Click here to switch to the map view.

The map label for this gene is aroB [H]

Identifier: 85373478

GI number: 85373478

Start: 687943

End: 689487

Strand: Direct

Name: aroB [H]

Synonym: ELI_03255

Alternate gene names: 85373478

Gene position: 687943-689487 (Clockwise)

Preceding gene: 85373477

Following gene: 85373479

Centisome position: 22.54

GC content: 65.18

Gene sequence:

>1545_bases
ATGGCGATCGGGGGGCGCCGTAGGGATCGGGACGGGCTCTTCATGGGCAACGTCCCGCACCGCGCGATCATTGATGTCGG
CTCCAACACGGTGCGCCTGGTGGTCTATGGCGGTTCGCCGCGCGCTCCGACGGTATTGCTCAATGAAAAGGTCGCCGCGC
GGCTAGGGCGCGATATCACCACTACAGGTGCCCTTGCCGAAGAAGCCATCGACCTCGCGATGCGCGGGCTCGAACGGTAT
GCGCTCCTTCTCCGGGACCTGGACATCCAAGAGGTCGATATGGTCGCGACCGCTGCGGCCCGCGATGCCAGCAACGGCCC
CGAATTCCTGCGCAAGGTGGAGGCGCTGGGCTTTTCGCCGCATCTCCTCTCGGGCGAGGAAGAGGGCAATATCAGCGCCT
GGGGCGTGCTCGGGGCGTTTCCAAAGGCGCGCGGCGTGGTGGCCGATCTGGGCGGGGGCAGTCTCGAGCTCGTCCATATC
GGTGACGGATCGCCGGACACTGCGATCAGCCTGCCGCTCGGCACCTTGCGGCTGACCGAGCTGGACGAGGCCAGTCCCGG
CAAACTGCACAAGGTGATCCAGTCACGGCTGAAGGACGCCAAGGCGCATAGATCCATCGACGGGGATCTGTATCTGGTCG
GCGGAACCTGGCGCGCCATGGCGGTCTACGCGATCGAGAAACTGGGCTTCCCGCTGACCGATCCGCACGGGCTCAGCCTG
CCTGCCGAAGAGGCGCTGGCGATGGCCAAGGAACTCGCGGAAAGCGATCCCGAGGACCTGCGATCGATGGAGCGAATATC
GACCATGCGCTCGGACACGATGCCGCTTGCGGCGGTCCTGCTGCAGGTGCTCATCAAGAAACTCCGGCCGGACCGGGTGA
TCGCATCGTCCTGGGGCATTCGCGAAGGGGTGTTGTACCAGTCGCTGGCCCCGCATGCCCGCGCGCAGGATCCGCTGATC
GCGGGCGTCTCGACCTTTGCCGCGTCGCGGGGTGCTTCGCCGACGATGGCAACGAGGATTGCCAGCTGGACGGTCGATGC
CGCACCTGCTCATGGGCGCGGTACCGAGCGGATCAGGTTGGCCGCGACCATGCTGTCGCTCGCGGCCATGCAGATCGAGC
CCAATTTACGCTTGCGGGTCGGTATCGAATGGGCGCTGCACAAGCGCTGGATTGCGATTGAGCCCGAGGGACGGGCGATG
ATTGCCGCAGCCATCTGTGCCAATCGCAACCATTGCGACCTGCCCGACGAGGTCAAGCAGCTGGCGAGCAAGAAGAGCCT
CGACCAGGCTATCGGATGGGGACTGGCCGTACGCCTGTGTCGCCGGATCGGTGGCAAATCGCGCCAGTCGCTGCAACGGA
CCCGCCTCCTCGTCGAGGACAAGCAATTGGTGCTTTCTCTGGACGAAAGCCATGCTGCGCTTTTCGGTATCCCGAACGAA
AAGGATCTGAACCTCTTGGCCGACTGGCTCGGCCTCGAGCCCGCGATGCGCGTGGAAGCATCGCCGTGGGTCGAAAGTCC
CGCGGACGCTGTTGCCGAGGGGTGA

Upstream 100 bases:

>100_bases
CCACCGCTATTTCATGACCAACCCGTCGCTCTCGGGGCGCGGGGGTGCATTGGAGGCCGGAGCCGTGCCCAAGCTTGCCT
TGCGGAAGGGTGCCGTCTGA

Downstream 100 bases:

>100_bases
CACTCGCGATGATCGAAATGCAGAGAATCGGGAACTTTCGCGCAATACTATTGCAACGCATACGTATTCCGGTTTAGCTT
CCTTCCCAGACGCCGCGCAA

Product: exopolyphosphatase

Products: NA

Alternate protein names: 3-dehydroquinate synthase; Unknown phosphatase [H]

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MAIGGRRRDRDGLFMGNVPHRAIIDVGSNTVRLVVYGGSPRAPTVLLNEKVAARLGRDITTTGALAEEAIDLAMRGLERY
ALLLRDLDIQEVDMVATAAARDASNGPEFLRKVEALGFSPHLLSGEEEGNISAWGVLGAFPKARGVVADLGGGSLELVHI
GDGSPDTAISLPLGTLRLTELDEASPGKLHKVIQSRLKDAKAHRSIDGDLYLVGGTWRAMAVYAIEKLGFPLTDPHGLSL
PAEEALAMAKELAESDPEDLRSMERISTMRSDTMPLAAVLLQVLIKKLRPDRVIASSWGIREGVLYQSLAPHARAQDPLI
AGVSTFAASRGASPTMATRIASWTVDAAPAHGRGTERIRLAATMLSLAAMQIEPNLRLRVGIEWALHKRWIAIEPEGRAM
IAAAICANRNHCDLPDEVKQLASKKSLDQAIGWGLAVRLCRRIGGKSRQSLQRTRLLVEDKQLVLSLDESHAALFGIPNE
KDLNLLADWLGLEPAMRVEASPWVESPADAVAEG

Sequences:

>Translated_514_residues
MAIGGRRRDRDGLFMGNVPHRAIIDVGSNTVRLVVYGGSPRAPTVLLNEKVAARLGRDITTTGALAEEAIDLAMRGLERY
ALLLRDLDIQEVDMVATAAARDASNGPEFLRKVEALGFSPHLLSGEEEGNISAWGVLGAFPKARGVVADLGGGSLELVHI
GDGSPDTAISLPLGTLRLTELDEASPGKLHKVIQSRLKDAKAHRSIDGDLYLVGGTWRAMAVYAIEKLGFPLTDPHGLSL
PAEEALAMAKELAESDPEDLRSMERISTMRSDTMPLAAVLLQVLIKKLRPDRVIASSWGIREGVLYQSLAPHARAQDPLI
AGVSTFAASRGASPTMATRIASWTVDAAPAHGRGTERIRLAATMLSLAAMQIEPNLRLRVGIEWALHKRWIAIEPEGRAM
IAAAICANRNHCDLPDEVKQLASKKSLDQAIGWGLAVRLCRRIGGKSRQSLQRTRLLVEDKQLVLSLDESHAALFGIPNE
KDLNLLADWLGLEPAMRVEASPWVESPADAVAEG
>Mature_513_residues
AIGGRRRDRDGLFMGNVPHRAIIDVGSNTVRLVVYGGSPRAPTVLLNEKVAARLGRDITTTGALAEEAIDLAMRGLERYA
LLLRDLDIQEVDMVATAAARDASNGPEFLRKVEALGFSPHLLSGEEEGNISAWGVLGAFPKARGVVADLGGGSLELVHIG
DGSPDTAISLPLGTLRLTELDEASPGKLHKVIQSRLKDAKAHRSIDGDLYLVGGTWRAMAVYAIEKLGFPLTDPHGLSLP
AEEALAMAKELAESDPEDLRSMERISTMRSDTMPLAAVLLQVLIKKLRPDRVIASSWGIREGVLYQSLAPHARAQDPLIA
GVSTFAASRGASPTMATRIASWTVDAAPAHGRGTERIRLAATMLSLAAMQIEPNLRLRVGIEWALHKRWIAIEPEGRAMI
AAAICANRNHCDLPDEVKQLASKKSLDQAIGWGLAVRLCRRIGGKSRQSLQRTRLLVEDKQLVLSLDESHAALFGIPNEK
DLNLLADWLGLEPAMRVEASPWVESPADAVAEG

Specific function: Conversion Of Pppgpp To Ppgpp. Guanosine Pentaphosphate (Pppgpp) Is A Cytoplasmic Signaling Molecule Which Together With Ppgpp Controls The "Stringent Response", An Adaptive Process That Allows Bacteria To Respond To Amino Acid Starvation, Resulting In T

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=158, Percent_Identity=33.5443037974684, Blast_Score=65, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6321185, Length=440, Percent_Identity=25.6818181818182, Blast_Score=87, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002658
- InterPro:   IPR016037
- InterPro:   IPR003695 [H]

Pfam domain/function: PF01761 DHQ_synthase; PF02541 Ppx-GppA [H]

EC number: =4.2.3.4 [H]

Molecular weight: Translated: 55385; Mature: 55254

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIGGRRRDRDGLFMGNVPHRAIIDVGSNTVRLVVYGGSPRAPTVLLNEKVAARLGRDIT
CCCCCCCCCCCCEEECCCCCEEEEECCCCEEEEEEECCCCCCCEEEECHHHHHHHCCCCC
TTGALAEEAIDLAMRGLERYALLLRDLDIQEVDMVATAAARDASNGPEFLRKVEALGFSP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCC
HLLSGEEEGNISAWGVLGAFPKARGVVADLGGGSLELVHIGDGSPDTAISLPLGTLRLTE
CCCCCCCCCCEEEEEHHHCCCCCCCEEEECCCCEEEEEECCCCCCCCEEECCCCEEEEEE
LDEASPGKLHKVIQSRLKDAKAHRSIDGDLYLVGGTWRAMAVYAIEKLGFPLTDPHGLSL
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCCC
PAEEALAMAKELAESDPEDLRSMERISTMRSDTMPLAAVLLQVLIKKLRPDRVIASSWGI
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEECCCCCC
REGVLYQSLAPHARAQDPLIAGVSTFAASRGASPTMATRIASWTVDAAPAHGRGTERIRL
HHCHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHEEEECCCCCCCCCHHHHH
AATMLSLAAMQIEPNLRLRVGIEWALHKRWIAIEPEGRAMIAAAICANRNHCDLPDEVKQ
HHHHHHHHHHEECCCCEEEEEEEEEEECEEEEECCCCCEEEEEEHHCCCCCCCCHHHHHH
LASKKSLDQAIGWGLAVRLCRRIGGKSRQSLQRTRLLVEDKQLVLSLDESHAALFGIPNE
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCC
KDLNLLADWLGLEPAMRVEASPWVESPADAVAEG
CCHHHHHHHHCCCCCCEECCCCCCCCCHHHHCCC
>Mature Secondary Structure 
AIGGRRRDRDGLFMGNVPHRAIIDVGSNTVRLVVYGGSPRAPTVLLNEKVAARLGRDIT
CCCCCCCCCCCEEECCCCCEEEEECCCCEEEEEEECCCCCCCEEEECHHHHHHHCCCCC
TTGALAEEAIDLAMRGLERYALLLRDLDIQEVDMVATAAARDASNGPEFLRKVEALGFSP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCC
HLLSGEEEGNISAWGVLGAFPKARGVVADLGGGSLELVHIGDGSPDTAISLPLGTLRLTE
CCCCCCCCCCEEEEEHHHCCCCCCCEEEECCCCEEEEEECCCCCCCCEEECCCCEEEEEE
LDEASPGKLHKVIQSRLKDAKAHRSIDGDLYLVGGTWRAMAVYAIEKLGFPLTDPHGLSL
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCCC
PAEEALAMAKELAESDPEDLRSMERISTMRSDTMPLAAVLLQVLIKKLRPDRVIASSWGI
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEECCCCCC
REGVLYQSLAPHARAQDPLIAGVSTFAASRGASPTMATRIASWTVDAAPAHGRGTERIRL
HHCHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHEEEECCCCCCCCCHHHHH
AATMLSLAAMQIEPNLRLRVGIEWALHKRWIAIEPEGRAMIAAAICANRNHCDLPDEVKQ
HHHHHHHHHHEECCCCEEEEEEEEEEECEEEEECCCCCEEEEEEHHCCCCCCCCHHHHHH
LASKKSLDQAIGWGLAVRLCRRIGGKSRQSLQRTRLLVEDKQLVLSLDESHAALFGIPNE
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCC
KDLNLLADWLGLEPAMRVEASPWVESPADAVAEG
CCHHHHHHHHCCCCCCEECCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11889109 [H]