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The map label for this gene is soxR [H]

Identifier: 85373417

GI number: 85373417

Start: 622928

End: 623371

Strand: Reverse

Name: soxR [H]

Synonym: ELI_02950

Alternate gene names: 85373417

Gene position: 623371-622928 (Counterclockwise)

Preceding gene: 85373419

Following gene: 85373416

Centisome position: 20.42

GC content: 68.24

Gene sequence:

>444_bases
ATGAAAGCGAACGATCTTCTGCCCATCGGCGAACTTGCGCGGCGGACCGGCCTCTCGGTATCCGCGATCCGCTATTACGA
GGACAAGGGCCTGGTCGAAGCGCTGCGTACCGGCGGCAACCAGCGCCGCTTCCTGCGCGGCGACATCCGGCGACTAAGTT
TTATCCTGATCGCCCAGCGGCTGGGCTTGTCGCTGGCCGAGATCGAAGACCAGCTCGCGCGCCTGCCGCAGGGTCGCAAT
CCGACCGCGCGCGACTGGAAGCGGATCAGCACCGCCATCCGCGGCCAGCTCGATGCGCGCATTGCGGAACTGGAGCGGGC
CCGCGACCGGCTCGACGGGTGCATCGGCTGCGGCTGCCTGAGCCTGAAGCACTGCGCGCTCTACAATCCGGACGATGCGC
TGGCCGCCGAGGGCGCGGGGCCGCGCCACGTGCTCGATCCTTAA

Upstream 100 bases:

>100_bases
CGGATCGCAACCGACCCGCGCTCCTGCCATGCAACGCCCACAGTGATGCAACCTCAAGCTGACTTGAGGTCAAGCCCGAT
TTTCCCTATCGGTCTGATCG

Downstream 100 bases:

>100_bases
CTACGCGCAATCCGCAGGTTTTCCTTACCAATTCCCTGCAACCGGGCGCTTTTCTCGGCAAATAGGATGAAAACGACAGG
CGTTTCGCCCGTTTTAACCA

Product: redox-sensitive transcriptional activator SoxR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 147; Mature: 147

Protein sequence:

>147_residues
MKANDLLPIGELARRTGLSVSAIRYYEDKGLVEALRTGGNQRRFLRGDIRRLSFILIAQRLGLSLAEIEDQLARLPQGRN
PTARDWKRISTAIRGQLDARIAELERARDRLDGCIGCGCLSLKHCALYNPDDALAAEGAGPRHVLDP

Sequences:

>Translated_147_residues
MKANDLLPIGELARRTGLSVSAIRYYEDKGLVEALRTGGNQRRFLRGDIRRLSFILIAQRLGLSLAEIEDQLARLPQGRN
PTARDWKRISTAIRGQLDARIAELERARDRLDGCIGCGCLSLKHCALYNPDDALAAEGAGPRHVLDP
>Mature_147_residues
MKANDLLPIGELARRTGLSVSAIRYYEDKGLVEALRTGGNQRRFLRGDIRRLSFILIAQRLGLSLAEIEDQLARLPQGRN
PTARDWKRISTAIRGQLDARIAELERARDRLDGCIGCGCLSLKHCALYNPDDALAAEGAGPRHVLDP

Specific function: Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster i

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790498, Length=141, Percent_Identity=48.936170212766, Blast_Score=139, Evalue=8e-35,
Organism=Escherichia coli, GI1789687, Length=127, Percent_Identity=34.6456692913386, Blast_Score=60, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR010211
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 16274; Mature: 16274

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKANDLLPIGELARRTGLSVSAIRYYEDKGLVEALRTGGNQRRFLRGDIRRLSFILIAQR
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LGLSLAEIEDQLARLPQGRNPTARDWKRISTAIRGQLDARIAELERARDRLDGCIGCGCL
HCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLKHCALYNPDDALAAEGAGPRHVLDP
HHHHHCCCCCCHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKANDLLPIGELARRTGLSVSAIRYYEDKGLVEALRTGGNQRRFLRGDIRRLSFILIAQR
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LGLSLAEIEDQLARLPQGRNPTARDWKRISTAIRGQLDARIAELERARDRLDGCIGCGCL
HCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLKHCALYNPDDALAAEGAGPRHVLDP
HHHHHCCCCCCHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9045804; 10984043 [H]