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The map label for this gene is hemA [H]

Identifier: 85373784

GI number: 85373784

Start: 988740

End: 989960

Strand: Reverse

Name: hemA [H]

Synonym: ELI_04785

Alternate gene names: 85373784

Gene position: 989960-988740 (Counterclockwise)

Preceding gene: 85373785

Following gene: 85373783

Centisome position: 32.43

GC content: 62.57

Gene sequence:

>1221_bases
ATGAATTACGACCAGATCTTCGACCAGGCGATCGATCGGCTTCATGCCGAGGGCCGCTACCGGGTGTTCATCGACATCCT
GCGCAACAAGGGTGCTTACCCCAACGCGCGGTGCTTCCACGGCCACAACGGGCCCAAGCCGATCACCGTGTGGTGCTCGA
ACGATTACCTTGCCATGGGGCAGCACCCCAAGGTGATCGAAGCGATGGAAGAGGCGCTGCACGATGTCGGCGCGGGTTCG
GGCGGCACGCGCAATATCGGCGGCAACACGCATTACCATGTCGAGCTTGAAGGCGAACTGGCCGACCTTCACGGCAAGCA
AGCCGCGCTGCTGTTTACCAGCGGCTATGTCTCCAACGACGCGACCCTCAGCACCCTCGCCAAGCTGCTGCCGGGCTGCG
TGATTTTCTCGGACGAACTGAACCACGCCAGCATGATCGCGGGCATCCGCAATTCGGGCTGCGAGAAGCGCGTTTTCCGC
CACAACGATCTCGACCATCTCGAGCAATTGCTGGCGGCCGAAGACGAGGCCGCGCCCAAGGTCATCGCTTTCGAAAGCGT
CTATTCGATGGATGGCGACGTTGCCCCGATCCACGCGATCTGCGACCTGGCCGAGAAGTACAACGCGCTCACCTATGTCG
ACGAAGTCCACGCCGTCGGCATGTATGGCGAACACGGCGGTGGCATTTCCGAGCGCGACGAGGCCGCGCACCGGATCGAC
ATTATCGAAGGCACGATGGGCAAGGCCTTCGGCGTGATGGGCGGCTATATCGCGGCCGACAAGAAGATCGTCGACTGCAT
CCGCTCTTACGCCCCCGGCTTCATCTTCACGACCTCGCTCAGCCCTGCCCTGGTGGCAGGTGTGCTCGCCAGCGTGAAGC
ACCTCAAGCAGTCGAGCGAAGAGCGCGACGCGCAGCAGGCCAATGCGGATTTGCTCAAGGGTAAATTCCGCGCAGCCGGC
CTGCCGGTGATGGACAGCACCACTCATATCGTTCCGCTGATGGTCGGCGATCCTGTCCGCGCCAAGAAGATCAGCGACAT
CCTGCTCGCCGAATACGGCGTCTATGTGCAGCCGATCAATTTCCCGACCGTCCCGCGCGGCACCGAGCGCCTGCGCTTCA
CGCCCGGCCCGATGCACACCGAAGCGATGATGAACGAGCTGACCGGCGCACTGGTCGAGATATGGGACAGGCTGGAGCTG
GACCTGCGCAAGGCCGCTTAG

Upstream 100 bases:

>100_bases
AATACGGTCTCGACTCGATCGAGGCATTCTGATGCGAATCATTCGCAAAGATCGCGCTGGATAGCGGCGGCTTTTGGCAT
TATCGGCCCTCATCGAGCTC

Downstream 100 bases:

>100_bases
CCGTGGCGCAGGCGGCCGATCCCGATTTTCGGCACGAAATGCCCCCTGAAATCGAAAAGCTGCTCGCTGCCGATGGCGAG
CTCAAATCGCGCTGGGACGC

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MNYDQIFDQAIDRLHAEGRYRVFIDILRNKGAYPNARCFHGHNGPKPITVWCSNDYLAMGQHPKVIEAMEEALHDVGAGS
GGTRNIGGNTHYHVELEGELADLHGKQAALLFTSGYVSNDATLSTLAKLLPGCVIFSDELNHASMIAGIRNSGCEKRVFR
HNDLDHLEQLLAAEDEAAPKVIAFESVYSMDGDVAPIHAICDLAEKYNALTYVDEVHAVGMYGEHGGGISERDEAAHRID
IIEGTMGKAFGVMGGYIAADKKIVDCIRSYAPGFIFTTSLSPALVAGVLASVKHLKQSSEERDAQQANADLLKGKFRAAG
LPVMDSTTHIVPLMVGDPVRAKKISDILLAEYGVYVQPINFPTVPRGTERLRFTPGPMHTEAMMNELTGALVEIWDRLEL
DLRKAA

Sequences:

>Translated_406_residues
MNYDQIFDQAIDRLHAEGRYRVFIDILRNKGAYPNARCFHGHNGPKPITVWCSNDYLAMGQHPKVIEAMEEALHDVGAGS
GGTRNIGGNTHYHVELEGELADLHGKQAALLFTSGYVSNDATLSTLAKLLPGCVIFSDELNHASMIAGIRNSGCEKRVFR
HNDLDHLEQLLAAEDEAAPKVIAFESVYSMDGDVAPIHAICDLAEKYNALTYVDEVHAVGMYGEHGGGISERDEAAHRID
IIEGTMGKAFGVMGGYIAADKKIVDCIRSYAPGFIFTTSLSPALVAGVLASVKHLKQSSEERDAQQANADLLKGKFRAAG
LPVMDSTTHIVPLMVGDPVRAKKISDILLAEYGVYVQPINFPTVPRGTERLRFTPGPMHTEAMMNELTGALVEIWDRLEL
DLRKAA
>Mature_406_residues
MNYDQIFDQAIDRLHAEGRYRVFIDILRNKGAYPNARCFHGHNGPKPITVWCSNDYLAMGQHPKVIEAMEEALHDVGAGS
GGTRNIGGNTHYHVELEGELADLHGKQAALLFTSGYVSNDATLSTLAKLLPGCVIFSDELNHASMIAGIRNSGCEKRVFR
HNDLDHLEQLLAAEDEAAPKVIAFESVYSMDGDVAPIHAICDLAEKYNALTYVDEVHAVGMYGEHGGGISERDEAAHRID
IIEGTMGKAFGVMGGYIAADKKIVDCIRSYAPGFIFTTSLSPALVAGVLASVKHLKQSSEERDAQQANADLLKGKFRAAG
LPVMDSTTHIVPLMVGDPVRAKKISDILLAEYGVYVQPINFPTVPRGTERLRFTPGPMHTEAMMNELTGALVEIWDRLEL
DLRKAA

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=406, Percent_Identity=51.4778325123153, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI83977440, Length=406, Percent_Identity=51.4778325123153, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI83977444, Length=406, Percent_Identity=51.4778325123153, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI4502025, Length=406, Percent_Identity=50, Blast_Score=407, Evalue=1e-114,
Organism=Homo sapiens, GI40316939, Length=406, Percent_Identity=50, Blast_Score=407, Evalue=1e-114,
Organism=Homo sapiens, GI7657118, Length=377, Percent_Identity=33.42175066313, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI284448556, Length=358, Percent_Identity=34.3575418994413, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI119220554, Length=366, Percent_Identity=30.0546448087432, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI4758668, Length=400, Percent_Identity=30, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI5454084, Length=251, Percent_Identity=27.4900398406374, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1790046, Length=351, Percent_Identity=37.3219373219373, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1786993, Length=331, Percent_Identity=35.9516616314199, Blast_Score=171, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71994529, Length=385, Percent_Identity=34.025974025974, Blast_Score=227, Evalue=7e-60,
Organism=Caenorhabditis elegans, GI32566772, Length=360, Percent_Identity=29.1666666666667, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17560914, Length=353, Percent_Identity=28.328611898017, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17560912, Length=353, Percent_Identity=28.328611898017, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71982617, Length=290, Percent_Identity=25.5172413793103, Blast_Score=104, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI71982625, Length=290, Percent_Identity=25.5172413793103, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320438, Length=422, Percent_Identity=46.2085308056872, Blast_Score=394, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6320267, Length=372, Percent_Identity=28.494623655914, Blast_Score=146, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6323954, Length=273, Percent_Identity=28.9377289377289, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI17137420, Length=403, Percent_Identity=50.6203473945409, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24662918, Length=356, Percent_Identity=36.7977528089888, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI17136286, Length=363, Percent_Identity=28.3746556473829, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24653280, Length=279, Percent_Identity=26.5232974910394, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24653276, Length=279, Percent_Identity=26.5232974910394, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24653278, Length=279, Percent_Identity=26.5232974910394, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 44297; Mature: 44297

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYDQIFDQAIDRLHAEGRYRVFIDILRNKGAYPNARCFHGHNGPKPITVWCSNDYLAMG
CCHHHHHHHHHHHHHCCCCEEEEEEEHHCCCCCCCCEEECCCCCCCCEEEEECCCEEECC
QHPKVIEAMEEALHDVGAGSGGTRNIGGNTHYHVELEGELADLHGKQAALLFTSGYVSND
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCHHCCCCCCEEEEEECCCCCCC
ATLSTLAKLLPGCVIFSDELNHASMIAGIRNSGCEKRVFRHNDLDHLEQLLAAEDEAAPK
HHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHCCCCCCCC
VIAFESVYSMDGDVAPIHAICDLAEKYNALTYVDEVHAVGMYGEHGGGISERDEAAHRID
EEEEHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHEEE
IIEGTMGKAFGVMGGYIAADKKIVDCIRSYAPGFIFTTSLSPALVAGVLASVKHLKQSSE
EEECCCHHHHHHHCCHHHCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHH
ERDAQQANADLLKGKFRAAGLPVMDSTTHIVPLMVGDPVRAKKISDILLAEYGVYVQPIN
HHHHHHHHHHHHHCHHHHCCCCEECCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEECC
FPTVPRGTERLRFTPGPMHTEAMMNELTGALVEIWDRLELDLRKAA
CCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNYDQIFDQAIDRLHAEGRYRVFIDILRNKGAYPNARCFHGHNGPKPITVWCSNDYLAMG
CCHHHHHHHHHHHHHCCCCEEEEEEEHHCCCCCCCCEEECCCCCCCCEEEEECCCEEECC
QHPKVIEAMEEALHDVGAGSGGTRNIGGNTHYHVELEGELADLHGKQAALLFTSGYVSND
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCHHCCCCCCEEEEEECCCCCCC
ATLSTLAKLLPGCVIFSDELNHASMIAGIRNSGCEKRVFRHNDLDHLEQLLAAEDEAAPK
HHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHCCCCCCCC
VIAFESVYSMDGDVAPIHAICDLAEKYNALTYVDEVHAVGMYGEHGGGISERDEAAHRID
EEEEHHHHCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHEEE
IIEGTMGKAFGVMGGYIAADKKIVDCIRSYAPGFIFTTSLSPALVAGVLASVKHLKQSSE
EEECCCHHHHHHHCCHHHCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHH
ERDAQQANADLLKGKFRAAGLPVMDSTTHIVPLMVGDPVRAKKISDILLAEYGVYVQPIN
HHHHHHHHHHHHHCHHHHCCCCEECCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEECC
FPTVPRGTERLRFTPGPMHTEAMMNELTGALVEIWDRLELDLRKAA
CCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3609750; 12597275 [H]