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The map label for this gene is nuoL [H]

Identifier: 85374149

GI number: 85374149

Start: 1373025

End: 1375100

Strand: Reverse

Name: nuoL [H]

Synonym: ELI_06610

Alternate gene names: 85374149

Gene position: 1375100-1373025 (Counterclockwise)

Preceding gene: 85374150

Following gene: 85374148

Centisome position: 45.05

GC content: 62.57

Gene sequence:

>2076_bases
GTGTCCTCGATCCTGATCATCGTTTTCGGCCCCTTGCTGGCGTCGATAATCGCCGGGCTGGTCAACAAGTCTGCGCCCAG
CGTGTTCGCCAAGGCGATCACGACCGGCGCGCTGTTCCTGTCCTGCGCGTTGAGCTGGCCGATCTTCATCGGCTTCCTCA
CCGGCACGCAGGAAGCGACCGTCGTGCCCGTGCTGCAATGGGTGCAGTCGGGCTCCATGAGCTTCGACTGGGCGCTGCGC
GTCGATGCGCTGACTGCTGTCATGCTGGTTGTGATCAACAGCGTTTCCGCGCTCGTGCACCTCTATTCCTGGGGGTACAT
GGAGGAAGACCCGGACCAGCCGCGCTTCTTCGCCTATCTCTCGTTGTTCACCTTCGCCATGCTGATGCTGGTGACCGCCG
ACAACCTGGTGCAGATGTTCTTCGGTTGGGAAGGCGTGGGCCTCGCCAGCTATCTGCTGATCGGGTTCTGGTTCAAGAAA
CCGAGCGCCAACGCCGCCGCGATCAAGGCTTTCGTGGTCAACCGCGTGGGCGACCTGGGCTTCATGCTCGGCATCTTCGG
CACTTTCCTCGTGTTCGGCACCGTTTCGATCCCCGAAATCCTCGAGATGGCACCGTCGATGAGCGGCAGCACAATCGGCG
CCTTCGGTTACCGCTTCTACACAATGGATATCCTCGCCATCCTGCTGTTCATCGGCGCGATGGGCAAATCGGCGCAGCTG
GGCCTGCACACCTGGTTGCCCGACGCGATGGAAGGCCCGACCCCGGTCTCTGCACTGATCCACGCCGCGACCATGGTGAC
CGCAGGCGTGTTCATGGTCTGCCGCCTGTCGCCGATGTTCGAAACCGCGCCGACGGCGCTGGCCATCGTGACTTTCATCG
GCGCAGCGACCTGCCTCTTCGCGGCGACGGTCGGCACGACGCAGTGGGACATCAAGCGCGTCATCGCCTATTCGACCTGC
TCGCAGCTCGGCTACATGTTCTTCGCCGCCGGTGTCGGCGCCTATGGCGTCGCCATGTTCCACCTCTTCACGCACGCCTT
CTTCAAGGCGCTGCTGTTCCTGGGCGCAGGCTCGGTCATCCACGCGATGCATCACGAGCAGGACATGCGCTATTACGGCG
CGCTGCGTAAGCATATCCCGATCACTTTCTGGGCCATGCTGGCGGGCACGCTGGCGATCACCGGCGTCGGCGTGCTGGGC
GTTTTCGGCTTCGCGGGGTTCTATTCGAAAGACGCGATTCTCGAGGCTGCCTTTGCGCGCGGCACCGACATGGGCATGTT
CGCCTTCTGGGCCGGCGCTTTCGCCGCGCTGCTGACCAGCTTCTACAGCTGGCGCCTGATGTTCCTGACTTTCTGGGGCA
AGCCGCGCTGGGCCGAAAGCGAGCATATCCAGCACGCGGTCCATCACGGGCACGACGATCCCGAACACGGCAATCCGCCG
GTGCAGGAAGACAGCGGCGACGATGTCGCGCATGCCGTGCCGTCGCCCGAGCACGCCGATGGCACCGCGGGCTATCACCC
GCACGAGAGTCCGTGGTCGATGCTGATCCCGCTGGTCGTCCTGACAATCGGCGCGATTTTCGCGGGCTATGTCTTCAAGT
ATCCGTTCGTGGACGGTTCGGCCGATGCGGTGAATGGCGCCTTCTGGGGCGATTCGATCTTCTTCAACGAAAACCTGATC
CACGCGCTGCATGCCGTCCCGCTGTGGGTGAAACTGACGGCTACAATCGTCATGATCCTCGGGTTCATCATCGCCTGGTT
TGCCTACATCAAGGACACGTCGATCCCGGGCAAGGCCGCCGAACAGCTTGGGCCGGTGTACAAATTCCTGTTCAACAAAT
GGTATTTCGACGAACTCTACAACGTGCTGTTCGTGAAGCCGGCCTTCTGGCTCGGGCGGCTGTTCTGGCACGTCATCGAT
GTCGGCGTGATCAAGCGCTTCGGACCTGACGGCGCGGCATGGGTCGTCATGCAAGGTTCTGGCGCGGCCAGGCGCCTGCA
GTCCGGTTATCTCTACAGCTACGCGCTGATCATGCTGCTGGGCCTGGTCGCCGCGGTTACCTGGGTGCTCCTGTGA

Upstream 100 bases:

>100_bases
GCAGGCGAGGCGGCTATCGGCCTCGCGATCCTCGTCATTTATTTCCGCAGCCGCGGCACGATCAGCGTCGACAGCGTCGA
CCGGCTCAAGGGGTAATCCG

Downstream 100 bases:

>100_bases
TGGAAGGCTTCCCTATCCTTACTGCTCTCCTGGTAGTGCCGCTGGTCGCGGCGCTTGCCTGCTATTTCCTCGAAGCGTCG
GCAGCGCGCATGGTCGCGCT

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 691; Mature: 690

Protein sequence:

>691_residues
MSSILIIVFGPLLASIIAGLVNKSAPSVFAKAITTGALFLSCALSWPIFIGFLTGTQEATVVPVLQWVQSGSMSFDWALR
VDALTAVMLVVINSVSALVHLYSWGYMEEDPDQPRFFAYLSLFTFAMLMLVTADNLVQMFFGWEGVGLASYLLIGFWFKK
PSANAAAIKAFVVNRVGDLGFMLGIFGTFLVFGTVSIPEILEMAPSMSGSTIGAFGYRFYTMDILAILLFIGAMGKSAQL
GLHTWLPDAMEGPTPVSALIHAATMVTAGVFMVCRLSPMFETAPTALAIVTFIGAATCLFAATVGTTQWDIKRVIAYSTC
SQLGYMFFAAGVGAYGVAMFHLFTHAFFKALLFLGAGSVIHAMHHEQDMRYYGALRKHIPITFWAMLAGTLAITGVGVLG
VFGFAGFYSKDAILEAAFARGTDMGMFAFWAGAFAALLTSFYSWRLMFLTFWGKPRWAESEHIQHAVHHGHDDPEHGNPP
VQEDSGDDVAHAVPSPEHADGTAGYHPHESPWSMLIPLVVLTIGAIFAGYVFKYPFVDGSADAVNGAFWGDSIFFNENLI
HALHAVPLWVKLTATIVMILGFIIAWFAYIKDTSIPGKAAEQLGPVYKFLFNKWYFDELYNVLFVKPAFWLGRLFWHVID
VGVIKRFGPDGAAWVVMQGSGAARRLQSGYLYSYALIMLLGLVAAVTWVLL

Sequences:

>Translated_691_residues
MSSILIIVFGPLLASIIAGLVNKSAPSVFAKAITTGALFLSCALSWPIFIGFLTGTQEATVVPVLQWVQSGSMSFDWALR
VDALTAVMLVVINSVSALVHLYSWGYMEEDPDQPRFFAYLSLFTFAMLMLVTADNLVQMFFGWEGVGLASYLLIGFWFKK
PSANAAAIKAFVVNRVGDLGFMLGIFGTFLVFGTVSIPEILEMAPSMSGSTIGAFGYRFYTMDILAILLFIGAMGKSAQL
GLHTWLPDAMEGPTPVSALIHAATMVTAGVFMVCRLSPMFETAPTALAIVTFIGAATCLFAATVGTTQWDIKRVIAYSTC
SQLGYMFFAAGVGAYGVAMFHLFTHAFFKALLFLGAGSVIHAMHHEQDMRYYGALRKHIPITFWAMLAGTLAITGVGVLG
VFGFAGFYSKDAILEAAFARGTDMGMFAFWAGAFAALLTSFYSWRLMFLTFWGKPRWAESEHIQHAVHHGHDDPEHGNPP
VQEDSGDDVAHAVPSPEHADGTAGYHPHESPWSMLIPLVVLTIGAIFAGYVFKYPFVDGSADAVNGAFWGDSIFFNENLI
HALHAVPLWVKLTATIVMILGFIIAWFAYIKDTSIPGKAAEQLGPVYKFLFNKWYFDELYNVLFVKPAFWLGRLFWHVID
VGVIKRFGPDGAAWVVMQGSGAARRLQSGYLYSYALIMLLGLVAAVTWVLL
>Mature_690_residues
SSILIIVFGPLLASIIAGLVNKSAPSVFAKAITTGALFLSCALSWPIFIGFLTGTQEATVVPVLQWVQSGSMSFDWALRV
DALTAVMLVVINSVSALVHLYSWGYMEEDPDQPRFFAYLSLFTFAMLMLVTADNLVQMFFGWEGVGLASYLLIGFWFKKP
SANAAAIKAFVVNRVGDLGFMLGIFGTFLVFGTVSIPEILEMAPSMSGSTIGAFGYRFYTMDILAILLFIGAMGKSAQLG
LHTWLPDAMEGPTPVSALIHAATMVTAGVFMVCRLSPMFETAPTALAIVTFIGAATCLFAATVGTTQWDIKRVIAYSTCS
QLGYMFFAAGVGAYGVAMFHLFTHAFFKALLFLGAGSVIHAMHHEQDMRYYGALRKHIPITFWAMLAGTLAITGVGVLGV
FGFAGFYSKDAILEAAFARGTDMGMFAFWAGAFAALLTSFYSWRLMFLTFWGKPRWAESEHIQHAVHHGHDDPEHGNPPV
QEDSGDDVAHAVPSPEHADGTAGYHPHESPWSMLIPLVVLTIGAIFAGYVFKYPFVDGSADAVNGAFWGDSIFFNENLIH
ALHAVPLWVKLTATIVMILGFIIAWFAYIKDTSIPGKAAEQLGPVYKFLFNKWYFDELYNVLFVKPAFWLGRLFWHVIDV
GVIKRFGPDGAAWVVMQGSGAARRLQSGYLYSYALIMLLGLVAAVTWVLL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cellular chromatophore membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=475, Percent_Identity=37.2631578947368, Blast_Score=290, Evalue=3e-78,
Organism=Escherichia coli, GI1788614, Length=629, Percent_Identity=36.5659777424483, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI1788829, Length=426, Percent_Identity=31.2206572769953, Blast_Score=142, Evalue=7e-35,
Organism=Escherichia coli, GI1788827, Length=425, Percent_Identity=29.1764705882353, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI1788831, Length=343, Percent_Identity=29.4460641399417, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1788613, Length=396, Percent_Identity=25.2525252525253, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI145693160, Length=276, Percent_Identity=26.0869565217391, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI2367154, Length=179, Percent_Identity=29.608938547486, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 75449; Mature: 75318

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSILIIVFGPLLASIIAGLVNKSAPSVFAKAITTGALFLSCALSWPIFIGFLTGTQEAT
CCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHH
VVPVLQWVQSGSMSFDWALRVDALTAVMLVVINSVSALVHLYSWGYMEEDPDQPRFFAYL
HHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
SLFTFAMLMLVTADNLVQMFFGWEGVGLASYLLIGFWFKKPSANAAAIKAFVVNRVGDLG
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
FMLGIFGTFLVFGTVSIPEILEMAPSMSGSTIGAFGYRFYTMDILAILLFIGAMGKSAQL
HHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GLHTWLPDAMEGPTPVSALIHAATMVTAGVFMVCRLSPMFETAPTALAIVTFIGAATCLF
CHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
AATVGTTQWDIKRVIAYSTCSQLGYMFFAAGVGAYGVAMFHLFTHAFFKALLFLGAGSVI
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
HAMHHEQDMRYYGALRKHIPITFWAMLAGTLAITGVGVLGVFGFAGFYSKDAILEAAFAR
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHC
GTDMGMFAFWAGAFAALLTSFYSWRLMFLTFWGKPRWAESEHIQHAVHHGHDDPEHGNPP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHCCCCCCCCCCCC
VQEDSGDDVAHAVPSPEHADGTAGYHPHESPWSMLIPLVVLTIGAIFAGYVFKYPFVDGS
CCCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ADAVNGAFWGDSIFFNENLIHALHAVPLWVKLTATIVMILGFIIAWFAYIKDTSIPGKAA
CCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
EQLGPVYKFLFNKWYFDELYNVLFVKPAFWLGRLFWHVIDVGVIKRFGPDGAAWVVMQGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
GAARRLQSGYLYSYALIMLLGLVAAVTWVLL
CHHHHHHCCHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
SSILIIVFGPLLASIIAGLVNKSAPSVFAKAITTGALFLSCALSWPIFIGFLTGTQEAT
CCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHH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CHHHHHHCCHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8566820 [H]