyl)-thiazole

Specific reaction: 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole = diphosphate + thiamine monophosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA