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The map label for this gene is adk

Identifier: 85374443

GI number: 85374443

Start: 1673132

End: 1673776

Strand: Reverse

Name: adk

Synonym: ELI_08080

Alternate gene names: 85374443

Gene position: 1673776-1673132 (Counterclockwise)

Preceding gene: 85374444

Following gene: 85374442

Centisome position: 54.83

GC content: 63.72

Gene sequence:

>645_bases
GTGAATATCATCCTTCTCGGCCCTCCGGGCGCAGGCAAGGGCACGCAATCGCAGCGGCTCGTCGAGCGGCATGGCATGCG
CCAGCTGTCGACCGGCGACATGCTCCGCGCCGCGGTGAAGGCGCAGACCCCCGTCGGTCTCAAGGCCAAGGCGGTGATGG
ATCGCGGCGAACTGGTTTCGGACGACATCGTCTCCGAGCTGATCGATGCGGAACTGACAGCCATGCACGGTAATGTCGGG
GCGATCTTCGATGGCTATCCGCGCACCGCGGCGCAGGCCGGGCAGCTCGACGTCATCCTCGCCAAGCATGATCGCTCGCT
GGACAAGGTGATCGAGCTCGAAGTCAATGAAGAAGCGCTGGTCGATCGTATCACCGGGCGCTTCACCTGCGCCAAGTGCG
GCACCGGTTATCATGACCGTCACAAGCAGCCCGCCAGGGAAGGCGTGTGCGATGTGTGCGGATCGACCGAGTTCAAGCGT
CGCCCCGACGACAATGAGGAAACCGTGCGCACACGGATGCAGGAATATCGGGCCAAGACGGCGCCGATCCTGCCGATCTA
CGAAGAGCGCGGGCTGGTCGAACGGGTCGATGGTATGGGCGGGATCGACGAGGTCACCGCCGCAATCGATGCGTTGCTGA
AGTAG

Upstream 100 bases:

>100_bases
TTGCTTGCTCACCAGTACGGTGATCTTATCAAGAAGGCCAAGCTGAAAGGCCGGATGCGCTGAGCCGACGCTGGCGGATC
GATTGAGGGGAATCGCGCAC

Downstream 100 bases:

>100_bases
GTCTTTTCCTCCGCCCTCGTCCGTGGAATAGGGCGAGGCAGCAAGGAGGGAACCGCAATGCTCCGTATGACTATCGCAAC
CGCCGCGCTGGCGTTGGCCG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MNIILLGPPGAGKGTQSQRLVERHGMRQLSTGDMLRAAVKAQTPVGLKAKAVMDRGELVSDDIVSELIDAELTAMHGNVG
AIFDGYPRTAAQAGQLDVILAKHDRSLDKVIELEVNEEALVDRITGRFTCAKCGTGYHDRHKQPAREGVCDVCGSTEFKR
RPDDNEETVRTRMQEYRAKTAPILPIYEERGLVERVDGMGGIDEVTAAIDALLK

Sequences:

>Translated_214_residues
MNIILLGPPGAGKGTQSQRLVERHGMRQLSTGDMLRAAVKAQTPVGLKAKAVMDRGELVSDDIVSELIDAELTAMHGNVG
AIFDGYPRTAAQAGQLDVILAKHDRSLDKVIELEVNEEALVDRITGRFTCAKCGTGYHDRHKQPAREGVCDVCGSTEFKR
RPDDNEETVRTRMQEYRAKTAPILPIYEERGLVERVDGMGGIDEVTAAIDALLK
>Mature_214_residues
MNIILLGPPGAGKGTQSQRLVERHGMRQLSTGDMLRAAVKAQTPVGLKAKAVMDRGELVSDDIVSELIDAELTAMHGNVG
AIFDGYPRTAAQAGQLDVILAKHDRSLDKVIELEVNEEALVDRITGRFTCAKCGTGYHDRHKQPAREGVCDVCGSTEFKR
RPDDNEETVRTRMQEYRAKTAPILPIYEERGLVERVDGMGGIDEVTAAIDALLK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=208, Percent_Identity=42.7884615384615, Blast_Score=164, Evalue=8e-41,
Organism=Homo sapiens, GI7524346, Length=208, Percent_Identity=42.7884615384615, Blast_Score=164, Evalue=8e-41,
Organism=Homo sapiens, GI310110345, Length=195, Percent_Identity=34.8717948717949, Blast_Score=121, Evalue=6e-28,
Organism=Homo sapiens, GI53832003, Length=195, Percent_Identity=34.8717948717949, Blast_Score=121, Evalue=6e-28,
Organism=Homo sapiens, GI8051579, Length=195, Percent_Identity=34.8717948717949, Blast_Score=121, Evalue=6e-28,
Organism=Homo sapiens, GI53832001, Length=195, Percent_Identity=34.8717948717949, Blast_Score=121, Evalue=6e-28,
Organism=Homo sapiens, GI19923437, Length=195, Percent_Identity=34.3589743589744, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI4502011, Length=208, Percent_Identity=28.3653846153846, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI28144897, Length=216, Percent_Identity=26.8518518518519, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI28144899, Length=216, Percent_Identity=26.8518518518519, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI7706497, Length=209, Percent_Identity=29.6650717703349, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=42.2018348623853, Blast_Score=156, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17552384, Length=210, Percent_Identity=40, Blast_Score=154, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17567503, Length=213, Percent_Identity=30.9859154929577, Blast_Score=107, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17537943, Length=192, Percent_Identity=28.6458333333333, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=198, Percent_Identity=43.4343434343434, Blast_Score=156, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6321018, Length=196, Percent_Identity=34.1836734693878, Blast_Score=131, Evalue=7e-32,
Organism=Drosophila melanogaster, GI22026816, Length=214, Percent_Identity=41.588785046729, Blast_Score=167, Evalue=4e-42,
Organism=Drosophila melanogaster, GI17737899, Length=195, Percent_Identity=35.8974358974359, Blast_Score=117, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24645822, Length=195, Percent_Identity=35.8974358974359, Blast_Score=117, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24663208, Length=217, Percent_Identity=32.7188940092166, Blast_Score=103, Evalue=7e-23,
Organism=Drosophila melanogaster, GI17647141, Length=217, Percent_Identity=32.7188940092166, Blast_Score=103, Evalue=7e-23,
Organism=Drosophila melanogaster, GI221459597, Length=212, Percent_Identity=24.5283018867925, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21356893, Length=212, Percent_Identity=24.5283018867925, Blast_Score=71, Evalue=6e-13,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_ERYLH (Q2N9D3)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_458505.1
- HSSP:   P16304
- ProteinModelPortal:   Q2N9D3
- SMR:   Q2N9D3
- STRING:   Q2N9D3
- GeneID:   3870564
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_08080
- NMPDR:   fig|314225.3.peg.1426
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- ProtClustDB:   PRK00279
- BioCyc:   ELIT314225:ELI_08080-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid; SSF57774 Adenylate_kinase_Znf_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23368; Mature: 23368

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIILLGPPGAGKGTQSQRLVERHGMRQLSTGDMLRAAVKAQTPVGLKAKAVMDRGELVS
CEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHCCCCCHH
DDIVSELIDAELTAMHGNVGAIFDGYPRTAAQAGQLDVILAKHDRSLDKVIELEVNEEAL
HHHHHHHHHHHHHHHCCCCCCEECCCCCHHHCCCCEEEEEECCCCCCHHEEEECCCHHHH
VDRITGRFTCAKCGTGYHDRHKQPAREGVCDVCGSTEFKRRPDDNEETVRTRMQEYRAKT
HHHHHCCEEEECCCCCCCHHCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHC
APILPIYEERGLVERVDGMGGIDEVTAAIDALLK
CCCCEEHHHCCHHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNIILLGPPGAGKGTQSQRLVERHGMRQLSTGDMLRAAVKAQTPVGLKAKAVMDRGELVS
CEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHCCCCCHH
DDIVSELIDAELTAMHGNVGAIFDGYPRTAAQAGQLDVILAKHDRSLDKVIELEVNEEAL
HHHHHHHHHHHHHHHCCCCCCEECCCCCHHHCCCCEEEEEECCCCCCHHEEEECCCHHHH
VDRITGRFTCAKCGTGYHDRHKQPAREGVCDVCGSTEFKRRPDDNEETVRTRMQEYRAKT
HHHHHCCEEEECCCCCCCHHCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHC
APILPIYEERGLVERVDGMGGIDEVTAAIDALLK
CCCCEEHHHCCHHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA