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The map label for this gene is divL [H]

Identifier: 85373836

GI number: 85373836

Start: 1037192

End: 1039534

Strand: Direct

Name: divL [H]

Synonym: ELI_05045

Alternate gene names: 85373836

Gene position: 1037192-1039534 (Clockwise)

Preceding gene: 85373835

Following gene: 85373837

Centisome position: 33.98

GC content: 64.19

Gene sequence:

>2343_bases
ATGGAACTTTCACCCACGATCATTGCCTTGCTTGGTCTGCTGCTCGCCGCTTGGACCGTGGGTGCTGCGTGGCTCATGAT
TTCAGCAGGGGCGAAGGCCAAGGGGGCGGAAAGCACGCGCAAGGCTGCGCGCCGCATGGCTCGCTTGCTCGATGAAGCCC
CGGCGATCCCTTTGCTCGTCCGCGCCGACGGCCGCATCGAAGGGTCGGATCGGCTCGCGCACTGGCTCGGCTTCGACGCA
TTGCCGCAATTCCTCAGCGAACTGGCGGATGCCGACGATCGCGGGCTGACCAAGGCGCAGCTAAGCGAGCTATCGGAAAA
GGTGCGCCGCGCGCAAAAGTCCGCTGCACCATTTCGCATGAATATCACTGTGCCCGGCTCGCAGCGCAGCCTGGCATTGC
GTGGGACTCTGGCGGATCCGCAGGTTTCGCCCGGCGGAGCAGCCCTGGTGTGGGTTTTCGACTTCAGCGAAAGCGCGACC
GAACTCAGCCGCATGCGCGAGGAATCGGCGCGGGCGAAAGGCGATTTTGCCGCTTTGGTGGGCCTGATCGAAGCGGCACC
GATGCCGATGTGGTTTCGCGGCACGGACACCCGGTTACGGCTCGTCAACAGCGCCTATGTCGAAGCAGTCGGCGCGGAAA
GCGCCGAAGGCGTCGTCGAGGGACAGGTCGAACTGATCGAAAGCGTTGACGGCCTCAGCGCGGCGCAGGTCGCGGGGCAG
GCGGTCCAACACAAGCAATCGGTCGAACGGATCGTCCAGGCGACTATCGGTGGCGAACGTCGCGCATTGCGCGTCTCGGA
CCTGCCGTTGGGCGAAGAAGGCGTTGCCGGATACGCGGTCGACATCCAAGAGATGGAAGAGCAGGCGCGCGCGCACCGGG
CCTATGCCAAGGCGCAGCGCAACATGCTCGATCGCCTGTCGGTCGGCGTGGCGCAGTTCGATGCCGAGCGTAAGCTGACT
TTTGCCAATCAACCTTTCCGCCGCATCTTCAATATGCGGCTCGGCGGGTTGGCCGACGGCTTGCCTTTCGAACGCCTGCT
CAGCGAGGCCCGCGATGCCGGGCGGACGCCCGAAGTTCGCGATTTTCCAGCTTGGCGGCAGGAGCATGTCGAGTGGTTCG
CGAGCGGCGAAACGCAGGAAGAGGCATGGCCGCTGTCCGACGGGACGCACCTGCGCATCGTGGCGCAACCGATGCCCGAT
GGCGGCCTTGCCATCATCGCAGAGGACCGTACCGAGCAGCTGGCGCTGTCGGCCACTCGCGACACCTTGCTGCGCACACG
CACGGCGACGCTCGACAGCTTGTTCGAAGCGCTCGCAGTTTTCGCTCCCGACGGTCATCTGCAGCTGTGGAACCGGAGCT
TCGCGAGCACTTGGGGTGTGGAAGCCGAAACGCTGGACGAGCACCCACTGGTCGACACCATGCTCGAGGAAATCGCCGGT
AATCTGGCCAAACCCAAACATATCAAGCGGGTCGGTGAGGTCATCCGTACGGCCACGCTCGACCGGAACGAAACCGGCAG
CCGGGTCGCGCTGGCCGATGGCCGCACGCTCGAATTCGCCGGCGTTCCGTTGCCCGATGGGAATGGCTTGCTCACCACGC
TCGATGTGACCGCCAACGAACAGGCGGAAACGGCGCTGCGAGAACGCAACCAGGCGCTCGAACAGGCGGACCAGGTCAAG
ACACGCTTCCTCGCCAATATGTCCTACGAATTCCGCACGCCGCTGACCTCGATCGGCGGCTTTGCCGAGCTGCTGGAGAG
TGGTGTCGCGGGCGAACTGTCACCGCAAGGCAGGGAATATGTGCAAGCAATCCTCGACTCGGTCGGACGCCTGACCGAGC
AGGTCGAGAATGTCCTCGACCTCTCGCAAAGCGAAGCCGGGCTTCTGCCGCTACGGAAGGAAAAACTCGAACTGCAGCCT
TTCGTCACACAGGTAGTGCGCGAGCGCGAGGCAGAGATCGAGGCCAAGGGGCTCTCGCTCGATCTGCGCGGCGGAGCCAA
TATCAAGGTCGAAGCCGATCGCCGACAATTGGCGCGGGCGGTTGGACATCTGCTCGACAATGCCATCGTGGCGACGGATC
GTGGTGGCAAGATCCTGGTCGATCTGGCCAAGAAACCCGAGGGCACCCGCATCGTCTTGTCGGATAACGGCGCGGGCATG
TCGAGCGAGGAATTGCGCCGGGCGCTTGAAGGTTTGCGCATAAGCGAGGATGGCGAGGGGATCGAGCGGCGGCAGGGGCT
CGGCATCCCGCTTGCCCGGCAATTGATCGAAGCGCACGGCGGAGACCTCACGATCCAGTCGCAAACCGGACTCGGCACTA
GCGCGACGATCCTGCTGCCGTGA

Upstream 100 bases:

>100_bases
CGGGAATTCGCGGAAAACGGACAAGCCCTCGCGATTGCGGGGGCTTTTCCTTTTCTGGCCAGTTGCATCGCCGCGCCGGG
CGGCATAGCTGCAATGCCGC

Downstream 100 bases:

>100_bases
TCGTGCGGCTGCCCGACCTTGCAGCCGTCGAGGCCTTCGGTGCGCGCATCGCTGCCAAACTGGGTGTGGGCGATGTCGTT
GCGCTTTCCGGTACGCTCGG

Product: two-component signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 780; Mature: 780

Protein sequence:

>780_residues
MELSPTIIALLGLLLAAWTVGAAWLMISAGAKAKGAESTRKAARRMARLLDEAPAIPLLVRADGRIEGSDRLAHWLGFDA
LPQFLSELADADDRGLTKAQLSELSEKVRRAQKSAAPFRMNITVPGSQRSLALRGTLADPQVSPGGAALVWVFDFSESAT
ELSRMREESARAKGDFAALVGLIEAAPMPMWFRGTDTRLRLVNSAYVEAVGAESAEGVVEGQVELIESVDGLSAAQVAGQ
AVQHKQSVERIVQATIGGERRALRVSDLPLGEEGVAGYAVDIQEMEEQARAHRAYAKAQRNMLDRLSVGVAQFDAERKLT
FANQPFRRIFNMRLGGLADGLPFERLLSEARDAGRTPEVRDFPAWRQEHVEWFASGETQEEAWPLSDGTHLRIVAQPMPD
GGLAIIAEDRTEQLALSATRDTLLRTRTATLDSLFEALAVFAPDGHLQLWNRSFASTWGVEAETLDEHPLVDTMLEEIAG
NLAKPKHIKRVGEVIRTATLDRNETGSRVALADGRTLEFAGVPLPDGNGLLTTLDVTANEQAETALRERNQALEQADQVK
TRFLANMSYEFRTPLTSIGGFAELLESGVAGELSPQGREYVQAILDSVGRLTEQVENVLDLSQSEAGLLPLRKEKLELQP
FVTQVVREREAEIEAKGLSLDLRGGANIKVEADRRQLARAVGHLLDNAIVATDRGGKILVDLAKKPEGTRIVLSDNGAGM
SSEELRRALEGLRISEDGEGIERRQGLGIPLARQLIEAHGGDLTIQSQTGLGTSATILLP

Sequences:

>Translated_780_residues
MELSPTIIALLGLLLAAWTVGAAWLMISAGAKAKGAESTRKAARRMARLLDEAPAIPLLVRADGRIEGSDRLAHWLGFDA
LPQFLSELADADDRGLTKAQLSELSEKVRRAQKSAAPFRMNITVPGSQRSLALRGTLADPQVSPGGAALVWVFDFSESAT
ELSRMREESARAKGDFAALVGLIEAAPMPMWFRGTDTRLRLVNSAYVEAVGAESAEGVVEGQVELIESVDGLSAAQVAGQ
AVQHKQSVERIVQATIGGERRALRVSDLPLGEEGVAGYAVDIQEMEEQARAHRAYAKAQRNMLDRLSVGVAQFDAERKLT
FANQPFRRIFNMRLGGLADGLPFERLLSEARDAGRTPEVRDFPAWRQEHVEWFASGETQEEAWPLSDGTHLRIVAQPMPD
GGLAIIAEDRTEQLALSATRDTLLRTRTATLDSLFEALAVFAPDGHLQLWNRSFASTWGVEAETLDEHPLVDTMLEEIAG
NLAKPKHIKRVGEVIRTATLDRNETGSRVALADGRTLEFAGVPLPDGNGLLTTLDVTANEQAETALRERNQALEQADQVK
TRFLANMSYEFRTPLTSIGGFAELLESGVAGELSPQGREYVQAILDSVGRLTEQVENVLDLSQSEAGLLPLRKEKLELQP
FVTQVVREREAEIEAKGLSLDLRGGANIKVEADRRQLARAVGHLLDNAIVATDRGGKILVDLAKKPEGTRIVLSDNGAGM
SSEELRRALEGLRISEDGEGIERRQGLGIPLARQLIEAHGGDLTIQSQTGLGTSATILLP
>Mature_780_residues
MELSPTIIALLGLLLAAWTVGAAWLMISAGAKAKGAESTRKAARRMARLLDEAPAIPLLVRADGRIEGSDRLAHWLGFDA
LPQFLSELADADDRGLTKAQLSELSEKVRRAQKSAAPFRMNITVPGSQRSLALRGTLADPQVSPGGAALVWVFDFSESAT
ELSRMREESARAKGDFAALVGLIEAAPMPMWFRGTDTRLRLVNSAYVEAVGAESAEGVVEGQVELIESVDGLSAAQVAGQ
AVQHKQSVERIVQATIGGERRALRVSDLPLGEEGVAGYAVDIQEMEEQARAHRAYAKAQRNMLDRLSVGVAQFDAERKLT
FANQPFRRIFNMRLGGLADGLPFERLLSEARDAGRTPEVRDFPAWRQEHVEWFASGETQEEAWPLSDGTHLRIVAQPMPD
GGLAIIAEDRTEQLALSATRDTLLRTRTATLDSLFEALAVFAPDGHLQLWNRSFASTWGVEAETLDEHPLVDTMLEEIAG
NLAKPKHIKRVGEVIRTATLDRNETGSRVALADGRTLEFAGVPLPDGNGLLTTLDVTANEQAETALRERNQALEQADQVK
TRFLANMSYEFRTPLTSIGGFAELLESGVAGELSPQGREYVQAILDSVGRLTEQVENVLDLSQSEAGLLPLRKEKLELQP
FVTQVVREREAEIEAKGLSLDLRGGANIKVEADRRQLARAVGHLLDNAIVATDRGGKILVDLAKKPEGTRIVLSDNGAGM
SSEELRRALEGLRISEDGEGIERRQGLGIPLARQLIEAHGGDLTIQSQTGLGTSATILLP

Specific function: Required for cell division and growth. It catalyzes the phosphorylation of CtrA and activates transcription in vitro of the cell cycle-regulated fliF promoter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=459, Percent_Identity=24.1830065359477, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1786600, Length=275, Percent_Identity=28.7272727272727, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788393, Length=236, Percent_Identity=30.0847457627119, Blast_Score=97, Evalue=5e-21,
Organism=Escherichia coli, GI1789149, Length=230, Percent_Identity=30.8695652173913, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1788713, Length=262, Percent_Identity=30.5343511450382, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI48994928, Length=238, Percent_Identity=26.4705882352941, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1786912, Length=261, Percent_Identity=26.0536398467433, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1788549, Length=241, Percent_Identity=24.0663900414938, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI87081816, Length=234, Percent_Identity=29.0598290598291, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI87082128, Length=227, Percent_Identity=29.5154185022026, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=25, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1786783, Length=241, Percent_Identity=27.8008298755187, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 84642; Mature: 84642

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELSPTIIALLGLLLAAWTVGAAWLMISAGAKAKGAESTRKAARRMARLLDEAPAIPLLV
CCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEE
RADGRIEGSDRLAHWLGFDALPQFLSELADADDRGLTKAQLSELSEKVRRAQKSAAPFRM
ECCCCCCCHHHHHHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEE
NITVPGSQRSLALRGTLADPQVSPGGAALVWVFDFSESATELSRMREESARAKGDFAALV
EEEECCCCCCEEEEECCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHH
GLIEAAPMPMWFRGTDTRLRLVNSAYVEAVGAESAEGVVEGQVELIESVDGLSAAQVAGQ
HHHHCCCCCEEECCCCCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
AVQHKQSVERIVQATIGGERRALRVSDLPLGEEGVAGYAVDIQEMEEQARAHRAYAKAQR
HHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHH
NMLDRLSVGVAQFDAERKLTFANQPFRRIFNMRLGGLADGLPFERLLSEARDAGRTPEVR
HHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCC
DFPAWRQEHVEWFASGETQEEAWPLSDGTHLRIVAQPMPDGGLAIIAEDRTEQLALSATR
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEECCCCHHHHHHHHH
DTLLRTRTATLDSLFEALAVFAPDGHLQLWNRSFASTWGVEAETLDEHPLVDTMLEEIAG
HHHHHHHHHHHHHHHHHHHHHCCCCCEEHHCCHHHHHCCCCHHCCCCCCHHHHHHHHHHC
NLAKPKHIKRVGEVIRTATLDRNETGSRVALADGRTLEFAGVPLPDGNGLLTTLDVTANE
CCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCCCCCCCEEEEEEECCCH
QAETALRERNQALEQADQVKTRFLANMSYEFRTPLTSIGGFAELLESGVAGELSPQGREY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHH
VQAILDSVGRLTEQVENVLDLSQSEAGLLPLRKEKLELQPFVTQVVREREAEIEAKGLSL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCEE
DLRGGANIKVEADRRQLARAVGHLLDNAIVATDRGGKILVDLAKKPEGTRIVLSDNGAGM
EECCCCEEEEECHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCCCCEEEEECCCCCC
SSEELRRALEGLRISEDGEGIERRQGLGIPLARQLIEAHGGDLTIQSQTGLGTSATILLP
CHHHHHHHHHCCEECCCCCCHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEEEC
>Mature Secondary Structure
MELSPTIIALLGLLLAAWTVGAAWLMISAGAKAKGAESTRKAARRMARLLDEAPAIPLLV
CCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEE
RADGRIEGSDRLAHWLGFDALPQFLSELADADDRGLTKAQLSELSEKVRRAQKSAAPFRM
ECCCCCCCHHHHHHHHCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEE
NITVPGSQRSLALRGTLADPQVSPGGAALVWVFDFSESATELSRMREESARAKGDFAALV
EEEECCCCCCEEEEECCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHH
GLIEAAPMPMWFRGTDTRLRLVNSAYVEAVGAESAEGVVEGQVELIESVDGLSAAQVAGQ
HHHHCCCCCEEECCCCCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
AVQHKQSVERIVQATIGGERRALRVSDLPLGEEGVAGYAVDIQEMEEQARAHRAYAKAQR
HHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHH
NMLDRLSVGVAQFDAERKLTFANQPFRRIFNMRLGGLADGLPFERLLSEARDAGRTPEVR
HHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCC
DFPAWRQEHVEWFASGETQEEAWPLSDGTHLRIVAQPMPDGGLAIIAEDRTEQLALSATR
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEECCCCHHHHHHHHH
DTLLRTRTATLDSLFEALAVFAPDGHLQLWNRSFASTWGVEAETLDEHPLVDTMLEEIAG
HHHHHHHHHHHHHHHHHHHHHCCCCCEEHHCCHHHHHCCCCHHCCCCCCHHHHHHHHHHC
NLAKPKHIKRVGEVIRTATLDRNETGSRVALADGRTLEFAGVPLPDGNGLLTTLDVTANE
CCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCCCCCCCEEEEEEECCCH
QAETALRERNQALEQADQVKTRFLANMSYEFRTPLTSIGGFAELLESGVAGELSPQGREY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHH
VQAILDSVGRLTEQVENVLDLSQSEAGLLPLRKEKLELQPFVTQVVREREAEIEAKGLSL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCEE
DLRGGANIKVEADRRQLARAVGHLLDNAIVATDRGGKILVDLAKKPEGTRIVLSDNGAGM
EECCCCEEEEECHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCCCCEEEEECCCCCC
SSEELRRALEGLRISEDGEGIERRQGLGIPLARQLIEAHGGDLTIQSQTGLGTSATILLP
CHHHHHHHHHCCEECCCCCCHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10557274; 11259647 [H]