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The map label for this gene is hmrR [H]

Identifier: 85373704

GI number: 85373704

Start: 905233

End: 905619

Strand: Reverse

Name: hmrR [H]

Synonym: ELI_04385

Alternate gene names: 85373704

Gene position: 905619-905233 (Counterclockwise)

Preceding gene: 85373707

Following gene: 85373701

Centisome position: 29.67

GC content: 59.69

Gene sequence:

>387_bases
ATGAAGATTGGTGCCCTGGCGCGGAAGACCGGCACGACCGCCGAAACGATCCGCTACTACGAACGGACCGGATTGCTGGA
GGAACCACCACGCACCGCCGGAAACTACCGGGACTATGGCCCGACCGAATTGGCCAGATTGCGGTTTATCCGCCGCGCAC
GCGACCTCGGCTTCACCATGGCGGAGGTGCGCCAATTGCTTTCTTTGTCGGATGATCCATCGCAATCGTGCGAAGCCGTG
GACTCTATTGCCAGCCTCCACCTACGCGAAGTGGATCGGAAGCTTGGTGACTTGCGAAAACTGCGAACCGAACTGCGCCA
TATGGTCGACGACTGCCAGCACGGAGCGGTTGGCGAATGCCGGATAATCGAAGTGCTTTCCGGCTAG

Upstream 100 bases:

>100_bases
AATGTCCTTCTTTGCCACAGGATTTTACCGTTCTGCTTGCATCTTCGAATCGTCTTATGCACCTTGTAGTGGCTACAAGG
TCAAGCATTGCGAGAAACCC

Downstream 100 bases:

>100_bases
CGGGACAGCGCGCGTTTATTCGAGCGGTGACGGGACGCAAACCATGATCATCTCGAAATTCGGGGCGTGTTCTGACATAT
CTCGTCGGTGCGTTCGACAA

Product: heavy metal resistance transcriptional regulator Hmrr, MerR family protein

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 128; Mature: 128

Protein sequence:

>128_residues
MKIGALARKTGTTAETIRYYERTGLLEEPPRTAGNYRDYGPTELARLRFIRRARDLGFTMAEVRQLLSLSDDPSQSCEAV
DSIASLHLREVDRKLGDLRKLRTELRHMVDDCQHGAVGECRIIEVLSG

Sequences:

>Translated_128_residues
MKIGALARKTGTTAETIRYYERTGLLEEPPRTAGNYRDYGPTELARLRFIRRARDLGFTMAEVRQLLSLSDDPSQSCEAV
DSIASLHLREVDRKLGDLRKLRTELRHMVDDCQHGAVGECRIIEVLSG
>Mature_128_residues
MKIGALARKTGTTAETIRYYERTGLLEEPPRTAGNYRDYGPTELARLRFIRRARDLGFTMAEVRQLLSLSDDPSQSCEAV
DSIASLHLREVDRKLGDLRKLRTELRHMVDDCQHGAVGECRIIEVLSG

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=129, Percent_Identity=37.984496124031, Blast_Score=92, Evalue=1e-20,
Organism=Escherichia coli, GI1786695, Length=128, Percent_Identity=33.59375, Blast_Score=82, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 14476; Mature: 14476

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGALARKTGTTAETIRYYERTGLLEEPPRTAGNYRDYGPTELARLRFIRRARDLGFTM
CCCCCHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCH
AEVRQLLSLSDDPSQSCEAVDSIASLHLREVDRKLGDLRKLRTELRHMVDDCQHGAVGEC
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
RIIEVLSG
HHHEECCC
>Mature Secondary Structure
MKIGALARKTGTTAETIRYYERTGLLEEPPRTAGNYRDYGPTELARLRFIRRARDLGFTM
CCCCCHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCH
AEVRQLLSLSDDPSQSCEAVDSIASLHLREVDRKLGDLRKLRTELRHMVDDCQHGAVGEC
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
RIIEVLSG
HHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]