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The map label for this gene is hisG

Identifier: 85373347

GI number: 85373347

Start: 562076

End: 562771

Strand: Reverse

Name: hisG

Synonym: ELI_02600

Alternate gene names: 85373347

Gene position: 562771-562076 (Counterclockwise)

Preceding gene: 85373349

Following gene: 85373346

Centisome position: 18.44

GC content: 63.36

Gene sequence:

>696_bases
TTGCTCTTTGCGCGCTCGCTGCCTATCTGCGCCGCCATGCCGCAAAGCCAGCTGACATTCGCCGTGCCCAAGGGCCGCAT
CCTGGAGGAAGCGCTTCCGGTTATGGCGCGCGCCGGTGTCGTGCCCGAGGACGGCTTCCACGACAAGTCCAACCGCGCGC
TGTCCTTTGCCACTTCGCGCGAGGACATGCGCATGATCCGCGTACGCGCCTTCGATGTCGCCACATTCGTCGCTCATGGT
GCCGCGCAGCTTGGGATCGTCGGCTCCGACGTGATCGAGGAATTCGACTATTCGGACCTCTACGCACCGGTCGATCTCGA
TATCGGGCATTGCCACCTGGCCGTGGCCGAACCTGCCGAGAGCGCGGGCGCGATCGGCAGCGCCAGCCACCTGCGCGTCG
CGACCAAATATCCCAACCTTACACGCCGCCATTTCGAGCGCATGGGCATTCAGGCCGAATGCGTGAAGCTCAATGGCGCG
ATGGAATTGGCGCCCTCGCTGGGTCTTGCCGGGTGCATCGTCGATCTCGTTTCGACCGGGCGCACGCTGAAGGAAAACGG
GCTTGTCGAAACCTCGCGCATACTCGACATTTCCGCGCGGCTGATCGTCAATCGCGCGGCGCTCAAGACCGATAGTCGCG
TAGCCGAGCTGGTCGAGGCATTCCGTGCCGATGCAGACAATCGGAAAGCAGCATAG

Upstream 100 bases:

>100_bases
TGCTGCGCCTGCCACTCGATCGCTTCGTCGAGGGACTTGATGTCCATTACGCCAGTCGTCGCCATAGCTCTTCGCCCCCG
TGAAACCTTGCCCTTTGCGA

Downstream 100 bases:

>100_bases
TGCAGCGCCTCAAGAACACCGATCCCGATTTCGAAGCGAAATTCGCCAAGATCGTCGAAGCCCGCCGCGAGAGTTCGCAG
GACGTAGGGCGCGACGTCTT

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MLFARSLPICAAMPQSQLTFAVPKGRILEEALPVMARAGVVPEDGFHDKSNRALSFATSREDMRMIRVRAFDVATFVAHG
AAQLGIVGSDVIEEFDYSDLYAPVDLDIGHCHLAVAEPAESAGAIGSASHLRVATKYPNLTRRHFERMGIQAECVKLNGA
MELAPSLGLAGCIVDLVSTGRTLKENGLVETSRILDISARLIVNRAALKTDSRVAELVEAFRADADNRKAA

Sequences:

>Translated_231_residues
MLFARSLPICAAMPQSQLTFAVPKGRILEEALPVMARAGVVPEDGFHDKSNRALSFATSREDMRMIRVRAFDVATFVAHG
AAQLGIVGSDVIEEFDYSDLYAPVDLDIGHCHLAVAEPAESAGAIGSASHLRVATKYPNLTRRHFERMGIQAECVKLNGA
MELAPSLGLAGCIVDLVSTGRTLKENGLVETSRILDISARLIVNRAALKTDSRVAELVEAFRADADNRKAA
>Mature_231_residues
MLFARSLPICAAMPQSQLTFAVPKGRILEEALPVMARAGVVPEDGFHDKSNRALSFATSREDMRMIRVRAFDVATFVAHG
AAQLGIVGSDVIEEFDYSDLYAPVDLDIGHCHLAVAEPAESAGAIGSASHLRVATKYPNLTRRHFERMGIQAECVKLNGA
MELAPSLGLAGCIVDLVSTGRTLKENGLVETSRILDISARLIVNRAALKTDSRVAELVEAFRADADNRKAA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=199, Percent_Identity=34.6733668341709, Blast_Score=94, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6320896, Length=211, Percent_Identity=29.3838862559242, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 24874; Mature: 24874

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFARSLPICAAMPQSQLTFAVPKGRILEEALPVMARAGVVPEDGFHDKSNRALSFATSR
CCCCCCCCHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCH
EDMRMIRVRAFDVATFVAHGAAQLGIVGSDVIEEFDYSDLYAPVDLDIGHCHLAVAEPAE
HHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCH
SAGAIGSASHLRVATKYPNLTRRHFERMGIQAECVKLNGAMELAPSLGLAGCIVDLVSTG
HCCCCCCCCCEEEEECCCCHHHHHHHHCCCEEEEEEECCCHHHCCCCCHHHHHHHHHHCC
RTLKENGLVETSRILDISARLIVNRAALKTDSRVAELVEAFRADADNRKAA
CCHHHCCCEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLFARSLPICAAMPQSQLTFAVPKGRILEEALPVMARAGVVPEDGFHDKSNRALSFATSR
CCCCCCCCHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCH
EDMRMIRVRAFDVATFVAHGAAQLGIVGSDVIEEFDYSDLYAPVDLDIGHCHLAVAEPAE
HHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCH
SAGAIGSASHLRVATKYPNLTRRHFERMGIQAECVKLNGAMELAPSLGLAGCIVDLVSTG
HCCCCCCCCCEEEEECCCCHHHHHHHHCCCEEEEEEECCCHHHCCCCCHHHHHHHHHHCC
RTLKENGLVETSRILDISARLIVNRAALKTDSRVAELVEAFRADADNRKAA
CCHHHCCCEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA