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The map label for this gene is lldD2 [H]

Identifier: 85373925

GI number: 85373925

Start: 1141030

End: 1142184

Strand: Reverse

Name: lldD2 [H]

Synonym: ELI_05490

Alternate gene names: 85373925

Gene position: 1142184-1141030 (Counterclockwise)

Preceding gene: 85373926

Following gene: 85373920

Centisome position: 37.42

GC content: 63.81

Gene sequence:

>1155_bases
GTGCGCCTCTCCGACTGCCACAATATCGAGGATTTTCGCCGCCTCGCAAAGACCCGTCTTCCGTGGCCGGTCTTCGACTA
TATCGATGGTGCCGCCGACGACGAATTGACCAAGGCCCGCAATACCGCAGCCTATGACGATGTCGATCTGGTACCCGATG
TGCTGGCTGGCGTGGCCGAGATCGACACGTCCTGCACGATCATGGGCCGCGAAAGCGCCCTTCCCCTGTTGCTCAGCCCG
ACGGCGGTGCAGCGCGCCTTCCATTGGCAGGGCGAAACCGCCGTGGCCAAGGCGGCGGAGAAATTCGGGCTGTGGTTCGG
CATCTCCAGCCTGGCGACGCGGAGTATCGAGGAAATTGCTGCGCTCACCCAGGGTCCCAAGCTGTTCCAGCTTTATGTGC
ACAAGGACAAGGGGCTGAATCAATCGATGATAGAACGCTGTCAGGCCGCGCAGTTCGATGCGCTCGCGCTCACGGTCGAC
ACCATTGTCTCCGGCAAGCGCGAGCGGTGCCTGCGAAGCGGCTTCACCACTCCGCCCAAGTTCTCACCAAGTGCGGTGTG
GAGCTACGCCACGCGGCCGCGCTGGACGCTCGATTACCTTTTCCGCGAGAGATTTCGCTTGCCCAATCTCGACACGCACG
TCGCGGAAGGGTCCCGCGAGGCTGTGAGCATCGCTGAGTATTTCAACACCATGCTCGATACCTCGATGAACTGGGACACT
GCCGCCAAGATCCGGCAGGACTGGGGCGGTACCTTCTGCCTGAAAGGGGTGATGAGTGCGGGCGATGCGCGACGCGCGGT
CGAGATCGGGGCCGATGCCATCATGATCTCCAATCACGGTGGGCGGCAGCTCGACGGCAGCCGCGCGCCCTTCGACCAAT
TGGGCGAAATCGTCAAGGCAGTCGGCGGCGAGATCGAGATCATTTGCGACGGCGGCGTGCGGCGCGGGACGCATGCGCTG
AAAGCTGTGAGTGCTGGCGCGACGGCGGCGAGCGGCGGGCGGCTCTACCTCTATGCGCTCGCGGCCGCAGGTCAGCCTGG
TGTCGAGCGCGCCATCGGCATTCTGAAGGACGAGATCGAGCGCGGGATGCGGTTGATGGGCGTGACCTCGGTCGATCAAC
TCACCGCGGACCGCCTGCGCTGGCGCTATTCGTGA

Upstream 100 bases:

>100_bases
GAAAAAATCCCCGCTGTTCGATCCCGAAACCAAAGAGCCGATTGCCAGTCCCCGCCGCGTGTCGCCTGAAGAGCGCGCCA
CTTTGGGCGAAGCCTGACAC

Downstream 100 bases:

>100_bases
AAAAGGGGCAGCCGGCGGGTAGACCGACTGCCCCGGACGAGCGGGCAAGGATGGGGAGGCCCCACTCGCCCTGCCGAGGG
GGTTAATCCCGGCCTTCCGG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MRLSDCHNIEDFRRLAKTRLPWPVFDYIDGAADDELTKARNTAAYDDVDLVPDVLAGVAEIDTSCTIMGRESALPLLLSP
TAVQRAFHWQGETAVAKAAEKFGLWFGISSLATRSIEEIAALTQGPKLFQLYVHKDKGLNQSMIERCQAAQFDALALTVD
TIVSGKRERCLRSGFTTPPKFSPSAVWSYATRPRWTLDYLFRERFRLPNLDTHVAEGSREAVSIAEYFNTMLDTSMNWDT
AAKIRQDWGGTFCLKGVMSAGDARRAVEIGADAIMISNHGGRQLDGSRAPFDQLGEIVKAVGGEIEIICDGGVRRGTHAL
KAVSAGATAASGGRLYLYALAAAGQPGVERAIGILKDEIERGMRLMGVTSVDQLTADRLRWRYS

Sequences:

>Translated_384_residues
MRLSDCHNIEDFRRLAKTRLPWPVFDYIDGAADDELTKARNTAAYDDVDLVPDVLAGVAEIDTSCTIMGRESALPLLLSP
TAVQRAFHWQGETAVAKAAEKFGLWFGISSLATRSIEEIAALTQGPKLFQLYVHKDKGLNQSMIERCQAAQFDALALTVD
TIVSGKRERCLRSGFTTPPKFSPSAVWSYATRPRWTLDYLFRERFRLPNLDTHVAEGSREAVSIAEYFNTMLDTSMNWDT
AAKIRQDWGGTFCLKGVMSAGDARRAVEIGADAIMISNHGGRQLDGSRAPFDQLGEIVKAVGGEIEIICDGGVRRGTHAL
KAVSAGATAASGGRLYLYALAAAGQPGVERAIGILKDEIERGMRLMGVTSVDQLTADRLRWRYS
>Mature_384_residues
MRLSDCHNIEDFRRLAKTRLPWPVFDYIDGAADDELTKARNTAAYDDVDLVPDVLAGVAEIDTSCTIMGRESALPLLLSP
TAVQRAFHWQGETAVAKAAEKFGLWFGISSLATRSIEEIAALTQGPKLFQLYVHKDKGLNQSMIERCQAAQFDALALTVD
TIVSGKRERCLRSGFTTPPKFSPSAVWSYATRPRWTLDYLFRERFRLPNLDTHVAEGSREAVSIAEYFNTMLDTSMNWDT
AAKIRQDWGGTFCLKGVMSAGDARRAVEIGADAIMISNHGGRQLDGSRAPFDQLGEIVKAVGGEIEIICDGGVRRGTHAL
KAVSAGATAASGGRLYLYALAAAGQPGVERAIGILKDEIERGMRLMGVTSVDQLTADRLRWRYS

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=373, Percent_Identity=34.5844504021448, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI54234014, Length=374, Percent_Identity=33.1550802139037, Blast_Score=198, Evalue=5e-51,
Organism=Homo sapiens, GI7705393, Length=374, Percent_Identity=33.1550802139037, Blast_Score=198, Evalue=5e-51,
Organism=Escherichia coli, GI1790033, Length=373, Percent_Identity=34.0482573726542, Blast_Score=208, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI193208036, Length=376, Percent_Identity=33.2446808510638, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI32566217, Length=287, Percent_Identity=32.0557491289199, Blast_Score=138, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6323587, Length=388, Percent_Identity=32.2164948453608, Blast_Score=183, Evalue=4e-47,
Organism=Drosophila melanogaster, GI78707188, Length=369, Percent_Identity=32.2493224932249, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI281363140, Length=369, Percent_Identity=32.2493224932249, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI78707190, Length=369, Percent_Identity=32.2493224932249, Blast_Score=186, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 42111; Mature: 42111

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLSDCHNIEDFRRLAKTRLPWPVFDYIDGAADDELTKARNTAAYDDVDLVPDVLAGVAE
CCCCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHH
IDTSCTIMGRESALPLLLSPTAVQRAFHWQGETAVAKAAEKFGLWFGISSLATRSIEEIA
CCCCEEEEECCCCCCEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALTQGPKLFQLYVHKDKGLNQSMIERCQAAQFDALALTVDTIVSGKRERCLRSGFTTPPK
HHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCHHHEEHHHHHCCHHHHHHHCCCCCCCC
FSPSAVWSYATRPRWTLDYLFRERFRLPNLDTHVAEGSREAVSIAEYFNTMLDTSMNWDT
CCCHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCHH
AAKIRQDWGGTFCLKGVMSAGDARRAVEIGADAIMISNHGGRQLDGSRAPFDQLGEIVKA
HHHHHHHCCCHHHHHHHHHCCCHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHH
VGGEIEIICDGGVRRGTHALKAVSAGATAASGGRLYLYALAAAGQPGVERAIGILKDEIE
CCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHH
RGMRLMGVTSVDQLTADRLRWRYS
CCHHEECCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MRLSDCHNIEDFRRLAKTRLPWPVFDYIDGAADDELTKARNTAAYDDVDLVPDVLAGVAE
CCCCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHH
IDTSCTIMGRESALPLLLSPTAVQRAFHWQGETAVAKAAEKFGLWFGISSLATRSIEEIA
CCCCEEEEECCCCCCEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALTQGPKLFQLYVHKDKGLNQSMIERCQAAQFDALALTVDTIVSGKRERCLRSGFTTPPK
HHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCHHHEEHHHHHCCHHHHHHHCCCCCCCC
FSPSAVWSYATRPRWTLDYLFRERFRLPNLDTHVAEGSREAVSIAEYFNTMLDTSMNWDT
CCCHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCHH
AAKIRQDWGGTFCLKGVMSAGDARRAVEIGADAIMISNHGGRQLDGSRAPFDQLGEIVKA
HHHHHHHCCCHHHHHHHHHCCCHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHH
VGGEIEIICDGGVRRGTHALKAVSAGATAASGGRLYLYALAAAGQPGVERAIGILKDEIE
CCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHH
RGMRLMGVTSVDQLTADRLRWRYS
CCHHEECCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]