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The map label for this gene is atoC [H]

Identifier: 85373892

GI number: 85373892

Start: 1101460

End: 1102824

Strand: Direct

Name: atoC [H]

Synonym: ELI_05325

Alternate gene names: 85373892

Gene position: 1101460-1102824 (Clockwise)

Preceding gene: 85373891

Following gene: 85373893

Centisome position: 36.09

GC content: 62.64

Gene sequence:

>1365_bases
ATGGCCCAGAACCGACCCAAACTGCTCGTGATTGAGGACGATCCCGGCCTGCAGGCCCAGCTCAAATGGGCTTACGAGGA
CTTCGAGGTCGTCATTGCCGGAAATCGCGAACAGGCGCTTGCGGCGGTGCGTTCGGACGAACCGGCGGTCGTAACGCTCG
ACCTCGGCCTGCCGCCCGACCCGGACGGTACGAGCGAGGGCTTTGCCGTGCTCGACGCCATCATGGCGATAAAACCCGAT
ACGAAAGTGATCGTTGCCTCGGGCCACGGTGCCAGGGAAAGCGCGCTTCAGGCGATCGCGCGCGGTGCCTATGACTTCTA
CCAGAAGCCCGTCGATATCGACGACCTCGGGCTGATCGTGCGGCGTGCCTTCAATCTGCATGCGATCGAAGCGGAGAACC
GCCGATTGGCGGATCAGGTCGGCGAAGACCGTACCGTGCTCGGTTCGCTCATCACCGGGGCGCCGGAAATGGCCAAGGTC
GCCCGCACGGTGGAGCGCGTCGCCAAGACCGACGTTTCGGTGATGCTGTTGGGCGCGAGCGGGACCGGAAAGGAGCTTCT
CGCGCGCGGCGTTCATGACAGCAGTGACCGTCGCGATGCGGCCTTCGTTGCCATCAATTGTGCGGCGATCCCGGAAAACC
TGCTGGAAAGCGAACTGTTCGGGCATGAAAAGGGCGCGTTTACCGGGGCGGTGAAAACGACCGAGGGCAAGATCGAACAG
GCCCACGGCGGTACGCTGTTTCTCGACGAGGTCGGTGACATTCCGCTGCCGTTACAGGTCAAGTTGCTTCGCTTCCTGCA
AGAGCGCACGATCGAAAGAATTGGCGGACGCAAGCAGATCGCTGTCGACACTCGCATCGTCTGCGCGACGCACCAGGATC
TCGAATCCATGACGGCGGAGGGTACGTTTCGCGAGGACCTGTTCTATCGCTTGGCCGAGATCGTCATCAAGATTCCGTCG
TTGGCAGAGCGGCCCGGCGACGCGGCGCTGCTGGCCAAGGCCTTTGTCACGCGCTTCGCCAAGGAAATGAACCCGCAGGT
CAAGGGCTTTGCTCCCGATGCGCTCGCGGCGATCGATGGCTGGGGCTGGCCAGGTAACGTCCGCGAGCTCGAGAACCGCG
TCAAGCGCGCCGTTATCATGGCCGACAGCCGATTGATCGGCGCCGAAGATCTCGATCTCGCTCCCGATGGCGAAGAGCAG
AGCCAGGCTCTCAACCTGAAGGCCGCGCGCGAACTGGCCGACCGCCGTGTGATCCGCCATGCGCTCGCGCGTACCGAAGG
CAATATCTCCAGTACAGCCAAGCTTCTGGGGATTAGCCGCCCGACGCTCTACGATTTGCTCAAGCAGTATGATCTGCACG
CGTAA

Upstream 100 bases:

>100_bases
TCCAGTCGCGCCCCGGTATCGGCTCGCGCTTCTCCATCACTTTGCCGCTTGCCGAAGCGGCGAGGTTCCTCTCCTCCAAT
AATGACCAAGAGGCTGCCTG

Downstream 100 bases:

>100_bases
AACCCTGCGCGGTATCTTCGGCGTTGCGGTATTCGCTTTGTCGCTTGCGGCCTGCAGCGAGAACACGCCCGAGCAGCCGC
CGCTCGAGCGGGCGATTGCG

Product: helix-turn-helix, Fis-type protein

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MAQNRPKLLVIEDDPGLQAQLKWAYEDFEVVIAGNREQALAAVRSDEPAVVTLDLGLPPDPDGTSEGFAVLDAIMAIKPD
TKVIVASGHGARESALQAIARGAYDFYQKPVDIDDLGLIVRRAFNLHAIEAENRRLADQVGEDRTVLGSLITGAPEMAKV
ARTVERVAKTDVSVMLLGASGTGKELLARGVHDSSDRRDAAFVAINCAAIPENLLESELFGHEKGAFTGAVKTTEGKIEQ
AHGGTLFLDEVGDIPLPLQVKLLRFLQERTIERIGGRKQIAVDTRIVCATHQDLESMTAEGTFREDLFYRLAEIVIKIPS
LAERPGDAALLAKAFVTRFAKEMNPQVKGFAPDALAAIDGWGWPGNVRELENRVKRAVIMADSRLIGAEDLDLAPDGEEQ
SQALNLKAARELADRRVIRHALARTEGNISSTAKLLGISRPTLYDLLKQYDLHA

Sequences:

>Translated_454_residues
MAQNRPKLLVIEDDPGLQAQLKWAYEDFEVVIAGNREQALAAVRSDEPAVVTLDLGLPPDPDGTSEGFAVLDAIMAIKPD
TKVIVASGHGARESALQAIARGAYDFYQKPVDIDDLGLIVRRAFNLHAIEAENRRLADQVGEDRTVLGSLITGAPEMAKV
ARTVERVAKTDVSVMLLGASGTGKELLARGVHDSSDRRDAAFVAINCAAIPENLLESELFGHEKGAFTGAVKTTEGKIEQ
AHGGTLFLDEVGDIPLPLQVKLLRFLQERTIERIGGRKQIAVDTRIVCATHQDLESMTAEGTFREDLFYRLAEIVIKIPS
LAERPGDAALLAKAFVTRFAKEMNPQVKGFAPDALAAIDGWGWPGNVRELENRVKRAVIMADSRLIGAEDLDLAPDGEEQ
SQALNLKAARELADRRVIRHALARTEGNISSTAKLLGISRPTLYDLLKQYDLHA
>Mature_453_residues
AQNRPKLLVIEDDPGLQAQLKWAYEDFEVVIAGNREQALAAVRSDEPAVVTLDLGLPPDPDGTSEGFAVLDAIMAIKPDT
KVIVASGHGARESALQAIARGAYDFYQKPVDIDDLGLIVRRAFNLHAIEAENRRLADQVGEDRTVLGSLITGAPEMAKVA
RTVERVAKTDVSVMLLGASGTGKELLARGVHDSSDRRDAAFVAINCAAIPENLLESELFGHEKGAFTGAVKTTEGKIEQA
HGGTLFLDEVGDIPLPLQVKLLRFLQERTIERIGGRKQIAVDTRIVCATHQDLESMTAEGTFREDLFYRLAEIVIKIPSL
AERPGDAALLAKAFVTRFAKEMNPQVKGFAPDALAAIDGWGWPGNVRELENRVKRAVIMADSRLIGAEDLDLAPDGEEQS
QALNLKAARELADRRVIRHALARTEGNISSTAKLLGISRPTLYDLLKQYDLHA

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=460, Percent_Identity=40.6521739130435, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI1790437, Length=456, Percent_Identity=40.3508771929825, Blast_Score=307, Evalue=1e-84,
Organism=Escherichia coli, GI1788905, Length=456, Percent_Identity=37.719298245614, Blast_Score=294, Evalue=8e-81,
Organism=Escherichia coli, GI1790299, Length=481, Percent_Identity=36.5904365904366, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI87082117, Length=284, Percent_Identity=46.4788732394366, Blast_Score=262, Evalue=4e-71,
Organism=Escherichia coli, GI1789087, Length=321, Percent_Identity=41.4330218068536, Blast_Score=241, Evalue=7e-65,
Organism=Escherichia coli, GI1789233, Length=312, Percent_Identity=43.9102564102564, Blast_Score=228, Evalue=4e-61,
Organism=Escherichia coli, GI87081872, Length=319, Percent_Identity=37.3040752351097, Blast_Score=211, Evalue=7e-56,
Organism=Escherichia coli, GI1786524, Length=324, Percent_Identity=39.1975308641975, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI87082152, Length=337, Percent_Identity=37.0919881305638, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI1787583, Length=325, Percent_Identity=34.7692307692308, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI1789828, Length=347, Percent_Identity=31.700288184438, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI87081858, Length=337, Percent_Identity=27.5964391691395, Blast_Score=134, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49358; Mature: 49227

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQNRPKLLVIEDDPGLQAQLKWAYEDFEVVIAGNREQALAAVRSDEPAVVTLDLGLPPD
CCCCCCCEEEEECCCCCCEEEEEEECCEEEEEECCHHHHHHHHCCCCCEEEEEECCCCCC
PDGTSEGFAVLDAIMAIKPDTKVIVASGHGARESALQAIARGAYDFYQKPVDIDDLGLIV
CCCCCCHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
RRAFNLHAIEAENRRLADQVGEDRTVLGSLITGAPEMAKVARTVERVAKTDVSVMLLGAS
HHHHCCEEECCCCHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEECC
GTGKELLARGVHDSSDRRDAAFVAINCAAIPENLLESELFGHEKGAFTGAVKTTEGKIEQ
CCCHHHHHHCCCCCCCCCCEEEEEEEEHHCCHHHHHHHHHCCCCCCEECEEECCCCCHHH
AHGGTLFLDEVGDIPLPLQVKLLRFLQERTIERIGGRKQIAVDTRIVCATHQDLESMTAE
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECEEEEEECHHHHHHHHCC
GTFREDLFYRLAEIVIKIPSLAERPGDAALLAKAFVTRFAKEMNPQVKGFAPDALAAIDG
CCHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCC
WGWPGNVRELENRVKRAVIMADSRLIGAEDLDLAPDGEEQSQALNLKAARELADRRVIRH
CCCCCCHHHHHHHHHHHHHEECCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ALARTEGNISSTAKLLGISRPTLYDLLKQYDLHA
HHHHCCCCHHHHHHHHCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
AQNRPKLLVIEDDPGLQAQLKWAYEDFEVVIAGNREQALAAVRSDEPAVVTLDLGLPPD
CCCCCCEEEEECCCCCCEEEEEEECCEEEEEECCHHHHHHHHCCCCCEEEEEECCCCCC
PDGTSEGFAVLDAIMAIKPDTKVIVASGHGARESALQAIARGAYDFYQKPVDIDDLGLIV
CCCCCCHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
RRAFNLHAIEAENRRLADQVGEDRTVLGSLITGAPEMAKVARTVERVAKTDVSVMLLGAS
HHHHCCEEECCCCHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEECC
GTGKELLARGVHDSSDRRDAAFVAINCAAIPENLLESELFGHEKGAFTGAVKTTEGKIEQ
CCCHHHHHHCCCCCCCCCCEEEEEEEEHHCCHHHHHHHHHCCCCCCEECEEECCCCCHHH
AHGGTLFLDEVGDIPLPLQVKLLRFLQERTIERIGGRKQIAVDTRIVCATHQDLESMTAE
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECEEEEEECHHHHHHHHCC
GTFREDLFYRLAEIVIKIPSLAERPGDAALLAKAFVTRFAKEMNPQVKGFAPDALAAIDG
CCHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCC
WGWPGNVRELENRVKRAVIMADSRLIGAEDLDLAPDGEEQSQALNLKAARELADRRVIRH
CCCCCCHHHHHHHHHHHHHEECCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ALARTEGNISSTAKLLGISRPTLYDLLKQYDLHA
HHHHCCCCHHHHHHHHCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]