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The map label for this gene is nuoH

Identifier: 85374153

GI number: 85374153

Start: 1376540

End: 1377586

Strand: Reverse

Name: nuoH

Synonym: ELI_06630

Alternate gene names: 85374153

Gene position: 1377586-1376540 (Counterclockwise)

Preceding gene: 85374154

Following gene: 85374152

Centisome position: 45.13

GC content: 60.27

Gene sequence:

>1047_bases
ATGACTGAATTCTTCCAAACCCTCGGCATGAATTACGAATGGGCGTGGTTTACCGCGACCATTGCCGGAATCCTGCTGAT
CGCGCTGCCGGTGATGCTGGCGGTCGCGATGGTGATCTATGTCGACCGCAAGGTGCTGGGCGCGATCATGCTGCGGCGCG
GGCCCAACGTGGTCGGGCCCTTCGGCCTGCTGCAAAGCTTCGCCGACGGGCTCAAGGTGTTCCTGCAGGAAACCATCATC
CCCAGCGCGGCGAACAAGGGTATTTTCCTGCTCGCACCGATCGTGACCTTCGTCGTTGCGCTAGTCGCCTGGGCGGTGAT
CCCGTTCGGCGACGGCATGGTGCTGGCGGATATCAATGTCGGCCTGCTCTACGTGCTCGCGATCAGCTCGCTGGGTGTCT
ACGGCATCGTCATGGCGGGCTGGGCTAGCAACTCCAAATACCCGTTCTTCTCCGCCATGCGCGCCGCCGCTCAGATGATC
TCTTACGAAGTCTCGATCGGCTTCATCCTGATCTGCGTCGTGCTGTGGGCGGGCACGTTCAACCTCAGCGAAATCGTCGA
GGCGCAGCGCGGGCACGGGCTCGGCATCGTCAACGGCTATTTCTTCAACATCCTGCTGTTCCCGATGTGGGTGCTGTTCT
TCATCTCCTGCCTCGCCGAAACGCAGCGCGCGCCCTTCGACCTGACCGAAGCGGAATCGGAGCTCGTGGCGGGCTACCAG
ACCGAATATTCCAGCATGAGCTTCGCGCTGTTCTGGCTCGGTGAGTATGCCAATATCCTGTTGCTGTGCTCGCTCAACAC
CGTGCTGTTCTTTGGCGGTTGGCTGCCGCCGATCGACTGGGCGCCGCTCTATTATGTGCCGGGCTTCCTCTGGTTCCTTA
TCAAGACCTTCCTGTTCTTCTTCATGTTCAGCTGGATCTGGGCGACCGTGCCCCGGTACCGTTACGACCAGCTGATGCGG
CTCGGATGGAAGGTCTTCCTGCCGATGAGCCTGCTCTTCGTTTTCCTTATCAGCGGCTATCTGATGGCCACGGGGCACTA
CGGATGA

Upstream 100 bases:

>100_bases
GTGAGCGCGCTGGAGCCGCTGGCCTTGGCTATGGTGCATATGCAGCTGGCCATGATCTTGGGAGCTCCGGCGCCGGAGAT
TGCGGCGGAGGAGGCGAATA

Downstream 100 bases:

>100_bases
CCACCGCAACCCAACTCCTCAAATCGTTCACCTTGTGGGAATTCCTCAAGGCGCATGCGCTGACCTTGAAGTATTTCTTC
AAGCCCAAGGCGACGATCAA

Product: NADH dehydrogenase I chain H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MTEFFQTLGMNYEWAWFTATIAGILLIALPVMLAVAMVIYVDRKVLGAIMLRRGPNVVGPFGLLQSFADGLKVFLQETII
PSAANKGIFLLAPIVTFVVALVAWAVIPFGDGMVLADINVGLLYVLAISSLGVYGIVMAGWASNSKYPFFSAMRAAAQMI
SYEVSIGFILICVVLWAGTFNLSEIVEAQRGHGLGIVNGYFFNILLFPMWVLFFISCLAETQRAPFDLTEAESELVAGYQ
TEYSSMSFALFWLGEYANILLLCSLNTVLFFGGWLPPIDWAPLYYVPGFLWFLIKTFLFFFMFSWIWATVPRYRYDQLMR
LGWKVFLPMSLLFVFLISGYLMATGHYG

Sequences:

>Translated_348_residues
MTEFFQTLGMNYEWAWFTATIAGILLIALPVMLAVAMVIYVDRKVLGAIMLRRGPNVVGPFGLLQSFADGLKVFLQETII
PSAANKGIFLLAPIVTFVVALVAWAVIPFGDGMVLADINVGLLYVLAISSLGVYGIVMAGWASNSKYPFFSAMRAAAQMI
SYEVSIGFILICVVLWAGTFNLSEIVEAQRGHGLGIVNGYFFNILLFPMWVLFFISCLAETQRAPFDLTEAESELVAGYQ
TEYSSMSFALFWLGEYANILLLCSLNTVLFFGGWLPPIDWAPLYYVPGFLWFLIKTFLFFFMFSWIWATVPRYRYDQLMR
LGWKVFLPMSLLFVFLISGYLMATGHYG
>Mature_347_residues
TEFFQTLGMNYEWAWFTATIAGILLIALPVMLAVAMVIYVDRKVLGAIMLRRGPNVVGPFGLLQSFADGLKVFLQETIIP
SAANKGIFLLAPIVTFVVALVAWAVIPFGDGMVLADINVGLLYVLAISSLGVYGIVMAGWASNSKYPFFSAMRAAAQMIS
YEVSIGFILICVVLWAGTFNLSEIVEAQRGHGLGIVNGYFFNILLFPMWVLFFISCLAETQRAPFDLTEAESELVAGYQT
EYSSMSFALFWLGEYANILLLCSLNTVLFFGGWLPPIDWAPLYYVPGFLWFLIKTFLFFFMFSWIWATVPRYRYDQLMRL
GWKVFLPMSLLFVFLISGYLMATGHYG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=298, Percent_Identity=43.9597315436242, Blast_Score=244, Evalue=9e-65,
Organism=Escherichia coli, GI1788618, Length=313, Percent_Identity=42.4920127795527, Blast_Score=239, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_ERYLH (Q2NA73)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_458215.1
- STRING:   Q2NA73
- GeneID:   3870390
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_06630
- NMPDR:   fig|314225.3.peg.1725
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   FMVEYGS
- PhylomeDB:   Q2NA73
- ProtClustDB:   CLSK843948
- BioCyc:   ELIT314225:ELI_06630-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 39029; Mature: 38898

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe419ac0)-; HASH(0x14d82f50)-; HASH(0x1464a02c)-; HASH(0x148dfe44)-; HASH(0x14b0eaf8)-; HASH(0xdd88788)-; HASH(0x13efed84)-; HASH(0xb5b0e7c)-;

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFFQTLGMNYEWAWFTATIAGILLIALPVMLAVAMVIYVDRKVLGAIMLRRGPNVVGP
CCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
FGLLQSFADGLKVFLQETIIPSAANKGIFLLAPIVTFVVALVAWAVIPFGDGMVLADINV
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCEEEEECCH
GLLYVLAISSLGVYGIVMAGWASNSKYPFFSAMRAAAQMISYEVSIGFILICVVLWAGTF
HHHHHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NLSEIVEAQRGHGLGIVNGYFFNILLFPMWVLFFISCLAETQRAPFDLTEAESELVAGYQ
CHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
TEYSSMSFALFWLGEYANILLLCSLNTVLFFGGWLPPIDWAPLYYVPGFLWFLIKTFLFF
HHHCCHHHHHHHHHHHHHEEHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FMFSWIWATVPRYRYDQLMRLGWKVFLPMSLLFVFLISGYLMATGHYG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure 
TEFFQTLGMNYEWAWFTATIAGILLIALPVMLAVAMVIYVDRKVLGAIMLRRGPNVVGP
CHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
FGLLQSFADGLKVFLQETIIPSAANKGIFLLAPIVTFVVALVAWAVIPFGDGMVLADINV
HHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCEEEEECCH
GLLYVLAISSLGVYGIVMAGWASNSKYPFFSAMRAAAQMISYEVSIGFILICVVLWAGTF
HHHHHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NLSEIVEAQRGHGLGIVNGYFFNILLFPMWVLFFISCLAETQRAPFDLTEAESELVAGYQ
CHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
TEYSSMSFALFWLGEYANILLLCSLNTVLFFGGWLPPIDWAPLYYVPGFLWFLIKTFLFF
HHHCCHHHHHHHHHHHHHEEHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FMFSWIWATVPRYRYDQLMRLGWKVFLPMSLLFVFLISGYLMATGHYG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA