Click here to switch to the map view.

The map label for this gene is fabH

Identifier: 85374551

GI number: 85374551

Start: 1761354

End: 1762319

Strand: Reverse

Name: fabH

Synonym: ELI_08620

Alternate gene names: 85374551

Gene position: 1762319-1761354 (Counterclockwise)

Preceding gene: 85374552

Following gene: 85374549

Centisome position: 57.74

GC content: 64.8

Gene sequence:

>966_bases
ATGATCCGCGCGGCCATCAAGGGCAGCGGATCGGCGCTTCCCCGGAAGGTCGTCACCAACGAGGAACTGGCCGCCAGGGT
CGATACCAGCGACGAGTGGATCGTCGAGCGAACCGGCATCCGTCAACGATACATAGCGGGCGCGGACGAATTCACGTCGA
CGCTCGCGATGGAAGCGTCGCGCAAGGCGCTCGAGGCAGCCGGTATAACGCCGGAAACCATTGATCTTATCGTGCTCGCC
ACCGCAACGCCCGACAACACCTTTCCCGCCACCGCCACCAAGGTCCAGGAAGCACTCGGCTGCAACGGGTGCATCGCCTT
CGATGTGCAGGCGGTCTGCTCGGGCTTTCTCTATGCGCTGGCGACCGCCGACTCGCTGCTCAAGACCGGCATGGCCAAGC
GCGCGCTAGTGATCGGGGCGGAAACCTTCAGCCGGATCCTCGACTGGGAAGATCGCACCACCTGCGTGCTGTTCGGCGAC
GGGGCCGGAGCGGTGGTGCTGGAAGCGGCCGAGGGCGATACGGAAGCGCCCGGCATCCTTGCCAGCCGCCTGCATGCCGA
CGGGGCGCAGCACGATTTGCTCTATGTCGATGGCGGACCGTCGACGACGCAAACGGTCGGCCACTTGCGCATGAGGGGCC
GCGAGGTGTTCCGCCACGCCGTCGTCAATCTTGCCGATGTGCTCAAGGAAGTGCTTGATGATGCTGGCGTTTCCGCCAGC
GACATCGACTGGGTGGTGCCGCATCAGGCCAATGCCCGCATCCTCGATGCAACCGCGCGCAAGCTGGGCCTGCCGATGGA
AAAGATCGTGGTGACGGTCGATCGACACGCCAATACTTCGGCTGCATCGGTTCCGCTCGCCTTCGATACCGCGGTCCGCG
ATGGCCGCATCAAGCCGGGCGACCTCGTAATGTTCGAAGCCATGGGCGGCGGTTTCACTTGGGGCGCGAGCCTGGTGCGC
TACTAG

Upstream 100 bases:

>100_bases
TGGAGAACGACCTCACCGCGCGGATCGCATCCGACCTCGCCGAATTGGGCGAGCGCATGTGGGATGCGACCGGTGGCAAC
GGCAACGGGCCGGCCCCAAA

Downstream 100 bases:

>100_bases
GCGCGGCCCGAGCGCCACTACGCTAACCTAGCGCGAGCAAACGATTTTTCTTTCCTGGCACGTTGCGATGCGGCGTGAAA
TCGGTTACGCATCCTATCAT

Product: 3-oxoacyl-acyl-carrier-protein synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MIRAAIKGSGSALPRKVVTNEELAARVDTSDEWIVERTGIRQRYIAGADEFTSTLAMEASRKALEAAGITPETIDLIVLA
TATPDNTFPATATKVQEALGCNGCIAFDVQAVCSGFLYALATADSLLKTGMAKRALVIGAETFSRILDWEDRTTCVLFGD
GAGAVVLEAAEGDTEAPGILASRLHADGAQHDLLYVDGGPSTTQTVGHLRMRGREVFRHAVVNLADVLKEVLDDAGVSAS
DIDWVVPHQANARILDATARKLGLPMEKIVVTVDRHANTSAASVPLAFDTAVRDGRIKPGDLVMFEAMGGGFTWGASLVR
Y

Sequences:

>Translated_321_residues
MIRAAIKGSGSALPRKVVTNEELAARVDTSDEWIVERTGIRQRYIAGADEFTSTLAMEASRKALEAAGITPETIDLIVLA
TATPDNTFPATATKVQEALGCNGCIAFDVQAVCSGFLYALATADSLLKTGMAKRALVIGAETFSRILDWEDRTTCVLFGD
GAGAVVLEAAEGDTEAPGILASRLHADGAQHDLLYVDGGPSTTQTVGHLRMRGREVFRHAVVNLADVLKEVLDDAGVSAS
DIDWVVPHQANARILDATARKLGLPMEKIVVTVDRHANTSAASVPLAFDTAVRDGRIKPGDLVMFEAMGGGFTWGASLVR
Y
>Mature_321_residues
MIRAAIKGSGSALPRKVVTNEELAARVDTSDEWIVERTGIRQRYIAGADEFTSTLAMEASRKALEAAGITPETIDLIVLA
TATPDNTFPATATKVQEALGCNGCIAFDVQAVCSGFLYALATADSLLKTGMAKRALVIGAETFSRILDWEDRTTCVLFGD
GAGAVVLEAAEGDTEAPGILASRLHADGAQHDLLYVDGGPSTTQTVGHLRMRGREVFRHAVVNLADVLKEVLDDAGVSAS
DIDWVVPHQANARILDATARKLGLPMEKIVVTVDRHANTSAASVPLAFDTAVRDGRIKPGDLVMFEAMGGGFTWGASLVR
Y

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=317, Percent_Identity=52.9968454258675, Blast_Score=333, Evalue=7e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_ERYLH (Q2N925)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_458613.1
- STRING:   Q2N925
- GeneID:   3871099
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_08620
- NMPDR:   fig|314225.3.peg.1318
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   ICATSTP
- PhylomeDB:   Q2N925
- ProtClustDB:   CLSK844009
- BioCyc:   ELIT314225:ELI_08620-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 34025; Mature: 34025

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: ACT_SITE 113-113 ACT_SITE 248-248 ACT_SITE 278-278

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRAAIKGSGSALPRKVVTNEELAARVDTSDEWIVERTGIRQRYIAGADEFTSTLAMEAS
CEEEEECCCCCCCCHHHCCCCHHHEECCCCCCEEEECCCCHHHHHCCHHHHHHHHHHHHH
RKALEAAGITPETIDLIVLATATPDNTFPATATKVQEALGCNGCIAFDVQAVCSGFLYAL
HHHHHHCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHH
ATADSLLKTGMAKRALVIGAETFSRILDWEDRTTCVLFGDGAGAVVLEAAEGDTEAPGIL
HHHHHHHHHCCHHHEEEEEHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCCHH
ASRLHADGAQHDLLYVDGGPSTTQTVGHLRMRGREVFRHAVVNLADVLKEVLDDAGVSAS
HHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DIDWVVPHQANARILDATARKLGLPMEKIVVTVDRHANTSAASVPLAFDTAVRDGRIKPG
CCCEECCCCCCCEEEHHHHHHHCCCHHHEEEEECCCCCCCCCCCCEEEHHHHCCCCCCCC
DLVMFEAMGGGFTWGASLVRY
CEEEEEECCCCCHHHHHHHCC
>Mature Secondary Structure
MIRAAIKGSGSALPRKVVTNEELAARVDTSDEWIVERTGIRQRYIAGADEFTSTLAMEAS
CEEEEECCCCCCCCHHHCCCCHHHEECCCCCCEEEECCCCHHHHHCCHHHHHHHHHHHHH
RKALEAAGITPETIDLIVLATATPDNTFPATATKVQEALGCNGCIAFDVQAVCSGFLYAL
HHHHHHCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHH
ATADSLLKTGMAKRALVIGAETFSRILDWEDRTTCVLFGDGAGAVVLEAAEGDTEAPGIL
HHHHHHHHHCCHHHEEEEEHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCCCCCHH
ASRLHADGAQHDLLYVDGGPSTTQTVGHLRMRGREVFRHAVVNLADVLKEVLDDAGVSAS
HHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DIDWVVPHQANARILDATARKLGLPMEKIVVTVDRHANTSAASVPLAFDTAVRDGRIKPG
CCCEECCCCCCCEEEHHHHHHHCCCHHHEEEEECCCCCCCCCCCCEEEHHHHCCCCCCCC
DLVMFEAMGGGFTWGASLVRY
CEEEEEECCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA