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The map label for this gene is smeA [H]

Identifier: 85374269

GI number: 85374269

Start: 1489321

End: 1490454

Strand: Reverse

Name: smeA [H]

Synonym: ELI_07210

Alternate gene names: 85374269

Gene position: 1490454-1489321 (Counterclockwise)

Preceding gene: 85374270

Following gene: 85374268

Centisome position: 48.83

GC content: 66.93

Gene sequence:

>1134_bases
ATGAGGATGCGCTACACGCTGATCGGGATTGCGTTGGTCCTTGCCGGTTGCGGCAATTCGGGAGGCGAAGATCCCGCCGC
GTTCCAGCAGCGCATCGAGGAAGTGGCGCAGGAGCCGCTGGTCGCGGCACCGTCGCCGGAAGAACGCGCTCTTGACCAGG
CGCTATTCGACATCGCCGCGCCTTTCGACGGCTATCTCGGCATCGCGGTGCACGATATCGCGCGCGACCGGACGGTGCAT
TTCAACGGCAACGAGCACTTGCCGCAACAGAGCCTCAGCAAGCTGTGGGTGACGCTGGCGGCCTTGCGCATGGTGGATGC
AGGCGAGCTCGACCTGTCCGAACGGGTCAGCATCCGCCGCAGCGACCTGACGCTGTTCCACCAGCCGGTGCGGCAGATCG
TGCTCGCCCGTGGCGGTTTCAATACGACCTATGGCGACCTGATGCGCCGCGCGATCACGGAGAGCGACAATACCGCCAAC
GATATGCTGCTGAAGCGCGTCGGCGGCCCGGCAGGTGTGCGCAACGCGATCGGCGAGGCACGGCTCGGTGCGATCCGTTT
CGGGCCCGGCGAGGTGCCGATGCAGAGCAAGATTGCGGGGGTGGAATGGGACCCGTCCTACTCGATCGGCAACGCCTTTT
TCGATGCCCGCAAGCGGGTGCCTGCCAGTGCGCGCGAAGCAGCGTTCACCGGCTATGTCCTCGACCCTGTCGACGGAGCC
ACGCCGCGGGCGATCGCGCTGGCCCTGGCCAGACTTGCGAGGGGAGAACTGCTGGAGCCGGGCACGACGGCGCTGTTCCT
CCAGCTCCTGAAAGACGTCAAGAGCGGTCCCAACCGGCTGAAGGGCGGCGTCCCGCCGGGCTGGAGCATCGGCCACAAGA
CGGGCACCGGCCAGGTCCTCGACAGCGCGCCTCCCGCCGAACAGGCGGGCTATAACGATGTCGGTATCCTTACCGCCCCC
GACGGCGCGCGCTATTCCGTGGTGGTGATGATCGGGCGCACCGCCGTGCCGCTGCCTGTGCGGATGGAGCTGATGCATAA
GGTGGTGGAAGCGATCGTGCGCTATCACCACGAGGCTGGCGGGGAAGCGATTCCCGACGCGCTGAGGCCCGAGCCGGTCC
TGGAGGAGCTGTGA

Upstream 100 bases:

>100_bases
TCGCCGGGCCGGGCGCGGGCAGCAAGCTCAAGAAGGCACAGGACCTCGGCATCGAAGTGATCGACGAAGCTGGTTGGGCC
GAAATCGTCGCAGCGGCGGG

Downstream 100 bases:

>100_bases
TACTGGAAGAACTGCAGCCCATGGCCCTGCGTATCGCTGATCGCCTGCGAGGGAAGGGAGAGAAAGTCGCCGTTGCCGAC
GGAGCGACCGGTGGTCTGAT

Product: putative beta-lactamase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MRMRYTLIGIALVLAGCGNSGGEDPAAFQQRIEEVAQEPLVAAPSPEERALDQALFDIAAPFDGYLGIAVHDIARDRTVH
FNGNEHLPQQSLSKLWVTLAALRMVDAGELDLSERVSIRRSDLTLFHQPVRQIVLARGGFNTTYGDLMRRAITESDNTAN
DMLLKRVGGPAGVRNAIGEARLGAIRFGPGEVPMQSKIAGVEWDPSYSIGNAFFDARKRVPASAREAAFTGYVLDPVDGA
TPRAIALALARLARGELLEPGTTALFLQLLKDVKSGPNRLKGGVPPGWSIGHKTGTGQVLDSAPPAEQAGYNDVGILTAP
DGARYSVVVMIGRTAVPLPVRMELMHKVVEAIVRYHHEAGGEAIPDALRPEPVLEEL

Sequences:

>Translated_377_residues
MRMRYTLIGIALVLAGCGNSGGEDPAAFQQRIEEVAQEPLVAAPSPEERALDQALFDIAAPFDGYLGIAVHDIARDRTVH
FNGNEHLPQQSLSKLWVTLAALRMVDAGELDLSERVSIRRSDLTLFHQPVRQIVLARGGFNTTYGDLMRRAITESDNTAN
DMLLKRVGGPAGVRNAIGEARLGAIRFGPGEVPMQSKIAGVEWDPSYSIGNAFFDARKRVPASAREAAFTGYVLDPVDGA
TPRAIALALARLARGELLEPGTTALFLQLLKDVKSGPNRLKGGVPPGWSIGHKTGTGQVLDSAPPAEQAGYNDVGILTAP
DGARYSVVVMIGRTAVPLPVRMELMHKVVEAIVRYHHEAGGEAIPDALRPEPVLEEL
>Mature_377_residues
MRMRYTLIGIALVLAGCGNSGGEDPAAFQQRIEEVAQEPLVAAPSPEERALDQALFDIAAPFDGYLGIAVHDIARDRTVH
FNGNEHLPQQSLSKLWVTLAALRMVDAGELDLSERVSIRRSDLTLFHQPVRQIVLARGGFNTTYGDLMRRAITESDNTAN
DMLLKRVGGPAGVRNAIGEARLGAIRFGPGEVPMQSKIAGVEWDPSYSIGNAFFDARKRVPASAREAAFTGYVLDPVDGA
TPRAIALALARLARGELLEPGTTALFLQLLKDVKSGPNRLKGGVPPGWSIGHKTGTGQVLDSAPPAEQAGYNDVGILTAP
DGARYSVVVMIGRTAVPLPVRMELMHKVVEAIVRYHHEAGGEAIPDALRPEPVLEEL

Specific function: Can hydrolyze carbapenem compounds [H]

COG id: COG2367

COG function: function code V; Beta-lactamase class A

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-A beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466
- InterPro:   IPR000871 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 40498; Mature: 40498

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMRYTLIGIALVLAGCGNSGGEDPAAFQQRIEEVAQEPLVAAPSPEERALDQALFDIAA
CCEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHC
PFDGYLGIAVHDIARDRTVHFNGNEHLPQQSLSKLWVTLAALRMVDAGELDLSERVSIRR
CCCCCHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
SDLTLFHQPVRQIVLARGGFNTTYGDLMRRAITESDNTANDMLLKRVGGPAGVRNAIGEA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHH
RLGAIRFGPGEVPMQSKIAGVEWDPSYSIGNAFFDARKRVPASAREAAFTGYVLDPVDGA
HHCEEEECCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCEEECCCCCC
TPRAIALALARLARGELLEPGTTALFLQLLKDVKSGPNRLKGGVPPGWSIGHKTGTGQVL
CHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCCC
DSAPPAEQAGYNDVGILTAPDGARYSVVVMIGRTAVPLPVRMELMHKVVEAIVRYHHEAG
CCCCCHHHCCCCCCEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCC
GEAIPDALRPEPVLEEL
CCCCCCCCCCCHHHHCC
>Mature Secondary Structure
MRMRYTLIGIALVLAGCGNSGGEDPAAFQQRIEEVAQEPLVAAPSPEERALDQALFDIAA
CCEEHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHC
PFDGYLGIAVHDIARDRTVHFNGNEHLPQQSLSKLWVTLAALRMVDAGELDLSERVSIRR
CCCCCHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
SDLTLFHQPVRQIVLARGGFNTTYGDLMRRAITESDNTANDMLLKRVGGPAGVRNAIGEA
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHH
RLGAIRFGPGEVPMQSKIAGVEWDPSYSIGNAFFDARKRVPASAREAAFTGYVLDPVDGA
HHCEEEECCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCEEECCCCCC
TPRAIALALARLARGELLEPGTTALFLQLLKDVKSGPNRLKGGVPPGWSIGHKTGTGQVL
CHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCCC
DSAPPAEQAGYNDVGILTAPDGARYSVVVMIGRTAVPLPVRMELMHKVVEAIVRYHHEAG
CCCCCHHHCCCCCCEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCC
GEAIPDALRPEPVLEEL
CCCCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8092824; 7793864 [H]