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The map label for this gene is folK [H]

Identifier: 85375081

GI number: 85375081

Start: 2279726

End: 2280223

Strand: Reverse

Name: folK [H]

Synonym: ELI_11270

Alternate gene names: 85375081

Gene position: 2280223-2279726 (Counterclockwise)

Preceding gene: 85375082

Following gene: 85375080

Centisome position: 74.7

GC content: 67.07

Gene sequence:

>498_bases
TTGCGAGGACATCTGAGCAGCACCTATCTCGTCGCGCTCGGAAGCAACCGGCCGCATCACCTCTATGGCCGTCCGCGCGC
GGTCGTGCATGCAGCGATGGAAGAGCTGGCGGTTCTCGGCACCGTCACGCACCGTTCGCCCATTATCGCCACCGCGCCGC
TTGGTGCAGCGCAACGCCGGTTCGCCAATGCCGCTGCGCTGGTCGAAAGCGAACTCGACCCGGAAGCGATGCTCGCCGGT
TTGCAGCATATCGAAAATGGCTTCGGTCGCCGCCGCTGGCGCCGCTGGGGCGACCGGGTGCTGGACCTCGATATCGTGCT
GTGGAGCGAAGGGGCTTTCGCTGCGCCGGGCCTCCAGATCCCCCATCCGGCATTCCGCGAGCGCGCCTTCGTCATGACCC
CTGCACTGGCCATAGCCCCTGCCTGGCGCGACCCCGTCTCCGGCCGTTCCCTGCGCCATCTAAATGCCCGCTTGACCCGC
AAGCACCCACGCCCCTAA

Upstream 100 bases:

>100_bases
ACGGTGTGCTGGTGGCAACCCTCGATCTCGACGAAGCTGCGAAACACCGTGCCGGGATGGGCTTTTTCCGCGATCGCCGC
CCGCAGCTCTATAGGCGGAT

Downstream 100 bases:

>100_bases
GGGGGCGCTCCGTGCCCGGCGATGTCGCTGCAGGCACATCGGTGGGCCCTTAGCTCAGTCGGTAGAGCAACTGACTTTTA
ATCAGTAGGTCGCAGGTTCG

Product: 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MRGHLSSTYLVALGSNRPHHLYGRPRAVVHAAMEELAVLGTVTHRSPIIATAPLGAAQRRFANAAALVESELDPEAMLAG
LQHIENGFGRRRWRRWGDRVLDLDIVLWSEGAFAAPGLQIPHPAFRERAFVMTPALAIAPAWRDPVSGRSLRHLNARLTR
KHPRP

Sequences:

>Translated_165_residues
MRGHLSSTYLVALGSNRPHHLYGRPRAVVHAAMEELAVLGTVTHRSPIIATAPLGAAQRRFANAAALVESELDPEAMLAG
LQHIENGFGRRRWRRWGDRVLDLDIVLWSEGAFAAPGLQIPHPAFRERAFVMTPALAIAPAWRDPVSGRSLRHLNARLTR
KHPRP
>Mature_165_residues
MRGHLSSTYLVALGSNRPHHLYGRPRAVVHAAMEELAVLGTVTHRSPIIATAPLGAAQRRFANAAALVESELDPEAMLAG
LQHIENGFGRRRWRRWGDRVLDLDIVLWSEGAFAAPGLQIPHPAFRERAFVMTPALAIAPAWRDPVSGRSLRHLNARLTR
KHPRP

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=148, Percent_Identity=35.1351351351351, Blast_Score=69, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18289; Mature: 18289

Theoretical pI: Translated: 12.00; Mature: 12.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGHLSSTYLVALGSNRPHHLYGRPRAVVHAAMEELAVLGTVTHRSPIIATAPLGAAQRR
CCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHH
FANAAALVESELDPEAMLAGLQHIENGFGRRRWRRWGDRVLDLDIVLWSEGAFAAPGLQI
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCCC
PHPAFRERAFVMTPALAIAPAWRDPVSGRSLRHLNARLTRKHPRP
CCHHHHCCEEEECCHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRGHLSSTYLVALGSNRPHHLYGRPRAVVHAAMEELAVLGTVTHRSPIIATAPLGAAQRR
CCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHH
FANAAALVESELDPEAMLAGLQHIENGFGRRRWRRWGDRVLDLDIVLWSEGAFAAPGLQI
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCCC
PHPAFRERAFVMTPALAIAPAWRDPVSGRSLRHLNARLTRKHPRP
CCHHHHCCEEEECCHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10080886 [H]