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The map label for this gene is mutY [H]

Identifier: 85374543

GI number: 85374543

Start: 1753800

End: 1754843

Strand: Reverse

Name: mutY [H]

Synonym: ELI_08580

Alternate gene names: 85374543

Gene position: 1754843-1753800 (Counterclockwise)

Preceding gene: 85374548

Following gene: 85374541

Centisome position: 57.49

GC content: 67.82

Gene sequence:

>1044_bases
GTGACCGCTAGCAGCAACGCCGCCAAGCCCACCGTTTCGGGGGTGCTTCTCGACTGGTACGATCGCCATGCCCGCGACCT
GCCGTGGCGCGCGCAGCCGGGGGAGCCTGCCGCCGATCCCTACCGCGTGTGGCTGAGCGAGATCATGCTGCAGCAGACCA
CCGTGGCTGCGGTGAAGCCGTATTTTGCCAGGTTCACCGAGGTCTGGCCGACGGTGGAAGCGCTTGCCGAAGCTTCGGAG
GAAGACGTCATGGCGGCGTGGGCCGGGCTTGGTTACTACTCGCGGGCGCGCAATCTGCTCATGGCCGCCAAAGCCGTGGG
CGACCTCGGCGGGTTCCCCGAAACCGAGGCCGAACTGCGGCGCCTGCCGGGCGTAGGCGAGTACACCGCTGCTGCGATTG
CCGCGATCGCCTTCGGCAGGCGGGCAGTAGTCGTCGATGCCAATGTCGAGCGGGTCGTGTCGCGCTTGTTCGCGATCGAA
GAACCGCTCCCGAAGGCGCGCAGGGCGATCCGCGCCCATGCCGATGCGATCACCCCCGATCGGCGCGCGGGCGATTTTGC
GCAGGCGATGATGGATCTGGGCTCGCAAGTCTGTACGACGCGTGCGCCGCAATGCCTGCTGTGCCCCCTGGCGCGATTCT
GCGAGGCGAGGACGCAGGAGCCGGAGCGGTTTCCTGTCAAGCCGCCAAGGAAAGCCAAGCCCCTCCGCAAGGGGAGGGCA
TTCTGGATCGAGCGAGAGGGAACGGTCTGGCTGGTCCGCCGCGAGGGCTCGGGAATGCTCGGTGGGATGCGCAGCCTGCC
GGACGACGGCTGGTCAGCACGGAGCGATGGTTCGGGTGAGTTACCGCTTGCAGGCGAGTGGGAGAATGCCGGCAGCGTGT
TCCACGTCTTCACCCATTTCGCGCTCGAACTGACTGTTCTGCGCCATGGCGGTGCGGAGCACCCGACGGGAGAGGGCGAG
TGGTGGCCCCTCGACGATCTCGGCAAGGCGGGCCTGCCGACGCTGTTCGCCAAGGCCGCGCGCAGGGCCAGGCAAATCAC
CTGA

Upstream 100 bases:

>100_bases
GAGCCTTTCCGGCCTGCCGCTCCGTTACCTGAGGCCTGTTTCCCTTTGGGCTGGTCTTTGTCCCGTTCCATCGTGCCGAG
GCCCATGCCATAGGCGCGGC

Downstream 100 bases:

>100_bases
GTCCCAGCGAAGGCTGGGACCTCGATCAACGGAGCGCCAAGTCGATGGAGGCCCCAGCCTACGCTGGGGCTCACAGAAAA
CTTAGAAAATCCCGCCGCCC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MTASSNAAKPTVSGVLLDWYDRHARDLPWRAQPGEPAADPYRVWLSEIMLQQTTVAAVKPYFARFTEVWPTVEALAEASE
EDVMAAWAGLGYYSRARNLLMAAKAVGDLGGFPETEAELRRLPGVGEYTAAAIAAIAFGRRAVVVDANVERVVSRLFAIE
EPLPKARRAIRAHADAITPDRRAGDFAQAMMDLGSQVCTTRAPQCLLCPLARFCEARTQEPERFPVKPPRKAKPLRKGRA
FWIEREGTVWLVRREGSGMLGGMRSLPDDGWSARSDGSGELPLAGEWENAGSVFHVFTHFALELTVLRHGGAEHPTGEGE
WWPLDDLGKAGLPTLFAKAARRARQIT

Sequences:

>Translated_347_residues
MTASSNAAKPTVSGVLLDWYDRHARDLPWRAQPGEPAADPYRVWLSEIMLQQTTVAAVKPYFARFTEVWPTVEALAEASE
EDVMAAWAGLGYYSRARNLLMAAKAVGDLGGFPETEAELRRLPGVGEYTAAAIAAIAFGRRAVVVDANVERVVSRLFAIE
EPLPKARRAIRAHADAITPDRRAGDFAQAMMDLGSQVCTTRAPQCLLCPLARFCEARTQEPERFPVKPPRKAKPLRKGRA
FWIEREGTVWLVRREGSGMLGGMRSLPDDGWSARSDGSGELPLAGEWENAGSVFHVFTHFALELTVLRHGGAEHPTGEGE
WWPLDDLGKAGLPTLFAKAARRARQIT
>Mature_346_residues
TASSNAAKPTVSGVLLDWYDRHARDLPWRAQPGEPAADPYRVWLSEIMLQQTTVAAVKPYFARFTEVWPTVEALAEASEE
DVMAAWAGLGYYSRARNLLMAAKAVGDLGGFPETEAELRRLPGVGEYTAAAIAAIAFGRRAVVVDANVERVVSRLFAIEE
PLPKARRAIRAHADAITPDRRAGDFAQAMMDLGSQVCTTRAPQCLLCPLARFCEARTQEPERFPVKPPRKAKPLRKGRAF
WIEREGTVWLVRREGSGMLGGMRSLPDDGWSARSDGSGELPLAGEWENAGSVFHVFTHFALELTVLRHGGAEHPTGEGEW
WPLDDLGKAGLPTLFAKAARRARQIT

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=360, Percent_Identity=37.5, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI115298654, Length=360, Percent_Identity=37.5, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI115298652, Length=360, Percent_Identity=37.5, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI115298650, Length=360, Percent_Identity=37.5, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI190358497, Length=360, Percent_Identity=37.5, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI6912520, Length=360, Percent_Identity=37.5, Blast_Score=176, Evalue=3e-44,
Organism=Escherichia coli, GI1789331, Length=301, Percent_Identity=40.1993355481728, Blast_Score=204, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.20

Molecular weight: Translated: 38130; Mature: 37999

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASSNAAKPTVSGVLLDWYDRHARDLPWRAQPGEPAADPYRVWLSEIMLQQTTVAAVKP
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
YFARFTEVWPTVEALAEASEEDVMAAWAGLGYYSRARNLLMAAKAVGDLGGFPETEAELR
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
RLPGVGEYTAAAIAAIAFGRRAVVVDANVERVVSRLFAIEEPLPKARRAIRAHADAITPD
HCCCCCHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
RRAGDFAQAMMDLGSQVCTTRAPQCLLCPLARFCEARTQEPERFPVKPPRKAKPLRKGRA
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCE
FWIEREGTVWLVRREGSGMLGGMRSLPDDGWSARSDGSGELPLAGEWENAGSVFHVFTHF
EEEECCCCEEEEEECCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
ALELTVLRHGGAEHPTGEGEWWPLDDLGKAGLPTLFAKAARRARQIT
HHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TASSNAAKPTVSGVLLDWYDRHARDLPWRAQPGEPAADPYRVWLSEIMLQQTTVAAVKP
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
YFARFTEVWPTVEALAEASEEDVMAAWAGLGYYSRARNLLMAAKAVGDLGGFPETEAELR
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
RLPGVGEYTAAAIAAIAFGRRAVVVDANVERVVSRLFAIEEPLPKARRAIRAHADAITPD
HCCCCCHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
RRAGDFAQAMMDLGSQVCTTRAPQCLLCPLARFCEARTQEPERFPVKPPRKAKPLRKGRA
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCE
FWIEREGTVWLVRREGSGMLGGMRSLPDDGWSARSDGSGELPLAGEWENAGSVFHVFTHF
EEEECCCCEEEEEECCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
ALELTVLRHGGAEHPTGEGEWWPLDDLGKAGLPTLFAKAARRARQIT
HHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]