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The map label for this gene is lon [H]

Identifier: 85373565

GI number: 85373565

Start: 762354

End: 764750

Strand: Direct

Name: lon [H]

Synonym: ELI_03690

Alternate gene names: 85373565

Gene position: 762354-764750 (Clockwise)

Preceding gene: 85373564

Following gene: 85373566

Centisome position: 24.98

GC content: 61.66

Gene sequence:

>2397_bases
ATGACACAGCTTTATCCATTGCTGCCGCTGCGCGACATCGTCGTGTTCCCGGGGATGGTGGTTCCCTTGTTCGTGGGCCG
CGACAAATCGGTGGCTGCGCTGGAAGCCGCCATGGAAGCGAGCAAAGACATCATGCTGCTCGCGCAGCTTGATCCCGGCT
GCGACGATCCGGTTCGCGAAGACCTGTATGATGTCGGCGTAGTTGCGCAGGTGCTGCAATTGCTCAAACTGCCAGATGGC
ACCGTGAGGGTCCTCGTCGAAGGCCAGACCCGTGCGCGCCTTTCGACCATGCGCGAAGAGGGCGACTTCGTGATTGCCGA
GGTCGAGCCGATCACGGCGGATGCGATCTCCGGAAGCGAGATCACGGCCCTGATGCGGTCGGTGATCGATCAGTTCGGCG
ATTACGCCAAGCTCAACAAACGGCTGGGCGAAGGTGCATCGGACGATCTGCAGGAGATTGAAGATGCGGGCCAACTGGCC
GATGCGATCGCAGCCGCCATCAACGTCAAGGTATCCGACAAGCAATCGCTCCTGAGCGAGCCCGACGTGCGCAAGCGCCT
GGAAATGGTGCTGTCCTTCATGGAAGGCGAGCTGTCGGTGCTGCAGGTCGAGAAGAAAATTCGAGGTCGCGTCAAGCGGC
AGATGGAGAAGACCCAGCGCGAATATTACCTCAACGAGCAGTTGAAGGCGATCCAGAACGAACTGGGTGGCGGCGACGGT
GAAGACGGCGACGAACTCGCCGAACTGGCCGAGAAGATCGAAAAGATCAAACTTTCCAAGGAAGCCAGGGCCAAGGCCAC
CAGCGAGCTCAAAAAGCTGCGGAGCATGCAGCCGATGAGCGCCGAGGCGACGGTCATCCGCAATTACCTCGATGTGCTGC
TCGGCCTGCCATGGGGCAAGAAGAGCCGCCTGAAGAAGGACATCGGCAAGGCGCAGGAAGTGCTCGACGCAGATCATTAT
GCGCTTGAGAAGGTCAAGGACCGGATCGTCGAATATCTGGCGGTGCAGGCGCGGACCAACAAGCTCAAGGGGCCGATCCT
GTGCCTCGTGGGCCCTCCAGGCGTCGGCAAGACCTCGCTCGGAAAGTCGATCGCCCGGGCTACAGGCCGCGAATTCGTCC
GGCAGTCGCTGGGCGGTGTGCGCGACGAGGCCGAGATCCGCGGTCACCGGCGTACCTACATCGGCTCGCTCCCCGGCAAA
ATCGTCACGAACCTGAAAAAGGCCGGGGCCAGCAACCCGCTGTTCCTGCTCGACGAGATCGACAAGCTGGGCCAGGATTT
CCGGGGCGATCCGGCCTCGGCTCTGCTCGAGGTCCTGGATCCCGAACAAAACAGCAAGTTCCAGGATCACTATCTCGAAC
TCGATATCGACCTGTCGGACATCATGTTCGTCTGCACGGCCAATTCGCTCAACCTGCCGCAGCCCTTGCTCGACCGGATG
GAGATCATCCGTCTGGAAGGCTACACCGAAGACGAGAAGGTCGAGATCGCGACCCGGCACCTGCTGGCGAAGCAGGTCAA
GGCGCACGGGTTGAAGGAAGAGGAGTTCGAGCTCACCGAAGACGGGCTGCGCGACCTGATCCGCTATTACACGCGCGAAG
CGGGCGTGCGCACACTCGAACGCGAAATCGCCAAGCTGGCGCGCAAGAGCCTGCGCAAGATTCTCGAAAAGGAAATCGAG
AGCGTGAGGATCACGCCTGAAAACCTGTCCGACTTCGCCGGCGTGCGCAAGTTCAAGCACGGCATGAGCGAGGAAGAGGC
GCAGATCGGCGCCGTGACCGGGCTCGCCTGGACCGAGGTCGGCGGAGAACTGCTGACCATCGAGAGTGTCACCACGCCAG
GCAAAGGCGAGATCAAGACGACCGGCAAGCTCGGCGAGGTCATGAACGAATCGGTCGCCGCGGCGTTCAGTTTCGTGAAG
GCGAGGGCGCCAGCCTATGGCATCAAGCCTTCGATCTTCCAGCGCAAGAACATCCACATCCACCTGCCCGAGGGGGCCGT
GCCGAAGGATGGACCGAGCGCAGGCATCGGCATGGTGACGTCGATCGTTTCGACGCTCTCGGGAATCGCCGTGCGGCCGG
ATGTCGCGATGACGGGCGAAGTCACGTTGCGCGGTCGTGTGCTAGCGATCGGCGGGCTGAAGGAAAAGCTGCTCGCCGCG
CTGCGGGGCGGGATCAAGACGGTTCTCATCCCGGAAGACAACGTCAAAGACTTGGCCGAGATACCCGAAAATGTGAAACA
GGGGCTGGAGATCCTGCCGGTCAGTCATGTCGACGAGGTTCTCGAGCAAGCGCTGGTCAGTCCGCCGGAACCCATCGAGT
GGACGGAAGCGGACGACCTCGCTAGCCAGCCGGTCAACGAGGTCGGCCAGACCGGCGCTTCACCTACCGCTCATTGA

Upstream 100 bases:

>100_bases
CACCGGTTTTCACAATTTGCAGTGAGCCTTACGTTGCAGCAACGGCCTGCCTTTCCCATATCCGGGGAATGATCAGTGCA
AGGCCAGATACGGAATACAA

Downstream 100 bases:

>100_bases
CGCAGCCGGGCGGTGTTTGAACGCCTCGGGTTGCACTCTGCGACCAAATGGTCGGTTTTCTCGGATAATCGCCCTAGACA
GAACACAGAAAAAAGAGTGT

Product: ATP-dependent Lon protease

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 798; Mature: 797

Protein sequence:

>798_residues
MTQLYPLLPLRDIVVFPGMVVPLFVGRDKSVAALEAAMEASKDIMLLAQLDPGCDDPVREDLYDVGVVAQVLQLLKLPDG
TVRVLVEGQTRARLSTMREEGDFVIAEVEPITADAISGSEITALMRSVIDQFGDYAKLNKRLGEGASDDLQEIEDAGQLA
DAIAAAINVKVSDKQSLLSEPDVRKRLEMVLSFMEGELSVLQVEKKIRGRVKRQMEKTQREYYLNEQLKAIQNELGGGDG
EDGDELAELAEKIEKIKLSKEARAKATSELKKLRSMQPMSAEATVIRNYLDVLLGLPWGKKSRLKKDIGKAQEVLDADHY
ALEKVKDRIVEYLAVQARTNKLKGPILCLVGPPGVGKTSLGKSIARATGREFVRQSLGGVRDEAEIRGHRRTYIGSLPGK
IVTNLKKAGASNPLFLLDEIDKLGQDFRGDPASALLEVLDPEQNSKFQDHYLELDIDLSDIMFVCTANSLNLPQPLLDRM
EIIRLEGYTEDEKVEIATRHLLAKQVKAHGLKEEEFELTEDGLRDLIRYYTREAGVRTLEREIAKLARKSLRKILEKEIE
SVRITPENLSDFAGVRKFKHGMSEEEAQIGAVTGLAWTEVGGELLTIESVTTPGKGEIKTTGKLGEVMNESVAAAFSFVK
ARAPAYGIKPSIFQRKNIHIHLPEGAVPKDGPSAGIGMVTSIVSTLSGIAVRPDVAMTGEVTLRGRVLAIGGLKEKLLAA
LRGGIKTVLIPEDNVKDLAEIPENVKQGLEILPVSHVDEVLEQALVSPPEPIEWTEADDLASQPVNEVGQTGASPTAH

Sequences:

>Translated_798_residues
MTQLYPLLPLRDIVVFPGMVVPLFVGRDKSVAALEAAMEASKDIMLLAQLDPGCDDPVREDLYDVGVVAQVLQLLKLPDG
TVRVLVEGQTRARLSTMREEGDFVIAEVEPITADAISGSEITALMRSVIDQFGDYAKLNKRLGEGASDDLQEIEDAGQLA
DAIAAAINVKVSDKQSLLSEPDVRKRLEMVLSFMEGELSVLQVEKKIRGRVKRQMEKTQREYYLNEQLKAIQNELGGGDG
EDGDELAELAEKIEKIKLSKEARAKATSELKKLRSMQPMSAEATVIRNYLDVLLGLPWGKKSRLKKDIGKAQEVLDADHY
ALEKVKDRIVEYLAVQARTNKLKGPILCLVGPPGVGKTSLGKSIARATGREFVRQSLGGVRDEAEIRGHRRTYIGSLPGK
IVTNLKKAGASNPLFLLDEIDKLGQDFRGDPASALLEVLDPEQNSKFQDHYLELDIDLSDIMFVCTANSLNLPQPLLDRM
EIIRLEGYTEDEKVEIATRHLLAKQVKAHGLKEEEFELTEDGLRDLIRYYTREAGVRTLEREIAKLARKSLRKILEKEIE
SVRITPENLSDFAGVRKFKHGMSEEEAQIGAVTGLAWTEVGGELLTIESVTTPGKGEIKTTGKLGEVMNESVAAAFSFVK
ARAPAYGIKPSIFQRKNIHIHLPEGAVPKDGPSAGIGMVTSIVSTLSGIAVRPDVAMTGEVTLRGRVLAIGGLKEKLLAA
LRGGIKTVLIPEDNVKDLAEIPENVKQGLEILPVSHVDEVLEQALVSPPEPIEWTEADDLASQPVNEVGQTGASPTAH
>Mature_797_residues
TQLYPLLPLRDIVVFPGMVVPLFVGRDKSVAALEAAMEASKDIMLLAQLDPGCDDPVREDLYDVGVVAQVLQLLKLPDGT
VRVLVEGQTRARLSTMREEGDFVIAEVEPITADAISGSEITALMRSVIDQFGDYAKLNKRLGEGASDDLQEIEDAGQLAD
AIAAAINVKVSDKQSLLSEPDVRKRLEMVLSFMEGELSVLQVEKKIRGRVKRQMEKTQREYYLNEQLKAIQNELGGGDGE
DGDELAELAEKIEKIKLSKEARAKATSELKKLRSMQPMSAEATVIRNYLDVLLGLPWGKKSRLKKDIGKAQEVLDADHYA
LEKVKDRIVEYLAVQARTNKLKGPILCLVGPPGVGKTSLGKSIARATGREFVRQSLGGVRDEAEIRGHRRTYIGSLPGKI
VTNLKKAGASNPLFLLDEIDKLGQDFRGDPASALLEVLDPEQNSKFQDHYLELDIDLSDIMFVCTANSLNLPQPLLDRME
IIRLEGYTEDEKVEIATRHLLAKQVKAHGLKEEEFELTEDGLRDLIRYYTREAGVRTLEREIAKLARKSLRKILEKEIES
VRITPENLSDFAGVRKFKHGMSEEEAQIGAVTGLAWTEVGGELLTIESVTTPGKGEIKTTGKLGEVMNESVAAAFSFVKA
RAPAYGIKPSIFQRKNIHIHLPEGAVPKDGPSAGIGMVTSIVSTLSGIAVRPDVAMTGEVTLRGRVLAIGGLKEKLLAAL
RGGIKTVLIPEDNVKDLAEIPENVKQGLEILPVSHVDEVLEQALVSPPEPIEWTEADDLASQPVNEVGQTGASPTAH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=681, Percent_Identity=41.1160058737151, Blast_Score=519, Evalue=1e-147,
Organism=Homo sapiens, GI31377667, Length=776, Percent_Identity=38.5309278350515, Blast_Score=508, Evalue=1e-144,
Organism=Escherichia coli, GI1786643, Length=773, Percent_Identity=59.379042690815, Blast_Score=927, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=716, Percent_Identity=38.268156424581, Blast_Score=489, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17556486, Length=544, Percent_Identity=39.3382352941176, Blast_Score=416, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6319449, Length=713, Percent_Identity=41.6549789621318, Blast_Score=524, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24666867, Length=683, Percent_Identity=40.99560761347, Blast_Score=506, Evalue=1e-143,
Organism=Drosophila melanogaster, GI221513036, Length=683, Percent_Identity=40.99560761347, Blast_Score=505, Evalue=1e-143,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87386; Mature: 87254

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLYPLLPLRDIVVFPGMVVPLFVGRDKSVAALEAAMEASKDIMLLAQLDPGCDDPVRE
CCCCCCCCCHHHHHHCCCHHHHHEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHH
DLYDVGVVAQVLQLLKLPDGTVRVLVEGQTRARLSTMREEGDFVIAEVEPITADAISGSE
HHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCHH
ITALMRSVIDQFGDYAKLNKRLGEGASDDLQEIEDAGQLADAIAAAINVKVSDKQSLLSE
HHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEECCHHHHHCC
PDVRKRLEMVLSFMEGELSVLQVEKKIRGRVKRQMEKTQREYYLNEQLKAIQNELGGGDG
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
EDGDELAELAEKIEKIKLSKEARAKATSELKKLRSMQPMSAEATVIRNYLDVLLGLPWGK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCC
KSRLKKDIGKAQEVLDADHYALEKVKDRIVEYLAVQARTNKLKGPILCLVGPPGVGKTSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHH
GKSIARATGREFVRQSLGGVRDEAEIRGHRRTYIGSLPGKIVTNLKKAGASNPLFLLDEI
HHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHCCCHHHHHHHHHCCCCCCEEHHHHH
DKLGQDFRGDPASALLEVLDPEQNSKFQDHYLELDIDLSDIMFVCTANSLNLPQPLLDRM
HHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCEEEECCHHHEEEEEECCCCCCCHHHHHHH
EIIRLEGYTEDEKVEIATRHLLAKQVKAHGLKEEEFELTEDGLRDLIRYYTREAGVRTLE
HHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
REIAKLARKSLRKILEKEIESVRITPENLSDFAGVRKFKHGMSEEEAQIGAVTGLAWTEV
HHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHC
GGELLTIESVTTPGKGEIKTTGKLGEVMNESVAAAFSFVKARAPAYGIKPSIFQRKNIHI
CCCEEEEEECCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
HLPEGAVPKDGPSAGIGMVTSIVSTLSGIAVRPDVAMTGEVTLRGRVLAIGGLKEKLLAA
ECCCCCCCCCCCCCHHHHHHHHHHHHHCCEECCCCEEECCEEECCEEEEECCHHHHHHHH
LRGGIKTVLIPEDNVKDLAEIPENVKQGLEILPVSHVDEVLEQALVSPPEPIEWTEADDL
HHCCCEEEEECCCCHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHCCCCCCCCCCCCHHH
ASQPVNEVGQTGASPTAH
HHCCHHHHHCCCCCCCCC
>Mature Secondary Structure 
TQLYPLLPLRDIVVFPGMVVPLFVGRDKSVAALEAAMEASKDIMLLAQLDPGCDDPVRE
CCCCCCCCHHHHHHCCCHHHHHEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHH
DLYDVGVVAQVLQLLKLPDGTVRVLVEGQTRARLSTMREEGDFVIAEVEPITADAISGSE
HHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCHH
ITALMRSVIDQFGDYAKLNKRLGEGASDDLQEIEDAGQLADAIAAAINVKVSDKQSLLSE
HHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCEECCHHHHHCC
PDVRKRLEMVLSFMEGELSVLQVEKKIRGRVKRQMEKTQREYYLNEQLKAIQNELGGGDG
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
EDGDELAELAEKIEKIKLSKEARAKATSELKKLRSMQPMSAEATVIRNYLDVLLGLPWGK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCC
KSRLKKDIGKAQEVLDADHYALEKVKDRIVEYLAVQARTNKLKGPILCLVGPPGVGKTSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHH
GKSIARATGREFVRQSLGGVRDEAEIRGHRRTYIGSLPGKIVTNLKKAGASNPLFLLDEI
HHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHCCCHHHHHHHHHCCCCCCEEHHHHH
DKLGQDFRGDPASALLEVLDPEQNSKFQDHYLELDIDLSDIMFVCTANSLNLPQPLLDRM
HHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCEEEECCHHHEEEEEECCCCCCCHHHHHHH
EIIRLEGYTEDEKVEIATRHLLAKQVKAHGLKEEEFELTEDGLRDLIRYYTREAGVRTLE
HHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
REIAKLARKSLRKILEKEIESVRITPENLSDFAGVRKFKHGMSEEEAQIGAVTGLAWTEV
HHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHC
GGELLTIESVTTPGKGEIKTTGKLGEVMNESVAAAFSFVKARAPAYGIKPSIFQRKNIHI
CCCEEEEEECCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
HLPEGAVPKDGPSAGIGMVTSIVSTLSGIAVRPDVAMTGEVTLRGRVLAIGGLKEKLLAA
ECCCCCCCCCCCCCHHHHHHHHHHHHHCCEECCCCEEECCEEECCEEEEECCHHHHHHHH
LRGGIKTVLIPEDNVKDLAEIPENVKQGLEILPVSHVDEVLEQALVSPPEPIEWTEADDL
HHCCCEEEEECCCCHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHCCCCCCCCCCCCHHH
ASQPVNEVGQTGASPTAH
HHCCHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655539 [H]