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The map label for this gene is ada [H]

Identifier: 85374576

GI number: 85374576

Start: 1781856

End: 1782893

Strand: Reverse

Name: ada [H]

Synonym: ELI_08745

Alternate gene names: 85374576

Gene position: 1782893-1781856 (Counterclockwise)

Preceding gene: 85374579

Following gene: 85374575

Centisome position: 58.41

GC content: 65.51

Gene sequence:

>1038_bases
ATGACCAACCAAGCTATCTCTCCCGATCATGCGTGGGCCGCTGTCCAGCGACGCGACCGCTCATTCGACGGGCGCTTCGT
CACCGGCGTGCTCACCACCGGGATCTATTGCCGCCCAAGCTGTGCCGCGCGGCATCCGGCGCGCGAGAACGTGCGCTTCT
TTGCCGATGGGGCGGAGGCGCGTGCTGCGGGATTGCGCGCCTGCGAGCGTTGCCTGCCCGACGATATCGGGCGCGACGAA
GCGGCGGTGCTGGCAGCGGTGGACGAGATCAAGGCCAGCGAGGGCAGGCCGACGCTCGACGAGCTGGCGACGCTGACGGG
CTATTCGCCGAGCCATTTCCAGCGGGTATTCAAGCGCGCGACCGGGCTTTCCCCGGCTGCCTATGCACGGGCTTTGCGCG
AAGAACGGGCGAAAGATGCGCTCGGCGAAGCAAAGCGGGTGACCGATGCGATTTACGATGCAGGCTATGAAGCGCCGAGC
CGGTTTTACGAAGGGATGCAGGGCAAGATGGGCATGAGCGCGAGCGACTGGAAGAACGGCGGCGAGGGTCGCGAAATCCA
TTACGCGGTGATCGAGACCTCGATTGCGCCGATGCTGGTGGCGGCCACGGACAGAGGCGTGTGCTGCCTTTCCTTCAATG
AAGGGGAGGAAGAGCTGCGTGCGCGTTTCCCCAAAGCCGATCTGGTCGAGGGCAGCGACAAGTTCCGAGACCTGTTCGAA
CGGGTCGCTGCCGCTGTCGAACAGCCCGGCACAGGCCAAGACGTCCCGCTCGACGTCAAAGGCACTGCCTTCCAACAGCG
CTGCTGGCAGGCCTTGCGCGAAATCCCACTGGGCGAAACACGCAGCTACGGCGAGCAGGCGGCGATGCTCGGCAATCCCA
AGGCCAGCCGTGCGGTCGGCAGTGCCAACGGCGCCAACAATATCGCAGTGCTGATCCCGTGCCACCGCGTGGTGCAAGCC
GATGGGTCGATCGGCGGCTACGCCTATGGGCCGGAGATCAAGGCTGAACTGCTGCGGCGGGAGTCGACTCGGCGCTGA

Upstream 100 bases:

>100_bases
AGGGTCAGCAAGCGGATCATCGACGCTGTGTTTGACCTCCCTTCGCTTTGATCGCAAGTTTCGGGATGAGGCGATCGACA
ACCGGGCGTAAACAGGCTGT

Downstream 100 bases:

>100_bases
GTTTGATGCAGCACTCCGAAATACGAGGAGGAGAGCTGAAATGAACAAGAAAACACACAACCCTACGCCGTGGCTGCAAG
GCTTCGGCCTCAATCATGCG

Product: ada regulatory of adaptative response protein

Products: NA

Alternate protein names: Regulatory protein of adaptative response; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MTNQAISPDHAWAAVQRRDRSFDGRFVTGVLTTGIYCRPSCAARHPARENVRFFADGAEARAAGLRACERCLPDDIGRDE
AAVLAAVDEIKASEGRPTLDELATLTGYSPSHFQRVFKRATGLSPAAYARALREERAKDALGEAKRVTDAIYDAGYEAPS
RFYEGMQGKMGMSASDWKNGGEGREIHYAVIETSIAPMLVAATDRGVCCLSFNEGEEELRARFPKADLVEGSDKFRDLFE
RVAAAVEQPGTGQDVPLDVKGTAFQQRCWQALREIPLGETRSYGEQAAMLGNPKASRAVGSANGANNIAVLIPCHRVVQA
DGSIGGYAYGPEIKAELLRRESTRR

Sequences:

>Translated_345_residues
MTNQAISPDHAWAAVQRRDRSFDGRFVTGVLTTGIYCRPSCAARHPARENVRFFADGAEARAAGLRACERCLPDDIGRDE
AAVLAAVDEIKASEGRPTLDELATLTGYSPSHFQRVFKRATGLSPAAYARALREERAKDALGEAKRVTDAIYDAGYEAPS
RFYEGMQGKMGMSASDWKNGGEGREIHYAVIETSIAPMLVAATDRGVCCLSFNEGEEELRARFPKADLVEGSDKFRDLFE
RVAAAVEQPGTGQDVPLDVKGTAFQQRCWQALREIPLGETRSYGEQAAMLGNPKASRAVGSANGANNIAVLIPCHRVVQA
DGSIGGYAYGPEIKAELLRRESTRR
>Mature_344_residues
TNQAISPDHAWAAVQRRDRSFDGRFVTGVLTTGIYCRPSCAARHPARENVRFFADGAEARAAGLRACERCLPDDIGRDEA
AVLAAVDEIKASEGRPTLDELATLTGYSPSHFQRVFKRATGLSPAAYARALREERAKDALGEAKRVTDAIYDAGYEAPSR
FYEGMQGKMGMSASDWKNGGEGREIHYAVIETSIAPMLVAATDRGVCCLSFNEGEEELRARFPKADLVEGSDKFRDLFER
VAAAVEQPGTGQDVPLDVKGTAFQQRCWQALREIPLGETRSYGEQAAMLGNPKASRAVGSANGANNIAVLIPCHRVVQAD
GSIGGYAYGPEIKAELLRRESTRR

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus. It activates the transcription of alkA, alkB and aidB [H]

COG id: COG0350

COG function: function code L; Methylated DNA-protein cysteine methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI197304670, Length=117, Percent_Identity=36.7521367521368, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1788542, Length=343, Percent_Identity=41.399416909621, Blast_Score=277, Evalue=6e-76,
Organism=Escherichia coli, GI1787596, Length=129, Percent_Identity=40.3100775193798, Blast_Score=96, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI115533070, Length=130, Percent_Identity=35.3846153846154, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI115533068, Length=130, Percent_Identity=35.3846153846154, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320001, Length=88, Percent_Identity=38.6363636363636, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17137554, Length=134, Percent_Identity=35.0746268656716, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR016221
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR001497
- InterPro:   IPR014048
- InterPro:   IPR008332
- InterPro:   IPR011991 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF01035 DNA_binding_1; PF00165 HTH_AraC; PF02870 Methyltransf_1N [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 37491; Mature: 37360

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS01124 HTH_ARAC_FAMILY_2 ; PS00374 MGMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNQAISPDHAWAAVQRRDRSFDGRFVTGVLTTGIYCRPSCAARHPARENVRFFADGAEA
CCCCCCCCHHHHHHHHHHCCCCCCCEEHHHHHCCCEECCCHHHCCCCHHCCEEEECCHHH
RAAGLRACERCLPDDIGRDEAAVLAAVDEIKASEGRPTLDELATLTGYSPSHFQRVFKRA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHH
TGLSPAAYARALREERAKDALGEAKRVTDAIYDAGYEAPSRFYEGMQGKMGMSASDWKNG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCHHCCCCC
GEGREIHYAVIETSIAPMLVAATDRGVCCLSFNEGEEELRARFPKADLVEGSDKFRDLFE
CCCCEEEEEEEHHHHCCEEEEECCCCEEEEECCCCHHHHHHHCCCCHHCCCCHHHHHHHH
RVAAAVEQPGTGQDVPLDVKGTAFQQRCWQALREIPLGETRSYGEQAAMLGNPKASRAVG
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHCC
SANGANNIAVLIPCHRVVQADGSIGGYAYGPEIKAELLRRESTRR
CCCCCCCEEEEECCHHHHHCCCCCCCEEECHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TNQAISPDHAWAAVQRRDRSFDGRFVTGVLTTGIYCRPSCAARHPARENVRFFADGAEA
CCCCCCCHHHHHHHHHHCCCCCCCEEHHHHHCCCEECCCHHHCCCCHHCCEEEECCHHH
RAAGLRACERCLPDDIGRDEAAVLAAVDEIKASEGRPTLDELATLTGYSPSHFQRVFKRA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHHHHH
TGLSPAAYARALREERAKDALGEAKRVTDAIYDAGYEAPSRFYEGMQGKMGMSASDWKNG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCHHCCCCC
GEGREIHYAVIETSIAPMLVAATDRGVCCLSFNEGEEELRARFPKADLVEGSDKFRDLFE
CCCCEEEEEEEHHHHCCEEEEECCCCEEEEECCCCHHHHHHHCCCCHHCCCCHHHHHHHH
RVAAAVEQPGTGQDVPLDVKGTAFQQRCWQALREIPLGETRSYGEQAAMLGNPKASRAVG
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHCC
SANGANNIAVLIPCHRVVQADGSIGGYAYGPEIKAELLRRESTRR
CCCCCCCEEEEECCHHHHHCCCCCCCEEECHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2987251; 3887409; 9097040; 9278503; 2982792; 3536913; 3009022; 3529081; 1581309; 8202360; 8500619; 8156986 [H]