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The map label for this gene is ppi [H]

Identifier: 85373944

GI number: 85373944

Start: 1157417

End: 1158112

Strand: Direct

Name: ppi [H]

Synonym: ELI_05585

Alternate gene names: 85373944

Gene position: 1157417-1158112 (Clockwise)

Preceding gene: 85373943

Following gene: 85373945

Centisome position: 37.92

GC content: 63.94

Gene sequence:

>696_bases
ATGATCAACCGTTTGATTGCCGCTACCGCGATTGCTTCCCTTGCTGCCACGCCGCTCGCCGCACAGGACGCGGAGATGGC
GACCGATGGCGGGGAAACGGTCAGCACGGCCCGCGCGCCGATGACCTACGCCAAGATCGACTATAATCTGAACGAAGACC
GGGAAAATATCCTGTTTCTCGATCTTTCCAATGGCGAGCGGGTCGCGATCCGGCTGATGCCCGACTGGGCGCCGAACCAC
GTCGAGCGCATCAAGACGCTGACCCGGCAGGGCTTCTACGACGGCATCGTCTTCCACCGCGTGATCGAAGGGTTCATGGC
GCAGACCGGCGATCCGACCGGCACGGGGCAGGGTGGCTCTGACCTTCCCGACCTCGAAGAGGAATTCAACCCCATGCCGC
ATGTCCGCGGCAGCGTCGCCATGGCGCGCGCGCAGAGCGAAGACAGCGCCAACAGCCAGTTCTTCCTCGTGTTCTATCCG
CGCTTCAGTCTCGACAAGCGCTACACAAATTTCGGGCGGGTCATCTCGAACATGGCGGCTGTCGATGCGATTAATCGCGG
CGAGCCGCCGGCCAACCCGACCCGCATCCTGCAGGCATCGATCGCTGCGGACAACAAGCCGCGGGCTATGCCTCGGCCGG
CCCAGCCCGAGCGCGAGATCACGCTCGACGAGCTGAGCGCTCCGATCGAGGGGTGA

Upstream 100 bases:

>100_bases
ACTATTGAGGTCCGCGCGCATTTCCCCAAGCTATTAATTGCGGAGACAGCGCGGCGCGGTTAATGCGCGGGCAGACACGC
CCCAACACTTCAGGATATCC

Downstream 100 bases:

>100_bases
CGCAGCGCGCGAGGGGCGCTAACCGCGCGCTTCGATGCGTGTAGACCTGTTCGATTTCGAACTCCCTCAGGAGCTGATTG
CGCTGCGCCCGGCGGTGCCG

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MINRLIAATAIASLAATPLAAQDAEMATDGGETVSTARAPMTYAKIDYNLNEDRENILFLDLSNGERVAIRLMPDWAPNH
VERIKTLTRQGFYDGIVFHRVIEGFMAQTGDPTGTGQGGSDLPDLEEEFNPMPHVRGSVAMARAQSEDSANSQFFLVFYP
RFSLDKRYTNFGRVISNMAAVDAINRGEPPANPTRILQASIAADNKPRAMPRPAQPEREITLDELSAPIEG

Sequences:

>Translated_231_residues
MINRLIAATAIASLAATPLAAQDAEMATDGGETVSTARAPMTYAKIDYNLNEDRENILFLDLSNGERVAIRLMPDWAPNH
VERIKTLTRQGFYDGIVFHRVIEGFMAQTGDPTGTGQGGSDLPDLEEEFNPMPHVRGSVAMARAQSEDSANSQFFLVFYP
RFSLDKRYTNFGRVISNMAAVDAINRGEPPANPTRILQASIAADNKPRAMPRPAQPEREITLDELSAPIEG
>Mature_231_residues
MINRLIAATAIASLAATPLAAQDAEMATDGGETVSTARAPMTYAKIDYNLNEDRENILFLDLSNGERVAIRLMPDWAPNH
VERIKTLTRQGFYDGIVFHRVIEGFMAQTGDPTGTGQGGSDLPDLEEEFNPMPHVRGSVAMARAQSEDSANSQFFLVFYP
RFSLDKRYTNFGRVISNMAAVDAINRGEPPANPTRILQASIAADNKPRAMPRPAQPEREITLDELSAPIEG

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=122, Percent_Identity=41.8032786885246, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI19557636, Length=123, Percent_Identity=37.3983739837398, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI7706339, Length=150, Percent_Identity=34, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI64276486, Length=145, Percent_Identity=35.1724137931034, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI1786736, Length=132, Percent_Identity=35.6060606060606, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789763, Length=149, Percent_Identity=32.8859060402685, Blast_Score=71, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17506311, Length=158, Percent_Identity=38.6075949367089, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71980594, Length=159, Percent_Identity=35.2201257861635, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17539496, Length=156, Percent_Identity=34.6153846153846, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71980590, Length=147, Percent_Identity=36.0544217687075, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17532641, Length=209, Percent_Identity=30.622009569378, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71997782, Length=151, Percent_Identity=34.4370860927152, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17986117, Length=154, Percent_Identity=34.4155844155844, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24652460, Length=130, Percent_Identity=38.4615384615385, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI19922376, Length=143, Percent_Identity=30.7692307692308, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357249, Length=160, Percent_Identity=30, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19922912, Length=143, Percent_Identity=41.2587412587413, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 25308; Mature: 25308

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINRLIAATAIASLAATPLAAQDAEMATDGGETVSTARAPMTYAKIDYNLNEDRENILFL
CCCHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHCCEEEEEEECCCCCCCCCEEEE
DLSNGERVAIRLMPDWAPNHVERIKTLTRQGFYDGIVFHRVIEGFMAQTGDPTGTGQGGS
ECCCCCEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DLPDLEEEFNPMPHVRGSVAMARAQSEDSANSQFFLVFYPRFSLDKRYTNFGRVISNMAA
CCCCHHHHCCCCCCCCCHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHH
VDAINRGEPPANPTRILQASIAADNKPRAMPRPAQPEREITLDELSAPIEG
HHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEHHHHCCCCCC
>Mature Secondary Structure
MINRLIAATAIASLAATPLAAQDAEMATDGGETVSTARAPMTYAKIDYNLNEDRENILFL
CCCHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHCCEEEEEEECCCCCCCCCEEEE
DLSNGERVAIRLMPDWAPNHVERIKTLTRQGFYDGIVFHRVIEGFMAQTGDPTGTGQGGS
ECCCCCEEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DLPDLEEEFNPMPHVRGSVAMARAQSEDSANSQFFLVFYPRFSLDKRYTNFGRVISNMAA
CCCCHHHHCCCCCCCCCHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHH
VDAINRGEPPANPTRILQASIAADNKPRAMPRPAQPEREITLDELSAPIEG
HHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA