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The map label for this gene is uppS [H]

Identifier: 85373586

GI number: 85373586

Start: 785669

End: 786346

Strand: Direct

Name: uppS [H]

Synonym: ELI_03795

Alternate gene names: 85373586

Gene position: 785669-786346 (Clockwise)

Preceding gene: 85373585

Following gene: 85373587

Centisome position: 25.74

GC content: 63.13

Gene sequence:

>678_bases
ATGTCCCATAATCCCGCCAAACACGTCGCCATCATCATGGATGGCAATGGGCGCTGGGCCAAGCGCAAGCACCTGCCGCG
CGCCATGGGGCACCGCAAGGGCGTTGAGGCGGTGCGCGAGCTGGTGCGCAGCCTCAAGGACACCGATATCGAGTGCCTGA
CGCTGTACGCCTTCAGCTCCGAAAACTGGAAGCGGCCCGAGGACGAGGTCGACGACCTGATGGATCTGATGCGCAAGTTC
ATCAAATCCGACTTGCCCGAGTTCATTGCCAACGACGTGAAGCTGCACATCCTTGGCGACTGGCGCGCGCTCGCGCCCGA
TATCGTCGCCATGCTGGAAGATGCGCTGGAGCAGACCAAAAACGGCTCGCGCACGATAGCGGTGGCGCTCAATTACGGTG
GCCAGGCGGAGATCGTCCACGCGGCGCGCGCGGCGGCCGCCACCGGTGAGATCACCGAAGAGGCTATCGAAGCCAATCTG
TTCTCGGCCGGGCTGCCGCCGCTCGACTTGCTGATCCGCACCAGCGGCGAGGTGCGGCTGTCGAATTTCCTGCTGTGGCA
AGCGGCCTATGCGGAAATGCTGTTTGTCGATACCTTGTGGCCCGACTTCACGCCTGCGCACCTGCAGCAGGCGCTCGACA
CTTTCGCCAACAGGGAGAGACGTTTTGGCGGACGCTGA

Upstream 100 bases:

>100_bases
GGGCTGAGCCTGTCGAAGCCCTGTCCTTTTTCTGGCGAGCGTGTGGCTTCAAAAGAAAGTGCAGCCCTTCGACAGGCTCA
GGGCGAACGGATTATGAATA

Downstream 100 bases:

>100_bases
CAACGCACAGGCCATGCCGGTCGGGCGTATTCCCAGGCGCAATGCGGATTTGCCGGTGCGGCTGGCTTCGGCCGTTGTGC
TGCTCGCGATCCTCGGTGCG

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MSHNPAKHVAIIMDGNGRWAKRKHLPRAMGHRKGVEAVRELVRSLKDTDIECLTLYAFSSENWKRPEDEVDDLMDLMRKF
IKSDLPEFIANDVKLHILGDWRALAPDIVAMLEDALEQTKNGSRTIAVALNYGGQAEIVHAARAAAATGEITEEAIEANL
FSAGLPPLDLLIRTSGEVRLSNFLLWQAAYAEMLFVDTLWPDFTPAHLQQALDTFANRERRFGGR

Sequences:

>Translated_225_residues
MSHNPAKHVAIIMDGNGRWAKRKHLPRAMGHRKGVEAVRELVRSLKDTDIECLTLYAFSSENWKRPEDEVDDLMDLMRKF
IKSDLPEFIANDVKLHILGDWRALAPDIVAMLEDALEQTKNGSRTIAVALNYGGQAEIVHAARAAAATGEITEEAIEANL
FSAGLPPLDLLIRTSGEVRLSNFLLWQAAYAEMLFVDTLWPDFTPAHLQQALDTFANRERRFGGR
>Mature_224_residues
SHNPAKHVAIIMDGNGRWAKRKHLPRAMGHRKGVEAVRELVRSLKDTDIECLTLYAFSSENWKRPEDEVDDLMDLMRKFI
KSDLPEFIANDVKLHILGDWRALAPDIVAMLEDALEQTKNGSRTIAVALNYGGQAEIVHAARAAAATGEITEEAIEANLF
SAGLPPLDLLIRTSGEVRLSNFLLWQAAYAEMLFVDTLWPDFTPAHLQQALDTFANRERRFGGR

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=221, Percent_Identity=37.5565610859729, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI45580742, Length=221, Percent_Identity=37.5565610859729, Blast_Score=139, Evalue=2e-33,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=45.1754385964912, Blast_Score=191, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI71993029, Length=222, Percent_Identity=36.9369369369369, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319474, Length=237, Percent_Identity=35.4430379746835, Blast_Score=135, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6323748, Length=214, Percent_Identity=34.1121495327103, Blast_Score=107, Evalue=1e-24,
Organism=Drosophila melanogaster, GI18857969, Length=212, Percent_Identity=32.5471698113208, Blast_Score=120, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 25248; Mature: 25117

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHNPAKHVAIIMDGNGRWAKRKHLPRAMGHRKGVEAVRELVRSLKDTDIECLTLYAFSS
CCCCCCCEEEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECC
ENWKRPEDEVDDLMDLMRKFIKSDLPEFIANDVKLHILGDWRALAPDIVAMLEDALEQTK
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHCC
NGSRTIAVALNYGGQAEIVHAARAAAATGEITEEAIEANLFSAGLPPLDLLIRTSGEVRL
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEECCCCEEH
SNFLLWQAAYAEMLFVDTLWPDFTPAHLQQALDTFANRERRFGGR
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SHNPAKHVAIIMDGNGRWAKRKHLPRAMGHRKGVEAVRELVRSLKDTDIECLTLYAFSS
CCCCCCEEEEEECCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECC
ENWKRPEDEVDDLMDLMRKFIKSDLPEFIANDVKLHILGDWRALAPDIVAMLEDALEQTK
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHCC
NGSRTIAVALNYGGQAEIVHAARAAAATGEITEEAIEANLFSAGLPPLDLLIRTSGEVRL
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEECCCCEEH
SNFLLWQAAYAEMLFVDTLWPDFTPAHLQQALDTFANRERRFGGR
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]