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The map label for this gene is ahcY [H]

Identifier: 85373835

GI number: 85373835

Start: 1035678

End: 1037087

Strand: Direct

Name: ahcY [H]

Synonym: ELI_05040

Alternate gene names: 85373835

Gene position: 1035678-1037087 (Clockwise)

Preceding gene: 85373833

Following gene: 85373836

Centisome position: 33.93

GC content: 60.0

Gene sequence:

>1410_bases
ATGTCCGCCAACGCCGATTATGTGATCAAGGATATCGCGCTCGCCAAATATGGCCGCGACGAGATGGCCATCGCTGAAAC
CGAGATGCCGGGCCTGATGGCCTTGCGCGATGAATATGGTGAGAGCCAGCCGCTCAAGGGCGCGCGCATCACTGGCTCGC
TCCACATGACCATCCAGACGGCGGTCTTGATCGAAACGCTGGTCGCGCTGGGTGCCGATGTGCGCTGGGCGACCTGCAAC
ATCTTCTCGACGCAGGATCATGCTGCCGCCGCGATTGCAGAGCAGGGTATCCCCGTGTTCGCGGTCAAGGGCGAGAGCCT
CGCCGATTACTGGGACTATGTCGGCCGCATTTTCGACTGGTCGACGAGCGAAGATGCCGACCAGACCGCCAACCTCATCC
TCGACGATGGCGGCGATGCCACGATGTTTGCGCTATGGGGCGCTCGTATCGAGGCGGGTGAAGAAATGCCTGAGCCCGCC
AATGCGGAAGAAATCGAGATGCAGCGCGCGCTCAAGGCCTTCGTCAAGGACAAGCCCGGTTACCTGACCCGGTCGGTCAA
GAATATCGTCGGCGTGTCTGAAGAGACCACCACCGGCGTTCACCGCCTCTATCACATCGCCAAGGGCGGCAAACTGCCGT
TCCCGGCGATCAATGTGAACGATAGCGTCACCAAGTCGAAATTCGACAATCTCTACGGCTGCCGCGAGTCGCTGGTCGAT
GCAATCCGCCGCGCCACCGATGTCATGCTGTCAGGTAAAGTCGCTTGCGTCGCCGGTTTCGGCGATGTCGGCAAGGGTTC
GGCCCAGTCGCTGCGCAACGGCGGCGCGCGGGTGCTGGTGACGGAAATCGACCCGATCTGCGCCCTTCAGGCCGCGATGG
ACGGCTTCGAAGTGGTAACGATGGAAGAGGCGGTGAAGGTCGCAGATATCTTCTGCACCGCAACCGGCAACGAGCATGTC
ATTACCGCCGAACACATGAAGGCGATGAAGGACAAGGCGATCGTCTGCAACATCGGGCACTTCGACAGTGAGATCCAGAT
TTCCGCGCTGAACAATTACGAGTGGAACGAGTTGAAGCCGGGCACCGATGTCGTGCGCTTCCCCGACGGCAAGGAAATCA
TCATCCTCGGCCAGGGCCGTCTGGTGAACCTCGCTTGTGCCACCGGCCACCCCAGCTTCGTCATGAGCTTCAGCTTTACC
AACCAGGTGCTGGCGCAGATCGAGCTGTGGACTAAGGGCGACGAATACAAGAACGAAGTCTACGTCCTGCCCAAGCATCT
CGACGAGAAGGTTGCAGCGCTGCATTTGAACAAGCTCGGCGTGAAGCTCACCAAGCTCAGCAAGGTCCAGGCCGACTATA
TCGGCGTACCGGTGGATGGCCCTTACAAGCCCGAACACTACCGCTACTGA

Upstream 100 bases:

>100_bases
ATCGTTATATTTGCTCTTTGAGGTACGCATCGCTAAGGCGCGCGCAATCATTTTCGCAGCGCGCAATCCGCCGCCCGCTG
CCACTCTCTAGGAGCAATTT

Downstream 100 bases:

>100_bases
TCGGCGGGAATTCGCGGAAAACGGACAAGCCCTCGCGATTGCGGGGGCTTTTCCTTTTCTGGCCAGTTGCATCGCCGCGC
CGGGCGGCATAGCTGCAATG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MSANADYVIKDIALAKYGRDEMAIAETEMPGLMALRDEYGESQPLKGARITGSLHMTIQTAVLIETLVALGADVRWATCN
IFSTQDHAAAAIAEQGIPVFAVKGESLADYWDYVGRIFDWSTSEDADQTANLILDDGGDATMFALWGARIEAGEEMPEPA
NAEEIEMQRALKAFVKDKPGYLTRSVKNIVGVSEETTTGVHRLYHIAKGGKLPFPAINVNDSVTKSKFDNLYGCRESLVD
AIRRATDVMLSGKVACVAGFGDVGKGSAQSLRNGGARVLVTEIDPICALQAAMDGFEVVTMEEAVKVADIFCTATGNEHV
ITAEHMKAMKDKAIVCNIGHFDSEIQISALNNYEWNELKPGTDVVRFPDGKEIIILGQGRLVNLACATGHPSFVMSFSFT
NQVLAQIELWTKGDEYKNEVYVLPKHLDEKVAALHLNKLGVKLTKLSKVQADYIGVPVDGPYKPEHYRY

Sequences:

>Translated_469_residues
MSANADYVIKDIALAKYGRDEMAIAETEMPGLMALRDEYGESQPLKGARITGSLHMTIQTAVLIETLVALGADVRWATCN
IFSTQDHAAAAIAEQGIPVFAVKGESLADYWDYVGRIFDWSTSEDADQTANLILDDGGDATMFALWGARIEAGEEMPEPA
NAEEIEMQRALKAFVKDKPGYLTRSVKNIVGVSEETTTGVHRLYHIAKGGKLPFPAINVNDSVTKSKFDNLYGCRESLVD
AIRRATDVMLSGKVACVAGFGDVGKGSAQSLRNGGARVLVTEIDPICALQAAMDGFEVVTMEEAVKVADIFCTATGNEHV
ITAEHMKAMKDKAIVCNIGHFDSEIQISALNNYEWNELKPGTDVVRFPDGKEIIILGQGRLVNLACATGHPSFVMSFSFT
NQVLAQIELWTKGDEYKNEVYVLPKHLDEKVAALHLNKLGVKLTKLSKVQADYIGVPVDGPYKPEHYRY
>Mature_468_residues
SANADYVIKDIALAKYGRDEMAIAETEMPGLMALRDEYGESQPLKGARITGSLHMTIQTAVLIETLVALGADVRWATCNI
FSTQDHAAAAIAEQGIPVFAVKGESLADYWDYVGRIFDWSTSEDADQTANLILDDGGDATMFALWGARIEAGEEMPEPAN
AEEIEMQRALKAFVKDKPGYLTRSVKNIVGVSEETTTGVHRLYHIAKGGKLPFPAINVNDSVTKSKFDNLYGCRESLVDA
IRRATDVMLSGKVACVAGFGDVGKGSAQSLRNGGARVLVTEIDPICALQAAMDGFEVVTMEEAVKVADIFCTATGNEHVI
TAEHMKAMKDKAIVCNIGHFDSEIQISALNNYEWNELKPGTDVVRFPDGKEIIILGQGRLVNLACATGHPSFVMSFSFTN
QVLAQIELWTKGDEYKNEVYVLPKHLDEKVAALHLNKLGVKLTKLSKVQADYIGVPVDGPYKPEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=471, Percent_Identity=56.9002123142251, Blast_Score=496, Evalue=1e-140,
Organism=Homo sapiens, GI239937451, Length=443, Percent_Identity=57.5620767494357, Blast_Score=474, Evalue=1e-134,
Organism=Homo sapiens, GI24308043, Length=472, Percent_Identity=47.2457627118644, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI195539337, Length=472, Percent_Identity=47.2457627118644, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI298286489, Length=472, Percent_Identity=47.2457627118644, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI195539349, Length=472, Percent_Identity=47.2457627118644, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI21361647, Length=469, Percent_Identity=46.4818763326226, Blast_Score=410, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17506425, Length=473, Percent_Identity=57.7167019027484, Blast_Score=512, Evalue=1e-145,
Organism=Saccharomyces cerevisiae, GI6320882, Length=487, Percent_Identity=56.2628336755647, Blast_Score=497, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24642172, Length=470, Percent_Identity=59.1489361702128, Blast_Score=516, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24656245, Length=470, Percent_Identity=47.4468085106383, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI45553387, Length=466, Percent_Identity=48.2832618025751, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI45553385, Length=465, Percent_Identity=48.1720430107527, Blast_Score=419, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 51189; Mature: 51058

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANADYVIKDIALAKYGRDEMAIAETEMPGLMALRDEYGESQPLKGARITGSLHMTIQT
CCCCCCEEHHHHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCCCCCCEEEEEEEEEEHHH
AVLIETLVALGADVRWATCNIFSTQDHAAAAIAEQGIPVFAVKGESLADYWDYVGRIFDW
HHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHEECC
STSEDADQTANLILDDGGDATMFALWGARIEAGEEMPEPANAEEIEMQRALKAFVKDKPG
CCCCCCCCCCEEEEECCCCEEEEEEECCEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCC
YLTRSVKNIVGVSEETTTGVHRLYHIAKGGKLPFPAINVNDSVTKSKFDNLYGCRESLVD
HHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHH
AIRRATDVMLSGKVACVAGFGDVGKGSAQSLRNGGARVLVTEIDPICALQAAMDGFEVVT
HHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHCCCCEEEEEECCCHHHHHHHCCCEEEEE
MEEAVKVADIFCTATGNEHVITAEHMKAMKDKAIVCNIGHFDSEIQISALNNYEWNELKP
HHHHHEEEEEEEEECCCCEEEEHHHHHHHCCCEEEEECCCCCCEEEEEEECCCCCCCCCC
GTDVVRFPDGKEIIILGQGRLVNLACATGHPSFVMSFSFTNQVLAQIELWTKGDEYKNEV
CCCEEECCCCCEEEEEECCCEEEEEEECCCCCEEEEECHHHHHHHEEEEEECCCCCCCEE
YVLPKHLDEKVAALHLNKLGVKLTKLSKVQADYIGVPVDGPYKPEHYRY
EEECCCCCCHHHHHHHHHHCEEEEHHHHHHHCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SANADYVIKDIALAKYGRDEMAIAETEMPGLMALRDEYGESQPLKGARITGSLHMTIQT
CCCCCEEHHHHHHHHCCCCCEEEEECCCCCHHHHHHHCCCCCCCCCEEEEEEEEEEHHH
AVLIETLVALGADVRWATCNIFSTQDHAAAAIAEQGIPVFAVKGESLADYWDYVGRIFDW
HHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHEECC
STSEDADQTANLILDDGGDATMFALWGARIEAGEEMPEPANAEEIEMQRALKAFVKDKPG
CCCCCCCCCCEEEEECCCCEEEEEEECCEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCC
YLTRSVKNIVGVSEETTTGVHRLYHIAKGGKLPFPAINVNDSVTKSKFDNLYGCRESLVD
HHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHH
AIRRATDVMLSGKVACVAGFGDVGKGSAQSLRNGGARVLVTEIDPICALQAAMDGFEVVT
HHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHCCCCEEEEEECCCHHHHHHHCCCEEEEE
MEEAVKVADIFCTATGNEHVITAEHMKAMKDKAIVCNIGHFDSEIQISALNNYEWNELKP
HHHHHEEEEEEEEECCCCEEEEHHHHHHHCCCEEEEECCCCCCEEEEEEECCCCCCCCCC
GTDVVRFPDGKEIIILGQGRLVNLACATGHPSFVMSFSFTNQVLAQIELWTKGDEYKNEV
CCCEEECCCCCEEEEEECCCEEEEEEECCCCCEEEEECHHHHHHHEEEEEECCCCCCCEE
YVLPKHLDEKVAALHLNKLGVKLTKLSKVQADYIGVPVDGPYKPEHYRY
EEECCCCCCHHHHHHHHHHCEEEEHHHHHHHCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA